Regulog PurR - Streptococcaceae

Properties
Regulator type:	Transcription factor
Regulator family:	PurR
Regulation mode:	repressor
Biological process:	Purine metabolism
Effector:	5-phosphoribosyl 1-pyrophosphate
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 100 sites [see more]

Member of regulog collections

By taxonomy - Streptococcaceae
By TF family - PurR
By effector - 5-phosphoribosyl 1-pyrophosphate
By pathway - Purine metabolism

Statistics of regulated genes
Genome	Genes	Operons
Lactococcus lactis subsp. cremoris SK11	21	13
Lactococcus lactis subsp. lactis Il1403	22	16
Streptococcus agalactiae 2603V/R	11	3
Streptococcus dysgalactiae subsp. equisimilis GGS_124	12	6
Streptococcus equi subsp. zooepidemicus MGCS10565	12	5
Streptococcus gallolyticus UCN34	15	6
Streptococcus gordonii str. Challis substr. CH1	14	5
Streptococcus mitis B6	13	5
Streptococcus mutans UA159	14	3
Streptococcus pneumoniae TIGR4	13	4
Streptococcus pyogenes M1 GAS	11	5
Streptococcus sanguinis SK36	13	5
Streptococcus suis 05ZYH33	12	4
Streptococcus thermophilus CNRZ1066	10	3
Streptococcus uberis 0140J	12	5

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
purR	* Lactococcus lactis subsp. cremoris SK11 Site: position = 6 score = 4.38394 sequence = AGAAACGAACGTT Gene: LACR_2590: Purine metabolism transcriptional regulator PurR, PurR family	* Lactococcus lactis subsp. lactis Il1403 Site: position = 6 score = 4.38394 sequence = AGAAACGAACGTT Gene: L134453: Purine metabolism transcriptional regulator PurR, PurR family	Streptococcus agalactiae 2603V/R Gene: SAG1772: Purine metabolism transcriptional regulator PurR, PurR family	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -85 score = 4.59761 sequence = AAAAACGGACATT Gene: SDEG_1941: Purine metabolism transcriptional regulator PurR, PurR family	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -109 score = 5.20161 sequence = AAAAACGAACATT Gene: Sez_0264: Purine metabolism transcriptional regulator PurR, PurR family	* Streptococcus gallolyticus UCN34 Site: position = -87 score = 3.88439 sequence = AAAAATGGACATT Gene: GALLO_2000: Purine metabolism transcriptional regulator PurR, PurR family	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -85 score = 4.59761 sequence = AAAAACGAGCATT Gene: SGO_0202: Purine metabolism transcriptional regulator PurR, PurR family	Streptococcus mitis B6 Gene: smi_0302: Purine metabolism transcriptional regulator PurR, PurR family	Streptococcus mutans UA159 Gene: SMU.356: Purine metabolism transcriptional regulator PurR, PurR family	Streptococcus pneumoniae TIGR4 Gene: SP_1979: Purine metabolism transcriptional regulator PurR, PurR family	Streptococcus pyogenes M1 GAS Gene: SPy0268: Purine metabolism transcriptional regulator PurR, PurR family	* Streptococcus sanguinis SK36 Site: position = -56 score = 3.88439 sequence = AAAAATGGACATT Gene: SSA_2114: Purine metabolism transcriptional regulator PurR, PurR family	Streptococcus suis 05ZYH33 Gene: SSU05_1988: Purine metabolism transcriptional regulator PurR, PurR family	Streptococcus thermophilus CNRZ1066 Gene: str1793: Purine metabolism transcriptional regulator PurR, PurR family	* Streptococcus uberis 0140J Site: position = -88 score = 4.16741 sequence = AAAGATGAACAAT Gene: SUB1636: Purine metabolism transcriptional regulator PurR, PurR family	Purine metabolism transcriptional regulator PurR, PurR family

CRON 2.
bmpA	* Lactococcus lactis subsp. cremoris SK11 Site: position = -124 score = 4.66748 sequence = ATTTCCGAACGTT Gene: LACR_1527: Predicted nucleoside ABC transporter, substrate-binding protein	* Lactococcus lactis subsp. lactis Il1403 Site: position = -124 score = 4.82735 sequence = ATTTCCGAACATT Gene: L61620: Predicted nucleoside ABC transporter, substrate-binding protein	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_1136: Predicted nucleoside ABC transporter, substrate-binding protein	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066 Gene: str0808: Predicted nucleoside ABC transporter, substrate-binding protein	Streptococcus uberis 0140J	Predicted nucleoside ABC transporter, substrate-binding protein

CRON 3.
purD	* Lactococcus lactis subsp. cremoris SK11 Site: position = -266 score = 4.94225 sequence = AATTCCGAACAAT Gene: LACR_1601: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -224 score = 5.04219 sequence = AATACCGAACAAT Gene: L153005: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	* Streptococcus agalactiae 2603V/R Site: position = -88 score = 4.53013 sequence = AAAAGCGAACAAA Gene: SAG0043: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -108 score = 4.92729 sequence = ATTAACGAACATT Site: position = -57 score = 4.49776 sequence = ATAAACGAACAAA Gene: SDEG_0051: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -14 score = 4.98201 sequence = ATAAACGAACAAT Gene: Sez_0030: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	* Streptococcus gallolyticus UCN34 Site: position = -116 score = 4.29075 sequence = ATTTCCGAACAAA Gene: GALLO_0032: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -121 score = 4.50514 sequence = TAAAACGAACGAT Gene: SGO_2092: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	* Streptococcus mitis B6 Site: position = -56 score = 4.55749 sequence = TAAAACGAACGTT Gene: smi_0073: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	* Streptococcus mutans UA159 Site: position = -122 score = 3.51291 sequence = ACTCCCGAACAAA Gene: SMU.48: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	* Streptococcus pneumoniae TIGR4 Site: position = -56 score = 4.17351 sequence = TAAAACGAACTTT Gene: SP_0051: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	* Streptococcus pyogenes M1 GAS Site: position = -55 score = 4.90686 sequence = AAAAGCGAACGTT Gene: SPy0032: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	* Streptococcus sanguinis SK36 Site: position = -121 score = 4.50514 sequence = TAAAACGAACGAT Gene: SSA_0037: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	* Streptococcus suis 05ZYH33 Site: position = -88 score = 4.54005 sequence = ATTCCCGAACATT Gene: SSU05_0033: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	* Streptococcus thermophilus CNRZ1066 Site: position = -121 score = 3.75908 sequence = ATCTCCGAACAAA Gene: str0040: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	* Streptococcus uberis 0140J Site: position = -57 score = 4.00345 sequence = ATTCACGAACAAA Gene: SUB0053: Phosphoribosylamine--glycine ligase (EC 6.3.4.13)	Phosphoribosylamine--glycine ligase (EC 6.3.4.13)
SP_0052	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4 Gene: SP_0052: Hypothetical protein	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Hypothetical protein
purE	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1599: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Lactococcus lactis subsp. lactis Il1403 Gene: L152487: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Streptococcus agalactiae 2603V/R Gene: SAG0044: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0052: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0031: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Streptococcus gallolyticus UCN34 Gene: GALLO_0034: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_2090: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Streptococcus mitis B6 Gene: smi_0074: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Streptococcus mutans UA159 Gene: SMU.50: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Streptococcus pneumoniae TIGR4 Gene: SP_0053: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Streptococcus pyogenes M1 GAS Gene: SPy0033: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Streptococcus sanguinis SK36 Gene: SSA_0039: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Streptococcus suis 05ZYH33 Gene: SSU05_0034: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Streptococcus thermophilus CNRZ1066 Gene: str0041: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Streptococcus uberis 0140J Gene: SUB0054: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)	Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)
purK	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1598: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Lactococcus lactis subsp. lactis Il1403 Gene: L151330: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Streptococcus agalactiae 2603V/R Gene: SAG0045: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0053: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0032: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Streptococcus gallolyticus UCN34 Gene: GALLO_0035: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_2089: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Streptococcus mitis B6 Gene: smi_0075: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Streptococcus mutans UA159 Gene: SMU.51: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Streptococcus pneumoniae TIGR4 Gene: SP_0054: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Streptococcus pyogenes M1 GAS Gene: SPy0034: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Streptococcus sanguinis SK36 Gene: SSA_0040: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Streptococcus suis 05ZYH33 Gene: SSU05_0035: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Streptococcus thermophilus CNRZ1066 Gene: str0042: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Streptococcus uberis 0140J Gene: SUB0055: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)	Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)
GALLO_0033	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_0033: Hypothetical protein	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Hypothetical protein
LACR_1600	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1600: Hypothetical hydrolase	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Hypothetical hydrolase
carB2	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_2091: Carbamoyl-phosphate synthase large subunit (EC 6.3.5.5) paralog	Streptococcus mitis B6	Streptococcus mutans UA159 Gene: SMU.49: Carbamoyl-phosphate synthase large subunit (EC 6.3.5.5) paralog	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Carbamoyl-phosphate synthase large subunit (EC 6.3.5.5) paralog

CRON 4.
fhs	* Lactococcus lactis subsp. cremoris SK11 Site: position = -134 score = 4.775 sequence = ATTTCCGAACAAT Gene: LACR_1007: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -131 score = 4.775 sequence = ATTTCCGAACAAT Gene: L159505: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	Streptococcus agalactiae 2603V/R Gene: SAG1055: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -93 score = 5.20161 sequence = AAAAACGAACATT Gene: SDEG_1033: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -94 score = 4.90686 sequence = AAAAGCGAACGTT Gene: Sez_0945: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus gallolyticus UCN34 Site: position = -100 score = 4.81437 sequence = AAACACGAACATT Gene: GALLO_1115: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -95 score = 4.76202 sequence = AAACACGAACAAT Gene: SGO_1210: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus mitis B6 Site: position = -90 score = 4.18323 sequence = TTTTACGAACGTT Gene: smi_1192: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus mutans UA159 Site: position = -90 score = 5.10167 sequence = AAATCCGAACATT Gene: SMU.1073: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus pneumoniae TIGR4 Site: position = -172 score = 4.59761 sequence = AAAAACGAAGATT Site: position = -89 score = 4.66748 sequence = ATTTACGAACGTT Gene: SP_1229: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus pyogenes M1 GAS Site: position = -93 score = 5.14926 sequence = AAAAACGAACAAT Gene: SPy1213: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus sanguinis SK36 Site: position = -93 score = 4.0558 sequence = TTTCCCGAACATT Gene: SSA_1200: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus suis 05ZYH33 Site: position = -97 score = 4.12417 sequence = AATTCCGTACGTT Gene: SSU05_0690: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	* Streptococcus thermophilus CNRZ1066 Site: position = -94 score = 5.20161 sequence = AAAACCGAACATT Gene: str0791: Formate--tetrahydrofolate ligase (EC 6.3.4.3)	Streptococcus uberis 0140J	Formate--tetrahydrofolate ligase (EC 6.3.4.3)

CRON 5.
folD	* Lactococcus lactis subsp. cremoris SK11 Site: position = -53 score = 4.94225 sequence = AATTACGAACAAT Gene: LACR_0921: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -53 score = 4.94225 sequence = AATTACGAACAAT Gene: L76582: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus agalactiae 2603V/R Gene: SAG0494: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_1488: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0614: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus gallolyticus UCN34 Gene: GALLO_0622: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0690: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus mitis B6	Streptococcus mutans UA159 Gene: SMU.572: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus pneumoniae TIGR4 Gene: SP_0825: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus pyogenes M1 GAS Gene: SPy1502: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus sanguinis SK36 Gene: SSA_0671: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus suis 05ZYH33 Gene: SSU05_0497: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus thermophilus CNRZ1066 Gene: str0611: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Streptococcus uberis 0140J Gene: SUB1277: Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)	Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)

CRON 6.
glyA	* Lactococcus lactis subsp. cremoris SK11 Site: position = -205 score = 4.775 sequence = ATTTCCGAACAAT Gene: LACR_0617: Serine hydroxymethyltransferase (EC 2.1.2.1)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -203 score = 4.82735 sequence = ATTTCCGAACATT Gene: L0082: Serine hydroxymethyltransferase (EC 2.1.2.1)	Streptococcus agalactiae 2603V/R Gene: SAG1074: Serine hydroxymethyltransferase (EC 2.1.2.1)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0904: Serine hydroxymethyltransferase (EC 2.1.2.1)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_1026: Serine hydroxymethyltransferase (EC 2.1.2.1)	Streptococcus gallolyticus UCN34 Gene: GALLO_1038: Serine hydroxymethyltransferase (EC 2.1.2.1)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_1151: Serine hydroxymethyltransferase (EC 2.1.2.1)	Streptococcus mitis B6 Gene: smi_1123: Serine hydroxymethyltransferase (EC 2.1.2.1)	Streptococcus mutans UA159 Gene: SMU.1082: Serine hydroxymethyltransferase (EC 2.1.2.1)	Streptococcus pneumoniae TIGR4 Gene: SP_1024: Serine hydroxymethyltransferase (EC 2.1.2.1)	Streptococcus pyogenes M1 GAS Gene: SPy1145: Serine hydroxymethyltransferase (EC 2.1.2.1)	Streptococcus sanguinis SK36 Gene: SSA_1155: Serine hydroxymethyltransferase (EC 2.1.2.1)	Streptococcus suis 05ZYH33 Gene: SSU05_0852: Serine hydroxymethyltransferase (EC 2.1.2.1)	Streptococcus thermophilus CNRZ1066 Gene: str0755: Serine hydroxymethyltransferase (EC 2.1.2.1)	Streptococcus uberis 0140J Gene: SUB0874: Serine hydroxymethyltransferase (EC 2.1.2.1)	Serine hydroxymethyltransferase (EC 2.1.2.1)

CRON 7.
purC	* Lactococcus lactis subsp. cremoris SK11 Site: position = -132 score = 4.82735 sequence = ATTTCCGAACATT Site: position = -115 score = 5.14926 sequence = AAAACCGAACAAT Gene: LACR_1622: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -132 score = 4.82735 sequence = ATTTCCGAACATT Site: position = -115 score = 5.14926 sequence = AAAACCGAACAAT Gene: L177350: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	* Streptococcus agalactiae 2603V/R Site: position = -108 score = 4.9418 sequence = AAATACGAACGTT Gene: SAG0024: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -106 score = 5.20161 sequence = AAAAACGAACATT Site: position = -13 score = 4.22242 sequence = AAAGACGAATATT Gene: SDEG_0043: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -110 score = 5.20161 sequence = AAAAACGAACATT Site: position = -16 score = 4.26151 sequence = AAAGGCGAACAAA Gene: Sez_0023: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	* Streptococcus gallolyticus UCN34 Site: position = -109 score = 4.27587 sequence = AATTTCGAACGTT Site: position = -16 score = 4.26151 sequence = AAAGGCGAACAAA Gene: GALLO_0025: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -16 score = 4.79811 sequence = AAAGGCGAACATT Gene: SGO_0034: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	* Streptococcus mitis B6 Site: position = 155 score = 4.25425 sequence = AAAGGCGAACTTT Gene: smi_0066: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	* Streptococcus mutans UA159 Site: position = -109 score = 4.75457 sequence = AAATGCGAACGAT Site: position = -16 score = 4.74576 sequence = AAAGGCGAACAAT Gene: SMU.29: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	* Streptococcus pneumoniae TIGR4 Site: position = -16 score = 4.25425 sequence = AAAGGCGAACTTT Gene: SP_0044: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	* Streptococcus pyogenes M1 GAS Site: position = -78 score = 4.65776 sequence = AAAAACGAACCTT Gene: SPy0024: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	* Streptococcus sanguinis SK36 Site: position = -16 score = 4.08755 sequence = AAAGGCGAATATT Gene: SSA_0028: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	* Streptococcus suis 05ZYH33 Site: position = -16 score = 4.79811 sequence = AAAGGCGAACATT Gene: SSU05_0026: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	* Streptococcus thermophilus CNRZ1066 Site: position = -109 score = 4.9418 sequence = AAATCCGAACGTT Site: position = -16 score = 4.58589 sequence = AAAGGCGAACGAT Gene: str0030: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	* Streptococcus uberis 0140J Site: position = -108 score = 5.20161 sequence = AAAAACGAACATT Site: position = -15 score = 4.74576 sequence = AAAGGCGAACAAT Gene: SUB0025: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)	Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)
purL	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1619: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Lactococcus lactis subsp. lactis Il1403 Gene: L173921: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Streptococcus agalactiae 2603V/R Gene: SAG0025: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0044: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0024: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Streptococcus gallolyticus UCN34 Gene: GALLO_0026: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0035: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Streptococcus mitis B6 Gene: smi_0067: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Streptococcus mutans UA159 Gene: SMU.30: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Streptococcus pneumoniae TIGR4 Gene: SP_0045: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Streptococcus pyogenes M1 GAS Gene: SPy0025: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Streptococcus sanguinis SK36 Gene: SSA_0030: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Streptococcus suis 05ZYH33 Gene: SSU05_0027: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Streptococcus thermophilus CNRZ1066 Gene: str0031: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Streptococcus uberis 0140J Gene: SUB0026: Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)
SMU.31	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159 Gene: SMU.31: DNA alkylation repair enzyme	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	DNA alkylation repair enzyme
purF	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1618: Amidophosphoribosyltransferase (EC 2.4.2.14)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -113 score = 4.29075 sequence = TTTTCCGAACAAT Site: position = -61 score = 4.06715 sequence = ATTTCCAAACAAT Gene: L171350: Amidophosphoribosyltransferase (EC 2.4.2.14)	Streptococcus agalactiae 2603V/R Gene: SAG0026: Amidophosphoribosyltransferase (EC 2.4.2.14)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0045: Amidophosphoribosyltransferase (EC 2.4.2.14)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0025: Amidophosphoribosyltransferase (EC 2.4.2.14)	Streptococcus gallolyticus UCN34 Gene: GALLO_0027: Amidophosphoribosyltransferase (EC 2.4.2.14)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0036: Amidophosphoribosyltransferase (EC 2.4.2.14)	Streptococcus mitis B6 Gene: smi_0068: Amidophosphoribosyltransferase (EC 2.4.2.14)	Streptococcus mutans UA159 Gene: SMU.32: Amidophosphoribosyltransferase (EC 2.4.2.14)	Streptococcus pneumoniae TIGR4 Gene: SP_0046: Amidophosphoribosyltransferase (EC 2.4.2.14)	Streptococcus pyogenes M1 GAS Gene: SPy0026: Amidophosphoribosyltransferase (EC 2.4.2.14)	Streptococcus sanguinis SK36 Gene: SSA_0031: Amidophosphoribosyltransferase (EC 2.4.2.14)	Streptococcus suis 05ZYH33 Gene: SSU05_0028: Amidophosphoribosyltransferase (EC 2.4.2.14)	Streptococcus thermophilus CNRZ1066 Gene: str0032: Amidophosphoribosyltransferase (EC 2.4.2.14)	Streptococcus uberis 0140J Gene: SUB0027: Amidophosphoribosyltransferase (EC 2.4.2.14)	Amidophosphoribosyltransferase (EC 2.4.2.14)
SMU.33	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159 Gene: SMU.33: Hypothetical protein	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Hypothetical protein
purM	* Lactococcus lactis subsp. cremoris SK11 Site: position = -115 score = 4.775 sequence = ATTTCCGAACAAT Gene: LACR_1611: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -115 score = 4.61513 sequence = ATTTCCGAACGAT Gene: L165202: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Streptococcus agalactiae 2603V/R Gene: SAG0027: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0046: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0026: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Streptococcus gallolyticus UCN34 Gene: GALLO_0028: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0037: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Streptococcus mitis B6 Gene: smi_0069: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Streptococcus mutans UA159 Gene: SMU.34: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Streptococcus pneumoniae TIGR4 Gene: SP_0047: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Streptococcus pyogenes M1 GAS Gene: SPy0027: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Streptococcus sanguinis SK36 Gene: SSA_0032: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Streptococcus suis 05ZYH33 Gene: SSU05_0029: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Streptococcus thermophilus CNRZ1066 Gene: str0033: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Streptococcus uberis 0140J Gene: SUB0028: Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)	Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)
purN	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1610: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Lactococcus lactis subsp. lactis Il1403 Gene: L164626: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Streptococcus agalactiae 2603V/R Gene: SAG0028: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0047: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0027: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Streptococcus gallolyticus UCN34 Gene: GALLO_0029: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0038: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Streptococcus mitis B6 Gene: smi_0070: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Streptococcus mutans UA159 Gene: SMU.35: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Streptococcus pneumoniae TIGR4 Gene: SP_0048: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Streptococcus pyogenes M1 GAS Gene: SPy0028: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Streptococcus sanguinis SK36 Gene: SSA_0033: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	2 Streptococcus suis 05ZYH33 Gene: SSU05_0030: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) Gene: SSU05_0031: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Streptococcus thermophilus CNRZ1066 Gene: str0034: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Streptococcus uberis 0140J Gene: SUB0029: Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)	Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2)
SMU.36	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159 Gene: SMU.36: Hypothetical protein	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Hypothetical protein
purH	* Lactococcus lactis subsp. cremoris SK11 Site: position = -171 score = 4.775 sequence = ATTTCCGAACAAT Gene: LACR_1605: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -170 score = 4.775 sequence = ATTTCCGAACAAT Gene: L158710: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	Streptococcus agalactiae 2603V/R Gene: SAG0030: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0049: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0028: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	Streptococcus gallolyticus UCN34 Gene: GALLO_0031: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0040: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	Streptococcus mitis B6 Gene: smi_0072: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	Streptococcus mutans UA159 Gene: SMU.37: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	Streptococcus pneumoniae TIGR4 Gene: SP_0050: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36 Gene: SSA_0035: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	Streptococcus suis 05ZYH33 Gene: SSU05_0032: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	Streptococcus thermophilus CNRZ1066 Gene: str0035: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	Streptococcus uberis 0140J Gene: SUB0030: IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)	IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)
SSA_0034	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36 Gene: SSA_0034: Hypothetical protein	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Hypothetical protein
SGO_0039	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0039: Hypothetical protein	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Hypothetical protein
ykjJ	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0048: Teicoplanin resistance protein, predicted	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4 Gene: SP_0049: Teicoplanin resistance protein, predicted	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Teicoplanin resistance protein, predicted
SAG0029	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R Gene: SAG0029: Acetyltransferase, GNAT family	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_0030: Acetyltransferase, GNAT family	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Acetyltransferase, GNAT family
smi_0071	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6 Gene: smi_0071: Acetyltransferase, putative	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Acetyltransferase, putative
purS	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1621: Phosphoribosylformylglycinamidine synthase, PurS subunit (EC 6.3.5.3)	Lactococcus lactis subsp. lactis Il1403 Gene: L177031: Phosphoribosylformylglycinamidine synthase, PurS subunit (EC 6.3.5.3)	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Phosphoribosylformylglycinamidine synthase, PurS subunit (EC 6.3.5.3)
purQ	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1620: Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Lactococcus lactis subsp. lactis Il1403 Gene: L176360: Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)

CRON 8.
hprT	* Lactococcus lactis subsp. cremoris SK11 Site: position = -109 score = 4.66748 sequence = ATTTCCGAACGTT Gene: LACR_1606: Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -110 score = 4.66748 sequence = ATTTCCGAACGTT Gene: L160442: Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)

CRON 9.
pbuO	* Lactococcus lactis subsp. cremoris SK11 Site: position = -184 score = 4.71507 sequence = ATTACCGAACGAT Gene: LACR_1894: Guanine/hypoxanthine permease	* Lactococcus lactis subsp. lactis Il1403 Site: position = -184 score = 4.87494 sequence = ATTACCGAACAAT Gene: L171588: Guanine/hypoxanthine permease	Streptococcus agalactiae 2603V/R Gene: SAG0365: Guanine/hypoxanthine permease	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -143 score = 4.33609 sequence = AAATAAGAACAAT Site: position = -100 score = 5.04932 sequence = AAATACGAACAAT Gene: SDEG_1804: Guanine/hypoxanthine permease	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0426: Guanine/hypoxanthine permease	* Streptococcus gallolyticus UCN34 Site: position = -96 score = 4.30116 sequence = AAAAGTGAACAAT Gene: GALLO_0354: Guanine/hypoxanthine permease	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0532: Guanine/hypoxanthine permease	Streptococcus mitis B6 Gene: smi_0277: Guanine/hypoxanthine permease	Streptococcus mutans UA159 Gene: SMU.408: Guanine/hypoxanthine permease	Streptococcus pneumoniae TIGR4 Gene: SP_0287: Guanine/hypoxanthine permease	* Streptococcus pyogenes M1 GAS Site: position = -102 score = 5.04219 sequence = AATACCGAACAAT Gene: SPy1736: Guanine/hypoxanthine permease	Streptococcus sanguinis SK36 Gene: SSA_1913: Guanine/hypoxanthine permease	Streptococcus suis 05ZYH33 Gene: SSU05_1776: Guanine/hypoxanthine permease	Streptococcus thermophilus CNRZ1066 Gene: str0336: Guanine/hypoxanthine permease	* Streptococcus uberis 0140J Site: position = -166 score = 4.90686 sequence = AAAAGCGAACGTT Gene: SUB1480: Guanine/hypoxanthine permease	Guanine/hypoxanthine permease

CRON 10.
ppa	* Lactococcus lactis subsp. cremoris SK11 Site: position = -157 score = 4.49776 sequence = ATAACCGAACAAA Gene: LACR_1998: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -158 score = 4.44415 sequence = CAAAACGAACAAT Gene: L62663: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	Streptococcus agalactiae 2603V/R Gene: SAG1397: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0429: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_1624: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	Streptococcus gallolyticus UCN34 Gene: GALLO_1779: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_1648: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	Streptococcus mitis B6 Gene: smi_1516: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	Streptococcus mutans UA159 Gene: SMU.1687: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	Streptococcus pneumoniae TIGR4 Gene: SP_1534: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	Streptococcus pyogenes M1 GAS Gene: SPy0380: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	Streptococcus sanguinis SK36 Gene: SSA_1748: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	Streptococcus suis 05ZYH33 Gene: SSU05_1665: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	Streptococcus thermophilus CNRZ1066 Gene: str0372: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	Streptococcus uberis 0140J Gene: SUB0418: Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)	Manganese-dependent inorganic pyrophosphatase (EC 3.6.1.1)

CRON 11.
purA	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_2207: Adenylosuccinate synthetase (EC 6.3.4.4)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -242 score = 4.61513 sequence = ATTTCCGAACGAT Gene: L12179: Adenylosuccinate synthetase (EC 6.3.4.4)	Streptococcus agalactiae 2603V/R Gene: SAG1818: Adenylosuccinate synthetase (EC 6.3.4.4)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0167: Adenylosuccinate synthetase (EC 6.3.4.4)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_1816: Adenylosuccinate synthetase (EC 6.3.4.4)	Streptococcus gallolyticus UCN34 Gene: GALLO_2134: Adenylosuccinate synthetase (EC 6.3.4.4)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_1989: Adenylosuccinate synthetase (EC 6.3.4.4)	* Streptococcus mitis B6 Site: position = -216 score = 4.29075 sequence = ATTTCCGAACAAA Gene: smi_0022: Adenylosuccinate synthetase (EC 6.3.4.4)	Streptococcus mutans UA159 Gene: SMU.268: Adenylosuccinate synthetase (EC 6.3.4.4)	Streptococcus pneumoniae TIGR4 Gene: SP_0019: Adenylosuccinate synthetase (EC 6.3.4.4)	Streptococcus pyogenes M1 GAS Gene: SPy0160: Adenylosuccinate synthetase (EC 6.3.4.4)	* Streptococcus sanguinis SK36 Site: position = -218 score = 4.45075 sequence = AATTCCGAACTTT Gene: SSA_2185: Adenylosuccinate synthetase (EC 6.3.4.4)	Streptococcus suis 05ZYH33 Gene: SSU05_1966: Adenylosuccinate synthetase (EC 6.3.4.4)	Streptococcus thermophilus CNRZ1066 Gene: str1940: Adenylosuccinate synthetase (EC 6.3.4.4)	Streptococcus uberis 0140J Gene: SUB0152: Adenylosuccinate synthetase (EC 6.3.4.4)	Adenylosuccinate synthetase (EC 6.3.4.4)

CRON 12.
fusA	Lactococcus lactis subsp. cremoris SK11	* Lactococcus lactis subsp. lactis Il1403 Site: position = -124 score = 5.20161 sequence = AAAAACGAACATT Gene: L0368: Translation elongation factor G	Streptococcus agalactiae 2603V/R Gene: SAG1769: Translation elongation factor G	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_1937: Translation elongation factor G	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0268: Translation elongation factor G	Streptococcus gallolyticus UCN34 Gene: GALLO_1997: Translation elongation factor G	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0206: Translation elongation factor G	Streptococcus mitis B6 Gene: smi_0263: Translation elongation factor G	Streptococcus mutans UA159 Gene: SMU.359: Translation elongation factor G	Streptococcus pneumoniae TIGR4 Gene: SP_0273: Translation elongation factor G	Streptococcus pyogenes M1 GAS Gene: SPy0273: Translation elongation factor G	Streptococcus sanguinis SK36 Gene: SSA_2109: Translation elongation factor G	Streptococcus suis 05ZYH33 Gene: SSU05_0152: Translation elongation factor G	Streptococcus thermophilus CNRZ1066 Gene: str1789: Translation elongation factor G	Streptococcus uberis 0140J Gene: SUB1631: Translation elongation factor G	Translation elongation factor G

CRON 13.
guaC	* Lactococcus lactis subsp. cremoris SK11 Site: position = -232 score = 4.66748 sequence = ATTTCCGAACGTT Gene: LACR_1256: GMP reductase (EC 1.7.1.7)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -227 score = 3.90457 sequence = ATTTCCGAATGAT Gene: L158186: GMP reductase (EC 1.7.1.7)	* Streptococcus agalactiae 2603V/R Site: position = -149 score = 5.20161 sequence = AAAAACGAACATT Gene: SAG1087: GMP reductase (EC 1.7.1.7)	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -205 score = 5.20161 sequence = AAAACCGAACATT Gene: SDEG_0894: GMP reductase (EC 1.7.1.7)	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -209 score = 5.04174 sequence = AAAAACGAACGTT Gene: Sez_1036: GMP reductase (EC 1.7.1.7)	* Streptococcus gallolyticus UCN34 Site: position = -260 score = 5.20161 sequence = AAAAACGAACATT Gene: GALLO_1025: GMP reductase (EC 1.7.1.7)	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -146 score = 4.66748 sequence = ATTTCCGAACGTT Gene: SGO_1159: GMP reductase (EC 1.7.1.7)	* Streptococcus mitis B6 Site: position = -141 score = 4.88945 sequence = AAATCCGAACGAT Gene: smi_1212: GMP reductase (EC 1.7.1.7)	Streptococcus mutans UA159	* Streptococcus pneumoniae TIGR4 Site: position = -141 score = 4.60215 sequence = AAACCCGAACGAT Gene: SP_1249: GMP reductase (EC 1.7.1.7)	* Streptococcus pyogenes M1 GAS Site: position = -205 score = 4.65776 sequence = AAAACCGAACTTT Gene: SPy1135: GMP reductase (EC 1.7.1.7)	Streptococcus sanguinis SK36	* Streptococcus suis 05ZYH33 Site: position = -87 score = 4.28137 sequence = AATTCTGAACATT Gene: SSU05_0815: GMP reductase (EC 1.7.1.7)	Streptococcus thermophilus CNRZ1066	* Streptococcus uberis 0140J Site: position = -187 score = 4.56507 sequence = AAATCCGAACAAA Gene: SUB0865: GMP reductase (EC 1.7.1.7)	GMP reductase (EC 1.7.1.7)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog PurR - Streptococcaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --