Statistics of regulated genes

Genome	Genes	Operons
Lactococcus lactis subsp. cremoris SK11
Lactococcus lactis subsp. lactis Il1403
Streptococcus agalactiae 2603V/R	6	2
Streptococcus dysgalactiae subsp. equisimilis GGS_124	5	2
Streptococcus equi subsp. zooepidemicus MGCS10565	4	1
Streptococcus gallolyticus UCN34	14	7
Streptococcus gordonii str. Challis substr. CH1	11	7
Streptococcus mitis B6	14	6
Streptococcus mutans UA159	15	7
Streptococcus pneumoniae TIGR4	15	7
Streptococcus pyogenes M1 GAS	3	1
Streptococcus sanguinis SK36	8	6
Streptococcus suis 05ZYH33	8	5
Streptococcus thermophilus CNRZ1066	18	7
Streptococcus uberis 0140J	9	3

Clusters of co-Regulated Orthologous operoNs (CRONs)

Genes																Function
CRON 1.
fhs	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1007: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	Lactococcus lactis subsp. lactis Il1403 Gene: L159505: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	Streptococcus agalactiae 2603V/R Gene: SAG1055: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_1033: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0945: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	Streptococcus gallolyticus UCN34 Gene: GALLO_1115: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -42 score = 4.7769 sequence = TTTTGTTATAATCTATA Gene: SGO_1210: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus mitis B6 Site: position = -157 score = 6.35878 sequence = TATAGTTTCAAACTATA Gene: smi_1192: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	Streptococcus mutans UA159 Gene: SMU.1073: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus pneumoniae TIGR4 Site: position = -156 score = 6.35878 sequence = TATAGTTTCAAACTATA Gene: SP_1229: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	Streptococcus pyogenes M1 GAS Gene: SPy1213: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	Streptococcus sanguinis SK36 Gene: SSA_1200: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	Streptococcus suis 05ZYH33 Gene: SSU05_0690: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	Streptococcus thermophilus CNRZ1066 Gene: str0791: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus uberis 0140J Site: position = -129 score = 4.59488 sequence = TAAAGATATACACTATA Gene: SUB0942: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	Formate--tetrahydrofolate ligase (EC 6.3.4.3)
CRON 2.
folD	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_0921: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Lactococcus lactis subsp. lactis Il1403 Gene: L76582: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus agalactiae 2603V/R Gene: SAG0494: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_1488: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0614: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus gallolyticus UCN34 Gene: GALLO_0622: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0690: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	* Streptococcus mitis B6 Site: position = -35 score = 6.15603 sequence = TATAGTTTGAAACTATA Gene: smi_0869: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	* Streptococcus mutans UA159 Site: position = -93 score = 4.62839 sequence = TATAATATTTAAATATA Gene: SMU.572: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	* Streptococcus pneumoniae TIGR4 Site: position = -98 score = 6.26 sequence = TATAGTTTAAAGCTATA Gene: SP_0825: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus pyogenes M1 GAS Gene: SPy1502: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus sanguinis SK36 Gene: SSA_0671: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus suis 05ZYH33 Gene: SSU05_0497: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus thermophilus CNRZ1066 Gene: str0611: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus uberis 0140J Gene: SUB1277: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
CRON 3.
metK	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_2161: S-adenosylmethionine synthetase (EC 2.5.1.6)	Lactococcus lactis subsp. lactis Il1403 Gene: L153408: S-adenosylmethionine synthetase (EC 2.5.1.6)	Streptococcus agalactiae 2603V/R Gene: SAG0831: S-adenosylmethionine synthetase (EC 2.5.1.6)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_1371: S-adenosylmethionine synthetase (EC 2.5.1.6)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0680: S-adenosylmethionine synthetase (EC 2.5.1.6)	Streptococcus gallolyticus UCN34 Gene: GALLO_0769: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -158 score = 5.79099 sequence = TATAGTTTATGTCTATA Gene: SGO_0987: S-adenosylmethionine synthetase (EC 2.5.1.6)	Streptococcus mitis B6 Gene: smi_1400: S-adenosylmethionine synthetase (EC 2.5.1.6)	Streptococcus mutans UA159 Gene: SMU.1573: S-adenosylmethionine synthetase (EC 2.5.1.6)	Streptococcus pneumoniae TIGR4 Gene: SP_0762: S-adenosylmethionine synthetase (EC 2.5.1.6)	Streptococcus pyogenes M1 GAS Gene: SPy1359: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Streptococcus sanguinis SK36 Site: position = -157 score = 6.25439 sequence = TATAGTTTTAATCTATA Gene: SSA_1495: S-adenosylmethionine synthetase (EC 2.5.1.6)	Streptococcus suis 05ZYH33 Gene: SSU05_1621: S-adenosylmethionine synthetase (EC 2.5.1.6)	Streptococcus thermophilus CNRZ1066 Gene: str1172: S-adenosylmethionine synthetase (EC 2.5.1.6)	Streptococcus uberis 0140J Gene: SUB1211: S-adenosylmethionine synthetase (EC 2.5.1.6)	S-adenosylmethionine synthetase (EC 2.5.1.6)
CRON 4.
mmuP	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R Gene: SAG1306: Predicted S-methylmethionine permease	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	* Streptococcus gallolyticus UCN34 Site: position = -94 score = 5.04541 sequence = TATAGTTTTTAACTAAT Gene: GALLO_1253: Predicted S-methylmethionine permease	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159 Gene: SMU.951: Predicted S-methylmethionine permease	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	*2 Streptococcus suis 05ZYH33 Site: position = -97 score = 5.59363 sequence = CATAGTTTGAAGCTATA Gene: SSU05_2026: Predicted S-methylmethionine permease Gene: SSU05_2025: Predicted S-methylmethionine permease	Streptococcus thermophilus CNRZ1066 Gene: str0583: Predicted S-methylmethionine permease	Streptococcus uberis 0140J	Predicted S-methylmethionine permease
mmuM	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R Gene: SAG1305: Homocysteine S-methyltransferase (EC 2.1.1.10)	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_1252: Homocysteine S-methyltransferase (EC 2.1.1.10)	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159 Gene: SMU.952: Homocysteine S-methyltransferase (EC 2.1.1.10)	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36 Gene: SSA_1096: Homocysteine S-methyltransferase (EC 2.1.1.10)	Streptococcus suis 05ZYH33 Gene: SSU05_2024: Homocysteine S-methyltransferase (EC 2.1.1.10)	Streptococcus thermophilus CNRZ1066 Gene: str0584: Homocysteine S-methyltransferase (EC 2.1.1.10)	Streptococcus uberis 0140J	Homocysteine S-methyltransferase (EC 2.1.1.10)
CRON 5.
COG1912	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_1836: Conserved hypothetical protein	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -30 score = 4.45684 sequence = TAAAGTTCAGGACTATA Gene: SGO_0468: Conserved hypothetical protein	* Streptococcus mitis B6 Site: position = -91 score = 4.6208 sequence = TATAAGGTAAAACTATA Gene: smi_1812: Conserved hypothetical protein	* Streptococcus mutans UA159 Site: position = -110 score = 5.44518 sequence = TATAGGTAATAACTATA Gene: SMU.1936c: Conserved hypothetical protein	* Streptococcus pneumoniae TIGR4 Site: position = -64 score = 4.6208 sequence = TATAAGGTAAAACTATA Gene: SP_0481: Conserved hypothetical protein	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36 Gene: SSA_0591: Conserved hypothetical protein	Streptococcus suis 05ZYH33	* Streptococcus thermophilus CNRZ1066 Site: position = -100 score = 4.51555 sequence = CATAGCCAAAGGCTATA Gene: str0304: Conserved hypothetical protein	* Streptococcus uberis 0140J Site: position = -106 score = 6.28427 sequence = TATAGTTTTAGACTATA Gene: SUB0314: Conserved hypothetical protein	Conserved hypothetical protein
mtsA	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_0367: Substrate-specific component MtsA of methionine-regulated ECF transporter	Lactococcus lactis subsp. lactis Il1403 Gene: L123147: Substrate-specific component MtsA of methionine-regulated ECF transporter	Streptococcus agalactiae 2603V/R Gene: SAG1634: Substrate-specific component MtsA of methionine-regulated ECF transporter	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_1835: Substrate-specific component MtsA of methionine-regulated ECF transporter	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0469: Substrate-specific component MtsA of methionine-regulated ECF transporter	Streptococcus mitis B6 Gene: smi_1811: Substrate-specific component MtsA of methionine-regulated ECF transporter	Streptococcus mutans UA159 Gene: SMU.1935c: Substrate-specific component MtsA of methionine-regulated ECF transporter	Streptococcus pneumoniae TIGR4 Gene: SP_0482: Substrate-specific component MtsA of methionine-regulated ECF transporter	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36 Gene: SSA_0592: Substrate-specific component MtsA of methionine-regulated ECF transporter	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066 Gene: str0306: Substrate-specific component MtsA of methionine-regulated ECF transporter	Streptococcus uberis 0140J Gene: SUB0313: Substrate-specific component MtsA of methionine-regulated ECF transporter	Substrate-specific component MtsA of methionine-regulated ECF transporter
mtsB	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_0368: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Lactococcus lactis subsp. lactis Il1403 Gene: L123777: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Streptococcus agalactiae 2603V/R Gene: SAG1633: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_1834: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0488: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Streptococcus mitis B6 Gene: smi_1810: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Streptococcus mutans UA159 Gene: SMU.1934c: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Streptococcus pneumoniae TIGR4 Gene: SP_0483: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36 Gene: SSA_0602: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Streptococcus suis 05ZYH33 Gene: SSU05_0409: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Streptococcus thermophilus CNRZ1066 Gene: str0308: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Streptococcus uberis 0140J Gene: SUB0312: Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter	Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter
mtsC	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_0369: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Lactococcus lactis subsp. lactis Il1403 Gene: L125503: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Streptococcus agalactiae 2603V/R Gene: SAG1632: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_1833: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0489: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Streptococcus mitis B6 Gene: smi_1809: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Streptococcus mutans UA159 Gene: SMU.1933c: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Streptococcus pneumoniae TIGR4 Gene: SP_0484: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36 Gene: SSA_0603: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Streptococcus suis 05ZYH33 Gene: SSU05_0410: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Streptococcus thermophilus CNRZ1066 Gene: str0310: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Streptococcus uberis 0140J Gene: SUB0311: Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter	Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter
CRON 6.
metE2	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	* Streptococcus gallolyticus UCN34 Site: position = -98 score = 5.9453 sequence = TATAGTTTGTAACTATA Gene: GALLO_0804: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -152 score = 6.29145 sequence = TATAGTTATAAACTATA Gene: SGO_0747: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Streptococcus mitis B6	* Streptococcus mutans UA159 Site: position = -100 score = 6.48238 sequence = TATAGTTTAAAACTATA Gene: SMU.1487: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	* Streptococcus sanguinis SK36 Site: position = -83 score = 5.22779 sequence = AATAGTTTTCGGCTATA Gene: SSA_0917: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	* Streptococcus suis 05ZYH33 Site: position = -102 score = 5.81111 sequence = TATAGTTTTTAACTATG Gene: SSU05_1320: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	*2 Streptococcus thermophilus CNRZ1066 Site: position = -257 score = 5.86158 sequence = TATAGTCTAAAACTATA Gene: str0905: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14) Gene: str0904: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Streptococcus uberis 0140J	Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
COG1878	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_1176: Metal-dependent hydrolase (EC 3.-.-.-)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0748: Metal-dependent hydrolase (EC 3.-.-.-)	Streptococcus mitis B6	Streptococcus mutans UA159 Gene: SMU.1172c: Metal-dependent hydrolase (EC 3.-.-.-)	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	* Streptococcus sanguinis SK36 Site: position = -178 score = 6.01876 sequence = TATAGCTTCAAACTATA Gene: SSA_1535: Metal-dependent hydrolase (EC 3.-.-.-)	* Streptococcus suis 05ZYH33 Site: position = -67 score = 5.41503 sequence = TATAGTTAAAAGCAATA Gene: SSU05_0510: Metal-dependent hydrolase (EC 3.-.-.-)	* Streptococcus thermophilus CNRZ1066 Site: position = -140 score = 5.91998 sequence = TATAGCTTAAAGCTATA Gene: str0334: Metal-dependent hydrolase (EC 3.-.-.-)	Streptococcus uberis 0140J	Metal-dependent hydrolase (EC 3.-.-.-)
metY	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	* Streptococcus gallolyticus UCN34 Site: position = -105 score = 6.48238 sequence = TATAGTTTAAAACTATA Gene: GALLO_1177: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6 Gene: smi_1010: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)	* Streptococcus mutans UA159 Site: position = -66 score = 6.27166 sequence = TATAGTTTATAACTATA Gene: SMU.1173: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36 Gene: SSA_0855: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)	* Streptococcus suis 05ZYH33 Site: position = -95 score = 5.85031 sequence = TATAGTTGTTAACTATA Gene: SSU05_1033: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)	Streptococcus thermophilus CNRZ1066 Gene: str0987: O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)	Streptococcus uberis 0140J	O-acetylhomoserine sulfhydrylase (EC 2.5.1.49)
CRON 7.
metA	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403 Gene: L0101: Homoserine O-succinyltransferase (EC 2.3.1.46)	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	* Streptococcus gallolyticus UCN34 Site: position = -105 score = 5.92415 sequence = TATAGCTAAAAACTATA Site: position = -71 score = 5.40125 sequence = TATAATTGAAAACTATA Gene: GALLO_0824: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -63 score = 5.40125 sequence = TATAATTGAAAACTATA Site: position = -97 score = 5.57098 sequence = CATAGTTTCAGGCTATA Gene: SGO_1002: Homoserine O-succinyltransferase (EC 2.3.1.46)	Streptococcus mitis B6 Gene: smi_1566: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Streptococcus mutans UA159 Site: position = -68 score = 5.19052 sequence = TATATTTGATAACTATA Site: position = -102 score = 5.28228 sequence = TATAGTTGGAACCTATA Gene: SMU.1466: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Streptococcus pneumoniae TIGR4 Site: position = -109 score = 5.40125 sequence = TATAATTGAAAACTATA Gene: SP_1576: Homoserine O-succinyltransferase (EC 2.3.1.46)	Streptococcus pyogenes M1 GAS	* Streptococcus sanguinis SK36 Site: position = -145 score = 5.80803 sequence = CATAGTTTCTAACTATA Site: position = -111 score = 5.40125 sequence = TATAATTGAAAACTATA Gene: SSA_1420: Homoserine O-succinyltransferase (EC 2.3.1.46)	Streptococcus suis 05ZYH33 Gene: SSU05_1306: Homoserine O-succinyltransferase (EC 2.3.1.46)	* Streptococcus thermophilus CNRZ1066 Site: position = -103 score = 5.62748 sequence = TATAGTTTAAAGTTATA Gene: str1222: Homoserine O-succinyltransferase (EC 2.3.1.46)	Streptococcus uberis 0140J	Homoserine O-succinyltransferase (EC 2.3.1.46)
CRON 8.
metE	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1368: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Lactococcus lactis subsp. lactis Il1403 Gene: L0100: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Streptococcus agalactiae 2603V/R Site: position = -132 score = 6.48238 sequence = TATAGTTTAAAACTATA Gene: SAG2049: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	* Streptococcus gallolyticus UCN34 Site: position = -139 score = 5.92415 sequence = TATAGCTAAAAACTATA Site: position = -36 score = 5.22886 sequence = TATAGTTTAAAACTAAT Site: position = -170 score = 6.26417 sequence = TATAGTTAAAAACTATA Gene: GALLO_1316: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -180 score = 5.44103 sequence = TATAGTTTTTGATTATA Site: position = -97 score = 5.85116 sequence = TATAGTTTTTGGCTATA Gene: SGO_0310: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Streptococcus mitis B6 Site: position = -99 score = 6.35878 sequence = TATAGTTTCAAACTATA Gene: smi_1600: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Streptococcus mutans UA159 Site: position = -186 score = 5.56445 sequence = TATAGATGAAAACTATA Site: position = -155 score = 6.14236 sequence = TATAGCTTAAAACTATA Gene: SMU.873: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Streptococcus pneumoniae TIGR4 Site: position = -99 score = 6.35878 sequence = TATAGTTTCAAACTATA Gene: SP_0585: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Streptococcus pyogenes M1 GAS	* Streptococcus sanguinis SK36 Site: position = -97 score = 6.28427 sequence = TATAGTTTTAGACTATA Site: position = -180 score = 4.75038 sequence = CATAATTTCTACCTATA Gene: SSA_0416: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Streptococcus suis 05ZYH33 Site: position = -99 score = 4.78846 sequence = TATAGTCAAAAGTTATA Site: position = -235 score = 5.19956 sequence = CATAGATAAAATCTATA Gene: SSU05_1774: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Streptococcus thermophilus CNRZ1066 Site: position = -130 score = 5.85833 sequence = TATAGTTATTAGCTATA Site: position = -58 score = 6.48238 sequence = TATAGTTTAAAACTATA Gene: str0785: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Streptococcus uberis 0140J	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
metF	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1367: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Lactococcus lactis subsp. lactis Il1403 Gene: L0099: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0311: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Streptococcus mitis B6 Gene: smi_1599: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4 Gene: SP_0586: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36 Gene: SSA_0417: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Streptococcus suis 05ZYH33 Gene: SSU05_1775: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Streptococcus thermophilus CNRZ1066 Gene: str0786: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Streptococcus uberis 0140J	5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)
metH	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R Gene: SAG2048: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_1315: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159 Gene: SMU.874: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) / Homolog of homocysteine-binding domain
CRON 9.
metQ	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	* Streptococcus agalactiae 2603V/R Site: position = -99 score = 6.48238 sequence = TATAGTTTAAAACTATA Gene: SAG1641: Methionine ABC transporter, substrate-binding protein	*2 Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -100 score = 6.29893 sequence = TATAGTTTTTAACTATA Gene: SDEG_0382: Methionine ABC transporter, substrate-binding protein Site: position = -102 score = 6.50966 sequence = TATAGTTTTAAACTATA Gene: SDEG_0383: Methionine ABC transporter, substrate-binding protein	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -103 score = 5.71342 sequence = TATAGCTAATAACTATA Gene: Sez_1679: Methionine ABC transporter, substrate-binding protein	* Streptococcus gallolyticus UCN34 Site: position = -102 score = 6.50966 sequence = TATAGTTTTAAACTATA Gene: GALLO_1844: Methionine ABC transporter, substrate-binding protein	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0458: Methionine ABC transporter, substrate-binding protein	* Streptococcus mitis B6 Site: position = -99 score = 6.16964 sequence = TATAGCTTTAAACTATA Gene: smi_1944: Methionine ABC transporter, substrate-binding protein	* Streptococcus mutans UA159 Site: position = -100 score = 6.07655 sequence = TATAGTTTTTAGCTATA Gene: SMU.1941: Methionine ABC transporter, substrate-binding protein	* Streptococcus pneumoniae TIGR4 Site: position = -99 score = 6.50966 sequence = TATAGTTTTAAACTATA Gene: SP_0149: Methionine ABC transporter, substrate-binding protein	* Streptococcus pyogenes M1 GAS Site: position = -103 score = 5.99457 sequence = TATAGTTTAAAACTATG Gene: SPy0319: Methionine ABC transporter, substrate-binding protein	Streptococcus sanguinis SK36 Gene: SSA_0375: Methionine ABC transporter, substrate-binding protein	Streptococcus suis 05ZYH33 Gene: SSU05_1771: Methionine ABC transporter, substrate-binding protein	* Streptococcus thermophilus CNRZ1066 Site: position = -103 score = 6.26417 sequence = TATAGTTAAAAACTATA Gene: str0297: Methionine ABC transporter, substrate-binding protein	* Streptococcus uberis 0140J Site: position = -101 score = 6.28727 sequence = TATAGTTTTAAGCTATA Gene: SUB0366: Methionine ABC transporter, substrate-binding protein	Methionine ABC transporter, substrate-binding protein
hmrB	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R Gene: SAG1640: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0384: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_1678: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)	Streptococcus gallolyticus UCN34 Gene: GALLO_1843: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0459: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)	Streptococcus mitis B6 Gene: smi_1943: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)	Streptococcus mutans UA159 Gene: SMU.1940c: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)	Streptococcus pneumoniae TIGR4 Gene: SP_0150: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33 Gene: SSU05_1770: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)	3 Streptococcus thermophilus CNRZ1066 Gene: str0300: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14) Gene: str0298: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14) Gene: str0299: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)	Streptococcus uberis 0140J Gene: SUB0367: N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)	N-acyl-L-amino acid amidohydrolase (EC 3.5.1.14)
metN	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_0365: Methionine ABC transporter, ATP-binding protein	Lactococcus lactis subsp. lactis Il1403 Gene: L121289: Methionine ABC transporter, ATP-binding protein	Streptococcus agalactiae 2603V/R Gene: SAG1639: Methionine ABC transporter, ATP-binding protein	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0385: Methionine ABC transporter, ATP-binding protein	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_1677: Methionine ABC transporter, ATP-binding protein	Streptococcus gallolyticus UCN34 Gene: GALLO_1842: Methionine ABC transporter, ATP-binding protein	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0460: Methionine ABC transporter, ATP-binding protein	Streptococcus mitis B6 Gene: smi_1942: Methionine ABC transporter, ATP-binding protein	Streptococcus mutans UA159 Gene: SMU.1939c: Methionine ABC transporter, ATP-binding protein	Streptococcus pneumoniae TIGR4 Gene: SP_0151: Methionine ABC transporter, ATP-binding protein	Streptococcus pyogenes M1 GAS Gene: SPy0320: Methionine ABC transporter, ATP-binding protein	Streptococcus sanguinis SK36 Gene: SSA_0376: Methionine ABC transporter, ATP-binding protein	Streptococcus suis 05ZYH33 Gene: SSU05_1769: Methionine ABC transporter, ATP-binding protein	Streptococcus thermophilus CNRZ1066 Gene: str0301: Methionine ABC transporter, ATP-binding protein	Streptococcus uberis 0140J Gene: SUB0368: Methionine ABC transporter, ATP-binding protein	Methionine ABC transporter, ATP-binding protein
metP	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_0366: Methionine ABC transporter, permease protein	Lactococcus lactis subsp. lactis Il1403 Gene: L122401: Methionine ABC transporter, permease protein	Streptococcus agalactiae 2603V/R Gene: SAG1638: Methionine ABC transporter, permease protein	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0386: Methionine ABC transporter, permease protein	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_1676: Methionine ABC transporter, permease protein	Streptococcus gallolyticus UCN34 Gene: GALLO_1841: Methionine ABC transporter, permease protein	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0461: Methionine ABC transporter, permease protein	Streptococcus mitis B6 Gene: smi_1941: Methionine ABC transporter, permease protein	Streptococcus mutans UA159 Gene: SMU.1938c: Methionine ABC transporter, permease protein	Streptococcus pneumoniae TIGR4 Gene: SP_0152: Methionine ABC transporter, permease protein	Streptococcus pyogenes M1 GAS Gene: SPy0321: Methionine ABC transporter, permease protein	Streptococcus sanguinis SK36 Gene: SSA_0377: Methionine ABC transporter, permease protein	Streptococcus suis 05ZYH33 Gene: SSU05_1768: Methionine ABC transporter, permease protein	Streptococcus thermophilus CNRZ1066 Gene: str0302: Methionine ABC transporter, permease protein	Streptococcus uberis 0140J Gene: SUB0369: Methionine ABC transporter, permease protein	Methionine ABC transporter, permease protein
CRON 10.
metB	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403 Gene: L0102: Cystathionine gamma-synthase (EC 2.5.1.48)	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	* Streptococcus gallolyticus UCN34 Site: position = -140 score = 5.24128 sequence = TATAGTTTTTACTTATA Gene: GALLO_1768: Cystathionine gamma-synthase (EC 2.5.1.48)	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -101 score = 6.13339 sequence = TATAGTTTCAGACTATA Gene: SGO_1636: Cystathionine gamma-synthase (EC 2.5.1.48)	* Streptococcus mitis B6 Site: position = -93 score = 6.15603 sequence = TATAGTTTGAAACTATA Gene: smi_1508: Cystathionine gamma-synthase (EC 2.5.1.48)	Streptococcus mutans UA159 Gene: SMU.1675: Cystathionine gamma-synthase (EC 2.5.1.48)	* Streptococcus pneumoniae TIGR4 Site: position = -93 score = 6.15603 sequence = TATAGTTTGAAACTATA Gene: SP_1525: Cystathionine gamma-synthase (EC 2.5.1.48)	Streptococcus pyogenes M1 GAS	* Streptococcus sanguinis SK36 Site: position = -44 score = 6.35878 sequence = TATAGTTTCAAACTATA Gene: SSA_1737: Cystathionine gamma-synthase (EC 2.5.1.48)	Streptococcus suis 05ZYH33 Gene: SSU05_1562: Cystathionine gamma-synthase (EC 2.5.1.48)	* Streptococcus thermophilus CNRZ1066 Site: position = -130 score = 5.88594 sequence = TATAGTAATAAACTATA Gene: str0352: Cystathionine gamma-synthase (EC 2.5.1.48)	Streptococcus uberis 0140J	Cystathionine gamma-synthase (EC 2.5.1.48)
csd	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_2187: Cysteine desulfurase (EC 2.8.1.7)	Lactococcus lactis subsp. lactis Il1403 Gene: L177593: Cysteine desulfurase (EC 2.8.1.7)	Streptococcus agalactiae 2603V/R Gene: SAG1587: Cysteine desulfurase (EC 2.8.1.7)	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_1767: Cysteine desulfurase (EC 2.8.1.7)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_1635: Cysteine desulfurase (EC 2.8.1.7)	Streptococcus mitis B6 Gene: smi_1507: Cysteine desulfurase (EC 2.8.1.7)	Streptococcus mutans UA159 Gene: SMU.1674: Cysteine desulfurase (EC 2.8.1.7)	Streptococcus pneumoniae TIGR4 Gene: SP_1524: Cysteine desulfurase (EC 2.8.1.7)	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36 Gene: SSA_1736: Cysteine desulfurase (EC 2.8.1.7)	Streptococcus suis 05ZYH33 Gene: SSU05_1561: Cysteine desulfurase (EC 2.8.1.7)	Streptococcus thermophilus CNRZ1066 Gene: str0353: Cysteine desulfurase (EC 2.8.1.7)	Streptococcus uberis 0140J Gene: SUB0427: Cysteine desulfurase (EC 2.8.1.7)	Cysteine desulfurase (EC 2.8.1.7)

Export

	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD