Regulog BirA - Enterobacteriales

Properties
Regulator type:	Transcription factor
Regulator family:	BirA
Regulation mode:	repressor
Biological process:	Biotin biosynthesis
Effector:	Biotin
Phylum:	Proteobacteria/gamma
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 27 sites [see more]

Member of regulog collections

By taxonomy - Enterobacteriales
By trascription factor - BirA
By TF family - BirA
By effector - Biotin
By pathway - Biotin biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Escherichia coli str. K-12 substr. MG1655	6	3
Salmonella typhimurium LT2	5	2
Citrobacter koseri ATCC BAA-895	5	2
Klebsiella pneumoniae subsp. pneumoniae MGH 78578	6	3
Enterobacter sp. 638	5	2
Erwinia amylovora ATCC 49946	5	2
Yersinia pestis KIM	6	3
Serratia proteamaculans 568	5	2
Erwinia carotovora subsp. atroseptica SCRI1043	5	2
Edwardsiella tarda EIB202	6	2
Proteus mirabilis HI4320	5	2
Photorhabdus luminescens subsp. laumondii TTO1	5	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes													Function

CRON 1.
bioB	* Escherichia coli str. K-12 substr. MG1655 Site: position = -79 score = 9.43903 sequence = TTGTAAACC-(16)-GGTTTACAA Gene: b0775: Biotin synthase (EC 2.8.1.6)	* Salmonella typhimurium LT2 Site: position = -79 score = 9.08123 sequence = TTGTAAACC-(16)-GGTTTACGA Gene: STM0794: Biotin synthase (EC 2.8.1.6)	* Citrobacter koseri ATCC BAA-895 Site: position = -79 score = 9.08123 sequence = TTGTAAACC-(16)-GGTTTACGA Gene: CKO_02353: Biotin synthase (EC 2.8.1.6)	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -230 score = 9.43903 sequence = TTGTAAACC-(16)-GGTTTACAA Gene: KPN_00800: Biotin synthase (EC 2.8.1.6)	* Enterobacter sp. 638 Site: position = -79 score = 8.66221 sequence = TTGTAAACC-(16)-GGTTTACCA Gene: Ent638_1266: Biotin synthase (EC 2.8.1.6)	* Erwinia amylovora ATCC 49946 Site: position = -80 score = 9.03293 sequence = TTGTAAACC-(15)-AGTTTACAA Gene: EAM_1210: Biotin synthase (EC 2.8.1.6)	* Yersinia pestis KIM Site: position = -89 score = 9.01262 sequence = TTGTAAACC-(16)-GGTTGACAG Gene: y3031: Biotin synthase (EC 2.8.1.6)	* Serratia proteamaculans 568 Site: position = -88 score = 9.01262 sequence = TTGTAAACC-(16)-GGTTgACAg Gene: Spro_1311: Biotin synthase (EC 2.8.1.6)	* Erwinia carotovora subsp. atroseptica SCRI1043 Site: position = -86 score = 8.65482 sequence = TCGTAAACC-(16)-GGTTGACAG Gene: ECA2825: Biotin synthase (EC 2.8.1.6)	* Edwardsiella tarda EIB202 Site: position = -94 score = 8.79814 sequence = CTGTAAACC-(16)-GGTTGACAT Gene: ETAE_2554: Biotin synthase (EC 2.8.1.6)	* Proteus mirabilis HI4320 Site: position = -85 score = 8.39204 sequence = ATGTAAACC-(16)-AGTTGACAT Gene: PMI0603: Biotin synthase (EC 2.8.1.6)	* Photorhabdus luminescens subsp. laumondii TTO1 Site: position = -86 score = 8.44034 sequence = ACGTAAACC-(15)-GGTTGACAG Gene: plu1485: Biotin synthase (EC 2.8.1.6)	Biotin synthase (EC 2.8.1.6)
bioF	Escherichia coli str. K-12 substr. MG1655 Gene: b0776: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Salmonella typhimurium LT2 Gene: STM0795: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Citrobacter koseri ATCC BAA-895 Gene: CKO_02352: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_00801: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Enterobacter sp. 638 Gene: Ent638_1267: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Erwinia amylovora ATCC 49946 Gene: EAM_1211: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Yersinia pestis KIM Gene: y3030: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Serratia proteamaculans 568 Gene: Spro_1312: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Erwinia carotovora subsp. atroseptica SCRI1043 Gene: ECA2824: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	2 Edwardsiella tarda EIB202 Gene: ETAE_2553: 8-amino-7-oxononanoate synthase (EC 2.3.1.47) Gene: ETAE_2552: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Proteus mirabilis HI4320 Gene: PMI0604: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu1486: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	8-amino-7-oxononanoate synthase (EC 2.3.1.47)
bioC	Escherichia coli str. K-12 substr. MG1655 Gene: b0777: Biotin synthesis protein bioC	Salmonella typhimurium LT2 Gene: STM0796: Biotin synthesis protein bioC	Citrobacter koseri ATCC BAA-895 Gene: CKO_02351: Biotin synthesis protein bioC	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_00802: Biotin synthesis protein bioC	Enterobacter sp. 638 Gene: Ent638_1268: Biotin synthesis protein bioC	Erwinia amylovora ATCC 49946 Gene: EAM_1212: Biotin synthesis protein bioC	Yersinia pestis KIM Gene: y3029: Biotin synthesis protein bioC	Serratia proteamaculans 568 Gene: Spro_1313: Biotin synthesis protein bioC	Erwinia carotovora subsp. atroseptica SCRI1043 Gene: ECA2823: Biotin synthesis protein bioC	Edwardsiella tarda EIB202 Gene: ETAE_2551: Biotin synthesis protein bioC	Proteus mirabilis HI4320 Gene: PMI0605: Biotin synthesis protein bioC	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu1487: Biotin synthesis protein bioC	Biotin synthesis protein bioC
bioD	Escherichia coli str. K-12 substr. MG1655 Gene: b0778: Dethiobiotin synthetase (EC 6.3.3.3)	Salmonella typhimurium LT2 Gene: STM0797: Dethiobiotin synthetase (EC 6.3.3.3)	Citrobacter koseri ATCC BAA-895 Gene: CKO_02350: Dethiobiotin synthetase (EC 6.3.3.3)	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_00803: Dethiobiotin synthetase (EC 6.3.3.3)	Enterobacter sp. 638 Gene: Ent638_1269: Dethiobiotin synthetase (EC 6.3.3.3)	Erwinia amylovora ATCC 49946 Gene: EAM_1213: Dethiobiotin synthetase (EC 6.3.3.3)	Yersinia pestis KIM Gene: y3028: Dethiobiotin synthetase (EC 6.3.3.3)	Serratia proteamaculans 568 Gene: Spro_1314: Dethiobiotin synthetase (EC 6.3.3.3)	Erwinia carotovora subsp. atroseptica SCRI1043 Gene: ECA2822: Dethiobiotin synthetase (EC 6.3.3.3)	Edwardsiella tarda EIB202 Gene: ETAE_2550: Dethiobiotin synthetase (EC 6.3.3.3)	Proteus mirabilis HI4320 Gene: PMI0606: Dethiobiotin synthetase (EC 6.3.3.3)	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu1488: Dethiobiotin synthetase (EC 6.3.3.3)	Dethiobiotin synthetase (EC 6.3.3.3)

CRON 2.
bioA	* Escherichia coli str. K-12 substr. MG1655 Site: position = -41 score = 9.43903 sequence = TTGTAAACC-(16)-GGTTTACAA Gene: b0774: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	* Salmonella typhimurium LT2 Site: position = -41 score = 9.08123 sequence = TCGTAAACC-(16)-GGTTTACAA Gene: STM0793: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	* Citrobacter koseri ATCC BAA-895 Site: position = -41 score = 9.08123 sequence = TCGTAAACC-(16)-GGTTTACAA Gene: CKO_02354: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -41 score = 9.43903 sequence = TTGTAAACC-(16)-GGTTTACAA Gene: KPN_00799: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	* Enterobacter sp. 638 Site: position = -22 score = 8.66221 sequence = TgGTAAACC-(16)-GGTTTACAA Gene: Ent638_1265: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	* Erwinia amylovora ATCC 49946 Site: position = -41 score = 9.03293 sequence = TTGTAAACT-(15)-GGTTTACAA Gene: EAM_1209: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	* Yersinia pestis KIM Site: position = -43 score = 9.01262 sequence = CTGTCAACC-(16)-GGTTTACAA Gene: y3032: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	* Serratia proteamaculans 568 Site: position = -17 score = 9.01262 sequence = cTGTcAACC-(16)-GGTTTACAA Gene: Spro_1310: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	* Erwinia carotovora subsp. atroseptica SCRI1043 Site: position = -43 score = 8.65482 sequence = CTGTCAACC-(16)-GGTTTACGA Gene: ECA2826: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	* Edwardsiella tarda EIB202 Site: position = -141 score = 8.79814 sequence = ATGTCAACC-(16)-GGTTTACAG Gene: ETAE_2555: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	* Proteus mirabilis HI4320 Site: position = -52 score = 8.39204 sequence = ATGTCAACT-(16)-GGTTTACAT Gene: PMI0602: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	* Photorhabdus luminescens subsp. laumondii TTO1 Site: position = -41 score = 8.44034 sequence = CTGTCAACC-(15)-GGTTTACGT Gene: plu1484: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)

CRON 3.
yigM	* Escherichia coli str. K-12 substr. MG1655 Site: position = -81 score = 6.05737 sequence = TCGTAATCG-(14)-AGTTGTCAA Gene: b3827: Predicted biotin transporter YigM	Salmonella typhimurium LT2 Gene: STM3963: Predicted biotin transporter YigM	Citrobacter koseri ATCC BAA-895 Gene: CKO_00168: Predicted biotin transporter YigM	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -82 score = 4.95947 sequence = TTGACGACT-(15)-AGTCGTCAA Gene: KPN_04323: Predicted biotin transporter YigM	Enterobacter sp. 638 Gene: Ent638_3969: Predicted biotin transporter YigM	Erwinia amylovora ATCC 49946	* Yersinia pestis KIM Site: position = -109 score = 5.60431 sequence = TTATCAACA-(15)-ATTTTAAAA Gene: y0440: Predicted biotin transporter YigM	Serratia proteamaculans 568 Gene: Spro_0240: Predicted biotin transporter YigM	Erwinia carotovora subsp. atroseptica SCRI1043 Gene: ECA0179: Predicted biotin transporter YigM	Edwardsiella tarda EIB202 Gene: ETAE_0141: Predicted biotin transporter YigM	Proteus mirabilis HI4320 Gene: PMI3527: Predicted biotin transporter YigM	Photorhabdus luminescens subsp. laumondii TTO1	Predicted biotin transporter YigM

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog BirA - Enterobacteriales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --