Regulog IolR2 - Bacillales

Properties
Regulator type:	Transcription factor
Regulator family:	LacI
Regulation mode:	repressor
Biological process:	Inositol utilization
Effector:
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 4 sites [see more]

Member of regulog collections

By taxonomy - Bacillales
By TF family - LacI
By pathway - Inositol utilization

Statistics of regulated genes
Genome	Genes	Operons
Bacillus subtilis subsp. subtilis str. 168
Bacillus amyloliquefaciens FZB42
Bacillus pumilus SAFR-032
Bacillus licheniformis DSM 13
Anoxybacillus flavithermus WK1
Geobacillus kaustophilus HTA426	5	1
Bacillus cereus ATCC 14579
Bacillus halodurans C-125	10	2
Bacillus clausii KSM-K16
Oceanobacillus iheyensis HTE831
Paenibacillus sp. JDR-2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes												Function

CRON 1.
iolB	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39750: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036770: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04250: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK1889: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Bacillus cereus ATCC 14579	* Bacillus halodurans C-125 Site: position = -45 score = 6.43928 sequence = AATGAAATCGATTACAAT Gene: BH2320: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Bacillus clausii KSM-K16 Gene: ABC0423: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_1953: 5-deoxy-glucuronate isomerase (EC 5.3.1.-)	5-deoxy-glucuronate isomerase (EC 5.3.1.-)
iolC	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39740: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036760: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04249: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2319: 5-keto-2-deoxygluconokinase (EC 2.7.1.92)	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	5-keto-2-deoxygluconokinase (EC 2.7.1.92)
iolD	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39730: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036750: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04248: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK1891: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2318: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase	Bacillus clausii KSM-K16 Gene: ABC0425: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_1948: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase	3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase
iolE	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39720: Inosose dehydratase (EC 4.2.1.44)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036740: Inosose dehydratase (EC 4.2.1.44)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04247: Inosose dehydratase (EC 4.2.1.44)	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2317: Inosose dehydratase (EC 4.2.1.44)	Bacillus clausii KSM-K16 Gene: ABC0426: Inosose dehydratase (EC 4.2.1.44)	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Inosose dehydratase (EC 4.2.1.44)
iolG	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39700: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036720: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04245: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2316: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Bacillus clausii KSM-K16 Gene: ABC0427: Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)
iolI	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39680: Inosose isomerase (EC 5.3.99.-)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036700: Inosose isomerase (EC 5.3.99.-)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04243: Inosose isomerase (EC 5.3.99.-)	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK1892: Inosose isomerase (EC 5.3.99.-)	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2315: Inosose isomerase (EC 5.3.99.-)	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Inosose isomerase (EC 5.3.99.-)
iolJ	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU39670: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_036690: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04242: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK1886: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2314: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Bacillus clausii KSM-K16 Gene: ABC0428: 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29)

CRON 2.
iolR2	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	* Geobacillus kaustophilus HTA426 Site: position = -37 score = 6.34656 sequence = TATGTAATCGATTACATA Gene: GK2115: Transcriptional regulator of inositol utilization	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2313: Transcriptional regulator of inositol utilization	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Transcriptional regulator of inositol utilization
GK2114	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	* Geobacillus kaustophilus HTA426 Site: position = -92 score = 5.61104 sequence = GATGTAATCGATTACATC Gene: GK2114: Predicted inositol derivative dehydrogenase	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	2 Paenibacillus sp. JDR-2 Gene: Pjdr2_5008: Predicted inositol derivative dehydrogenase Gene: Pjdr2_2539: Predicted inositol derivative dehydrogenase	Predicted inositol derivative dehydrogenase
BH1247	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK2113: Hypotetical protein	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH1247: Hypotetical protein	Bacillus clausii KSM-K16 Gene: ABC1573: Hypotetical protein	Oceanobacillus iheyensis HTE831 Gene: OB2566: Hypotetical protein	2 Paenibacillus sp. JDR-2 Gene: Pjdr2_4862: Hypotetical protein Gene: Pjdr2_5588: Hypotetical protein	Hypotetical protein
GK2112	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK2112: Predicted inositol derivative dehydrogenase	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Predicted inositol derivative dehydrogenase
BH1249	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK2111: Predicted inosose isomerase (EC 5.3.99.-)	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH1249: Predicted inosose isomerase (EC 5.3.99.-)	Bacillus clausii KSM-K16 Gene: ABC0795: Predicted inosose isomerase (EC 5.3.99.-)	Oceanobacillus iheyensis HTE831 Gene: OB2563: Predicted inosose isomerase (EC 5.3.99.-)	Paenibacillus sp. JDR-2 Gene: Pjdr2_5725: Predicted inosose isomerase (EC 5.3.99.-)	Predicted inosose isomerase (EC 5.3.99.-)

CRON 3.
iolA	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK1887: Methylmalonate-semialdehyde dehydrogenase [inositol] (EC 1.2.1.27)	Bacillus cereus ATCC 14579	* Bacillus halodurans C-125 Site: position = -86 score = 6.56016 sequence = AATGAAATCGATTTCAAT Gene: BH2312: Methylmalonate-semialdehyde dehydrogenase [inositol] (EC 1.2.1.27)	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_1951: Methylmalonate-semialdehyde dehydrogenase [inositol] (EC 1.2.1.27)	Methylmalonate-semialdehyde dehydrogenase [inositol] (EC 1.2.1.27)
yxlH	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU38640: Probable inositol derivative MFS-type transporter	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi04110: Probable inositol derivative MFS-type transporter	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426 Gene: GK1885: Probable inositol derivative MFS-type transporter	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2311: Probable inositol derivative MFS-type transporter	Bacillus clausii KSM-K16 Gene: ABC3967: Probable inositol derivative MFS-type transporter	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_3363: Probable inositol derivative MFS-type transporter	Probable inositol derivative MFS-type transporter
iolH	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125 Gene: BH2310: Glyceraldehyde-3-phosphate ketol-isomerase (EC 5.3.1.1)	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Glyceraldehyde-3-phosphate ketol-isomerase (EC 5.3.1.1)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog IolR2 - Bacillales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --