Regulog GalR - Lactobacillaceae

Properties
Regulator type:	Transcription factor
Regulator family:	LacI
Regulation mode:	repressor
Biological process:	Galactosides utilization; Galactose utilization
Effector:	Galactose
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 30 sites [see more]

Member of regulog collections

By taxonomy - Lactobacillaceae
By TF family - LacI
By effector - Galactose
By pathway - Galactosides utilization
By pathway - Galactose utilization

Statistics of regulated genes
Genome	Genes	Operons
Lactobacillus acidophilus NCFM
Lactobacillus brevis ATCC 367	7	3
Lactobacillus casei ATCC 334	5	1
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365
Lactobacillus fermentum IFO 3956	2	1
Lactobacillus helveticus DPC 4571
Lactobacillus johnsonii NCC 533
Lactobacillus plantarum WCFS1	8	3
Lactobacillus reuteri JCM 1112	7	4
Lactobacillus rhamnosus GG	5	1
Lactobacillus sakei subsp. sakei 23K	7	3
Lactobacillus salivarius subsp. salivarius UCC118	5	3
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	4	1
Oenococcus oeni PSU-1	7	1
Pediococcus pentosaceus ATCC 25745	8	5

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
lacL	Lactobacillus acidophilus NCFM Gene: LBA1467: Beta-galactosidase large subunit (EC 3.2.1.23)	Lactobacillus brevis ATCC 367 Gene: LVIS_2259: Beta-galactosidase large subunit (EC 3.2.1.23)	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_1114: Beta-galactosidase large subunit (EC 3.2.1.23) / Beta-galactosidase small subunit (EC 3.2.1.23)	* Lactobacillus fermentum IFO 3956 Site: position = -91 score = 5.51933 sequence = TAATATTTACTAAACTTTT Gene: LAF_0247: Beta-galactosidase large subunit (EC 3.2.1.23)	Lactobacillus helveticus DPC 4571 Gene: lhv_1549: Beta-galactosidase large subunit (EC 3.2.1.23)	Lactobacillus johnsonii NCC 533 Gene: LJ0855: Beta-galactosidase large subunit (EC 3.2.1.23)	* Lactobacillus plantarum WCFS1 Site: position = -266 score = 5.86403 sequence = ATAGTTTTACTAAAATTTT Gene: lp_3483: Beta-galactosidase large subunit (EC 3.2.1.23)	* Lactobacillus reuteri JCM 1112 Site: position = -95 score = 4.8753 sequence = AAAATTTACGTAAATTTTA Gene: LAR_0276: Beta-galactosidase large subunit (EC 3.2.1.23)	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K Gene: LSA1711: Beta-galactosidase large subunit (EC 3.2.1.23)	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -86 score = 5.49169 sequence = AATATTTTAGTAAAAAGTA Gene: LSL_0376: Beta-galactosidase large subunit (EC 3.2.1.23) / Beta-galactosidase small subunit (EC 3.2.1.23)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	* Pediococcus pentosaceus ATCC 25745 Site: position = -266 score = 6.17867 sequence = ATAATTTTACTAAAATTTT Site: position = -94 score = 5.13391 sequence = AAATTTTAACTAAAACAAC Gene: PEPE_0205: Beta-galactosidase large subunit (EC 3.2.1.23)	Beta-galactosidase large subunit (EC 3.2.1.23)
lacM	Lactobacillus acidophilus NCFM Gene: LBA1468: Beta-galactosidase small subunit (EC 3.2.1.23)	Lactobacillus brevis ATCC 367 Gene: LVIS_2258: Beta-galactosidase small subunit (EC 3.2.1.23)	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_0248: Beta-galactosidase small subunit (EC 3.2.1.23)	Lactobacillus helveticus DPC 4571 Gene: lhv_1550: Beta-galactosidase small subunit (EC 3.2.1.23)	Lactobacillus johnsonii NCC 533 Gene: LJ0854: Beta-galactosidase small subunit (EC 3.2.1.23)	Lactobacillus plantarum WCFS1 Gene: lp_3484: Beta-galactosidase small subunit (EC 3.2.1.23)	Lactobacillus reuteri JCM 1112 Gene: LAR_0277: Beta-galactosidase small subunit (EC 3.2.1.23)	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K Gene: LSA1710: Beta-galactosidase small subunit (EC 3.2.1.23)	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0204: Beta-galactosidase small subunit (EC 3.2.1.23)	Beta-galactosidase small subunit (EC 3.2.1.23)

CRON 2.
OEOE_0356	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	* Oenococcus oeni PSU-1 Site: position = -231 score = 5.50887 sequence = AATATTTTAGTAAAGATTT Gene: OEOE_0307: Transposase, IS30 family	Pediococcus pentosaceus ATCC 25745	Transposase, IS30 family
LVIS_1906	Lactobacillus acidophilus NCFM	* Lactobacillus brevis ATCC 367 Site: position = -222 score = 5.08976 sequence = ATTGATTTACTAAATTTTT Gene: LVIS_1906: Conserved hypothetical protein	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	* Lactobacillus sakei subsp. sakei 23K Site: position = -111 score = 5.51027 sequence = AAAAGTTTAGTAAAATGAA Gene: LSA0184: Conserved hypothetical protein	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1 Gene: OEOE_0306: Conserved hypothetical protein	Pediococcus pentosaceus ATCC 25745	Conserved hypothetical protein
lacS	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367 Gene: LVIS_1905: Lactose and galactose permease, GPH translocator family	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K Gene: LSA0185: Lactose and galactose permease, GPH translocator family	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1 Gene: OEOE_0305: Lactose and galactose permease, GPH translocator family	Pediococcus pentosaceus ATCC 25745	Lactose and galactose permease, GPH translocator family
galK	Lactobacillus acidophilus NCFM Gene: LBA1459: Galactokinase (EC 2.7.1.6)	* Lactobacillus brevis ATCC 367 Site: position = -38 score = 5.86403 sequence = AAAACTTTACTAAAAATTT Gene: LVIS_1904: Galactokinase (EC 2.7.1.6)	* Lactobacillus casei ATCC 334 Site: position = -79 score = 5.80407 sequence = TTATTTTTAGTAAAATAAA Gene: LSEI_0664: Galactokinase (EC 2.7.1.6)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_1792: Galactokinase (EC 2.7.1.6)	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	* Lactobacillus plantarum WCFS1 Site: position = -36 score = 5.95267 sequence = AAAATTTTAGTAAAACTAT Gene: lp_3482: Galactokinase (EC 2.7.1.6)	* Lactobacillus reuteri JCM 1112 Site: position = -53 score = 4.90499 sequence = TTGTATTTAGTAAAAGTTT Gene: LAR_1662: Galactokinase (EC 2.7.1.6)	* Lactobacillus rhamnosus GG Site: position = -78 score = 5.85359 sequence = TTAATTTTAGTAAAATAAA Gene: LGG_00653: Galactokinase (EC 2.7.1.6)	* Lactobacillus sakei subsp. sakei 23K Site: position = -45 score = 5.46075 sequence = AAATGTTTAGTAAAATGAA Gene: LSA0764: Galactokinase (EC 2.7.1.6)	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -101 score = 5.78437 sequence = ATATTTTTAGTAAATTTTA Site: position = -79 score = 5.46075 sequence = AAAAGTTTACTAAAAAGTA Gene: LSL_0381: Galactokinase (EC 2.7.1.6)	2 Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0883: Galactokinase (EC 2.7.1.6) Gene: LEUM_0883: Galactokinase (EC 2.7.1.6)	Oenococcus oeni PSU-1 Gene: OEOE_0304: Galactokinase (EC 2.7.1.6)	* Pediococcus pentosaceus ATCC 25745 Site: position = -33 score = 6.26731 sequence = AAAATTTTAGTAAAATTAT Site: position = -193 score = 5.17056 sequence = AAAATTTAACCAAAATTAA Gene: PEPE_0206: Galactokinase (EC 2.7.1.6)	Galactokinase (EC 2.7.1.6)
galT	Lactobacillus acidophilus NCFM Gene: LBA1458: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)	Lactobacillus brevis ATCC 367 Gene: LVIS_1902: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)	Lactobacillus casei ATCC 334 Gene: LSEI_0666: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_1791: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_3480: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)	Lactobacillus reuteri JCM 1112 Gene: LAR_1661: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)	Lactobacillus rhamnosus GG Gene: LGG_00655: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)	Lactobacillus sakei subsp. sakei 23K Gene: LSA0766: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0383: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)	2 Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0884: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10) Gene: LEUM_0884: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)	Oenococcus oeni PSU-1 Gene: OEOE_0303: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0208: Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)	Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)
galR	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367 Gene: LVIS_1901: Galactose utilization transcriptional regulator GalR, LacI family	Lactobacillus casei ATCC 334 Gene: LSEI_0667: Galactose utilization transcriptional regulator GalR, LacI family	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_1790: Galactose utilization transcriptional regulator GalR, LacI family	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	2 Lactobacillus plantarum WCFS1 Gene: lp_3488: Galactose utilization transcriptional regulator GalR, LacI family Gene: lp_3479: Galactose utilization transcriptional regulator GalR, LacI family	2 Lactobacillus reuteri JCM 1112* Gene: LAR_1660: Galactose utilization transcriptional regulator GalR, LacI family Site: position = -54 score = 5.54939 sequence = AAACGTTTACTAAAAATAT Gene: LAR_0856: Galactose utilization transcriptional regulator GalR, LacI family	Lactobacillus rhamnosus GG Gene: LGG_00656: Galactose utilization transcriptional regulator GalR, LacI family	* Lactobacillus sakei subsp. sakei 23K Site: position = -101 score = 5.40378 sequence = AAACATTTACTAAAAAATC Gene: LSA0763: Galactose utilization transcriptional regulator GalR, LacI family	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -89 score = 5.90543 sequence = TAAAATTTACTAAAAATAT Gene: LSL_0380: Galactose utilization transcriptional regulator GalR, LacI family	* Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Site: position = -106 score = 5.11966 sequence = TACTTTTTAGTAAATATTT Gene: LEUM_0881: Galactose utilization transcriptional regulator GalR, LacI family	Oenococcus oeni PSU-1 Gene: OEOE_0302: Galactose utilization transcriptional regulator GalR, LacI family	* Pediococcus pentosaceus ATCC 25745 Site: position = -177 score = 5.1775 sequence = CAAAATTTTGTAAAAATAT Gene: PEPE_0201: Galactose utilization transcriptional regulator GalR, LacI family	Galactose utilization transcriptional regulator GalR, LacI family
galM	Lactobacillus acidophilus NCFM Gene: LBA1457: Aldose 1-epimerase (EC 5.1.3.3)	* Lactobacillus brevis ATCC 367 Site: position = -84 score = 5.29823 sequence = CGAATTTTAGTAAAAAATT Gene: LVIS_1908: Aldose 1-epimerase (EC 5.1.3.3)	Lactobacillus casei ATCC 334 Gene: LSEI_0668: Aldose 1-epimerase (EC 5.1.3.3)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_3487: Aldose 1-epimerase (EC 5.1.3.3)	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG Gene: LGG_00657: Aldose 1-epimerase (EC 5.1.3.3)	Lactobacillus sakei subsp. sakei 23K Gene: LSA0767: Aldose 1-epimerase (EC 5.1.3.3)	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1 Gene: OEOE_0301: Aldose 1-epimerase (EC 5.1.3.3)	* Pediococcus pentosaceus ATCC 25745 Site: position = -89 score = 5.42754 sequence = TTATTTTAACTAAAATATT Gene: PEPE_0202: Aldose 1-epimerase (EC 5.1.3.3)	Aldose 1-epimerase (EC 5.1.3.3)
galE	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367 Gene: LVIS_1903: UDP-glucose 4-epimerase (EC 5.1.3.2)	Lactobacillus casei ATCC 334 Gene: LSEI_0665: UDP-glucose 4-epimerase (EC 5.1.3.2)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_3481: UDP-glucose 4-epimerase (EC 5.1.3.2)	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG Gene: LGG_00654: UDP-glucose 4-epimerase (EC 5.1.3.2)	2 Lactobacillus sakei subsp. sakei 23K Gene: LSA1280: UDP-glucose 4-epimerase (EC 5.1.3.2) Gene: LSA0765: UDP-glucose 4-epimerase (EC 5.1.3.2)	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_0382: UDP-glucose 4-epimerase (EC 5.1.3.2)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0207: UDP-glucose 4-epimerase (EC 5.1.3.2)	UDP-glucose 4-epimerase (EC 5.1.3.2)
melA	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_3485: Alpha-galactosidase (EC 3.2.1.22)	* Lactobacillus reuteri JCM 1112 Site: position = -128 score = 5.42842 sequence = ATATTTTTAGTAAACGTTT Gene: LAR_0857: Alpha-galactosidase (EC 3.2.1.22)	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0882: Alpha-galactosidase (EC 3.2.1.22)	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Alpha-galactosidase (EC 3.2.1.22)
lacS2	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	* Lactobacillus plantarum WCFS1 Site: position = -88 score = 5.70467 sequence = CAAATTTTACTAAAAATCA Gene: lp_3486: Lactose and galactose permease, GPH translocator family	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	* Pediococcus pentosaceus ATCC 25745 Site: position = -108 score = 5.13166 sequence = ACTAATTTACTAAAATAAT Site: position = -85 score = 5.58529 sequence = CAAATTTTACTAAAAAACA Gene: PEPE_0203: Lactose and galactose permease, GPH translocator family	Lactose and galactose permease, GPH translocator family

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog GalR - Lactobacillaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --