Regulon of PurR in Streptococcus pyogenes M1 GAS

Properties
Regulator type:	Transcription factor
TF locus tag:	SPy0268
Regulator family:	PurR
Regulation mode:	repressor
Biological process:	Purine metabolism
Effector:	5-phosphoribosyl 1-pyrophosphate
Regulog:	PurR - Streptococcaceae
Statistics of regulated genes:
- Genes	11
- Operons	5
Visualization:
	Allows to visualize regulon content in the context of metabolic pathways

Built upon 100 sites [see more]

Member of regulog collections

By taxonomy - Streptococcaceae
By TF family - PurR
By effector - 5-phosphoribosyl 1-pyrophosphate
By pathway - Purine metabolism

Regulated operons
	Locus Tag	Name	Function
Position: -78 Score: 4.7 Sequence: AAAAACGAACCTT Locus tag: SPy0024 Name: purC Funciton: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) Locus tag: SPy0025 Name: purL Funciton: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3) Locus tag: SPy0026 Name: purF Funciton: Amidophosphoribosyltransferase (EC 2.4.2.14) Locus tag: SPy0027 Name: purM Funciton: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) Locus tag: SPy0028 Name: purN Funciton: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)
	SPy0024	purC	Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)
	SPy0025	purL	Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)
	SPy0026	purF	Amidophosphoribosyltransferase (EC 2.4.2.14)
	SPy0027	purM	Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)
	SPy0028	purN	Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)
Position: -205 Score: 4.7 Sequence: AAAACCGAACTTT Locus tag: SPy1135 Name: guaC Funciton: GMP reductase (EC 1.7.1.7)
	SPy1135	guaC	GMP reductase (EC 1.7.1.7)
Position: -55 Score: 4.9 Sequence: AAAAGCGAACGTT Locus tag: SPy0032 Name: purD Funciton: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) Locus tag: SPy0033 Name: purE Funciton: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21) Locus tag: SPy0034 Name: purK Funciton: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)
	SPy0032	purD	Phosphoribosylamine--glycine ligase (EC 6.3.4.13)
	SPy0033	purE	Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)
	SPy0034	purK	Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)
Position: -93 Score: 5.1 Sequence: AAAAACGAACAAT Locus tag: SPy1213 Name: fhs Funciton: Formate--tetrahydrofolate ligase (EC 6.3.4.3)
	SPy1213	fhs	Formate--tetrahydrofolate ligase (EC 6.3.4.3)
Position: -102 Score: 5 Sequence: AATACCGAACAAT Locus tag: SPy1736 Name: pbuO Funciton: Guanine/hypoxanthine permease
	SPy1736	pbuO	Guanine/hypoxanthine permease

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