Regulon of CodY in Streptococcus mitis B6

Properties
Regulator type:	Transcription factor
TF locus tag:	smi_0687
Regulator family:	CodY
Regulation mode:	repressor (activator)
Biological process:	Amino acid metabolism
Effector:	Guanosine triphosphate; Branched-chain amino acids
Regulog:	CodY - Streptococcaceae
Statistics of regulated genes:
- Genes	50
- Operons	22
Visualization:
	Allows to visualize regulon content in the context of metabolic pathways

Built upon 273 sites [see more]

Member of regulog collections

By taxonomy - Streptococcaceae
By TF family - CodY
By effector - Guanosine triphosphate
By effector - Branched-chain amino acids
By pathway - Amino acid metabolism

Regulated operons
	Locus Tag	Name	Function
Position: -95 Score: 5.5 Sequence: AATTTTTAGAAAATT Locus tag: smi_0814 Name: gdhA Funciton: NADP-specific glutamate dehydrogenase (EC 1.4.1.4)
	smi_0814	gdhA	NADP-specific glutamate dehydrogenase (EC 1.4.1.4)
Position: -93 Score: 5.2 Sequence: AATTATCAAAAAATT Locus tag: smi_0683 Name: nrgA Funciton: Ammonium transporter Locus tag: smi_0684 Name: nrgB Funciton: Nitrogen regulatory protein P-II
	smi_0683	nrgA	Ammonium transporter
	smi_0684	nrgB	Nitrogen regulatory protein P-II
Position: -71 Score: 5.6 Sequence: AATTTTCAGATAATT Locus tag: smi_0687 Name: codY Funciton: Nutrient limitation global transcriptional regulator CodY, CodY family Locus tag: smi_0688 Name: pncA Funciton: Nicotinamidase (EC 3.5.1.19)
	smi_0687	codY	Nutrient limitation global transcriptional regulator CodY, CodY family
	smi_0688	pncA	Nicotinamidase (EC 3.5.1.19)
Position: -56 Score: 4.7 Sequence: AATTGTCAGATAATA Locus tag: smi_1568 Name: ubiE Funciton: SAM-dependent methyltransferase
	smi_1568	ubiE	SAM-dependent methyltransferase
Position: -259 Score: 5.3 Sequence: AATTTTCAGAAAATA Locus tag: smi_1218 Name: leuA Funciton: 2-isopropylmalate synthase (EC 2.3.3.13) Locus tag: smi_1217 Name: leuB Funciton: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) Locus tag: smi_1216 Name: ygaE Funciton: Predicted transmembrane protein Locus tag: smi_1215 Name: leuC Funciton: 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) Locus tag: smi_1214 Name: leuD Funciton: 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) Locus tag: smi_1213 Name: yfjA Funciton: Conserved hypothetical protein
	smi_1218	leuA	2-isopropylmalate synthase (EC 2.3.3.13)
	smi_1217	leuB	3-isopropylmalate dehydrogenase (EC 1.1.1.85)
	smi_1216	ygaE	Predicted transmembrane protein
	smi_1215	leuC	3-isopropylmalate dehydratase large subunit (EC 4.2.1.33)
	smi_1214	leuD	3-isopropylmalate dehydratase small subunit (EC 4.2.1.33)
	smi_1213	yfjA	Conserved hypothetical protein
Position: -83 Score: 5.6 Sequence: AATATTCTGAAAATT Locus tag: smi_0322 Name: oppA2 Funciton: Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1) Locus tag: smi_0323 Name: oppB2 Funciton: Oligopeptide ABC transporter, permease protein 1 (TC 3.A.1.5.1) Locus tag: smi_0324 Name: oppC2 Funciton: Oligopeptide ABC transporter, permease protein 2 (TC 3.A.1.5.1) Locus tag: smi_0325 Name: oppD2 Funciton: Oligopeptide ABC transporter, ATP-binding protein 1 (TC 3.A.1.5.1) Locus tag: smi_0326 Name: oppF2 Funciton: Oligopeptide ABC transporter, ATP-binding protein 2 (TC 3.A.1.5.1)
	smi_0322	oppA2	Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
	smi_0323	oppB2	Oligopeptide ABC transporter, permease protein 1 (TC 3.A.1.5.1)
	smi_0324	oppC2	Oligopeptide ABC transporter, permease protein 2 (TC 3.A.1.5.1)
	smi_0325	oppD2	Oligopeptide ABC transporter, ATP-binding protein 1 (TC 3.A.1.5.1)
	smi_0326	oppF2	Oligopeptide ABC transporter, ATP-binding protein 2 (TC 3.A.1.5.1)
Position: -71 Score: 5.3 Sequence: AAAATTCAGAAAATT Locus tag: smi_1758 Name: oppA2 Funciton: Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
	smi_1758	oppA2	Oligopeptide ABC transporter, substrate-binding protein (TC 3.A.1.5.1)
Position: -57 Score: 5.4 Sequence: AATTTTCTGAAAAAT Locus tag: smi_0193 Name: thrC Funciton: Threonine synthase (EC 4.2.3.1)
	smi_0193	thrC	Threonine synthase (EC 4.2.3.1)
Position: -88 Score: 5.8 Sequence: AATTTTCTGAAAATT Locus tag: smi_0906 Name: ilvE Funciton: Branched-chain amino acid aminotransferase (EC 2.6.1.42)
	smi_0906	ilvE	Branched-chain amino acid aminotransferase (EC 2.6.1.42)
Position: -93 Score: 5.3 Sequence: AAAATTCAGAAAATT Locus tag: smi_1825 Name: ilvB Funciton: Acetolactate synthase large subunit (EC 2.2.1.6) Locus tag: smi_1824 Name: ilvN Funciton: Acetolactate synthase small subunit (EC 2.2.1.6) Locus tag: smi_1823 Name: ilvC Funciton: Ketol-acid reductoisomerase (EC 1.1.1.86) Locus tag: smi_1822 Name: ilvA Funciton: Threonine dehydratase (EC 4.3.1.19)
	smi_1825	ilvB	Acetolactate synthase large subunit (EC 2.2.1.6)
	smi_1824	ilvN	Acetolactate synthase small subunit (EC 2.2.1.6)
	smi_1823	ilvC	Ketol-acid reductoisomerase (EC 1.1.1.86)
	smi_1822	ilvA	Threonine dehydratase (EC 4.3.1.19)
Position: -85 Score: 5.8 Sequence: AATTTTCTGAAAATT Locus tag: smi_0113 Name: ilvD Funciton: Dihydroxy-acid dehydratase (EC 4.2.1.9)
	smi_0113	ilvD	Dihydroxy-acid dehydratase (EC 4.2.1.9)
Position: -92 Score: 4.7 Sequence: ACTTTTCTGAATTTT Locus tag: smi_1410 Name: acuB Funciton: Acetoin utilization protein AcuB
	smi_1410	acuB	Acetoin utilization protein AcuB
Position: -69 Score: 4.6 Sequence: AAGTGTCAGAATATT Locus tag: smi_1950 Name: mutR Funciton: Predicted transcriptional regulator, Xre family
	smi_1950	mutR	Predicted transcriptional regulator, Xre family
Position: -56 Score: 5.2 Sequence: AATTTTCACAAAATT Locus tag: smi_0773 Name: hom Funciton: Homoserine dehydrogenase (EC 1.1.1.3) Locus tag: smi_0774 Name: thrB Funciton: Homoserine kinase (EC 2.7.1.39)
	smi_0773	hom	Homoserine dehydrogenase (EC 1.1.1.3)
	smi_0774	thrB	Homoserine kinase (EC 2.7.1.39)
Position: -92 Score: 5.4 Sequence: AATTTTCTGACAATT Locus tag: smi_1278 Name: efeO Funciton: Ferrous iron transport periplasmic protein EfeO, contains peptidase-M75 domain and (frequently) cupredoxin-like domain Locus tag: smi_1277 Name: efeB Funciton: Ferrous iron transport peroxidase EfeB Locus tag: smi_1276 Name: efeU Funciton: Ferrous iron transport permease EfeU Locus tag: smi_1275 Name: tatC Funciton: Twin-arginine translocation protein TatC Locus tag: smi_1274 Name: tatA Funciton: Twin-arginine translocation protein TatA
	smi_1278	efeO	Ferrous iron transport periplasmic protein EfeO, contains peptidase-M75 domain and (frequently) cupredoxin-like domain
	smi_1277	efeB	Ferrous iron transport peroxidase EfeB
	smi_1276	efeU	Ferrous iron transport permease EfeU
	smi_1275	tatC	Twin-arginine translocation protein TatC
	smi_1274	tatA	Twin-arginine translocation protein TatA
Position: -57 Score: 5.6 Sequence: AATTTTCAGATAATT Locus tag: smi_1398 Name: scpC Funciton: Serine endopeptidase ScpC (EC 3.4.21.-)
	smi_1398	scpC	Serine endopeptidase ScpC (EC 3.4.21.-)
Position: 4 Score: 5.3 Sequence: AAAATTCTGAAAATT Locus tag: smi_1990 Name: ymdE Funciton: Conserved hypothetical protein
	smi_1990	ymdE	Conserved hypothetical protein
Position: -64 Score: 5.4 Sequence: ATTTTTCAGAAAATT Locus tag: smi_1779 Name: dtpT Funciton: Di- and tripeptide permease DtpT
	smi_1779	dtpT	Di- and tripeptide permease DtpT
Position: -124 Score: 5.3 Sequence: AAATTTCAGAAATTT Locus tag: smi_1436 Name: str1582 Funciton: Predicted amino acid ABC transporter, permease protein 1 Locus tag: smi_1437 Name: str1581 Funciton: Predicted amino acid ABC transporter, permease protein 2 Locus tag: smi_1438 Name: str1580 Funciton: Predicted amino acid ABC transporter, ATP-binding protein Locus tag: smi_1439 Name: str1579 Funciton: Predicted amino acid ABC transporter, substrate-binding protein
	smi_1436	str1582	Predicted amino acid ABC transporter, permease protein 1
	smi_1437	str1581	Predicted amino acid ABC transporter, permease protein 2
	smi_1438	str1580	Predicted amino acid ABC transporter, ATP-binding protein
	smi_1439	str1579	Predicted amino acid ABC transporter, substrate-binding protein
Position: -61 Score: 5.6 Sequence: AATTTTCTGATAATT Locus tag: smi_1415 Name: livK Funciton: Branched-chain amino acids ABC transporter, substrate-binding protein (TC 3.A.1.4.1) Locus tag: smi_1414 Name: livH Funciton: Branched-chain amino acids ABC transporter, permease protein 1 (TC 3.A.1.4.1) Locus tag: smi_1413 Name: livM Funciton: Branched-chain amino acids ABC transporter, permease protein 2 (TC 3.A.1.4.1) Locus tag: smi_1412 Name: livG Funciton: Branched-chain amino acids ABC transporter, ATP-binding protein 1 (TC 3.A.1.4.1) Locus tag: smi_1411 Name: livF Funciton: Branched-chain amino acids ABC transporter, ATP-binding protein 2 (TC 3.A.1.4.1)
	smi_1415	livK	Branched-chain amino acids ABC transporter, substrate-binding protein (TC 3.A.1.4.1)
	smi_1414	livH	Branched-chain amino acids ABC transporter, permease protein 1 (TC 3.A.1.4.1)
	smi_1413	livM	Branched-chain amino acids ABC transporter, permease protein 2 (TC 3.A.1.4.1)
	smi_1412	livG	Branched-chain amino acids ABC transporter, ATP-binding protein 1 (TC 3.A.1.4.1)
	smi_1411	livF	Branched-chain amino acids ABC transporter, ATP-binding protein 2 (TC 3.A.1.4.1)
Position: -113 Score: 5 Sequence: AAGATTCTGAAAATT Locus tag: smi_1847 Name: rpoB Funciton: DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) Locus tag: smi_1846 Name: rpoC Funciton: DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6)
	smi_1847	rpoB	DNA-directed RNA polymerase beta subunit (EC 2.7.7.6)
	smi_1846	rpoC	DNA-directed RNA polymerase beta' subunit (EC 2.7.7.6)
Position: -31 Score: 5.5 Sequence: AATTTTTAGAAAATT Locus tag: smi_1133 Name: asd Funciton: Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) Locus tag: smi_1132 Name: dapA Funciton: Dihydrodipicolinate synthase (EC 4.2.1.52)
	smi_1133	asd	Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11)
	smi_1132	dapA	Dihydrodipicolinate synthase (EC 4.2.1.52)

Export
	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulon of CodY in Streptococcus mitis B6

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --