Regulog TPP - Streptococcaceae

Properties
Regulator type:	RNA regulatory element
Name:	TPP
RFAM:	RF00059
Regulation mode:
Biological process:	Thiamine biosynthesis
Effector:	Thiamine pyrophosphate
Phylum:	Firmicutes

Member of regulog collections

By taxonomy - Streptococcaceae
By RNA motif - TPP
By effector - Thiamine pyrophosphate
By pathway - Thiamine biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Streptococcus pneumoniae TIGR4	15	4
Streptococcus gallolyticus UCN34	8	2
Streptococcus dysgalactiae subsp. equisimilis GGS_124	1	1
Streptococcus suis 05ZYH33	5	2
Lactococcus lactis subsp. lactis Il1403	4	2
Lactococcus lactis subsp. cremoris SK11	4	2
Streptococcus uberis 0140J	1	1
Streptococcus agalactiae 2603V/R	9	2
Streptococcus sanguinis SK36	3	1
Streptococcus pyogenes M1 GAS	1	1
Streptococcus mutans UA159	1	1
Streptococcus thermophilus CNRZ1066	1	1
Streptococcus gordonii str. Challis substr. CH1	4	1
Streptococcus equi subsp. zooepidemicus MGCS10565	1	1
Streptococcus mitis B6	4	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
thiT	Streptococcus pneumoniae TIGR4	* Streptococcus gallolyticus UCN34 Site: position = -174 score = 71.14 sequence = TAGATTCACAAAGGA... Gene: GALLO_0703: Substrate-specific component ThiT of thiamin ECF transporter	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -112 score = 67.67 sequence = ATGATTCACAAAGGA... Gene: SDEG_0615: Substrate-specific component ThiT of thiamin ECF transporter	* Streptococcus suis 05ZYH33 Site: position = -155 score = 66.39 sequence = CATATACACAAAGGA... Gene: SSU05_0523: Substrate-specific component ThiT of thiamin ECF transporter	* Lactococcus lactis subsp. lactis Il1403 Site: position = -120 score = 55.63 sequence = ATATTTGCACAATGG... Gene: L116212: Substrate-specific component ThiT of thiamin ECF transporter	* Lactococcus lactis subsp. cremoris SK11 Site: position = -147 score = 55.47 sequence = ATATTTGCACAATGG... Gene: LACR_0359: Substrate-specific component ThiT of thiamin ECF transporter	* Streptococcus uberis 0140J Site: position = -150 score = 68.62 sequence = ATATTTCACAAAGGA... Gene: SUB0597: Substrate-specific component ThiT of thiamin ECF transporter	* Streptococcus agalactiae 2603V/R Site: position = -157 score = 58.74 sequence = TAAATACACAAGGGA... Gene: SAG0817: Substrate-specific component ThiT of thiamin ECF transporter	Streptococcus sanguinis SK36	* Streptococcus pyogenes M1 GAS Site: position = -142 score = 70.23 sequence = ATATTTCACAAAGGA... Gene: SPy0600: Substrate-specific component ThiT of thiamin ECF transporter	* Streptococcus mutans UA159 Site: position = -111 score = 77.59 sequence = TAAATATCACAAGGA... Gene: SMU.706c: Substrate-specific component ThiT of thiamin ECF transporter	* Streptococcus thermophilus CNRZ1066 Site: position = -197 score = 59.23 sequence = AGAGTCACAAGAGGA... Gene: str1571: Substrate-specific component ThiT of thiamin ECF transporter	Streptococcus gordonii str. Challis substr. CH1	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -144 score = 71.89 sequence = AATTATCACAAAGGA... Gene: Sez_0708: Substrate-specific component ThiT of thiamin ECF transporter	Streptococcus mitis B6	Substrate-specific component ThiT of thiamin ECF transporter

CRON 2.
thiW	Streptococcus pneumoniae TIGR4 Gene: SP_0723: Substrate-specific component ThiW of predicted thiazole ECF transporter	* Streptococcus gallolyticus UCN34 Site: position = -267 score = 63.44 sequence = ATAAAGACATTTGGG... Gene: GALLO_1184: Substrate-specific component ThiW of predicted thiazole ECF transporter	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus suis 05ZYH33	Lactococcus lactis subsp. lactis Il1403	Lactococcus lactis subsp. cremoris SK11	Streptococcus uberis 0140J	* Streptococcus agalactiae 2603V/R Site: position = -244 score = 60.3 sequence = TAGGACATTTGGGGT... Gene: SAG0835: Substrate-specific component ThiW of predicted thiazole ECF transporter	Streptococcus sanguinis SK36	Streptococcus pyogenes M1 GAS	Streptococcus mutans UA159	Streptococcus thermophilus CNRZ1066	Streptococcus gordonii str. Challis substr. CH1	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus mitis B6	Substrate-specific component ThiW of predicted thiazole ECF transporter
ykoE	* Streptococcus pneumoniae TIGR4 Site: position = -349 score = 67.67 sequence = AAAGACATTTGGGGT... Gene: SP_0719: Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Streptococcus gallolyticus UCN34	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus suis 05ZYH33	Lactococcus lactis subsp. lactis Il1403	Lactococcus lactis subsp. cremoris SK11	Streptococcus uberis 0140J	Streptococcus agalactiae 2603V/R Gene: SAG0836: Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Streptococcus sanguinis SK36	Streptococcus pyogenes M1 GAS	Streptococcus mutans UA159	Streptococcus thermophilus CNRZ1066	Streptococcus gordonii str. Challis substr. CH1	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus mitis B6	Substrate-specific component YkoE of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
ykoD	Streptococcus pneumoniae TIGR4 Gene: SP_0720: Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Streptococcus gallolyticus UCN34	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus suis 05ZYH33	Lactococcus lactis subsp. lactis Il1403	Lactococcus lactis subsp. cremoris SK11	Streptococcus uberis 0140J	Streptococcus agalactiae 2603V/R Gene: SAG0837: Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Streptococcus sanguinis SK36	Streptococcus pyogenes M1 GAS	Streptococcus mutans UA159	Streptococcus thermophilus CNRZ1066	Streptococcus gordonii str. Challis substr. CH1	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus mitis B6	Duplicated ATPase component YkoD of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
ykoC	Streptococcus pneumoniae TIGR4 Gene: SP_0721: Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Streptococcus gallolyticus UCN34	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus suis 05ZYH33	Lactococcus lactis subsp. lactis Il1403	Lactococcus lactis subsp. cremoris SK11	Streptococcus uberis 0140J	Streptococcus agalactiae 2603V/R Gene: SAG0838: Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine	Streptococcus sanguinis SK36	Streptococcus pyogenes M1 GAS	Streptococcus mutans UA159	Streptococcus thermophilus CNRZ1066	Streptococcus gordonii str. Challis substr. CH1	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus mitis B6	Transmembrane component YkoC of energizing module of thiamin-regulated ECF transporter for HydroxyMethylPyrimidine
tenA	2 Streptococcus pneumoniae TIGR4* Site: position = -302 score = 68.17 sequence = AGAGACATTTGGGGT... Gene: SP_0716: Thiaminase II (EC 3.5.99.2) Gene: SP_0722: Thiaminase II (EC 3.5.99.2)	Streptococcus gallolyticus UCN34 Gene: GALLO_1181: Thiaminase II (EC 3.5.99.2)	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus suis 05ZYH33	Lactococcus lactis subsp. lactis Il1403 Gene: L0228: Thiaminase II (EC 3.5.99.2)	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1950: Thiaminase II (EC 3.5.99.2)	Streptococcus uberis 0140J	Streptococcus agalactiae 2603V/R Gene: SAG0839: Thiaminase II (EC 3.5.99.2)	Streptococcus sanguinis SK36	Streptococcus pyogenes M1 GAS	Streptococcus mutans UA159	Streptococcus thermophilus CNRZ1066	Streptococcus gordonii str. Challis substr. CH1	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus mitis B6	Thiaminase II (EC 3.5.99.2)
thiD	* Streptococcus pneumoniae TIGR4 Site: position = -183 score = 59.01 sequence = AAACAACCACTAGGG... Gene: SP_0726: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Streptococcus gallolyticus UCN34 Gene: GALLO_1180: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus suis 05ZYH33 Gene: SSU05_0733: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Lactococcus lactis subsp. lactis Il1403 Gene: L0200: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1376: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Streptococcus uberis 0140J	Streptococcus agalactiae 2603V/R Gene: SAG0840: Phosphomethylpyrimidine kinase (EC 2.7.4.7)	Streptococcus sanguinis SK36	Streptococcus pyogenes M1 GAS	Streptococcus mutans UA159	Streptococcus thermophilus CNRZ1066	Streptococcus gordonii str. Challis substr. CH1	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus mitis B6	Phosphomethylpyrimidine kinase (EC 2.7.4.7)
thiM	2 Streptococcus pneumoniae TIGR4 Gene: SP_0717: Hydroxyethylthiazole kinase (EC 2.7.1.50) Gene: SP_0724: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Streptococcus gallolyticus UCN34 Gene: GALLO_1179: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus suis 05ZYH33 Gene: SSU05_0734: Hydroxyethylthiazole kinase (EC 2.7.1.50)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -184 score = 55.02 sequence = TCAATAACACAATGG... Gene: L94809: Hydroxyethylthiazole kinase (EC 2.7.1.50)	* Lactococcus lactis subsp. cremoris SK11 Site: position = -183 score = 52.64 sequence = TCTAATACACAATGG... Gene: LACR_1377: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Streptococcus uberis 0140J	Streptococcus agalactiae 2603V/R Gene: SAG0841: Hydroxyethylthiazole kinase (EC 2.7.1.50)	Streptococcus sanguinis SK36	Streptococcus pyogenes M1 GAS	Streptococcus mutans UA159	Streptococcus thermophilus CNRZ1066	Streptococcus gordonii str. Challis substr. CH1	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus mitis B6	Hydroxyethylthiazole kinase (EC 2.7.1.50)
thiE	2 Streptococcus pneumoniae TIGR4 Gene: SP_0718: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3) Gene: SP_0725: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Streptococcus gallolyticus UCN34 Gene: GALLO_1178: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus suis 05ZYH33 Gene: SSU05_0735: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Lactococcus lactis subsp. lactis Il1403 Gene: L0201: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1375: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Streptococcus uberis 0140J	Streptococcus agalactiae 2603V/R Gene: SAG0842: Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)	Streptococcus sanguinis SK36	Streptococcus pyogenes M1 GAS	Streptococcus mutans UA159	Streptococcus thermophilus CNRZ1066	Streptococcus gordonii str. Challis substr. CH1	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus mitis B6	Thiamin-phosphate pyrophosphorylase (EC 2.5.1.3)
GALLO_1183	Streptococcus pneumoniae TIGR4	Streptococcus gallolyticus UCN34 Gene: GALLO_1183: hypothetical protein	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus suis 05ZYH33	Lactococcus lactis subsp. lactis Il1403	Lactococcus lactis subsp. cremoris SK11	Streptococcus uberis 0140J	Streptococcus agalactiae 2603V/R	Streptococcus sanguinis SK36	Streptococcus pyogenes M1 GAS	Streptococcus mutans UA159	Streptococcus thermophilus CNRZ1066	Streptococcus gordonii str. Challis substr. CH1	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus mitis B6	hypothetical protein
SSU05_0732	Streptococcus pneumoniae TIGR4	Streptococcus gallolyticus UCN34 Gene: GALLO_1182: putative HAD-superfamily hydrolase / phosphatase	Streptococcus dysgalactiae subsp. equisimilis GGS_124	* Streptococcus suis 05ZYH33 Site: position = -423 score = 68.32 sequence = TAGAACATTTGGGGT... Gene: SSU05_0732: putative HAD-superfamily hydrolase / phosphatase	Lactococcus lactis subsp. lactis Il1403	Lactococcus lactis subsp. cremoris SK11	Streptococcus uberis 0140J	Streptococcus agalactiae 2603V/R	Streptococcus sanguinis SK36	Streptococcus pyogenes M1 GAS	Streptococcus mutans UA159	Streptococcus thermophilus CNRZ1066	Streptococcus gordonii str. Challis substr. CH1	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus mitis B6	putative HAD-superfamily hydrolase / phosphatase

CRON 3.
COG0011	* Streptococcus pneumoniae TIGR4 Site: position = -174 score = 47.78 sequence = ACATATAATATATGG... Gene: SP_2199: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family	Streptococcus gallolyticus UCN34	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus suis 05ZYH33	Lactococcus lactis subsp. lactis Il1403	Lactococcus lactis subsp. cremoris SK11	Streptococcus uberis 0140J	Streptococcus agalactiae 2603V/R	Streptococcus sanguinis SK36	Streptococcus pyogenes M1 GAS	Streptococcus mutans UA159	Streptococcus thermophilus CNRZ1066	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -327 score = 51.89 sequence = AATATACATATATGG... Gene: SGO_2102: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family	Streptococcus equi subsp. zooepidemicus MGCS10565	* Streptococcus mitis B6 Site: position = -172 score = 49.96 sequence = CTATATAATATATGG... Gene: smi_2050: Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family	Cytoplasmic thiamin-binding component of thiamin ABC transporter, COG0011 family
thiX	Streptococcus pneumoniae TIGR4 Gene: SP_2198: Thiamin ABC transporter, transmembrane component	Streptococcus gallolyticus UCN34	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus suis 05ZYH33	Lactococcus lactis subsp. lactis Il1403	Lactococcus lactis subsp. cremoris SK11	Streptococcus uberis 0140J	Streptococcus agalactiae 2603V/R	* Streptococcus sanguinis SK36 Site: position = -216 score = 43.99 sequence = TCCTATATATGGGAG... Gene: SSA_2353: Thiamin ABC transporter, transmembrane component	Streptococcus pyogenes M1 GAS	Streptococcus mutans UA159	Streptococcus thermophilus CNRZ1066	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_2101: Thiamin ABC transporter, transmembrane component	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus mitis B6 Gene: smi_2049: Thiamin ABC transporter, transmembrane component	Thiamin ABC transporter, transmembrane component
thiY	Streptococcus pneumoniae TIGR4 Gene: SP_2197: Thiamin ABC transporter, substrate-binding component	Streptococcus gallolyticus UCN34	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus suis 05ZYH33	Lactococcus lactis subsp. lactis Il1403	Lactococcus lactis subsp. cremoris SK11	Streptococcus uberis 0140J	Streptococcus agalactiae 2603V/R	Streptococcus sanguinis SK36 Gene: SSA_2352: Thiamin ABC transporter, substrate-binding component	Streptococcus pyogenes M1 GAS	Streptococcus mutans UA159	Streptococcus thermophilus CNRZ1066	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_2100: Thiamin ABC transporter, substrate-binding component	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus mitis B6 Gene: smi_2048: Thiamin ABC transporter, substrate-binding component	Thiamin ABC transporter, substrate-binding component
thiZ	Streptococcus pneumoniae TIGR4 Gene: SP_2196: Thiamin ABC transporter, ATPase component	Streptococcus gallolyticus UCN34	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus suis 05ZYH33	Lactococcus lactis subsp. lactis Il1403	Lactococcus lactis subsp. cremoris SK11	Streptococcus uberis 0140J	Streptococcus agalactiae 2603V/R	Streptococcus sanguinis SK36 Gene: SSA_2351: Thiamin ABC transporter, ATPase component	Streptococcus pyogenes M1 GAS	Streptococcus mutans UA159	Streptococcus thermophilus CNRZ1066	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_2099: Thiamin ABC transporter, ATPase component	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus mitis B6 Gene: smi_2047: Thiamin ABC transporter, ATPase component	Thiamin ABC transporter, ATPase component

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog TPP - Streptococcaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --