Regulog BirA - Streptococcaceae

Properties
Regulator type:	Transcription factor
Regulator family:	BirA
Regulation mode:	repressor
Biological process:	Biotin biosynthesis
Effector:	Biotin
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 29 sites [see more]

Member of regulog collections

By taxonomy - Streptococcaceae
By trascription factor - BirA
By TF family - BirA
By effector - Biotin
By pathway - Biotin biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Lactococcus lactis subsp. cremoris SK11	6	2
Lactococcus lactis subsp. lactis Il1403	5	2
Streptococcus agalactiae 2603V/R	7	3
Streptococcus dysgalactiae subsp. equisimilis GGS_124	6	3
Streptococcus equi subsp. zooepidemicus MGCS10565	5	2
Streptococcus gallolyticus UCN34	6	3
Streptococcus gordonii str. Challis substr. CH1	1	1
Streptococcus mitis B6	1	1
Streptococcus mutans UA159	1	1
Streptococcus pneumoniae TIGR4	1	1
Streptococcus pyogenes M1 GAS	4	2
Streptococcus sanguinis SK36	1	1
Streptococcus suis 05ZYH33	1	1
Streptococcus thermophilus CNRZ1066	2	2
Streptococcus uberis 0140J	2	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
SAG0465	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	* Streptococcus agalactiae 2603V/R Site: position = -79 score = 7.98278 sequence = ATTGTAAAC-(16)-GTTAACAAT Gene: SAG0465: putative thioesterase	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -32 score = 7.95649 sequence = AAAGTTAAC-(16)-GGTGACAAT Gene: SDEG_0560: putative thioesterase	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -32 score = 7.8237 sequence = AAAGTTAAC-(16)-GGTTACAAT Gene: Sez_1400: putative thioesterase	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	putative thioesterase
yhfS	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1956: Putative acetyl-CoA acetyltransferase (EC 2.3.1.9)	Lactococcus lactis subsp. lactis Il1403 Gene: L25946: Putative acetyl-CoA acetyltransferase (EC 2.3.1.9)	Streptococcus agalactiae 2603V/R Gene: SAG0466: Putative acetyl-CoA acetyltransferase (EC 2.3.1.9)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0561: Putative acetyl-CoA acetyltransferase (EC 2.3.1.9)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_1399: Putative acetyl-CoA acetyltransferase (EC 2.3.1.9)	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	* Streptococcus pyogenes M1 GAS Site: position = -269 score = 6.46373 sequence = AAAGTCACC-(16)-GGTTACAGT Gene: SPy0524: Putative acetyl-CoA acetyltransferase (EC 2.3.1.9)	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Putative acetyl-CoA acetyltransferase (EC 2.3.1.9)
yhfT	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1955: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	* Lactococcus lactis subsp. lactis Il1403 Site: position = -79 score = 7.41687 sequence = ACAGTAACC-(16)-GTTAACTGT Gene: L24742: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Streptococcus agalactiae 2603V/R Gene: SAG0467: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_0562: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_1398: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS Gene: SPy0526: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
LACR_2462	* Lactococcus lactis subsp. cremoris SK11 Site: position = -136 score = 7.22946 sequence = ATAGTAACC-(16)-GTTAACTGC Gene: LACR_1954: Transposase	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Transposase

CRON 2.
bioY	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_0357: Substrate-specific component BioY of biotin ECF transporter	Lactococcus lactis subsp. lactis Il1403 Gene: L1011: Substrate-specific component BioY of biotin ECF transporter	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	* Streptococcus gallolyticus UCN34 Site: position = -52 score = 8.66198 sequence = TTAGTTAAC-(16)-GTTAACTAA Gene: GALLO_1527: Substrate-specific component BioY of biotin ECF transporter	2 Streptococcus gordonii str. Challis substr. CH1* Site: position = -35 score = 8.55306 sequence = ATAGTTACC-(16)-GTTTACTAT Gene: SGO_0746: Substrate-specific component BioY of biotin ECF transporter Gene: SGO_1070: Substrate-specific component BioY of biotin ECF transporter	* Streptococcus mitis B6 Site: position = -87 score = 8.34502 sequence = TTTGTTACC-(16)-GTTGACAAT Site: position = -35 score = 8.17947 sequence = ATAGTTACT-(16)-GTTAACTAT Gene: smi_0834: Substrate-specific component BioY of biotin ECF transporter	Streptococcus mutans UA159	* Streptococcus pneumoniae TIGR4 Site: position = -35 score = 8.17947 sequence = ATAGTTACT-(16)-GTTAACTAT Site: position = -87 score = 7.39502 sequence = TTTGTTACC-(16)-GTTGACATC Gene: SP_0783: Substrate-specific component BioY of biotin ECF transporter	Streptococcus pyogenes M1 GAS	* Streptococcus sanguinis SK36 Site: position = -36 score = 8.55306 sequence = ATAGTTACC-(16)-GTTTACTAT Gene: SSA_1536: Substrate-specific component BioY of biotin ECF transporter	* Streptococcus suis 05ZYH33 Site: position = -33 score = 7.79421 sequence = TTTGTTAAC-(16)-GATAACAAA Gene: SSU05_0509: Substrate-specific component BioY of biotin ECF transporter	2 Streptococcus thermophilus CNRZ1066* Site: position = -35 score = 7.84135 sequence = TAAGTTAAC-(16)-GTTAACTCA Site: position = -89 score = 8.66198 sequence = TTAGTTAAC-(16)-GTTGACTAA Gene: str0674: Substrate-specific component BioY of biotin ECF transporter Site: position = -171 score = 7.90485 sequence = AAAGTTAAC-(16)-GTTAACATA Gene: str1308: Substrate-specific component BioY of biotin ECF transporter	Streptococcus uberis 0140J	Substrate-specific component BioY of biotin ECF transporter

CRON 3.
bioB	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	* Streptococcus agalactiae 2603V/R Site: position = -78 score = 8.35637 sequence = ATTGTTAAC-(16)-GTTTACAAT Gene: SAG0464: Biotin synthase (EC 2.8.1.6)	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -50 score = 7.45011 sequence = AAAGTAAAC-(16)-GGTAACAAT Gene: SDEG_0379: Biotin synthase (EC 2.8.1.6)	Streptococcus equi subsp. zooepidemicus MGCS10565	* Streptococcus gallolyticus UCN34 Site: position = -51 score = 7.98339 sequence = ACAGTTAAC-(16)-GTTAACTGT Gene: GALLO_1916: Biotin synthase (EC 2.8.1.6)	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Biotin synthase (EC 2.8.1.6)
bioD	Lactococcus lactis subsp. cremoris SK11	Lactococcus lactis subsp. lactis Il1403	Streptococcus agalactiae 2603V/R	Streptococcus dysgalactiae subsp. equisimilis GGS_124	Streptococcus equi subsp. zooepidemicus MGCS10565	Streptococcus gallolyticus UCN34 Gene: GALLO_1915: Dethiobiotin synthetase (EC 6.3.3.3)	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J	Dethiobiotin synthetase (EC 6.3.3.3)
bioY2	* Lactococcus lactis subsp. cremoris SK11 Site: position = -98 score = 7.39609 sequence = GCAGTTAAC-(16)-GGTTACTAT Gene: LACR_1953: Substrate-specific component BioY of biotin ECF transporter	* Lactococcus lactis subsp. lactis Il1403 Site: position = -99 score = 7.43287 sequence = ACAGTTAAC-(16)-GGTTACTGT Gene: L24031: Substrate-specific component BioY of biotin ECF transporter	2 Streptococcus agalactiae 2603V/R Gene: SAG0398: Substrate-specific component BioY of biotin ECF transporter Gene: SAG0463: Substrate-specific component BioY of biotin ECF transporter	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_1996: Substrate-specific component BioY of biotin ECF transporter	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0192: Substrate-specific component BioY of biotin ECF transporter	2 Streptococcus gallolyticus UCN34 Gene: GALLO_1914: Substrate-specific component BioY of biotin ECF transporter Gene: GALLO_2101: Substrate-specific component BioY of biotin ECF transporter	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	* Streptococcus mutans UA159 Site: position = -48 score = 8.74599 sequence = ATAGTTAAC-(16)-GTTAACTAA Gene: SMU.1827: Substrate-specific component BioY of biotin ECF transporter	Streptococcus pneumoniae TIGR4	Streptococcus pyogenes M1 GAS Gene: SPy0207: Substrate-specific component BioY of biotin ECF transporter	Streptococcus sanguinis SK36	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066	Streptococcus uberis 0140J Gene: SUB1709: Substrate-specific component BioY of biotin ECF transporter	Substrate-specific component BioY of biotin ECF transporter
birA	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1952: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Lactococcus lactis subsp. lactis Il1403 Gene: L0191: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Streptococcus agalactiae 2603V/R Gene: SAG0830: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Streptococcus dysgalactiae subsp. equisimilis GGS_124 Gene: SDEG_1373: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Streptococcus equi subsp. zooepidemicus MGCS10565 Gene: Sez_0678: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Streptococcus gallolyticus UCN34 Gene: GALLO_0768: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Streptococcus gordonii str. Challis substr. CH1 Gene: SGO_0903: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Streptococcus mitis B6 Gene: smi_0511: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Streptococcus mutans UA159 Gene: SMU.1578: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Streptococcus pneumoniae TIGR4 Gene: SP_1900: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Streptococcus pyogenes M1 GAS Gene: SPy1362: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Streptococcus sanguinis SK36 Gene: SSA_0999: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Streptococcus suis 05ZYH33 Gene: SSU05_1625: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Streptococcus thermophilus CNRZ1066 Gene: str1173: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Streptococcus uberis 0140J Gene: SUB1213: Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)	Biotin biosynthesis repressor; Biotin-protein ligase (EC 6.3.4.15)
yemC	Lactococcus lactis subsp. cremoris SK11 Gene: LACR_1951: Zinc finger protein	Lactococcus lactis subsp. lactis Il1403 Gene: L200067: Zinc finger protein	* Streptococcus agalactiae 2603V/R Site: position = -72 score = 8.40516 sequence = TTTGTTAAC-(15)-GTTGACAAT Gene: SAG0397: Zinc finger protein	* Streptococcus dysgalactiae subsp. equisimilis GGS_124 Site: position = -73 score = 8.66535 sequence = ATAGTTACC-(16)-GTTGACAAA Gene: SDEG_1997: Zinc finger protein	* Streptococcus equi subsp. zooepidemicus MGCS10565 Site: position = -74 score = 8.07496 sequence = TTAGTAACC-(16)-GTTGACAAA Gene: Sez_0191: Zinc finger protein	* Streptococcus gallolyticus UCN34 Site: position = -69 score = 8.20667 sequence = AGAGTTAAC-(16)-GTTGACTAA Gene: GALLO_2102: Zinc finger protein	Streptococcus gordonii str. Challis substr. CH1	Streptococcus mitis B6	Streptococcus mutans UA159	Streptococcus pneumoniae TIGR4 Gene: SP_1428: Zinc finger protein	* Streptococcus pyogenes M1 GAS Site: position = -73 score = 8.37211 sequence = ACAGTTACC-(16)-GTTGACAAA Gene: SPy0205: Zinc finger protein	Streptococcus sanguinis SK36 Gene: SSA_1540: Zinc finger protein	Streptococcus suis 05ZYH33	Streptococcus thermophilus CNRZ1066 Gene: str0673: Zinc finger protein	* Streptococcus uberis 0140J Site: position = -61 score = 7.87566 sequence = TTTGTTACC-(16)-GTTGACACA Gene: SUB1710: Zinc finger protein	Zinc finger protein

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog BirA - Streptococcaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --