Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulon of CcpA in Streptococcus mutans UA159

Properties
Regulator type: Transcription factor
TF locus tag: SMU.1591
Regulator family: LacI
Regulation mode:
Biological process: Global catabolite repression
Effector: Fructose-1,6-bisphosphate; HPr, phosphocarrier protein
Regulog: CcpA - Streptococcaceae
Statistics of regulated genes:
- Genes 99
- Operons 48
Visualization:
Allows to visualize regulon content in the context of metabolic pathways
Built upon 968 sites [see more]
Member of regulog collections
Regulated operons
Locus Tag Name Function

Position: -28
Score: 4.3
Sequence: TCGTAAACGATTTCAT
Locus tag: SMU.1978
Name: ackA
Funciton: Acetate kinase (EC 2.7.2.1)
ackA
Acetate kinase (EC 2.7.2.1)

Position: -165
Score: 4.7
Sequence: AAGATAGCGCTTACAA
Locus tag: SMU.78
Name: sacC
Funciton: Fructanase (EC 3.2.1.80) / Levanase (EC 3.2.1.65)
sacC
Fructanase (EC 3.2.1.80) / Levanase (EC 3.2.1.65)

Position: -46
Score: 3.9
Sequence: TTGAAATTGTTTGCTA
Locus tag: SMU.1601
Name: bglA
Funciton: 6-phospho-beta-glucosidase (EC 3.2.1.86)
bglA
6-phospho-beta-glucosidase (EC 3.2.1.86)

Position: -78
Score: 4.7
Sequence: ATGTAAACGCTTGCTT
Locus tag: SMU.179
Name: yieF
Funciton: Predicted NADH-dependent flavin oxidoreductase
Locus tag: SMU.180
Name: frd2
Funciton: Predicted NADPH-dependent FMN reductase
yieF
Predicted NADH-dependent flavin oxidoreductase
frd2
Predicted NADPH-dependent FMN reductase

Position: -65
Score: 4.4
Sequence: ATAACAGCGTTTACAT
Locus tag: SMU.1389
Name: pck
Funciton: Phosphoenolpyruvate carboxykinase (EC 4.1.1.49)
pck
Phosphoenolpyruvate carboxykinase (EC 4.1.1.49)

Position: -69
Score: 4.5
Sequence: ATGAAAGTGCTATCAT
Locus tag: SMU.113
Name: fruK2
Funciton: Fructose-1-phosphate kinase (EC 2.7.1.56)
Locus tag: SMU.114
Name: fruA2
Funciton: Fructose-specific PTS system, IIBC component
Locus tag: SMU.115
Name: fruB2
Funciton: Fructose-specific PTS system, IIA component
Locus tag: SMU.116
Name: lacD1
Funciton: tagatose1,6-diphosphatealdolase
fruK2
Fructose-1-phosphate kinase (EC 2.7.1.56)
fruA2
Fructose-specific PTS system, IIBC component
fruB2
Fructose-specific PTS system, IIA component
lacD1
tagatose1,6-diphosphatealdolase

Position: -106
Score: 4.8
Sequence: TTGAAAACACTTTCAA
Locus tag: SMU.1592
Name: pepQ
Funciton: Xaa-Pro dipeptidase (EC 3.4.13.9)
pepQ
Xaa-Pro dipeptidase (EC 3.4.13.9)

Position: -77
Score: 4.8
Sequence: TTGTAATCGTTTACAA
Locus tag: SMU.2038
Name: treP
Funciton: Trehalose-specific PTS system, IIABC components (EC 2.7.1.69)
Locus tag: SMU.2037
Name: treA
Funciton: Trehalose-6-phosphate hydrolase (EC 3.2.1.93)
treP
Trehalose-specific PTS system, IIABC components (EC 2.7.1.69)
treA
Trehalose-6-phosphate hydrolase (EC 3.2.1.93)

Position: -51
Score: 4.1
Sequence: TAGAAAGCGGTTCAAA
Locus tag: SMU.127
Name: acoA
Funciton: Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-)
Locus tag: SMU.128
Name: acoB
Funciton: Acetoin dehydrogenase E1 component beta-subunit (EC 1.2.4.-)
acoA
Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-)
acoB
Acetoin dehydrogenase E1 component beta-subunit (EC 1.2.4.-)

Position: -95
Score: 4.2
Sequence: TTGAAATCCCTATCAA
Position: -58
Score: 5.2
Sequence: TAGAAAGCGTTTTCAA
Locus tag: SMU.1424
Name: pdhD
Funciton: Dihydrolipoamide dehydrogenase of acetoin dehydrogenase (EC 1.8.1.4)
Locus tag: SMU.1423
Name: pdhA
Funciton: Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-)
Locus tag: SMU.1422
Name: pdhB
Funciton: Acetoin dehydrogenase E1 component beta-subunit (EC 1.2.4.-)
Locus tag: SMU.1421
Name: pdhC
Funciton: Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex (EC 2.3.1.-)
pdhD
Dihydrolipoamide dehydrogenase of acetoin dehydrogenase (EC 1.8.1.4)
pdhA
Acetoin dehydrogenase E1 component alpha-subunit (EC 1.2.4.-)
pdhB
Acetoin dehydrogenase E1 component beta-subunit (EC 1.2.4.-)
pdhC
Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex (EC 2.3.1.-)

Position: -95
Score: 4.3
Sequence: TTTAAAACATTTACAT
Locus tag: SMU.546
Name: typA
Funciton: GTP-binding protein TypA/BipA
typA
GTP-binding protein TypA/BipA

Position: -103
Score: 3.9
Sequence: CTGAAAACGCTTTTTC
Locus tag: SMU.1191
Name: pfk
Funciton: 6-phosphofructokinase (EC 2.7.1.11)
Locus tag: SMU.1190
Name: pyk
Funciton: Pyruvate kinase (EC 2.7.1.40)
pfk
6-phosphofructokinase (EC 2.7.1.11)
pyk
Pyruvate kinase (EC 2.7.1.40)

Position: -127
Score: 3.9
Sequence: TTGAAAACGATCATTT
Locus tag: SMU.611
Name: rheA
Funciton: Cold-shock DEAD-box protein A
rheA
Cold-shock DEAD-box protein A

Position: -105
Score: 4.4
Sequence: ATGTAAACGTTTTACA
Locus tag: SMU.1877
Name: manL
Funciton: PTS system, mannose-specific IIAB components
Locus tag: SMU.1878
Name: manM
Funciton: PTS system, mannose-specific IIC component (EC 2.7.1.69)
Locus tag: SMU.1879
Name: manN
Funciton: PTS system, mannose-specific IID component (EC 2.7.1.69)
manL
PTS system, mannose-specific IIAB components
manM
PTS system, mannose-specific IIC component (EC 2.7.1.69)
manN
PTS system, mannose-specific IID component (EC 2.7.1.69)

Position: -154
Score: 4.9
Sequence: TAGTAAACGTTTTCTT
Position: -47
Score: 4.9
Sequence: AAAAAAACGCTTTCAA
Locus tag: SMU.1841
Name: scrA
Funciton: Sucrose-specific PTS system, IIABC component (EC 2.7.1.69)
Locus tag: SMU.1840
Name: scrK
Funciton: Fructokinase (EC 2.7.1.4)
scrA
Sucrose-specific PTS system, IIABC component (EC 2.7.1.69)
scrK
Fructokinase (EC 2.7.1.4)

Position: -75
Score: 4.5
Sequence: ATGATAGCACTTTCAT
Locus tag: SMU.112c
Name: fruR2
Funciton: Predicted fructose utilization transcriptional regulator FruR2, RpiR family
fruR2
Predicted fructose utilization transcriptional regulator FruR2, RpiR family

Position: -43
Score: 4.5
Sequence: ATGCAAACGTTTGCAT
Locus tag: SMU.2047
Name: ptsG
Funciton: PTS system glucose-specific EIICBA component (EC 2.7.1.69)
Locus tag: SMU.2046c
Name: rgfB
Funciton: Exodeoxyribonuclease III (EC 3.1.11.2)
ptsG
PTS system glucose-specific EIICBA component (EC 2.7.1.69)
rgfB
Exodeoxyribonuclease III (EC 3.1.11.2)

Position: -112
Score: 4.8
Sequence: TTGTAAACGATTACAA
Locus tag: SMU.2040
Name: treR
Funciton: Trehalose utilization transcriptional regulator TreR, GntR family
treR
Trehalose utilization transcriptional regulator TreR, GntR family

Position: -112
Score: 4.6
Sequence: ATAAAAGGGCTTTCAT
Locus tag: SMU.1824c
Name: codY
Funciton: Amino acid metabolism global transcriptional regulator CodY, CodY family
Locus tag: SMU.1823
Name: pncA
Funciton: Nicotinamidase (EC 3.5.1.19)
codY
Amino acid metabolism global transcriptional regulator CodY, CodY family
pncA
Nicotinamidase (EC 3.5.1.19)

Position: -50
Score: 4.6
Sequence: CAGAAAACGCTATCAT
Locus tag: SMU.1088
Name: apbE
Funciton: Predicted thiamine biosynthesis lipoprotein
apbE
Predicted thiamine biosynthesis lipoprotein

Position: -66
Score: 4.5
Sequence: TTGAAAACGTTTTACA
Locus tag: SMU.575c
Name: lrgA
Funciton: Antiholin-like protein LrgA
Locus tag: SMU.574c
Name: lrgB
Funciton: LrgA-associated membrane protein LrgB
lrgA
Antiholin-like protein LrgA
lrgB
LrgA-associated membrane protein LrgB

Position: -58
Score: 3.9
Sequence: AGGCAAGCGCTTGCAA
Locus tag: SMU.541
Name: yvaA
Funciton: Bacterial conserved protein of unknown function (DUF910) family
Locus tag: SMU.542
Name: glcK
Funciton: Glucokinase (EC 2.7.1.2)
Locus tag: SMU.543
Name: yvaB
Funciton: Rhodanese-like domain protein
yvaA
Bacterial conserved protein of unknown function (DUF910) family
glcK
Glucokinase (EC 2.7.1.2)
yvaB
Rhodanese-like domain protein

Position: -50
Score: 4.6
Sequence: TTTAAAACGGTTACAA
Locus tag: SMU.877
Name: agaL
Funciton: Alpha-galactosidase (EC 3.2.1.22)
Locus tag: SMU.878
Name: msmE
Funciton: Multiple sugar ABC transporter, substrate-binding protein
Locus tag: SMU.879
Name: msmF
Funciton: Multiple sugar ABC transporter, permease protein 2
Locus tag: SMU.880
Name: msmG
Funciton: Multiple sugar ABC transporter, permease protein 1
agaL
Alpha-galactosidase (EC 3.2.1.22)
msmE
Multiple sugar ABC transporter, substrate-binding protein
msmF
Multiple sugar ABC transporter, permease protein 2
msmG
Multiple sugar ABC transporter, permease protein 1

Position: -52
Score: 4.5
Sequence: TTGAAACGGTTTTCAA
Locus tag: SMU.1126
Name: coaA
Funciton: Pantothenate kinase (EC 2.7.1.33)
coaA
Pantothenate kinase (EC 2.7.1.33)

Position: -189
Score: 3.8
Sequence: TTGTTAACCTTTTATA
Locus tag: SMU.1568
Name: malE
Funciton: Maltose/maltodextrin ABC transporter, substrate-binding protein
Locus tag: SMU.1569
Name: malF
Funciton: Maltose/maltodextrin ABC transporter, permease protein 1
Locus tag: SMU.1570
Name: malG
Funciton: Maltose/maltodextrin ABC transporter, permease protein 2
malE
Maltose/maltodextrin ABC transporter, substrate-binding protein
malF
Maltose/maltodextrin ABC transporter, permease protein 1
malG
Maltose/maltodextrin ABC transporter, permease protein 2

Position: -72
Score: 4.8
Sequence: TTGAAAGTGTTTTCAA
Locus tag: SMU.1591
Name: ccpA
Funciton: Carbon catabolism global transcriptional regulator CcpA, LacI family
ccpA
Carbon catabolism global transcriptional regulator CcpA, LacI family

Position: -58
Score: 4.5
Sequence: ATGAAAGCGATATAAT
Locus tag: SMU.500
Name: raiA
Funciton: Ribosome-associated protein Y
raiA
Ribosome-associated protein Y

Position: -53
Score: 4.3
Sequence: AAGTAAGCGTTTTATG
Locus tag: SMU.291
Name: tkt2
Funciton: Transketolase (EC 2.2.1.1)
tkt2
Transketolase (EC 2.2.1.1)

Position: -55
Score: 4.7
Sequence: ATGAAAGCGGTTAAAT
Locus tag: SMU.1077
Name: pgm
Funciton: Phosphoglucomutase (EC 5.4.2.2)
pgm
Phosphoglucomutase (EC 5.4.2.2)

Position: -160
Score: 3.9
Sequence: TTTAAAATGTTTTTTT
Position: -115
Score: 5
Sequence: TTTTAAGCGCTTTCAT
Locus tag: SMU.1013c
Name: citN
Funciton: Mg2+/citrate complex secondary transporter
citN
Mg2+/citrate complex secondary transporter

Position: -113
Score: 4.9
Sequence: AAGAAATCGCTTACAA
Locus tag: SMU.402
Name: pfl
Funciton: Pyruvate formate-lyase (EC 2.3.1.54)
pfl
Pyruvate formate-lyase (EC 2.3.1.54)

Position: -164
Score: 4.9
Sequence: TTGAAAGCGTTTTTTT
Position: -57
Score: 4.9
Sequence: AAGAAAACGTTTACTA
Locus tag: SMU.1843
Name: scrB
Funciton: Sucrose-6-phosphate hydrolase (EC 3.2.1.26)
Locus tag: SMU.1844
Name: scrR
Funciton: Sucrose operon repressor ScrR, LacI family
scrB
Sucrose-6-phosphate hydrolase (EC 3.2.1.26)
scrR
Sucrose operon repressor ScrR, LacI family

Position: -57
Score: 4.8
Sequence: TTGAAATCGGTTTCAA
Locus tag: SMU.2127
Name: gabD
Funciton: Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16)
gabD
Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NADP+] (EC 1.2.1.16)

Position: -100
Score: 4.8
Sequence: AAGTAAACGTTTTAAT
Locus tag: SMU.396
Name: glpF2
Funciton: Glycerol uptake facilitator protein
glpF2
Glycerol uptake facilitator protein

Position: -60
Score: 4.3
Sequence: TTGTAAGGGTTATCAT
Locus tag: SMU.674
Name: ptsH
Funciton: Phosphotransferase system, HPr-related protein
Locus tag: SMU.675
Name: ptsI
Funciton: Phosphoenolpyruvate-protein kinase, PTS system component (EC 2.7.3.9)
ptsH
Phosphotransferase system, HPr-related protein
ptsI
Phosphoenolpyruvate-protein kinase, PTS system component (EC 2.7.3.9)

Position: 22
Score: 4.4
Sequence: GTGTAAACGATTTCAA
Locus tag: SMU.870
Name: fruR
Funciton: Fructose utilization transcriptional regulator FruR, DeoR family
Locus tag: SMU.871
Name: fruB
Funciton: 1-phosphofructokinase (EC 2.7.1.56)
Locus tag: SMU.872
Name: fruA
Funciton: Fructose-specific PTS system, IIABC component (EC 2.7.1.69)
fruR
Fructose utilization transcriptional regulator FruR, DeoR family
fruB
1-phosphofructokinase (EC 2.7.1.56)
fruA
Fructose-specific PTS system, IIABC component (EC 2.7.1.69)

Position: -85
Score: 4.9
Sequence: ATGAAAGCGTTTTATA
Locus tag: SMU.307
Name: pgi
Funciton: Glucose-6-phosphate isomerase (EC 5.3.1.9)
pgi
Glucose-6-phosphate isomerase (EC 5.3.1.9)

Position: -28
Score: 4
Sequence: AGAAAAACGTTTACAG
Locus tag: SMU.1692
Name: pflA
Funciton: Pyruvate formate-lyase activating enzyme (EC 1.97.1.4)
pflA
Pyruvate formate-lyase activating enzyme (EC 1.97.1.4)

Position: -161
Score: 4.1
Sequence: TTAAAAGCGTCTTCTA
Locus tag: SMU.1534
Name: atpE
Funciton: ATP synthase C chain (EC 3.6.3.14)
Locus tag: SMU.1533
Name: atpB
Funciton: ATP synthase A chain (EC 3.6.3.14)
Locus tag: SMU.1532
Name: atpF
Funciton: ATP synthase B chain (EC 3.6.3.14)
Locus tag: SMU.1531
Name: atpH
Funciton: ATP synthase delta chain (EC 3.6.3.14)
Locus tag: SMU.1530
Name: atpA
Funciton: ATP synthase alpha chain (EC 3.6.3.14)
Locus tag: SMU.1529
Name: atpG
Funciton: ATP synthase gamma chain (EC 3.6.3.14)
Locus tag: SMU.1528
Name: atpD
Funciton: ATP synthase beta chain (EC 3.6.3.14)
Locus tag: SMU.1527
Name: atpC
Funciton: ATP synthase epsilon chain (EC 3.6.3.14)
atpE
ATP synthase C chain (EC 3.6.3.14)
atpB
ATP synthase A chain (EC 3.6.3.14)
atpF
ATP synthase B chain (EC 3.6.3.14)
atpH
ATP synthase delta chain (EC 3.6.3.14)
atpA
ATP synthase alpha chain (EC 3.6.3.14)
atpG
ATP synthase gamma chain (EC 3.6.3.14)
atpD
ATP synthase beta chain (EC 3.6.3.14)
atpC
ATP synthase epsilon chain (EC 3.6.3.14)

Position: -30
Score: 4.8
Sequence: ATTAAAACGTTTACTT
Locus tag: SMU.395
Name: pepX
Funciton: Xaa-Pro dipeptidyl-peptidase
pepX
Xaa-Pro dipeptidyl-peptidase

Position: -72
Score: 4.2
Sequence: TTGTTAGCATTTTCAA
Locus tag: SMU.270
Name: sgaT
Funciton: Ascorbate-specific PTS system, IIC component
Locus tag: SMU.271
Name: sgaB
Funciton: Ascorbate-specific PTS system, IIB component (EC 2.7.1.69)
Locus tag: SMU.272
Name: sgaC
Funciton: Ascorbate-specific PTS system, IIA component (EC 2.7.1.-)
Locus tag: SMU.273
Name: sgaH
Funciton: 3-keto-L-gulonate 6-phosphate decarboxylase (EC 4.1.1.85)
Locus tag: SMU.274
Name: sgaU
Funciton: L-xylulose 5-phosphate 3-epimerase (EC 5.1.3.-)
Locus tag: SMU.275
Name: sgaE
Funciton: L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4)
sgaT
Ascorbate-specific PTS system, IIC component
sgaB
Ascorbate-specific PTS system, IIB component (EC 2.7.1.69)
sgaC
Ascorbate-specific PTS system, IIA component (EC 2.7.1.-)
sgaH
3-keto-L-gulonate 6-phosphate decarboxylase (EC 4.1.1.85)
sgaU
L-xylulose 5-phosphate 3-epimerase (EC 5.1.3.-)
sgaE
L-ribulose-5-phosphate 4-epimerase (EC 5.1.3.4)

Position: -161
Score: 4.6
Sequence: ATGAAAAGGATTTCAT
Locus tag: SMU.91
Name: ropA
Funciton: Cell division trigger factor (EC 5.2.1.8)
ropA
Cell division trigger factor (EC 5.2.1.8)

Position: -92
Score: 4.6
Sequence: ATGAAATCCTTTTCAT
Locus tag: SMU.89c
Name: yrhG
Funciton: Predicted permease
yrhG
Predicted permease

Position: -56
Score: 4.2
Sequence: TTGTGAGCGCTTTATA
Locus tag: SMU.308
Name: sorD
Funciton: Sorbitol-6-phosphate 2-dehydrogenase (EC 1.1.1.140)
Locus tag: SMU.309
Name: srlM
Funciton: Sorbitol operon transcription regulator
Locus tag: SMU.310
Name: srlR
Funciton: Glucitol operon activator protein
Locus tag: SMU.311
Name: srlA
Funciton: Glucitol/sorbitol-specific PTS system, IIC component (EC 2.7.1.69)
Locus tag: SMU.312
Name: srlE
Funciton: Glucitol/sorbitol-specific PTS system, IIBC components (EC 2.7.1.69)
Locus tag: SMU.313
Name: srlB
Funciton: Glucitol/sorbitol-specific PTS system, IIA component (EC 2.7.1.69)
sorD
Sorbitol-6-phosphate 2-dehydrogenase (EC 1.1.1.140)
srlM
Sorbitol operon transcription regulator
srlR
Glucitol operon activator protein
srlA
Glucitol/sorbitol-specific PTS system, IIC component (EC 2.7.1.69)
srlE
Glucitol/sorbitol-specific PTS system, IIBC components (EC 2.7.1.69)
srlB
Glucitol/sorbitol-specific PTS system, IIA component (EC 2.7.1.69)

Position: -73
Score: 4.6
Sequence: TTGTAACCGTTTTAAA
Locus tag: SMU.876
Name: msmR
Funciton: Predicted multiple sugar utilization transcriptional regulator, AraC family
msmR
Predicted multiple sugar utilization transcriptional regulator, AraC family

Position: -189
Score: 4.1
Sequence: ATAGAAACGCTTACAG
Locus tag: SMU.1405c
Name: cas9
Funciton: CRISPR/Cas system-associated protein Cas9
Locus tag: SMU.1404c
Name: cas1
Funciton: CRISPR/Cas system-associated protein Cas1
Locus tag: SMU.1403c
Name: cas2
Funciton: CRISPR/Cas system-associated protein Cas2
Locus tag: SMU.1402c
Name: csn2
Funciton: CRISPR/Cas system-associated protein Csn2
cas9
CRISPR/Cas system-associated protein Cas9
cas1
CRISPR/Cas system-associated protein Cas1
cas2
CRISPR/Cas system-associated protein Cas2
csn2
CRISPR/Cas system-associated protein Csn2

Position: -109
Score: 4.3
Sequence: TAGGAAACGCTTCCAA
Locus tag: SMU.799c
Name: SPy1339
Funciton: Dihydrolipoamide acyltransferase
SPy1339
Dihydrolipoamide acyltransferase

Position: -55
Score: 4.8
Sequence: TTGTAAGCGCTTTTTT
Locus tag: SMU.1600
Name: celB
Funciton: Cellobiose-specific PTS, component EIIB
Locus tag: SMU.1599
Name: celR
Funciton: Cellobiose utilization transcriptional regulator CelR, BglG family
Locus tag: SMU.1598
Name: celA
Funciton: Cellobiose-specific PTS, component EIIA
Locus tag: SMU.1597c
Name: SP_0309
Funciton: Conserved hypothetical protein
Locus tag: SMU.1596
Name: celD
Funciton: Cellobiose-specific PTS, component EIIC
celB
Cellobiose-specific PTS, component EIIB
celR
Cellobiose utilization transcriptional regulator CelR, BglG family
celA
Cellobiose-specific PTS, component EIIA
SP_0309
Conserved hypothetical protein
celD
Cellobiose-specific PTS, component EIIC
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