The RegPrecise is a database for capturing, visualization and analysis of transcription factor regulons that were reconstructed by the comparative genomic approach in a wide variety of prokaryotic genomes.more
Manually Curated
Regulon Collections
This section of the database
represents the results of manually curated reconstrutions of
transcriptional regulons using the comparative genomics
approach. Browse collections that organize the reconstructed regulons by phylogenetic, structural or functional properties of regulators.
Propagated
Propagated Regulons
This
section of the database represents the results of accurate
automatic propagation of the manually curated regulons to novel
closely related genomes.For each regulog, the propagation procedure checks for the presence of orthologs for both a transcription factor gene and target genes (regulog members), and then performs search for candidate TF-binding sites in upstream regions of orthologous target genes
This procedure is considered to be accurate and conservative since it relies on the manually curated regulons and does not make an attempt for automatic prediction of new members of regulon.
Please cite:
RegPrecise 3.0 - A resource for genome-scale exploration of
transcriptional regulation in bacteria. Novichkov PS, Kazakov AE,
Ravcheev DA, Leyn SA, Kovaleva GY, Sutormin RA, Kazanov MD, Riehl
W, Arkin AP, Dubchak I, Rodionov DA. BMC Genomics. 2013 Nov
1;14:745
Funding statement: RegPrecise development is sponsored by
the Office of Science (BER), U.S. Department of Energy under
contracts DE-AC02-05CH11231 with Lawrence Berkeley National
Laboratory, and DE-SC000499 with Sanford-Burnham Medical Research
Institute and Lawrence Berkeley National Laboratory; and National
Science Foundation under contract DBI-0850546 with Sanford-Burnham
Medical Research Institute.