Regulog NmlR - Streptococcaceae

Properties
Regulator type:	Transcription factor
Regulator family:	MerR
Regulation mode:	activator
Biological process:	Carbonyl stress response
Effector:	Methylglyoxal; Formaldehyde; Nitric oxide
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 14 sites [see more]

Member of regulog collections

By taxonomy - Streptococcaceae
By TF family - MerR
By effector - Methylglyoxal
By effector - Formaldehyde
By effector - Nitric oxide
By pathway - Carbonyl stress response

Statistics of regulated genes
Genome	Genes	Operons
Lactococcus lactis subsp. cremoris SK11	6	2
Lactococcus lactis subsp. lactis Il1403	6	2
Streptococcus agalactiae 2603V/R	4	2
Streptococcus dysgalactiae subsp. equisimilis GGS_124
Streptococcus equi subsp. zooepidemicus MGCS10565
Streptococcus gallolyticus UCN34	4	2
Streptococcus gordonii str. Challis substr. CH1
Streptococcus mitis B6
Streptococcus mutans UA159	4	2
Streptococcus pneumoniae TIGR4	2	1
Streptococcus pyogenes M1 GAS
Streptococcus sanguinis SK36
Streptococcus suis 05ZYH33	1	1
Streptococcus thermophilus CNRZ1066
Streptococcus uberis 0140J	4	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
ypiA	* Lactococcus lactis subsp. cremoris SK11 Site: position = -50 score = 6.28964 sequence = AGTTGACTTGAAGTGGACT Gene: LACR_1627: Short chain dehydrogenase	* Lactococcus lactis subsp. lactis Il1403 Site: position = -65 score = 6.47133 sequence = AGTTGACTTGAAGTGAACT Gene: L179660: Short chain dehydrogenase	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Short chain dehydrogenase
yphK	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1626: hypothetical protein	Lactococcus lactis subsp. lactis Il1403 Gene: L179277: hypothetical protein	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	hypothetical protein
yphJ	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1625: 4-carboxymuconolactone decarboxylase (EC 4.1.1.44)	Lactococcus lactis subsp. lactis Il1403 Gene: L178933: 4-carboxymuconolactone decarboxylase (EC 4.1.1.44)	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	4-carboxymuconolactone decarboxylase (EC 4.1.1.44)
yphI	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1624: hypothetical protein	Lactococcus lactis subsp. lactis Il1403 Gene: L178621: hypothetical protein	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	hypothetical protein
yphH	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1623: Hypothetical protein	Lactococcus lactis subsp. lactis Il1403 Gene: L178204: Hypothetical protein	Streptococcus agalactiae 2603V/R Gene: SAG0426: Hypothetical protein	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J Gene: SUB1074: Hypothetical protein	Hypothetical protein
nmlR	* Lactococcus lactis subsp. cremoris SK11 Site: position = -39 score = 5.60265 sequence = TATTGACTTAAAGTTCACT Gene: LACR_2072: Carbonyl stress response transcriptional regulator, MerR family	* Lactococcus lactis subsp. lactis Il1403 Site: position = -39 score = 5.60265 sequence = TATTGACTTAAAGTTCACT Gene: L0246: Carbonyl stress response transcriptional regulator, MerR family	Streptococcus agalactiae 2603V/R Gene: SAG0427: Carbonyl stress response transcriptional regulator, MerR family	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	* Streptococcus gallolyticus UCN34 Site: position = -61 score = 6.32917 sequence = GCTTGACTTGGAGTTAGCT Gene: GALLO_0910: Carbonyl stress response transcriptional regulator, MerR family	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	* Streptococcus mutans UA159 Site: position = -66 score = 6.62048 sequence = ACTTGACTTGAAGTAGACT Gene: SMU.677: Carbonyl stress response transcriptional regulator, MerR family	* Streptococcus pneumoniae TIGR4 Site: position = -91 score = 6.85286 sequence = GCTTGACTTGGAGTCAACT Gene: SP_1856: Carbonyl stress response transcriptional regulator, MerR family	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33 Gene: SSU05_0503: Carbonyl stress response transcriptional regulator, MerR family	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J Gene: SUB1075: Carbonyl stress response transcriptional regulator, MerR family	Carbonyl stress response transcriptional regulator, MerR family
adhY	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	2 Streptococcus gallolyticus UCN34 Gene: GALLO_0911: Predicted aldo/keto reductase Gene: GALLO_1311: Predicted aldo/keto reductase	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	2 Streptococcus mutans UA159 Gene: SMU.678: Predicted aldo/keto reductase Gene: SMU.679: Predicted aldo/keto reductase	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Predicted aldo/keto reductase
adhC	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	2 Streptococcus agalactiae 2603V/R* Site: position = -58 score = 6.76413 sequence = TCTTGACTTGAAGTTAACT Gene: SAG0428: Alcohol dehydrogenase, zinc-containing (EC 1.1.1.1) Site: position = -66 score = 6.80218 sequence = CCTTGACTTGGAGTTAACT Gene: SAG0429: Alcohol dehydrogenase, zinc-containing (EC 1.1.1.1)	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	2 Streptococcus gallolyticus UCN34* Site: position = -73 score = 7.05071 sequence = ACTTGACTTGGAGTTAACT Gene: GALLO_1312: Alcohol dehydrogenase, zinc-containing (EC 1.1.1.1) Gene: GALLO_1932: Alcohol dehydrogenase, zinc-containing (EC 1.1.1.1)	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	* Streptococcus mutans UA159 Site: position = -61 score = 6.39193 sequence = ACTTGACTTAGAGTCCACT Gene: SMU.1867c: Alcohol dehydrogenase, zinc-containing (EC 1.1.1.1)	Streptococcus pneumoniae TIGR4 Gene: SP_1855: Alcohol dehydrogenase, zinc-containing (EC 1.1.1.1)	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36 Gene: SSA_0921: Alcohol dehydrogenase, zinc-containing (EC 1.1.1.1)	* Streptococcus suis 05ZYH33 Site: position = -12 score = 6.50938 sequence = ACTTGACTTAGAGTGAACT Gene: SSU05_1388: Alcohol dehydrogenase, zinc-containing (EC 1.1.1.1)	Streptococcus thermophilus CNRZ1066 Gene: str0936: Alcohol dehydrogenase, zinc-containing (EC 1.1.1.1)	2 Streptococcus uberis 0140J* Site: position = -57 score = 6.86259 sequence = GCTTGACTTGAAGTTAACT Gene: SUB1076: Alcohol dehydrogenase, zinc-containing (EC 1.1.1.1) Site: position = -92 score = 5.82046 sequence = ACTTGACTTAGAGCCCACT Gene: SUB0101: Alcohol dehydrogenase, zinc-containing (EC 1.1.1.1)	Alcohol dehydrogenase, zinc-containing (EC 1.1.1.1)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog NmlR - Streptococcaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --