Collection of regulogs for BirA transcription factor

The transcription repressor BirA protein was experimentally analyzed in Escherichia coli. BirA is a bifunctional protein that acts as a repressor of biotin biosynthesis genes and as an enzyme, biotin-protein ligase, that charges the biotin-dependent enzymes with the co-factor. The BirA repressor binds to the promoter regions of the regulated genes in the presence of the biotinyl-5'-adenylate. We used a comparative genomics approach to reconstruct transcriptional regulons controlled by BirA orthologs in different lineages of Proteobacteria and Firmicutes. The reconstructed BirA regulons include multiple genes involved in the biotin metabolism and transport [12368242].