Collection of regulogs in Streptococcaceae taxonomic group

General statistics
Genomes	15
TF regulogs	70
TF regulons	595
TF binding sites	3131
RNA regulogs	29
RNA regulons	330
RNA sites	406

This collection involves all regulons that were tentatively predicted by applying integrative comparative genomic approach to a single taxonomic group of closely-related genomes. To infer the regulons operated by transcription factors (TFs), we combined the identification of TF binding sites and cross-genome comparison of regulons with the analysis of the genomic and functional context of candidate target genes. To infer the regulons operated by regulatory RNAs such as riboswitches, we identified candidate RNA regulatory elements using HMM profiles and further analyzed their genomic and functional context.

Studied genomes and reconstructed regulon statistics
	TF		RNA		Total
Genomes	Regulons	Sites	Regulons	Sites	Regulons	Sites
Lactococcus lactis subsp. cremoris SK11	37	159	25	31	62	190
Lactococcus lactis subsp. lactis Il1403	35	173	24	31	59	204
Streptococcus agalactiae 2603V/R	38	222	21	28	59	250
Streptococcus dysgalactiae subsp. equisimilis GGS_124	43	227	22	26	65	253
Streptococcus equi subsp. zooepidemicus MGCS10565	42	195	20	24	62	219
Streptococcus gallolyticus UCN34	41	246	23	29	64	275
Streptococcus gordonii str. Challis substr. CH1	42	233	22	30	64	263
Streptococcus mitis B6	35	201	22	26	57	227
Streptococcus mutans UA159	42	209	23	24	65	233
Streptococcus pneumoniae TIGR4	42	233	21	30	63	263
Streptococcus pyogenes M1 GAS	40	215	21	24	61	239
Streptococcus sanguinis SK36	43	226	23	27	66	253
Streptococcus suis 05ZYH33	43	204	21	28	64	232
Streptococcus thermophilus CNRZ1066	30	169	20	23	50	192
Streptococcus uberis 0140J	42	219	22	25	64	244

Genomic distribution of regulons
Family	Type	Regulator																Function
ArgR	TF	ArgR	5 ArgR Streptococcus pyogenes M1 GAS	5 ArgR Streptococcus dysgalactiae subsp. equisimilis GGS_124	4 ArgR Streptococcus equi subsp. zooepidemicus MGCS10565	7 ArgR Streptococcus uberis 0140J	4 ArgR Streptococcus agalactiae 2603V/R	5 ArgR Streptococcus mutans UA159	6 ArgR Streptococcus gallolyticus UCN34	5 ArgR Streptococcus thermophilus CNRZ1066	7 ArgR Streptococcus pneumoniae TIGR4	5 ArgR Streptococcus mitis B6	2 ArgR Streptococcus sanguinis SK36	5 ArgR Streptococcus gordonii str. Challis substr. CH1	6 ArgR Streptococcus suis 05ZYH33	6 ArgR Lactococcus lactis subsp. cremoris SK11	6 ArgR Lactococcus lactis subsp. lactis Il1403	Arginine biosynthesis; Arginine degradation
BglG	TF	CelR	2 CelR Streptococcus pyogenes M1 GAS	1 CelR Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 CelR Streptococcus equi subsp. zooepidemicus MGCS10565	1 CelR Streptococcus uberis 0140J		1 CelR Streptococcus mutans UA159	2 CelR Streptococcus gallolyticus UCN34		2 CelR Streptococcus pneumoniae TIGR4			2 CelR Streptococcus gordonii str. Challis substr. CH1	2 CelR Streptococcus suis 05ZYH33			Cellobiose utilization
	TF	GutR			1 GutR Streptococcus equi subsp. zooepidemicus MGCS10565	1 GutR Streptococcus uberis 0140J		1 GutR Streptococcus mutans UA159										Sorbitol utilization
	TF	MtlR				1 MtlR Streptococcus uberis 0140J		1 MtlR Streptococcus mutans UA159	1 MtlR Streptococcus gallolyticus UCN34		1 MtlR Streptococcus pneumoniae TIGR4					1 MtlR Lactococcus lactis subsp. cremoris SK11	1 MtlR Lactococcus lactis subsp. lactis Il1403	Mannitol utilization
	TF	SgaR	2 SgaR Streptococcus pyogenes M1 GAS	2 SgaR Streptococcus dysgalactiae subsp. equisimilis GGS_124	2 SgaR Streptococcus equi subsp. zooepidemicus MGCS10565	2 SgaR Streptococcus uberis 0140J	2 SgaR Streptococcus agalactiae 2603V/R	2 SgaR Streptococcus mutans UA159	1 SgaR Streptococcus gallolyticus UCN34		1 SgaR Streptococcus pneumoniae TIGR4	1 SgaR Streptococcus mitis B6	2 SgaR Streptococcus sanguinis SK36		2 SgaR Streptococcus suis 05ZYH33			Ascorbate utilization
	TF	SgaR2	1 SgaR2 Streptococcus pyogenes M1 GAS	1 SgaR2 Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 SgaR2 Streptococcus equi subsp. zooepidemicus MGCS10565	1 SgaR2 Streptococcus uberis 0140J	1 SgaR2 Streptococcus agalactiae 2603V/R				1 SgaR2 Streptococcus pneumoniae TIGR4	1 SgaR2 Streptococcus mitis B6			1 SgaR2 Streptococcus suis 05ZYH33			Ascorbate utilization
BirA	TF	BirA	2 BirA Streptococcus pyogenes M1 GAS	3 BirA Streptococcus dysgalactiae subsp. equisimilis GGS_124	2 BirA Streptococcus equi subsp. zooepidemicus MGCS10565	1 BirA Streptococcus uberis 0140J	3 BirA Streptococcus agalactiae 2603V/R	1 BirA Streptococcus mutans UA159	3 BirA Streptococcus gallolyticus UCN34	2 BirA Streptococcus thermophilus CNRZ1066	1 BirA Streptococcus pneumoniae TIGR4	1 BirA Streptococcus mitis B6	1 BirA Streptococcus sanguinis SK36	1 BirA Streptococcus gordonii str. Challis substr. CH1	1 BirA Streptococcus suis 05ZYH33	2 BirA Lactococcus lactis subsp. cremoris SK11	2 BirA Lactococcus lactis subsp. lactis Il1403	Biotin biosynthesis
CRP	TF	FlpA														2 FlpA Lactococcus lactis subsp. cremoris SK11	2 FlpA Lactococcus lactis subsp. lactis Il1403	Heavy metal resistance
CcpN	TF	CcpN		1 CcpN Streptococcus dysgalactiae subsp. equisimilis GGS_124		1 CcpN Streptococcus uberis 0140J	1 CcpN Streptococcus agalactiae 2603V/R						2 CcpN Streptococcus sanguinis SK36	2 CcpN Streptococcus gordonii str. Challis substr. CH1				Gluconeogenesis
CodY	TF	CodY	8 CodY Streptococcus pyogenes M1 GAS	12 CodY Streptococcus dysgalactiae subsp. equisimilis GGS_124	7 CodY Streptococcus equi subsp. zooepidemicus MGCS10565	17 CodY Streptococcus uberis 0140J	18 CodY Streptococcus agalactiae 2603V/R	24 CodY Streptococcus mutans UA159	28 CodY Streptococcus gallolyticus UCN34	24 CodY Streptococcus thermophilus CNRZ1066	20 CodY Streptococcus pneumoniae TIGR4	22 CodY Streptococcus mitis B6	21 CodY Streptococcus sanguinis SK36	21 CodY Streptococcus gordonii str. Challis substr. CH1	14 CodY Streptococcus suis 05ZYH33	12 CodY Lactococcus lactis subsp. cremoris SK11	13 CodY Lactococcus lactis subsp. lactis Il1403	Amino acid metabolism
CopY	TF	CopR	1 CopR Streptococcus pyogenes M1 GAS	1 CopR Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 CopR Streptococcus equi subsp. zooepidemicus MGCS10565	1 CopR Streptococcus uberis 0140J	1 CopR Streptococcus agalactiae 2603V/R	1 CopR Streptococcus mutans UA159	1 CopR Streptococcus gallolyticus UCN34	1 CopR Streptococcus thermophilus CNRZ1066	1 CopR Streptococcus pneumoniae TIGR4	1 CopR Streptococcus mitis B6	1 CopR Streptococcus sanguinis SK36	2 CopR Streptococcus gordonii str. Challis substr. CH1	1 CopR Streptococcus suis 05ZYH33	6 CopR Lactococcus lactis subsp. cremoris SK11	5 CopR Lactococcus lactis subsp. lactis Il1403	Copper homeostasis
CtsR	TF	CtsR	5 CtsR Streptococcus pyogenes M1 GAS	4 CtsR Streptococcus dysgalactiae subsp. equisimilis GGS_124	5 CtsR Streptococcus equi subsp. zooepidemicus MGCS10565	4 CtsR Streptococcus uberis 0140J	5 CtsR Streptococcus agalactiae 2603V/R	3 CtsR Streptococcus mutans UA159	5 CtsR Streptococcus gallolyticus UCN34	5 CtsR Streptococcus thermophilus CNRZ1066	5 CtsR Streptococcus pneumoniae TIGR4	5 CtsR Streptococcus mitis B6	4 CtsR Streptococcus sanguinis SK36	4 CtsR Streptococcus gordonii str. Challis substr. CH1	4 CtsR Streptococcus suis 05ZYH33	5 CtsR Lactococcus lactis subsp. cremoris SK11	5 CtsR Lactococcus lactis subsp. lactis Il1403	Heat shock response
DeoR	TF	FruR	1 FruR Streptococcus pyogenes M1 GAS	1 FruR Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 FruR Streptococcus equi subsp. zooepidemicus MGCS10565	1 FruR Streptococcus uberis 0140J	1 FruR Streptococcus agalactiae 2603V/R	1 FruR Streptococcus mutans UA159	1 FruR Streptococcus gallolyticus UCN34	1 FruR Streptococcus thermophilus CNRZ1066	1 FruR Streptococcus pneumoniae TIGR4	1 FruR Streptococcus mitis B6	1 FruR Streptococcus sanguinis SK36	1 FruR Streptococcus gordonii str. Challis substr. CH1	1 FruR Streptococcus suis 05ZYH33	1 FruR Lactococcus lactis subsp. cremoris SK11	1 FruR Lactococcus lactis subsp. lactis Il1403	Fructose utilization
	TF	FucR									2 FucR Streptococcus pneumoniae TIGR4							Fucose utilization
	TF	LacR	3 LacR Streptococcus pyogenes M1 GAS	2 LacR Streptococcus dysgalactiae subsp. equisimilis GGS_124	2 LacR Streptococcus equi subsp. zooepidemicus MGCS10565	4 LacR Streptococcus uberis 0140J	3 LacR Streptococcus agalactiae 2603V/R	1 LacR Streptococcus mutans UA159	4 LacR Streptococcus gallolyticus UCN34		2 LacR Streptococcus pneumoniae TIGR4	3 LacR Streptococcus mitis B6	1 LacR Streptococcus sanguinis SK36	1 LacR Streptococcus gordonii str. Challis substr. CH1	1 LacR Streptococcus suis 05ZYH33	2 LacR Lactococcus lactis subsp. cremoris SK11		Lactose utilization; Galactose utilization
	TF	PflR	3 PflR Streptococcus pyogenes M1 GAS	3 PflR Streptococcus dysgalactiae subsp. equisimilis GGS_124	3 PflR Streptococcus equi subsp. zooepidemicus MGCS10565	3 PflR Streptococcus uberis 0140J	2 PflR Streptococcus agalactiae 2603V/R	3 PflR Streptococcus mutans UA159			3 PflR Streptococcus pneumoniae TIGR4		3 PflR Streptococcus sanguinis SK36	3 PflR Streptococcus gordonii str. Challis substr. CH1	2 PflR Streptococcus suis 05ZYH33			Formate metabolism
DtxR	TF	MntR	3 MntR Streptococcus pyogenes M1 GAS	3 MntR Streptococcus dysgalactiae subsp. equisimilis GGS_124	3 MntR Streptococcus equi subsp. zooepidemicus MGCS10565	4 MntR Streptococcus uberis 0140J	4 MntR Streptococcus agalactiae 2603V/R	1 MntR Streptococcus mutans UA159	2 MntR Streptococcus gallolyticus UCN34		2 MntR Streptococcus pneumoniae TIGR4	3 MntR Streptococcus mitis B6	1 MntR Streptococcus sanguinis SK36	1 MntR Streptococcus gordonii str. Challis substr. CH1	2 MntR Streptococcus suis 05ZYH33	1 MntR Lactococcus lactis subsp. cremoris SK11	2 MntR Lactococcus lactis subsp. lactis Il1403	Manganese homeostasis
FUR	TF	PerR	6 PerR Streptococcus pyogenes M1 GAS	7 PerR Streptococcus dysgalactiae subsp. equisimilis GGS_124	5 PerR Streptococcus equi subsp. zooepidemicus MGCS10565	6 PerR Streptococcus uberis 0140J	4 PerR Streptococcus agalactiae 2603V/R	5 PerR Streptococcus mutans UA159	4 PerR Streptococcus gallolyticus UCN34	4 PerR Streptococcus thermophilus CNRZ1066			6 PerR Streptococcus sanguinis SK36	4 PerR Streptococcus gordonii str. Challis substr. CH1	4 PerR Streptococcus suis 05ZYH33	1 PerR Lactococcus lactis subsp. cremoris SK11	1 PerR Lactococcus lactis subsp. lactis Il1403	Iron homeostasis; Manganese homeostasis; Oxidative stress response
GntR/MocR	TF	PdxR	2 PdxR Streptococcus pyogenes M1 GAS	2 PdxR Streptococcus dysgalactiae subsp. equisimilis GGS_124	2 PdxR Streptococcus equi subsp. zooepidemicus MGCS10565			2 PdxR Streptococcus mutans UA159	2 PdxR Streptococcus gallolyticus UCN34				2 PdxR Streptococcus sanguinis SK36	2 PdxR Streptococcus gordonii str. Challis substr. CH1				Pyridoxine biosynthesis
	TF	SMU640c						2 SMU640c Streptococcus mutans UA159
GntR/Others	TF	AgaR		2 AgaR Streptococcus dysgalactiae subsp. equisimilis GGS_124	2 AgaR Streptococcus equi subsp. zooepidemicus MGCS10565	2 AgaR Streptococcus uberis 0140J					2 AgaR Streptococcus pneumoniae TIGR4	2 AgaR Streptococcus mitis B6	2 AgaR Streptococcus sanguinis SK36	2 AgaR Streptococcus gordonii str. Challis substr. CH1	2 AgaR Streptococcus suis 05ZYH33			N-acetylgalactosamine utilization
	TF	AgaR2	1 AgaR2 Streptococcus pyogenes M1 GAS	1 AgaR2 Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 AgaR2 Streptococcus equi subsp. zooepidemicus MGCS10565	1 AgaR2 Streptococcus uberis 0140J									4 AgaR2 Streptococcus suis 05ZYH33			N-acetylgalactosamine utilization
	TF	BusR											1 BusR Streptococcus sanguinis SK36			1 BusR Lactococcus lactis subsp. cremoris SK11	1 BusR Lactococcus lactis subsp. lactis Il1403	Betaine utilization
	TF	NagR	3 NagR Streptococcus pyogenes M1 GAS	3 NagR Streptococcus dysgalactiae subsp. equisimilis GGS_124	3 NagR Streptococcus equi subsp. zooepidemicus MGCS10565	3 NagR Streptococcus uberis 0140J	3 NagR Streptococcus agalactiae 2603V/R	3 NagR Streptococcus mutans UA159	3 NagR Streptococcus gallolyticus UCN34	2 NagR Streptococcus thermophilus CNRZ1066	3 NagR Streptococcus pneumoniae TIGR4	3 NagR Streptococcus mitis B6	3 NagR Streptococcus sanguinis SK36	3 NagR Streptococcus gordonii str. Challis substr. CH1	2 NagR Streptococcus suis 05ZYH33	3 NagR Lactococcus lactis subsp. cremoris SK11	3 NagR Lactococcus lactis subsp. lactis Il1403	N-acetylglucosamine utilization
	TF	SPy1285	3 SPy1285 Streptococcus pyogenes M1 GAS	3 SPy1285 Streptococcus dysgalactiae subsp. equisimilis GGS_124	3 SPy1285 Streptococcus equi subsp. zooepidemicus MGCS10565	3 SPy1285 Streptococcus uberis 0140J	3 SPy1285 Streptococcus agalactiae 2603V/R	3 SPy1285 Streptococcus mutans UA159	3 SPy1285 Streptococcus gallolyticus UCN34	1 SPy1285 Streptococcus thermophilus CNRZ1066	3 SPy1285 Streptococcus pneumoniae TIGR4	2 SPy1285 Streptococcus mitis B6		1 SPy1285 Streptococcus gordonii str. Challis substr. CH1	3 SPy1285 Streptococcus suis 05ZYH33			Transport
	TF	TreR (RgrA)														2 TreR (RgrA) Lactococcus lactis subsp. cremoris SK11	2 TreR (RgrA) Lactococcus lactis subsp. lactis Il1403	Trehalose utilization
	TF	TreR	2 TreR Streptococcus pyogenes M1 GAS	2 TreR Streptococcus dysgalactiae subsp. equisimilis GGS_124		2 TreR Streptococcus uberis 0140J		2 TreR Streptococcus mutans UA159	2 TreR Streptococcus gallolyticus UCN34		2 TreR Streptococcus pneumoniae TIGR4		2 TreR Streptococcus sanguinis SK36	2 TreR Streptococcus gordonii str. Challis substr. CH1				Trehalose utilization
	TF	UxuR														2 UxuR Lactococcus lactis subsp. cremoris SK11	2 UxuR Lactococcus lactis subsp. lactis Il1403	Glucuronate utilization
HrcA	TF	HrcA	2 HrcA Streptococcus pyogenes M1 GAS	3 HrcA Streptococcus dysgalactiae subsp. equisimilis GGS_124	3 HrcA Streptococcus equi subsp. zooepidemicus MGCS10565	3 HrcA Streptococcus uberis 0140J	3 HrcA Streptococcus agalactiae 2603V/R	2 HrcA Streptococcus mutans UA159	3 HrcA Streptococcus gallolyticus UCN34	2 HrcA Streptococcus thermophilus CNRZ1066	2 HrcA Streptococcus pneumoniae TIGR4	2 HrcA Streptococcus mitis B6	2 HrcA Streptococcus sanguinis SK36	2 HrcA Streptococcus gordonii str. Challis substr. CH1	2 HrcA Streptococcus suis 05ZYH33	3 HrcA Lactococcus lactis subsp. cremoris SK11	3 HrcA Lactococcus lactis subsp. lactis Il1403	Heat shock response
LacI	TF	AlsR														2 AlsR Lactococcus lactis subsp. cremoris SK11		Allose utilization
	TF	BfrR				1 BfrR Streptococcus uberis 0140J					1 BfrR Streptococcus pneumoniae TIGR4			1 BfrR Streptococcus gordonii str. Challis substr. CH1	1 BfrR Streptococcus suis 05ZYH33			Fructooligosaccharides utilization
	TF	CcpA	69 CcpA Streptococcus pyogenes M1 GAS	68 CcpA Streptococcus dysgalactiae subsp. equisimilis GGS_124	52 CcpA Streptococcus equi subsp. zooepidemicus MGCS10565	61 CcpA Streptococcus uberis 0140J	65 CcpA Streptococcus agalactiae 2603V/R	48 CcpA Streptococcus mutans UA159	52 CcpA Streptococcus gallolyticus UCN34	35 CcpA Streptococcus thermophilus CNRZ1066	73 CcpA Streptococcus pneumoniae TIGR4	59 CcpA Streptococcus mitis B6	66 CcpA Streptococcus sanguinis SK36	69 CcpA Streptococcus gordonii str. Challis substr. CH1	67 CcpA Streptococcus suis 05ZYH33	32 CcpA Lactococcus lactis subsp. cremoris SK11	31 CcpA Lactococcus lactis subsp. lactis Il1403	Global catabolite repression
	TF	CcpB		1 CcpB Streptococcus dysgalactiae subsp. equisimilis GGS_124			1 CcpB Streptococcus agalactiae 2603V/R		1 CcpB Streptococcus gallolyticus UCN34							1 CcpB Lactococcus lactis subsp. cremoris SK11	1 CcpB Lactococcus lactis subsp. lactis Il1403	Sugar utilization
	TF	GalR			2 GalR Streptococcus equi subsp. zooepidemicus MGCS10565			2 GalR Streptococcus mutans UA159	3 GalR Streptococcus gallolyticus UCN34	3 GalR Streptococcus thermophilus CNRZ1066	2 GalR Streptococcus pneumoniae TIGR4	2 GalR Streptococcus mitis B6	2 GalR Streptococcus sanguinis SK36	2 GalR Streptococcus gordonii str. Challis substr. CH1	2 GalR Streptococcus suis 05ZYH33			Galactose utilization
	TF	LACR_0766		2 LACR_0766 Streptococcus dysgalactiae subsp. equisimilis GGS_124												1 LACR_0766 Lactococcus lactis subsp. cremoris SK11		Sugar utilization
	TF	MalR	6 MalR Streptococcus pyogenes M1 GAS	4 MalR Streptococcus dysgalactiae subsp. equisimilis GGS_124	6 MalR Streptococcus equi subsp. zooepidemicus MGCS10565	4 MalR Streptococcus uberis 0140J	6 MalR Streptococcus agalactiae 2603V/R	4 MalR Streptococcus mutans UA159	7 MalR Streptococcus gallolyticus UCN34	2 MalR Streptococcus thermophilus CNRZ1066	6 MalR Streptococcus pneumoniae TIGR4	7 MalR Streptococcus mitis B6	6 MalR Streptococcus sanguinis SK36	5 MalR Streptococcus gordonii str. Challis substr. CH1	4 MalR Streptococcus suis 05ZYH33	2 MalR Lactococcus lactis subsp. cremoris SK11	2 MalR Lactococcus lactis subsp. lactis Il1403	Maltose utilization; Maltodextrin utilization
	TF	MalR2	1 MalR2 Streptococcus pyogenes M1 GAS	1 MalR2 Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 MalR2 Streptococcus equi subsp. zooepidemicus MGCS10565				1 MalR2 Streptococcus gallolyticus UCN34									Maltose utilization; Maltodextrin utilization
	TF	MdxR													1 MdxR Streptococcus suis 05ZYH33			Maltose utilization; Maltodextrin utilization
	TF	NigR						1 NigR Streptococcus mutans UA159										Nigerose utilization
	TF	RbsR2	1 RbsR2 Streptococcus pyogenes M1 GAS	1 RbsR2 Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 RbsR2 Streptococcus equi subsp. zooepidemicus MGCS10565	1 RbsR2 Streptococcus uberis 0140J	1 RbsR2 Streptococcus agalactiae 2603V/R									1 RbsR2 Lactococcus lactis subsp. cremoris SK11	1 RbsR2 Lactococcus lactis subsp. lactis Il1403	Ribose utilization
	TF	RegR	3 RegR Streptococcus pyogenes M1 GAS	2 RegR Streptococcus dysgalactiae subsp. equisimilis GGS_124	2 RegR Streptococcus equi subsp. zooepidemicus MGCS10565		3 RegR Streptococcus agalactiae 2603V/R				3 RegR Streptococcus pneumoniae TIGR4				2 RegR Streptococcus suis 05ZYH33			Hyaluronate utilization
	TF	SAG1808					1 SAG1808 Streptococcus agalactiae 2603V/R						1 SAG1808 Streptococcus sanguinis SK36					Sugar utilization
	TF	ScrR	2 ScrR Streptococcus pyogenes M1 GAS	2 ScrR Streptococcus dysgalactiae subsp. equisimilis GGS_124	2 ScrR Streptococcus equi subsp. zooepidemicus MGCS10565	2 ScrR Streptococcus uberis 0140J	2 ScrR Streptococcus agalactiae 2603V/R	2 ScrR Streptococcus mutans UA159	2 ScrR Streptococcus gallolyticus UCN34	2 ScrR Streptococcus thermophilus CNRZ1066	2 ScrR Streptococcus pneumoniae TIGR4	2 ScrR Streptococcus mitis B6	2 ScrR Streptococcus sanguinis SK36	2 ScrR Streptococcus gordonii str. Challis substr. CH1	2 ScrR Streptococcus suis 05ZYH33			Sucrose utilization
LysR	TF	CmbR	2 CmbR Streptococcus pyogenes M1 GAS	3 CmbR Streptococcus dysgalactiae subsp. equisimilis GGS_124	4 CmbR Streptococcus equi subsp. zooepidemicus MGCS10565	4 CmbR Streptococcus uberis 0140J	4 CmbR Streptococcus agalactiae 2603V/R	6 CmbR Streptococcus mutans UA159	9 CmbR Streptococcus gallolyticus UCN34	10 CmbR Streptococcus thermophilus CNRZ1066	7 CmbR Streptococcus pneumoniae TIGR4	6 CmbR Streptococcus mitis B6	5 CmbR Streptococcus sanguinis SK36	5 CmbR Streptococcus gordonii str. Challis substr. CH1	4 CmbR Streptococcus suis 05ZYH33	5 CmbR Lactococcus lactis subsp. cremoris SK11	9 CmbR Lactococcus lactis subsp. lactis Il1403	Cysteine metabolism
	TF	HomR						4 HomR Streptococcus mutans UA159	4 HomR Streptococcus gallolyticus UCN34	2 HomR Streptococcus thermophilus CNRZ1066	1 HomR Streptococcus pneumoniae TIGR4	1 HomR Streptococcus mitis B6	1 HomR Streptococcus sanguinis SK36	1 HomR Streptococcus gordonii str. Challis substr. CH1	1 HomR Streptococcus suis 05ZYH33	1 HomR Lactococcus lactis subsp. cremoris SK11	2 HomR Lactococcus lactis subsp. lactis Il1403	Methionine metabolism; Cysteine metabolism
	TF	MleR						1 MleR Streptococcus mutans UA159	2 MleR Streptococcus gallolyticus UCN34				1 MleR Streptococcus sanguinis SK36	2 MleR Streptococcus gordonii str. Challis substr. CH1		1 MleR Lactococcus lactis subsp. cremoris SK11	1 MleR Lactococcus lactis subsp. lactis Il1403	Malate utilization
	TF	MtaR	1 MtaR Streptococcus pyogenes M1 GAS	2 MtaR Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 MtaR Streptococcus equi subsp. zooepidemicus MGCS10565	3 MtaR Streptococcus uberis 0140J	2 MtaR Streptococcus agalactiae 2603V/R	7 MtaR Streptococcus mutans UA159	7 MtaR Streptococcus gallolyticus UCN34	7 MtaR Streptococcus thermophilus CNRZ1066	7 MtaR Streptococcus pneumoniae TIGR4	6 MtaR Streptococcus mitis B6	6 MtaR Streptococcus sanguinis SK36	7 MtaR Streptococcus gordonii str. Challis substr. CH1	5 MtaR Streptococcus suis 05ZYH33			Methionine metabolism
MarR	TF	AdcR	7 AdcR Streptococcus pyogenes M1 GAS	9 AdcR Streptococcus dysgalactiae subsp. equisimilis GGS_124	10 AdcR Streptococcus equi subsp. zooepidemicus MGCS10565	5 AdcR Streptococcus uberis 0140J	9 AdcR Streptococcus agalactiae 2603V/R	2 AdcR Streptococcus mutans UA159	3 AdcR Streptococcus gallolyticus UCN34	2 AdcR Streptococcus thermophilus CNRZ1066	6 AdcR Streptococcus pneumoniae TIGR4	4 AdcR Streptococcus mitis B6	3 AdcR Streptococcus sanguinis SK36	2 AdcR Streptococcus gordonii str. Challis substr. CH1	3 AdcR Streptococcus suis 05ZYH33	1 AdcR Lactococcus lactis subsp. cremoris SK11	2 AdcR Lactococcus lactis subsp. lactis Il1403	Zinc homeostasis
	TF	FabT	3 FabT Streptococcus pyogenes M1 GAS	3 FabT Streptococcus dysgalactiae subsp. equisimilis GGS_124	3 FabT Streptococcus equi subsp. zooepidemicus MGCS10565	3 FabT Streptococcus uberis 0140J	3 FabT Streptococcus agalactiae 2603V/R	3 FabT Streptococcus mutans UA159	3 FabT Streptococcus gallolyticus UCN34	3 FabT Streptococcus thermophilus CNRZ1066	3 FabT Streptococcus pneumoniae TIGR4	3 FabT Streptococcus mitis B6	3 FabT Streptococcus sanguinis SK36	3 FabT Streptococcus gordonii str. Challis substr. CH1	3 FabT Streptococcus suis 05ZYH33	3 FabT Lactococcus lactis subsp. cremoris SK11	3 FabT Lactococcus lactis subsp. lactis Il1403	Fatty acid biosynthesis
	TF	SAG1910	1 SAG1910 Streptococcus pyogenes M1 GAS	2 SAG1910 Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 SAG1910 Streptococcus equi subsp. zooepidemicus MGCS10565	2 SAG1910 Streptococcus uberis 0140J	3 SAG1910 Streptococcus agalactiae 2603V/R	3 SAG1910 Streptococcus mutans UA159	1 SAG1910 Streptococcus gallolyticus UCN34	2 SAG1910 Streptococcus thermophilus CNRZ1066			2 SAG1910 Streptococcus sanguinis SK36	2 SAG1910 Streptococcus gordonii str. Challis substr. CH1	2 SAG1910 Streptococcus suis 05ZYH33			unknown
	TF	YjdR	1 YjdR Streptococcus pyogenes M1 GAS	1 YjdR Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 YjdR Streptococcus equi subsp. zooepidemicus MGCS10565	2 YjdR Streptococcus uberis 0140J	2 YjdR Streptococcus agalactiae 2603V/R	1 YjdR Streptococcus mutans UA159	1 YjdR Streptococcus gallolyticus UCN34	1 YjdR Streptococcus thermophilus CNRZ1066	1 YjdR Streptococcus pneumoniae TIGR4	1 YjdR Streptococcus mitis B6	1 YjdR Streptococcus sanguinis SK36	1 YjdR Streptococcus gordonii str. Challis substr. CH1	1 YjdR Streptococcus suis 05ZYH33			Multidrug resistance
MerR	TF	GlnR	2 GlnR Streptococcus pyogenes M1 GAS	2 GlnR Streptococcus dysgalactiae subsp. equisimilis GGS_124	2 GlnR Streptococcus equi subsp. zooepidemicus MGCS10565	3 GlnR Streptococcus uberis 0140J	3 GlnR Streptococcus agalactiae 2603V/R	6 GlnR Streptococcus mutans UA159	7 GlnR Streptococcus gallolyticus UCN34	7 GlnR Streptococcus thermophilus CNRZ1066	5 GlnR Streptococcus pneumoniae TIGR4	4 GlnR Streptococcus mitis B6	6 GlnR Streptococcus sanguinis SK36	5 GlnR Streptococcus gordonii str. Challis substr. CH1	4 GlnR Streptococcus suis 05ZYH33	3 GlnR Lactococcus lactis subsp. cremoris SK11	3 GlnR Lactococcus lactis subsp. lactis Il1403	Nitrogen assimilation
	TF	NmlR				2 NmlR Streptococcus uberis 0140J	2 NmlR Streptococcus agalactiae 2603V/R	2 NmlR Streptococcus mutans UA159	2 NmlR Streptococcus gallolyticus UCN34		1 NmlR Streptococcus pneumoniae TIGR4				1 NmlR Streptococcus suis 05ZYH33	2 NmlR Lactococcus lactis subsp. cremoris SK11	2 NmlR Lactococcus lactis subsp. lactis Il1403	Carbonyl stress response
NiaR	TF	NiaR	3 NiaR Streptococcus pyogenes M1 GAS	2 NiaR Streptococcus dysgalactiae subsp. equisimilis GGS_124	2 NiaR Streptococcus equi subsp. zooepidemicus MGCS10565	1 NiaR Streptococcus uberis 0140J	1 NiaR Streptococcus agalactiae 2603V/R	2 NiaR Streptococcus mutans UA159	3 NiaR Streptococcus gallolyticus UCN34	1 NiaR Streptococcus thermophilus CNRZ1066	3 NiaR Streptococcus pneumoniae TIGR4	1 NiaR Streptococcus mitis B6	1 NiaR Streptococcus sanguinis SK36	1 NiaR Streptococcus gordonii str. Challis substr. CH1	1 NiaR Streptococcus suis 05ZYH33			NAD biosynthesis
NrdR	TF	NrdR	3 NrdR Streptococcus pyogenes M1 GAS	3 NrdR Streptococcus dysgalactiae subsp. equisimilis GGS_124	3 NrdR Streptococcus equi subsp. zooepidemicus MGCS10565	2 NrdR Streptococcus uberis 0140J	3 NrdR Streptococcus agalactiae 2603V/R	2 NrdR Streptococcus mutans UA159	2 NrdR Streptococcus gallolyticus UCN34	2 NrdR Streptococcus thermophilus CNRZ1066	2 NrdR Streptococcus pneumoniae TIGR4	2 NrdR Streptococcus mitis B6	2 NrdR Streptococcus sanguinis SK36	2 NrdR Streptococcus gordonii str. Challis substr. CH1	2 NrdR Streptococcus suis 05ZYH33	2 NrdR Lactococcus lactis subsp. cremoris SK11	2 NrdR Lactococcus lactis subsp. lactis Il1403	Deoxyribonucleotide biosynthesis
NrtR	TF	NrtR								1 NrtR Streptococcus thermophilus CNRZ1066		1 NrtR Streptococcus mitis B6	1 NrtR Streptococcus sanguinis SK36	1 NrtR Streptococcus gordonii str. Challis substr. CH1	1 NrtR Streptococcus suis 05ZYH33			NAD biosynthesis
PadR	TF	PadR							1 PadR Streptococcus gallolyticus UCN34								1 PadR Lactococcus lactis subsp. lactis Il1403	Phenolic acid stress response
	TF	YwzG	1 YwzG Streptococcus pyogenes M1 GAS	1 YwzG Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 YwzG Streptococcus equi subsp. zooepidemicus MGCS10565	1 YwzG Streptococcus uberis 0140J		1 YwzG Streptococcus mutans UA159	1 YwzG Streptococcus gallolyticus UCN34	1 YwzG Streptococcus thermophilus CNRZ1066	1 YwzG Streptococcus pneumoniae TIGR4	1 YwzG Streptococcus mitis B6	1 YwzG Streptococcus sanguinis SK36	1 YwzG Streptococcus gordonii str. Challis substr. CH1	2 YwzG Streptococcus suis 05ZYH33			Transport
PurR	TF	PurR	5 PurR Streptococcus pyogenes M1 GAS	6 PurR Streptococcus dysgalactiae subsp. equisimilis GGS_124	5 PurR Streptococcus equi subsp. zooepidemicus MGCS10565	5 PurR Streptococcus uberis 0140J	3 PurR Streptococcus agalactiae 2603V/R	3 PurR Streptococcus mutans UA159	6 PurR Streptococcus gallolyticus UCN34	3 PurR Streptococcus thermophilus CNRZ1066	4 PurR Streptococcus pneumoniae TIGR4	5 PurR Streptococcus mitis B6	5 PurR Streptococcus sanguinis SK36	5 PurR Streptococcus gordonii str. Challis substr. CH1	4 PurR Streptococcus suis 05ZYH33	13 PurR Lactococcus lactis subsp. cremoris SK11	16 PurR Lactococcus lactis subsp. lactis Il1403	Purine metabolism
ROK	TF	CelQ			2 CelQ Streptococcus equi subsp. zooepidemicus MGCS10565						2 CelQ Streptococcus pneumoniae TIGR4		2 CelQ Streptococcus sanguinis SK36		2 CelQ Streptococcus suis 05ZYH33			Cellobiose utilization
Rex	TF	Rex	10 Rex Streptococcus pyogenes M1 GAS	10 Rex Streptococcus dysgalactiae subsp. equisimilis GGS_124	11 Rex Streptococcus equi subsp. zooepidemicus MGCS10565	10 Rex Streptococcus uberis 0140J	10 Rex Streptococcus agalactiae 2603V/R	9 Rex Streptococcus mutans UA159	6 Rex Streptococcus gallolyticus UCN34	6 Rex Streptococcus thermophilus CNRZ1066	9 Rex Streptococcus pneumoniae TIGR4	9 Rex Streptococcus mitis B6	10 Rex Streptococcus sanguinis SK36	9 Rex Streptococcus gordonii str. Challis substr. CH1	5 Rex Streptococcus suis 05ZYH33	6 Rex Lactococcus lactis subsp. cremoris SK11	7 Rex Lactococcus lactis subsp. lactis Il1403	Energy metabolism
RpiR	TF	GntR1														3 GntR1 Lactococcus lactis subsp. cremoris SK11	3 GntR1 Lactococcus lactis subsp. lactis Il1403	Gluconate utilization
	TF	MurR														1 MurR Lactococcus lactis subsp. cremoris SK11	1 MurR Lactococcus lactis subsp. lactis Il1403	N-acetylmuramate utilization
	TF	NanR	1 NanR Streptococcus pyogenes M1 GAS	1 NanR Streptococcus dysgalactiae subsp. equisimilis GGS_124	2 NanR Streptococcus equi subsp. zooepidemicus MGCS10565	1 NanR Streptococcus uberis 0140J	1 NanR Streptococcus agalactiae 2603V/R				3 NanR Streptococcus pneumoniae TIGR4	3 NanR Streptococcus mitis B6	1 NanR Streptococcus sanguinis SK36	1 NanR Streptococcus gordonii str. Challis substr. CH1	1 NanR Streptococcus suis 05ZYH33			Sialic acid utilization
	TF	TagR						2 TagR Streptococcus mutans UA159										Tagatose utilization
TetR	TF	FlrR														1 FlrR Lactococcus lactis subsp. cremoris SK11	2 FlrR Lactococcus lactis subsp. lactis Il1403	Drug resistance
	TF	PipR	2 PipR Streptococcus pyogenes M1 GAS	2 PipR Streptococcus dysgalactiae subsp. equisimilis GGS_124	2 PipR Streptococcus equi subsp. zooepidemicus MGCS10565	2 PipR Streptococcus uberis 0140J	2 PipR Streptococcus agalactiae 2603V/R	2 PipR Streptococcus mutans UA159	2 PipR Streptococcus gallolyticus UCN34	2 PipR Streptococcus thermophilus CNRZ1066	2 PipR Streptococcus pneumoniae TIGR4	2 PipR Streptococcus mitis B6	1 PipR Streptococcus sanguinis SK36	2 PipR Streptococcus gordonii str. Challis substr. CH1	2 PipR Streptococcus suis 05ZYH33	1 PipR Lactococcus lactis subsp. cremoris SK11	2 PipR Lactococcus lactis subsp. lactis Il1403	Phage infection protein
	TF	SczA	2 SczA Streptococcus pyogenes M1 GAS				2 SczA Streptococcus agalactiae 2603V/R			2 SczA Streptococcus thermophilus CNRZ1066	2 SczA Streptococcus pneumoniae TIGR4	2 SczA Streptococcus mitis B6	2 SczA Streptococcus sanguinis SK36	4 SczA Streptococcus gordonii str. Challis substr. CH1				Zinc resistance
	TF	YxeR														1 YxeR Lactococcus lactis subsp. cremoris SK11	1 YxeR Lactococcus lactis subsp. lactis Il1403	Antibiotic resistance
XRE	TF	Rgg							3 Rgg Streptococcus gallolyticus UCN34			1 Rgg Streptococcus mitis B6	3 Rgg Streptococcus sanguinis SK36	3 Rgg Streptococcus gordonii str. Challis substr. CH1				Cell wall metabolism
RF00050	RNA	FMN	1 FMN Streptococcus pyogenes M1 GAS	1 FMN Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 FMN Streptococcus equi subsp. zooepidemicus MGCS10565	1 FMN Streptococcus uberis 0140J	2 FMN Streptococcus agalactiae 2603V/R	1 FMN Streptococcus mutans UA159	2 FMN Streptococcus gallolyticus UCN34	1 FMN Streptococcus thermophilus CNRZ1066	2 FMN Streptococcus pneumoniae TIGR4	1 FMN Streptococcus mitis B6	1 FMN Streptococcus sanguinis SK36	1 FMN Streptococcus gordonii str. Challis substr. CH1	1 FMN Streptococcus suis 05ZYH33	1 FMN Lactococcus lactis subsp. cremoris SK11	2 FMN Lactococcus lactis subsp. lactis Il1403	Riboflavin biosynthesis
RF00059	RNA	TPP	1 TPP Streptococcus pyogenes M1 GAS	1 TPP Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 TPP Streptococcus equi subsp. zooepidemicus MGCS10565	1 TPP Streptococcus uberis 0140J	2 TPP Streptococcus agalactiae 2603V/R	1 TPP Streptococcus mutans UA159	2 TPP Streptococcus gallolyticus UCN34	1 TPP Streptococcus thermophilus CNRZ1066	4 TPP Streptococcus pneumoniae TIGR4	1 TPP Streptococcus mitis B6	1 TPP Streptococcus sanguinis SK36	1 TPP Streptococcus gordonii str. Challis substr. CH1	2 TPP Streptococcus suis 05ZYH33	2 TPP Lactococcus lactis subsp. cremoris SK11	2 TPP Lactococcus lactis subsp. lactis Il1403	Thiamine biosynthesis
RF00080	RNA	yybP-ykoY	1 yybP-ykoY Streptococcus pyogenes M1 GAS	1 yybP-ykoY Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 yybP-ykoY Streptococcus equi subsp. zooepidemicus MGCS10565	1 yybP-ykoY Streptococcus uberis 0140J	1 yybP-ykoY Streptococcus agalactiae 2603V/R	1 yybP-ykoY Streptococcus mutans UA159	1 yybP-ykoY Streptococcus gallolyticus UCN34	1 yybP-ykoY Streptococcus thermophilus CNRZ1066	1 yybP-ykoY Streptococcus pneumoniae TIGR4	1 yybP-ykoY Streptococcus mitis B6	1 yybP-ykoY Streptococcus sanguinis SK36	1 yybP-ykoY Streptococcus gordonii str. Challis substr. CH1	1 yybP-ykoY Streptococcus suis 05ZYH33	1 yybP-ykoY Lactococcus lactis subsp. cremoris SK11	1 yybP-ykoY Lactococcus lactis subsp. lactis Il1403
RF00114	RNA	S15	1 S15 Streptococcus pyogenes M1 GAS	1 S15 Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 S15 Streptococcus equi subsp. zooepidemicus MGCS10565	1 S15 Streptococcus uberis 0140J	1 S15 Streptococcus agalactiae 2603V/R	1 S15 Streptococcus mutans UA159	1 S15 Streptococcus gallolyticus UCN34	1 S15 Streptococcus thermophilus CNRZ1066	1 S15 Streptococcus pneumoniae TIGR4	1 S15 Streptococcus mitis B6	1 S15 Streptococcus sanguinis SK36	1 S15 Streptococcus gordonii str. Challis substr. CH1	1 S15 Streptococcus suis 05ZYH33	1 S15 Lactococcus lactis subsp. cremoris SK11	1 S15 Lactococcus lactis subsp. lactis Il1403	Ribosome biogenesis
RF00167	RNA	Purine	1 Purine Streptococcus pyogenes M1 GAS	1 Purine Streptococcus dysgalactiae subsp. equisimilis GGS_124		1 Purine Streptococcus uberis 0140J	1 Purine Streptococcus agalactiae 2603V/R		1 Purine Streptococcus gallolyticus UCN34	1 Purine Streptococcus thermophilus CNRZ1066	1 Purine Streptococcus pneumoniae TIGR4	1 Purine Streptococcus mitis B6		1 Purine Streptococcus gordonii str. Challis substr. CH1		1 Purine Lactococcus lactis subsp. cremoris SK11	1 Purine Lactococcus lactis subsp. lactis Il1403	Purine metabolism
RF00168	RNA	Lysine														2 Lysine Lactococcus lactis subsp. cremoris SK11	2 Lysine Lactococcus lactis subsp. lactis Il1403	Lysine biosynthesis
RF00230	RNA	T-box(Ala)	1 T-box(Ala) Streptococcus pyogenes M1 GAS	1 T-box(Ala) Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 T-box(Ala) Streptococcus equi subsp. zooepidemicus MGCS10565	1 T-box(Ala) Streptococcus uberis 0140J	1 T-box(Ala) Streptococcus agalactiae 2603V/R	1 T-box(Ala) Streptococcus mutans UA159	1 T-box(Ala) Streptococcus gallolyticus UCN34	1 T-box(Ala) Streptococcus thermophilus CNRZ1066	1 T-box(Ala) Streptococcus pneumoniae TIGR4	1 T-box(Ala) Streptococcus mitis B6	1 T-box(Ala) Streptococcus sanguinis SK36	1 T-box(Ala) Streptococcus gordonii str. Challis substr. CH1	1 T-box(Ala) Streptococcus suis 05ZYH33	1 T-box(Ala) Lactococcus lactis subsp. cremoris SK11	1 T-box(Ala) Lactococcus lactis subsp. lactis Il1403	Amino acid metabolism
	RNA	T-box(Asn)						1 T-box(Asn) Streptococcus mutans UA159					1 T-box(Asn) Streptococcus sanguinis SK36	1 T-box(Asn) Streptococcus gordonii str. Challis substr. CH1				Amino acid metabolism
	RNA	T-box(Asp)														1 T-box(Asp) Lactococcus lactis subsp. cremoris SK11	1 T-box(Asp) Lactococcus lactis subsp. lactis Il1403	Amino acid metabolism
	RNA	T-box(Gly)	1 T-box(Gly) Streptococcus pyogenes M1 GAS	1 T-box(Gly) Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 T-box(Gly) Streptococcus equi subsp. zooepidemicus MGCS10565	1 T-box(Gly) Streptococcus uberis 0140J	1 T-box(Gly) Streptococcus agalactiae 2603V/R	1 T-box(Gly) Streptococcus mutans UA159	1 T-box(Gly) Streptococcus gallolyticus UCN34	1 T-box(Gly) Streptococcus thermophilus CNRZ1066	1 T-box(Gly) Streptococcus pneumoniae TIGR4	1 T-box(Gly) Streptococcus mitis B6	1 T-box(Gly) Streptococcus sanguinis SK36	1 T-box(Gly) Streptococcus gordonii str. Challis substr. CH1	1 T-box(Gly) Streptococcus suis 05ZYH33	1 T-box(Gly) Lactococcus lactis subsp. cremoris SK11	1 T-box(Gly) Lactococcus lactis subsp. lactis Il1403	Amino acid metabolism
	RNA	T-box(His)						1 T-box(His) Streptococcus mutans UA159	1 T-box(His) Streptococcus gallolyticus UCN34				1 T-box(His) Streptococcus sanguinis SK36	2 T-box(His) Streptococcus gordonii str. Challis substr. CH1		1 T-box(His) Lactococcus lactis subsp. cremoris SK11	1 T-box(His) Lactococcus lactis subsp. lactis Il1403	Amino acid metabolism
	RNA	T-box(Ile)	1 T-box(Ile) Streptococcus pyogenes M1 GAS	1 T-box(Ile) Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 T-box(Ile) Streptococcus equi subsp. zooepidemicus MGCS10565	1 T-box(Ile) Streptococcus uberis 0140J	1 T-box(Ile) Streptococcus agalactiae 2603V/R	1 T-box(Ile) Streptococcus mutans UA159	1 T-box(Ile) Streptococcus gallolyticus UCN34	1 T-box(Ile) Streptococcus thermophilus CNRZ1066	1 T-box(Ile) Streptococcus pneumoniae TIGR4	1 T-box(Ile) Streptococcus mitis B6	1 T-box(Ile) Streptococcus sanguinis SK36	1 T-box(Ile) Streptococcus gordonii str. Challis substr. CH1	1 T-box(Ile) Streptococcus suis 05ZYH33	1 T-box(Ile) Lactococcus lactis subsp. cremoris SK11	1 T-box(Ile) Lactococcus lactis subsp. lactis Il1403	Amino acid metabolism
	RNA	T-box(Met)														1 T-box(Met) Lactococcus lactis subsp. cremoris SK11	1 T-box(Met) Lactococcus lactis subsp. lactis Il1403	Amino acid metabolism
	RNA	T-box(Phe)	1 T-box(Phe) Streptococcus pyogenes M1 GAS	1 T-box(Phe) Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 T-box(Phe) Streptococcus equi subsp. zooepidemicus MGCS10565	1 T-box(Phe) Streptococcus uberis 0140J	1 T-box(Phe) Streptococcus agalactiae 2603V/R	1 T-box(Phe) Streptococcus mutans UA159	1 T-box(Phe) Streptococcus gallolyticus UCN34	1 T-box(Phe) Streptococcus thermophilus CNRZ1066	1 T-box(Phe) Streptococcus pneumoniae TIGR4	1 T-box(Phe) Streptococcus mitis B6	1 T-box(Phe) Streptococcus sanguinis SK36	1 T-box(Phe) Streptococcus gordonii str. Challis substr. CH1	1 T-box(Phe) Streptococcus suis 05ZYH33	1 T-box(Phe) Lactococcus lactis subsp. cremoris SK11	1 T-box(Phe) Lactococcus lactis subsp. lactis Il1403	Amino acid metabolism
	RNA	T-box(Ser)	1 T-box(Ser) Streptococcus pyogenes M1 GAS	1 T-box(Ser) Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 T-box(Ser) Streptococcus equi subsp. zooepidemicus MGCS10565	1 T-box(Ser) Streptococcus uberis 0140J	1 T-box(Ser) Streptococcus agalactiae 2603V/R	1 T-box(Ser) Streptococcus mutans UA159	1 T-box(Ser) Streptococcus gallolyticus UCN34	1 T-box(Ser) Streptococcus thermophilus CNRZ1066	1 T-box(Ser) Streptococcus pneumoniae TIGR4	1 T-box(Ser) Streptococcus mitis B6	1 T-box(Ser) Streptococcus sanguinis SK36	1 T-box(Ser) Streptococcus gordonii str. Challis substr. CH1	1 T-box(Ser) Streptococcus suis 05ZYH33	1 T-box(Ser) Lactococcus lactis subsp. cremoris SK11	1 T-box(Ser) Lactococcus lactis subsp. lactis Il1403	Amino acid metabolism
	RNA	T-box(Thr)	1 T-box(Thr) Streptococcus pyogenes M1 GAS	1 T-box(Thr) Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 T-box(Thr) Streptococcus equi subsp. zooepidemicus MGCS10565	1 T-box(Thr) Streptococcus uberis 0140J	1 T-box(Thr) Streptococcus agalactiae 2603V/R	1 T-box(Thr) Streptococcus mutans UA159	1 T-box(Thr) Streptococcus gallolyticus UCN34	1 T-box(Thr) Streptococcus thermophilus CNRZ1066	1 T-box(Thr) Streptococcus pneumoniae TIGR4	1 T-box(Thr) Streptococcus mitis B6	1 T-box(Thr) Streptococcus sanguinis SK36	1 T-box(Thr) Streptococcus gordonii str. Challis substr. CH1	1 T-box(Thr) Streptococcus suis 05ZYH33	1 T-box(Thr) Lactococcus lactis subsp. cremoris SK11	1 T-box(Thr) Lactococcus lactis subsp. lactis Il1403	Amino acid metabolism
	RNA	T-box(Trp)	1 T-box(Trp) Streptococcus pyogenes M1 GAS	1 T-box(Trp) Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 T-box(Trp) Streptococcus equi subsp. zooepidemicus MGCS10565	1 T-box(Trp) Streptococcus uberis 0140J		1 T-box(Trp) Streptococcus mutans UA159	2 T-box(Trp) Streptococcus gallolyticus UCN34	2 T-box(Trp) Streptococcus thermophilus CNRZ1066	2 T-box(Trp) Streptococcus pneumoniae TIGR4	1 T-box(Trp) Streptococcus mitis B6	3 T-box(Trp) Streptococcus sanguinis SK36	3 T-box(Trp) Streptococcus gordonii str. Challis substr. CH1	2 T-box(Trp) Streptococcus suis 05ZYH33	2 T-box(Trp) Lactococcus lactis subsp. cremoris SK11	2 T-box(Trp) Lactococcus lactis subsp. lactis Il1403	Amino acid metabolism
	RNA	T-box(Val)	1 T-box(Val) Streptococcus pyogenes M1 GAS	1 T-box(Val) Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 T-box(Val) Streptococcus equi subsp. zooepidemicus MGCS10565	1 T-box(Val) Streptococcus uberis 0140J	1 T-box(Val) Streptococcus agalactiae 2603V/R	1 T-box(Val) Streptococcus mutans UA159	1 T-box(Val) Streptococcus gallolyticus UCN34	1 T-box(Val) Streptococcus thermophilus CNRZ1066	1 T-box(Val) Streptococcus pneumoniae TIGR4	1 T-box(Val) Streptococcus mitis B6	1 T-box(Val) Streptococcus sanguinis SK36	1 T-box(Val) Streptococcus gordonii str. Challis substr. CH1	1 T-box(Val) Streptococcus suis 05ZYH33	1 T-box(Val) Lactococcus lactis subsp. cremoris SK11	1 T-box(Val) Lactococcus lactis subsp. lactis Il1403	Amino acid metabolism
RF00380	RNA	ykoK										1 ykoK Streptococcus mitis B6	1 ykoK Streptococcus sanguinis SK36	1 ykoK Streptococcus gordonii str. Challis substr. CH1		1 ykoK Lactococcus lactis subsp. cremoris SK11	1 ykoK Lactococcus lactis subsp. lactis Il1403	Magnesium homeostasis
RF00504	RNA	Glycine	1 Glycine Streptococcus pyogenes M1 GAS	1 Glycine Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 Glycine Streptococcus equi subsp. zooepidemicus MGCS10565	1 Glycine Streptococcus uberis 0140J	1 Glycine Streptococcus agalactiae 2603V/R	1 Glycine Streptococcus mutans UA159	1 Glycine Streptococcus gallolyticus UCN34	1 Glycine Streptococcus thermophilus CNRZ1066	1 Glycine Streptococcus pneumoniae TIGR4	1 Glycine Streptococcus mitis B6	1 Glycine Streptococcus sanguinis SK36		1 Glycine Streptococcus suis 05ZYH33			Glycine metabolism
RF00515	RNA	PyrR	3 PyrR Streptococcus pyogenes M1 GAS	4 PyrR Streptococcus dysgalactiae subsp. equisimilis GGS_124	4 PyrR Streptococcus equi subsp. zooepidemicus MGCS10565	3 PyrR Streptococcus uberis 0140J	5 PyrR Streptococcus agalactiae 2603V/R	2 PyrR Streptococcus mutans UA159	3 PyrR Streptococcus gallolyticus UCN34	3 PyrR Streptococcus thermophilus CNRZ1066	5 PyrR Streptococcus pneumoniae TIGR4	5 PyrR Streptococcus mitis B6	3 PyrR Streptococcus sanguinis SK36	6 PyrR Streptococcus gordonii str. Challis substr. CH1	6 PyrR Streptococcus suis 05ZYH33	4 PyrR Lactococcus lactis subsp. cremoris SK11	4 PyrR Lactococcus lactis subsp. lactis Il1403	Pyrimidine metabolism
RF00522	RNA	PreQ1		1 PreQ1 Streptococcus dysgalactiae subsp. equisimilis GGS_124			1 PreQ1 Streptococcus agalactiae 2603V/R											Queuosine biosynthesis
RF00555	RNA	L13_leader	1 L13_leader Streptococcus pyogenes M1 GAS	1 L13_leader Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 L13_leader Streptococcus equi subsp. zooepidemicus MGCS10565	1 L13_leader Streptococcus uberis 0140J	1 L13_leader Streptococcus agalactiae 2603V/R	1 L13_leader Streptococcus mutans UA159	1 L13_leader Streptococcus gallolyticus UCN34	1 L13_leader Streptococcus thermophilus CNRZ1066	1 L13_leader Streptococcus pneumoniae TIGR4	1 L13_leader Streptococcus mitis B6	1 L13_leader Streptococcus sanguinis SK36	1 L13_leader Streptococcus gordonii str. Challis substr. CH1	1 L13_leader Streptococcus suis 05ZYH33	1 L13_leader Lactococcus lactis subsp. cremoris SK11	1 L13_leader Lactococcus lactis subsp. lactis Il1403	Ribosome biogenesis
RF00556	RNA	L19_leader	1 L19_leader Streptococcus pyogenes M1 GAS	1 L19_leader Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 L19_leader Streptococcus equi subsp. zooepidemicus MGCS10565	1 L19_leader Streptococcus uberis 0140J	1 L19_leader Streptococcus agalactiae 2603V/R	1 L19_leader Streptococcus mutans UA159	1 L19_leader Streptococcus gallolyticus UCN34	1 L19_leader Streptococcus thermophilus CNRZ1066	1 L19_leader Streptococcus pneumoniae TIGR4	1 L19_leader Streptococcus mitis B6	1 L19_leader Streptococcus sanguinis SK36		1 L19_leader Streptococcus suis 05ZYH33	1 L19_leader Lactococcus lactis subsp. cremoris SK11		Ribosome biogenesis
RF00557	RNA	L10_leader	1 L10_leader Streptococcus pyogenes M1 GAS	1 L10_leader Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 L10_leader Streptococcus equi subsp. zooepidemicus MGCS10565	1 L10_leader Streptococcus uberis 0140J	1 L10_leader Streptococcus agalactiae 2603V/R	1 L10_leader Streptococcus mutans UA159	1 L10_leader Streptococcus gallolyticus UCN34	1 L10_leader Streptococcus thermophilus CNRZ1066	1 L10_leader Streptococcus pneumoniae TIGR4	1 L10_leader Streptococcus mitis B6	1 L10_leader Streptococcus sanguinis SK36	1 L10_leader Streptococcus gordonii str. Challis substr. CH1	1 L10_leader Streptococcus suis 05ZYH33	1 L10_leader Lactococcus lactis subsp. cremoris SK11	1 L10_leader Lactococcus lactis subsp. lactis Il1403	Ribosome biogenesis
RF00558	RNA	L20_leader	1 L20_leader Streptococcus pyogenes M1 GAS	1 L20_leader Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 L20_leader Streptococcus equi subsp. zooepidemicus MGCS10565	1 L20_leader Streptococcus uberis 0140J	1 L20_leader Streptococcus agalactiae 2603V/R	1 L20_leader Streptococcus mutans UA159	1 L20_leader Streptococcus gallolyticus UCN34	1 L20_leader Streptococcus thermophilus CNRZ1066	1 L20_leader Streptococcus pneumoniae TIGR4	1 L20_leader Streptococcus mitis B6	1 L20_leader Streptococcus sanguinis SK36	1 L20_leader Streptococcus gordonii str. Challis substr. CH1	1 L20_leader Streptococcus suis 05ZYH33	1 L20_leader Lactococcus lactis subsp. cremoris SK11	1 L20_leader Lactococcus lactis subsp. lactis Il1403	Ribosome biogenesis
RF00559	RNA	L21_leader	1 L21_leader Streptococcus pyogenes M1 GAS	1 L21_leader Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 L21_leader Streptococcus equi subsp. zooepidemicus MGCS10565	1 L21_leader Streptococcus uberis 0140J	1 L21_leader Streptococcus agalactiae 2603V/R	1 L21_leader Streptococcus mutans UA159	1 L21_leader Streptococcus gallolyticus UCN34	1 L21_leader Streptococcus thermophilus CNRZ1066	1 L21_leader Streptococcus pneumoniae TIGR4	1 L21_leader Streptococcus mitis B6	1 L21_leader Streptococcus sanguinis SK36	1 L21_leader Streptococcus gordonii str. Challis substr. CH1	1 L21_leader Streptococcus suis 05ZYH33	1 L21_leader Lactococcus lactis subsp. cremoris SK11	1 L21_leader Lactococcus lactis subsp. lactis Il1403	Ribosome biogenesis
RF01054	RNA	preQ1-II	1 preQ1-II Streptococcus pyogenes M1 GAS	1 preQ1-II Streptococcus dysgalactiae subsp. equisimilis GGS_124	1 preQ1-II Streptococcus equi subsp. zooepidemicus MGCS10565	1 preQ1-II Streptococcus uberis 0140J	1 preQ1-II Streptococcus agalactiae 2603V/R	1 preQ1-II Streptococcus mutans UA159	1 preQ1-II Streptococcus gallolyticus UCN34		1 preQ1-II Streptococcus pneumoniae TIGR4	1 preQ1-II Streptococcus mitis B6	1 preQ1-II Streptococcus sanguinis SK36	1 preQ1-II Streptococcus gordonii str. Challis substr. CH1	1 preQ1-II Streptococcus suis 05ZYH33	1 preQ1-II Lactococcus lactis subsp. cremoris SK11	1 preQ1-II Lactococcus lactis subsp. lactis Il1403	Queuosine biosynthesis
RF01831	RNA	THF				1 THF Streptococcus uberis 0140J		1 THF Streptococcus mutans UA159	1 THF Streptococcus gallolyticus UCN34						1 THF Streptococcus suis 05ZYH33			Folate metabolism

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Collection of regulogs in Streptococcaceae taxonomic group

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --