Regulog MntR - Streptococcaceae

Properties
Regulator type:	Transcription factor
Regulator family:	DtxR
Regulation mode:	repressor
Biological process:	Manganese homeostasis
Effector:	Manganese ion, (Mn2+)
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 37 sites [see more]

Member of regulog collections

By taxonomy - Streptococcaceae
By trascription factor - MntR
By TF family - DtxR
By effector - Manganese ion, (Mn2+)
By pathway - Manganese homeostasis

Statistics of regulated genes
Genome	Genes	Operons
Lactococcus lactis subsp. cremoris SK11	1	1
Lactococcus lactis subsp. lactis Il1403	4	2
Streptococcus agalactiae 2603V/R	10	4
Streptococcus dysgalactiae subsp. equisimilis GGS_124	5	3
Streptococcus equi subsp. zooepidemicus MGCS10565	9	3
Streptococcus gallolyticus UCN34	4	2
Streptococcus gordonii str. Challis substr. CH1	3	1
Streptococcus mitis B6	5	3
Streptococcus mutans UA159	3	1
Streptococcus pneumoniae TIGR4	4	2
Streptococcus pyogenes M1 GAS	5	3
Streptococcus sanguinis SK36	3	1
Streptococcus suis 05ZYH33	2	2
Streptococcus thermophilus CNRZ1066
Streptococcus uberis 0140J	6	4

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
SPy1434	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -54 score = 5.02662 sequence = ATAATTAATATATCTTAAAGAT Gene: SDEG_1473: Predicted cation transporting ATPase (EC 3.6.3.3)	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159 Gene: SMU.2057c: Predicted cation transporting ATPase (EC 3.6.3.3)	Streptococcus pneumoniae TIGR4	* Streptococcus pyogenes M1 GAS Site: position = -86 score = 5.10521 sequence = CTAAATTACTTGACTTATTTAT Site: position = -53 score = 5.02662 sequence = ATAATTAATATATCTTAAAGAT Gene: SPy1434: Predicted cation transporting ATPase (EC 3.6.3.3)	Streptococcus sanguinis SK36	* Streptococcus suis 05ZYH33 Site: position = -135 score = 5.35356 sequence = ATAAATAACTTGACTTTCTTTT Site: position = -103 score = 5.27973 sequence = ATAATTAACTTAGTTAAATGAT Gene: SSU05_0309: Predicted cation transporting ATPase (EC 3.6.3.3)	Streptococcus thermophilus CNRZ1066	* Streptococcus uberis 0140J Site: position = -54 score = 5.34384 sequence = ATAATTAAGATGAATTAAATTG Gene: SUB1266: Predicted cation transporting ATPase (EC 3.6.3.3)	Predicted cation transporting ATPase (EC 3.6.3.3)

CRON 2.
mntR	* Lactococcus lactis subsp. cremoris SK11 Site: position = -31 score = 5.12554 sequence = ATAATTAAATGGAGAAAAGTAA Gene: LACR_1369: Manganese homeostasis transcriptional regulator MntR, DtxR family	* Lactococcus lactis subsp. lactis Il1403 Site: position = -31 score = 5.09735 sequence = ATAATTAAATCAAGAAAAGTAA Gene: L84767: Manganese homeostasis transcriptional regulator MntR, DtxR family	* Streptococcus agalactiae 2603V/R Site: position = -151 score = 5.05341 sequence = AAAATTAATATAAGTTATGTAT Site: position = -129 score = 6.20842 sequence = TAAATTAAGTTAACTTAATTTT Gene: SAG1534: Manganese homeostasis transcriptional regulator MntR, DtxR family	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -116 score = 5.97345 sequence = TTAATTAAGTATAGTTAAATAT Gene: SDEG_0487: Manganese homeostasis transcriptional regulator MntR, DtxR family	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -116 score = 6.20754 sequence = TTAATTAAGTATAGTTAATTAT Gene: Sez_1470: Manganese homeostasis transcriptional regulator MntR, DtxR family	Streptococcus gallolyticus UCN34 Gene: GALLO_1718: Manganese homeostasis transcriptional regulator MntR, DtxR family	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_1816: Manganese homeostasis transcriptional regulator MntR, DtxR family	Streptococcus mitis B6 Gene: smi_0645: Manganese homeostasis transcriptional regulator MntR, DtxR family	Streptococcus mutans UA159 Gene: SMU.186: Manganese homeostasis transcriptional regulator MntR, DtxR family	Streptococcus pneumoniae TIGR4 Gene: SP_1638: Manganese homeostasis transcriptional regulator MntR, DtxR family	* Streptococcus pyogenes M1 GAS Site: position = -116 score = 6.25894 sequence = TTAATTAAGTTTAGTTAATTAT Gene: SPy0450: Manganese homeostasis transcriptional regulator MntR, DtxR family	Streptococcus sanguinis SK36 Gene: SSA_0256: Manganese homeostasis transcriptional regulator MntR, DtxR family	Streptococcus suis 05ZYH33 Gene: SSU05_2087: Manganese homeostasis transcriptional regulator MntR, DtxR family	Streptococcus thermophilus CNRZ1066	* Streptococcus uberis 0140J Site: position = -117 score = 5.9289 sequence = TTAATTAAGTATGGTTAATTAT Gene: SUBp03: Manganese homeostasis transcriptional regulator MntR, DtxR family	Manganese homeostasis transcriptional regulator MntR, DtxR family

CRON 3.
nikA	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	* Streptococcus agalactiae 2603V/R Site: position = -56 score = 5.18199 sequence = CTAATTAAGTTTGCTTAAAAAA Site: position = -34 score = 5.21345 sequence = ATAATTAACTAAACTTAAAAGA Gene: SAG1518: Nickel ABC transporter, substrate-binding protein	Streptococcus dysgalactiae subsp. equisimilis GGS_124	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -79 score = 5.91236 sequence = TAAATTAACCATACTTAATTTT Gene: Sez_1456: Nickel ABC transporter, substrate-binding protein	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Nickel ABC transporter, substrate-binding protein
nikB	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R Gene: SAG1517: Nickel ABC transporter, permease protein 1	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_1455: Nickel ABC transporter, permease protein 1	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Nickel ABC transporter, permease protein 1
nikC	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R Gene: SAG1516: Nickel ABC transporter, permease protein 2	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_1454: Nickel ABC transporter, permease protein 2	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Nickel ABC transporter, permease protein 2
nikD	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R Gene: SAG1515: Nickel ABC transporter, ATP-binding protein 1	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_1453: Nickel ABC transporter, ATP-binding protein 1	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Nickel ABC transporter, ATP-binding protein 1
nikE	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R Gene: SAG1514: Nickel ABC transporter, ATP-binding protein 2	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_1452: Nickel ABC transporter, ATP-binding protein 2	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Nickel ABC transporter, ATP-binding protein 2

CRON 4.
mntH	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	* Streptococcus agalactiae 2603V/R Site: position = -85 score = 5.53946 sequence = ATTATTAAGTAGCGTTAATTTT Gene: SAG0745: Manganese transport protein MntH	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	* Streptococcus gallolyticus UCN34 Site: position = -78 score = 5.2153 sequence = TTAATTAAATACGCTTTATTTT Gene: GALLO_0590: Manganese transport protein MntH	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0217: Manganese transport protein MntH	* Streptococcus mitis B6 Site: position = -164 score = 5.20338 sequence = AAAATTAACCAATATTAATAAT Gene: smi_1232: Manganese transport protein MntH	Streptococcus mutans UA159 Gene: SMU.770c: Manganese transport protein MntH	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066 Gene: str0677: Manganese transport protein MntH	Streptococcus uberis 0140J	Manganese transport protein MntH

CRON 5.
mntB	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1440: Manganese ABC transporter, ATP-binding protein	* Lactococcus lactis subsp. lactis Il1403 Site: position = -87 score = 4.90626 sequence = CAAAATATATTGATTTAATTTT Gene: L150744: Manganese ABC transporter, ATP-binding protein	Streptococcus agalactiae 2603V/R Gene: SAG1532: Manganese ABC transporter, ATP-binding protein	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0489: Manganese ABC transporter, ATP-binding protein	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_1468: Manganese ABC transporter, ATP-binding protein	Streptococcus gallolyticus UCN34 Gene: GALLO_2046: Manganese ABC transporter, ATP-binding protein	* Streptococcus gordonii str. Challis substr. CH1 Site: position = -60 score = 6.43283 sequence = AAAATTAACTTGACTTAATTTT Gene: SGO_1800: Manganese ABC transporter, ATP-binding protein	* Streptococcus mitis B6 Site: position = -62 score = 6.07966 sequence = AAAATTAACTTGACTTAACTTT Gene: smi_0636: Manganese ABC transporter, ATP-binding protein	* Streptococcus mutans UA159 Site: position = -57 score = 6.43283 sequence = AAAATTAACTTGACTTAATTTT Gene: SMU.182: Manganese ABC transporter, ATP-binding protein	* Streptococcus pneumoniae TIGR4 Site: position = -62 score = 6.43283 sequence = AAAATTAACTTGACTTAATTTT Gene: SP_1648: Manganese ABC transporter, ATP-binding protein	Streptococcus pyogenes M1 GAS Gene: SPy0454: Manganese ABC transporter, ATP-binding protein	* Streptococcus sanguinis SK36 Site: position = -29 score = 6.43283 sequence = AAAATTAACTTGACTTAATTTT Gene: SSA_0262: Manganese ABC transporter, ATP-binding protein	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J Gene: SUB0474: Manganese ABC transporter, ATP-binding protein	Manganese ABC transporter, ATP-binding protein
mntC	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1439: Manganese ABC transporter, permease protein	Lactococcus lactis subsp. lactis Il1403 Gene: L149891: Manganese ABC transporter, permease protein	Streptococcus agalactiae 2603V/R Gene: SAG1531: Manganese ABC transporter, permease protein	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0490: Manganese ABC transporter, permease protein	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_1467: Manganese ABC transporter, permease protein	Streptococcus gallolyticus UCN34 Gene: GALLO_2045: Manganese ABC transporter, permease protein	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_1801: Manganese ABC transporter, permease protein	Streptococcus mitis B6 Gene: smi_0635: Manganese ABC transporter, permease protein	Streptococcus mutans UA159 Gene: SMU.183: Manganese ABC transporter, permease protein	Streptococcus pneumoniae TIGR4 Gene: SP_1649: Manganese ABC transporter, permease protein	Streptococcus pyogenes M1 GAS Gene: SPy0456: Manganese ABC transporter, permease protein	Streptococcus sanguinis SK36 Gene: SSA_0261: Manganese ABC transporter, permease protein	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J Gene: SUB0475: Manganese ABC transporter, permease protein	Manganese ABC transporter, permease protein
mntA	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403 Gene: L148957: Manganese ABC transporter, substrate-binding protein	* Streptococcus agalactiae 2603V/R Site: position = -59 score = 6.26389 sequence = AAAATTAAGTTAACTTAATTTA Gene: SAG1533: Manganese ABC transporter, substrate-binding protein	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -51 score = 6.07104 sequence = ATATTTAACTATACTTAATTAA Gene: SDEG_0488: Manganese ABC transporter, substrate-binding protein	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -51 score = 6.3792 sequence = ATAATTAACTATACTTAATTAA Gene: Sez_1469: Manganese ABC transporter, substrate-binding protein	* Streptococcus gallolyticus UCN34 Site: position = -53 score = 5.78171 sequence = AAAATTAAGCATGCTTAATTTT Gene: GALLO_2047: Manganese ABC transporter, substrate-binding protein	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_1802: Manganese ABC transporter, substrate-binding protein	Streptococcus mitis B6 Gene: smi_0634: Manganese ABC transporter, substrate-binding protein	Streptococcus mutans UA159 Gene: SMU.184: Manganese ABC transporter, substrate-binding protein	Streptococcus pneumoniae TIGR4 Gene: SP_1650: Manganese ABC transporter, substrate-binding protein	* Streptococcus pyogenes M1 GAS Site: position = -51 score = 6.35101 sequence = ATAATTAACTAAACTTAATTAA Gene: SPy0453: Manganese ABC transporter, substrate-binding protein	Streptococcus sanguinis SK36 Gene: SSA_0260: Manganese ABC transporter, substrate-binding protein	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	* Streptococcus uberis 0140J Site: position = -32 score = 4.90236 sequence = TTAATTATATAATATAAATTAA Site: position = -50 score = 6.08223 sequence = ATAATTAACCATACTTAATTAA Gene: SUB0473: Manganese ABC transporter, substrate-binding protein	Manganese ABC transporter, substrate-binding protein

CRON 6.
prtA	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	* Streptococcus mitis B6 Site: position = -194 score = 5.6468 sequence = AAAATTAACCAGCCTTAATTTT Gene: smi_0705: C5a peptidase precursor (EC 3.4.21.-)	Streptococcus mutans UA159	* Streptococcus pneumoniae TIGR4 Site: position = -194 score = 5.84153 sequence = TAAATTAACTAATGTTAATTTT Gene: SP_0641: C5a peptidase precursor (EC 3.4.21.-)	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	* Streptococcus suis 05ZYH33 Site: position = -32 score = 5.14573 sequence = TAAATTAATTAAACTTAAAAAA Gene: SSU05_1982: C5a peptidase precursor (EC 3.4.21.-)	Streptococcus thermophilus CNRZ1066	* Streptococcus uberis 0140J Site: position = -83 score = 5.65866 sequence = ATTATTAAGTATACTTAATAAT Gene: SUB0826: C5a peptidase precursor (EC 3.4.21.-)	C5a peptidase precursor (EC 3.4.21.-)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog MntR - Streptococcaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --