Collection of regulogs for LacI transcription factor family

LacI family of transcription factors includes widespread bacterial regulators of carbohydrate catabolic pathways (e.g. pathways utilizing lactose, galactose, ribose, fructose, gluconate, maltose etc) [8543068]. In most cases, effectors of LacI-family regulators are sugars or their phosphorylated counterparts. The global catabolite control regulator CcpA controls major sugar catabolic pathways in Firmicutes in response to glucose availability [22900538]. The purine repressor PurR in Enterobacteria controls the nucleotide uptake and biosynthesis genes in response to hypoxanthine or guanine [21572102]. more

Most of LacI-family regulators are repressors, while some act as both repressors and activators. Binding of an effector ligand changes DNA-binding affinity of a LacI-family regulator [19269243]. LacI-family regulators consist of two characteristic domains, an N-terminal HTH DNA binding domain (PF00356) and a C-terminal effector binding domain (PF00532).