Regulog BirA - Clostridia-1

Properties
Regulator type:	Transcription factor
Regulator family:	BirA
Regulation mode:	repressor
Biological process:	Biotin biosynthesis
Effector:	Biotin
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 19 sites [see more]

Member of regulog collections

By trascription factor - BirA
By taxonomy - Clostridia-1
By TF family - BirA
By effector - Biotin
By pathway - Biotin biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Clostridium acetobutylicum ATCC 824	8	4
Clostridium beijerincki NCIMB 8052	3	2
Clostridium botulinum A str. ATCC 3502	3	1
Clostridium butyricum 5521	5	3
Clostridium kluyveri DSM 555	6	3
Clostridium novyi NT	6	2
Clostridium perfringens ATCC 13124
Clostridium tetani E88	4	3

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes									Function

CRON 1.
bioY1	2 Clostridium acetobutylicum ATCC 824* Site: position = -51 score = 9.0642 sequence = TTGTAAAC-(16)-GTTTACAA Gene: CAC0211: Substrate-specific component BioY of biotin ECF transporter Site: position = -68 score = 8.8728 sequence = TTGTTAAC-(16)-GTTAACAA Gene: CAC1360: Substrate-specific component BioY of biotin ECF transporter	Clostridium beijerincki NCIMB 8052	* Clostridium botulinum A str. ATCC 3502 Site: position = -93 score = 9.03168 sequence = TTGTCAAC-(15)-GTTGACAA Gene: CBO2260: Substrate-specific component BioY of biotin ECF transporter	* Clostridium butyricum 5521 Site: position = -73 score = 8.95224 sequence = TTGTTAAC-(15)-GTTGACAA Gene: CBY_3768: Substrate-specific component BioY of biotin ECF transporter	* Clostridium kluyveri DSM 555 Site: position = -93 score = 8.46559 sequence = TTGTAAAC-(16)-GTTGACTA Gene: CKL_0936: Substrate-specific component BioY of biotin ECF transporter	* Clostridium novyi NT Site: position = -48 score = 9.0642 sequence = TTGTAAAC-(16)-GTTTACAA Gene: NT01CX_1467: Substrate-specific component BioY of biotin ECF transporter	Clostridium perfringens ATCC 13124	* Clostridium tetani E88 Site: position = -325 score = 9.04794 sequence = TTGTAAAC-(16)-GTTGACAA Gene: CTC01861: Substrate-specific component BioY of biotin ECF transporter	Substrate-specific component BioY of biotin ECF transporter
bioD	Clostridium acetobutylicum ATCC 824 Gene: CAC1361: Dethiobiotin synthetase (EC 6.3.3.3)	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502 Gene: CBO2258: Dethiobiotin synthetase (EC 6.3.3.3)	Clostridium butyricum 5521 Gene: CBY_3767: Dethiobiotin synthetase (EC 6.3.3.3)	Clostridium kluyveri DSM 555 Gene: CKL_0937: Dethiobiotin synthetase (EC 6.3.3.3)	Clostridium novyi NT Gene: NT01CX_1468: Dethiobiotin synthetase (EC 6.3.3.3)	Clostridium perfringens ATCC 13124 Gene: CPF_1794: Dethiobiotin synthetase (EC 6.3.3.3)	Clostridium tetani E88 Gene: CTC01860: Dethiobiotin synthetase (EC 6.3.3.3)	Dethiobiotin synthetase (EC 6.3.3.3)
bioA	Clostridium acetobutylicum ATCC 824 Gene: CAC1362: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3766: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Clostridium kluyveri DSM 555 Gene: CKL_0938: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Clostridium novyi NT Gene: NT01CX_1469: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
bioB	Clostridium acetobutylicum ATCC 824 Gene: CAC0210: Biotin synthase (EC 2.8.1.6)	* Clostridium beijerincki NCIMB 8052 Site: position = -96 score = 8.95224 sequence = TTGTTAAC-(16)-GTTGACAA Gene: Cbei_1914: Biotin synthase (EC 2.8.1.6)	Clostridium botulinum A str. ATCC 3502 Gene: CBO2259: Biotin synthase (EC 2.8.1.6)	Clostridium butyricum 5521	* Clostridium kluyveri DSM 555 Site: position = -87 score = 9.0642 sequence = TTGTAAAC-(15)-GTTTACAA Gene: CKL_1696: Biotin synthase (EC 2.8.1.6)	Clostridium novyi NT Gene: NT01CX_1470: Biotin synthase (EC 2.8.1.6)	Clostridium perfringens ATCC 13124 Gene: CPF_1795: Biotin synthase (EC 2.8.1.6)	* Clostridium tetani E88 Site: position = -84 score = 8.28056 sequence = CTGTTAAC-(16)-GTTTACAA Gene: CTC00151: Biotin synthase (EC 2.8.1.6)	Biotin synthase (EC 2.8.1.6)
bioY2	* Clostridium acetobutylicum ATCC 824 Site: position = -46 score = 9.0642 sequence = TTGTAAAC-(16)-GTTTACAA Gene: CAC3456: Substrate-specific component BioY of biotin ECF transporter	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1913: Substrate-specific component BioY of biotin ECF transporter	Clostridium botulinum A str. ATCC 3502	* Clostridium butyricum 5521 Site: position = -106 score = 8.95224 sequence = TTGTTAAC-(15)-GTTGACAA Gene: CBY_1671: Substrate-specific component BioY of biotin ECF transporter	* Clostridium kluyveri DSM 555 Site: position = -108 score = 9.04794 sequence = TTGTAAAC-(15)-GTTGACAA Gene: CKL_2248: Substrate-specific component BioY of biotin ECF transporter	* Clostridium novyi NT Site: position = -105 score = 8.95224 sequence = TTGTTAAC-(16)-GTTGACAA Site: position = -47 score = 9.0642 sequence = TTGTAAAC-(16)-GTTTACAA Gene: NT01CX_0019: Substrate-specific component BioY of biotin ECF transporter	Clostridium perfringens ATCC 13124	* Clostridium tetani E88 Site: position = -53 score = 8.26429 sequence = TTGTCATC-(16)-GTTAACAA Gene: CTC02091: Substrate-specific component BioY of biotin ECF transporter	Substrate-specific component BioY of biotin ECF transporter
CAC3455	Clostridium acetobutylicum ATCC 824 Gene: CAC3455: Iron-sulfur binding protein, hypothetical	* Clostridium beijerincki NCIMB 8052 Site: position = -84 score = 8.44933 sequence = TAGTCAAC-(16)-GTTGACAA Gene: Cbei_1756: Iron-sulfur binding protein, hypothetical	Clostridium botulinum A str. ATCC 3502	* Clostridium butyricum 5521 Site: position = -142 score = 8.26429 sequence = TTGTTTAC-(15)-GTTGACAA Gene: CBY_0442: Iron-sulfur binding protein, hypothetical	Clostridium kluyveri DSM 555 Gene: CKL_2249: Iron-sulfur binding protein, hypothetical	Clostridium novyi NT Gene: NT01CX_0018: Iron-sulfur binding protein, hypothetical	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Iron-sulfur binding protein, hypothetical

CRON 2.
birA	2 Clostridium acetobutylicum ATCC 824* Site: position = -147 score = 9.0642 sequence = TTGTAAAC-(16)-GTTTACAA Gene: CAC0212: Biotin-protein ligase (EC 6.3.4.15) / Biotin operon repressor Gene: CAC0589: Biotin-protein ligase (EC 6.3.4.15) / Biotin operon repressor	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1015: Biotin-protein ligase (EC 6.3.4.15) / Biotin operon repressor	Clostridium botulinum A str. ATCC 3502 Gene: CBO1117: Biotin-protein ligase (EC 6.3.4.15) / Biotin operon repressor	Clostridium butyricum 5521 Gene: CBY_2753: Biotin-protein ligase (EC 6.3.4.15) / Biotin operon repressor	Clostridium kluyveri DSM 555 Gene: CKL_2417: Biotin-protein ligase (EC 6.3.4.15) / Biotin operon repressor	Clostridium novyi NT Gene: NT01CX_0898: Biotin-protein ligase (EC 6.3.4.15) / Biotin operon repressor	Clostridium perfringens ATCC 13124	Clostridium tetani E88 Gene: CTC00852: Biotin-protein ligase (EC 6.3.4.15) / Biotin operon repressor	Biotin-protein ligase (EC 6.3.4.15) / Biotin operon repressor

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog BirA - Clostridia-1

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --