Regulog MtlR - Streptococcaceae

Properties
Regulator type:	Transcription factor
Regulator family:	BglG
Regulation mode:	activator
Biological process:	Mannitol utilization
Effector:	MtlA, mannitol-specific enzyme IICB PTS component; HPr, phosphocarrier protein
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 6 sites [see more]

Member of regulog collections

By taxonomy - Streptococcaceae
By TF family - BglG
By effector - MtlA, mannitol-specific enzyme IICB PTS component
By effector - HPr, phosphocarrier protein
By pathway - Mannitol utilization

Statistics of regulated genes
Genome	Genes	Operons
Lactococcus lactis subsp. cremoris SK11	3	1
Lactococcus lactis subsp. lactis Il1403	3	1
Streptococcus agalactiae 2603V/R
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34	4	1
Streptococcus gordonii str. Challis substr. CH1
Streptococcus mitis B6
Streptococcus mutans UA159	4	1
Streptococcus pneumoniae TIGR4	4	1
Streptococcus pyogenes M1 GAS
Streptococcus sanguinis SK36
Streptococcus suis 05ZYH33
Streptococcus thermophilus CNRZ1066
Streptococcus uberis 0140J	4	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
mtlA	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_0027: PTS system, mannitol-specific IIB component (EC 2.7.1.69) / PTS system, mannitol-specific IIC component (EC 2.7.1.69)	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	* Streptococcus gallolyticus UCN34 Site: position = -87 score = 7.21928 sequence = TTTGTCACAAATTTTGTGACAAA Gene: GALLO_0993: PTS system, mannitol-specific IIB component (EC 2.7.1.69) / PTS system, mannitol-specific IIC component (EC 2.7.1.69)	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	* Streptococcus mutans UA159 Site: position = -149 score = 6.60957 sequence = TTTGGCAAAACTTTTGTGCCAAA Gene: SMU.1185: PTS system, mannitol-specific IIB component (EC 2.7.1.69) / PTS system, mannitol-specific IIC component (EC 2.7.1.69)	* Streptococcus pneumoniae TIGR4 Site: position = -85 score = 6.87521 sequence = TTTGACACAAAATCTGTGACAAA Gene: SP_0394: PTS system, mannitol-specific IIB component (EC 2.7.1.69) / PTS system, mannitol-specific IIC component (EC 2.7.1.69)	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	* Streptococcus uberis 0140J Site: position = -89 score = 6.66489 sequence = TGTGTCACAGCTTTTGTGCCAAA Gene: SUB0997: PTS system, mannitol-specific IIB component (EC 2.7.1.69) / PTS system, mannitol-specific IIC component (EC 2.7.1.69)	PTS system, mannitol-specific IIB component (EC 2.7.1.69) / PTS system, mannitol-specific IIC component (EC 2.7.1.69)
mtlR	* Lactococcus lactis subsp. cremoris SK11 Site: position = -551 score = 6.06395 sequence = TTTGACACAATTGTCGTCACACA Gene: LACR_0028: Mannitol utilization transcription activator MtlR, BglG family	* Lactococcus lactis subsp. lactis Il1403 Site: position = -550 score = 6.4554 sequence = TCTGACACAATTGTTGTGACACA Gene: L30901: Mannitol utilization transcription activator MtlR, BglG family	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_0994: Mannitol utilization transcription activator MtlR, BglG family	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159 Gene: SMU.1184c: Mannitol utilization transcription activator MtlR, BglG family	Streptococcus pneumoniae TIGR4 Gene: SP_0395: Mannitol utilization transcription activator MtlR, BglG family	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J Gene: SUB0996: Mannitol utilization transcription activator MtlR, BglG family	Mannitol utilization transcription activator MtlR, BglG family
mtlF	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_0029: PTS system, mannitol-specific IIA component (EC 2.7.1.69)	Lactococcus lactis subsp. lactis Il1403 Gene: L32907: PTS system, mannitol-specific IIA component (EC 2.7.1.69)	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_0995: PTS system, mannitol-specific IIA component (EC 2.7.1.69)	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159 Gene: SMU.1183: PTS system, mannitol-specific IIA component (EC 2.7.1.69)	Streptococcus pneumoniae TIGR4 Gene: SP_0396: PTS system, mannitol-specific IIA component (EC 2.7.1.69)	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J Gene: SUB0995: PTS system, mannitol-specific IIA component (EC 2.7.1.69)	PTS system, mannitol-specific IIA component (EC 2.7.1.69)
mtlD	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_0030: Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)	Lactococcus lactis subsp. lactis Il1403 Gene: L33416: Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_0996: Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159 Gene: SMU.1182: Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)	Streptococcus pneumoniae TIGR4 Gene: SP_0397: Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J Gene: SUB0994: Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)	Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog MtlR - Streptococcaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --