Regulog BirA - Clostridia-3

Properties
Regulator type:	Transcription factor
Regulator family:	BirA
Regulation mode:	repressor
Biological process:	Biotin biosynthesis
Effector:	Biotin
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 25 sites [see more]

Member of regulog collections

By trascription factor - BirA
By taxonomy - Clostridia-3
By TF family - BirA
By effector - Biotin
By pathway - Biotin biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Bacteroides pectinophilus ATCC 43243	2	2
Blautia hansenii DSM 20583	2	1
Bryantella formatexigens DSM 14469	2	1
Clostridiales bacterium 1_7_47_FAA	3	1
Clostridium bolteae ATCC BAA-613	4	1
Clostridium nexile DSM 1787	1	1
Clostridium scindens ATCC 35704	2	2
Dorea formicigenerans ATCC 27755	2	1
Dorea longicatena DSM 13814	4	3
Eubacterium eligens ATCC 27750	2	2
Eubacterium rectale ATCC 33656	2	2
Roseburia intestinalis L1-82	7	2
Ruminococcus gnavus ATCC 29149	2	2
Ruminococcus lactaris ATCC 29176	2	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes															Function

CRON 1.
bioY	Bacteroides pectinophilus ATCC 43243	* Blautia hansenii DSM 20583 Site: position = -94 score = 8.86983 sequence = TTGTAAAC-(16)-GTTGACAA Gene: BLAHAN_02475: Substrate-specific component BioY of biotin ECF transporter	* Bryantella formatexigens DSM 14469 Site: position = -154 score = 8.86983 sequence = TTGTAAAC-(16)-GTTGACAA Site: position = -96 score = 8.4065 sequence = ATGTAAAC-(16)-GTTTACAA Gene: BRYFOR_01898: Substrate-specific component BioY of biotin ECF transporter	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613	* Clostridium nexile DSM 1787 Site: position = -85 score = 8.98585 sequence = TTGTTAAC-(15)-GTTGACAA Gene: CLONEX_00515: Substrate-specific component BioY of biotin ECF transporter	* Clostridium scindens ATCC 35704 Site: position = -142 score = 8.7149 sequence = TTGTTAAC-(15)-GTTGACAT Gene: CLOSCI_02690: Substrate-specific component BioY of biotin ECF transporter	Dorea formicigenerans ATCC 27755 Gene: DORFOR_03063: Substrate-specific component BioY of biotin ECF transporter	2 Dorea longicatena DSM 13814* Site: position = -88 score = 8.86983 sequence = TTGTAAAC-(15)-GTTGACAA Gene: DORLON_01236: Substrate-specific component BioY of biotin ECF transporter Site: position = -123 score = 8.7149 sequence = TTGTTAAC-(15)-GTTGACAT Gene: DORLON_00987: Substrate-specific component BioY of biotin ECF transporter	* Eubacterium eligens ATCC 27750 Site: position = -95 score = 8.79125 sequence = ATGTCAAC-(15)-GTTGACAA Gene: EUBELI_01172: Substrate-specific component BioY of biotin ECF transporter	* Eubacterium rectale ATCC 33656 Site: position = -104 score = 8.86983 sequence = TTGTAAAC-(16)-GTTGACAA Gene: EUBREC_3289: Substrate-specific component BioY of biotin ECF transporter	3 Roseburia intestinalis L1-82* Site: position = -66 score = 8.86983 sequence = TTGTAAAC-(16)-GTTGACAA Gene: ROSINTL182_00207: Substrate-specific component BioY of biotin ECF transporter Site: position = -86 score = 8.44394 sequence = ATGTTAAC-(16)-GTTGACAT Site: position = -33 score = 8.9095 sequence = TTGTTAAC-(16)-GTTAACAA Gene: ROSINTL182_04738: Substrate-specific component BioY of biotin ECF transporter Gene: ROSINTL182_04737: Substrate-specific component BioY of biotin ECF transporter	* Ruminococcus gnavus ATCC 29149 Site: position = -86 score = 8.7149 sequence = ATGTTAAC-(15)-GTTGACAA Gene: RUMGNA_01549: Substrate-specific component BioY of biotin ECF transporter	* Ruminococcus lactaris ATCC 29176 Site: position = -102 score = 8.98585 sequence = TTGTTAAC-(15)-GTTGACAA Gene: RUMLAC_01841: Substrate-specific component BioY of biotin ECF transporter	Substrate-specific component BioY of biotin ECF transporter
bioB	* Bacteroides pectinophilus ATCC 43243 Site: position = -154 score = 8.7149 sequence = TTGTCAAC-(15)-GTTAACAT Gene: BACPEC_02754: Biotin synthase (EC 2.8.1.6)	Blautia hansenii DSM 20583	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613	Clostridium nexile DSM 1787	* Clostridium scindens ATCC 35704 Site: position = -85 score = 8.23167 sequence = CTGTAAAC-(15)-GTTGACAA Gene: CLOSCI_01529: Biotin synthase (EC 2.8.1.6)	* Dorea formicigenerans ATCC 27755 Site: position = -110 score = 8.79125 sequence = TTGTCAAC-(16)-GTTGACAT Gene: DORFOR_03064: Biotin synthase (EC 2.8.1.6)	* Dorea longicatena DSM 13814 Site: position = -65 score = 8.63854 sequence = ATGTTAAC-(15)-GTTAACAA Gene: DORLON_02721: Biotin synthase (EC 2.8.1.6)	* Eubacterium eligens ATCC 27750 Site: position = -14 score = 8.5203 sequence = ATGTCAAC-(15)-GTTGACAT Gene: EUBELI_20420: Biotin synthase (EC 2.8.1.6)	* Eubacterium rectale ATCC 33656 Site: position = -70 score = 8.98585 sequence = TTGTTAAC-(16)-GTTGACAA Gene: EUBREC_0920: Biotin synthase (EC 2.8.1.6)	Roseburia intestinalis L1-82 Gene: ROSINTL182_04736: Biotin synthase (EC 2.8.1.6)	* Ruminococcus gnavus ATCC 29149 Site: position = -84 score = 8.67745 sequence = TTGTAAAC-(15)-GTTTACAA Gene: RUMGNA_00689: Biotin synthase (EC 2.8.1.6)	* Ruminococcus lactaris ATCC 29176 Site: position = -135 score = 8.59888 sequence = ATGTAAAC-(16)-GTTGACAA Gene: RUMLAC_00062: Biotin synthase (EC 2.8.1.6)	Biotin synthase (EC 2.8.1.6)
bioD	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613	Clostridium nexile DSM 1787	Clostridium scindens ATCC 35704	Dorea formicigenerans ATCC 27755	Dorea longicatena DSM 13814 Gene: DORLON_01235: Dethiobiotin synthetase (EC 6.3.3.3)	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82 Gene: ROSINTL182_04735: Dethiobiotin synthetase (EC 6.3.3.3)	Ruminococcus gnavus ATCC 29149	Ruminococcus lactaris ATCC 29176	Dethiobiotin synthetase (EC 6.3.3.3)
bioA	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583 Gene: BLAHAN_00622: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613	Clostridium nexile DSM 1787	Clostridium scindens ATCC 35704	Dorea formicigenerans ATCC 27755	Dorea longicatena DSM 13814	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82 Gene: ROSINTL182_04734: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Ruminococcus gnavus ATCC 29149 Gene: RUMGNA_01526: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Ruminococcus lactaris ATCC 29176	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
PF06935	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583 Gene: BLAHAN_02474: Protein of unknown function DUF1284	Bryantella formatexigens DSM 14469 Gene: BRYFOR_01899: Protein of unknown function DUF1284	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613	Clostridium nexile DSM 1787 Gene: CLONEX_02146: Protein of unknown function DUF1284	Clostridium scindens ATCC 35704	Dorea formicigenerans ATCC 27755	Dorea longicatena DSM 13814	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82 Gene: ROSINTL182_00208: Protein of unknown function DUF1284	Ruminococcus gnavus ATCC 29149	Ruminococcus lactaris ATCC 29176	Protein of unknown function DUF1284

CRON 2.
SSF54637	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583	Bryantella formatexigens DSM 14469	* Clostridiales bacterium 1_7_47_FAA Site: position = -97 score = 8.98585 sequence = TTGTTAAC-(15)-GTTGACAA Gene: Cbac1_010100014191: Thioesterase/thiol ester dehydrase-isomerase	* Clostridium bolteae ATCC BAA-613 Site: position = -66 score = 8.98585 sequence = TTGTTAAC-(16)-GTTGACAA Gene: CLOBOL_00883: Thioesterase/thiol ester dehydrase-isomerase	Clostridium nexile DSM 1787	Clostridium scindens ATCC 35704	Dorea formicigenerans ATCC 27755	Dorea longicatena DSM 13814	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82	Ruminococcus gnavus ATCC 29149	Ruminococcus lactaris ATCC 29176	Thioesterase/thiol ester dehydrase-isomerase
bioY2	* Bacteroides pectinophilus ATCC 43243 Site: position = -142 score = 8.7149 sequence = ATGTTAAC-(15)-GTTGACAA Gene: BACPEC_02755: Substrate-specific component BioY of biotin ECF transporter	Blautia hansenii DSM 20583	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA Gene: Cbac1_010100014196: Substrate-specific component BioY of biotin ECF transporter	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_00884: Substrate-specific component BioY of biotin ECF transporter	Clostridium nexile DSM 1787	Clostridium scindens ATCC 35704	Dorea formicigenerans ATCC 27755	Dorea longicatena DSM 13814	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82	Ruminococcus gnavus ATCC 29149	Ruminococcus lactaris ATCC 29176	Substrate-specific component BioY of biotin ECF transporter
yhfS	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA Gene: Cbac1_010100014201: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_00885: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Clostridium nexile DSM 1787	Clostridium scindens ATCC 35704	Dorea formicigenerans ATCC 27755	Dorea longicatena DSM 13814	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82	Ruminococcus gnavus ATCC 29149	Ruminococcus lactaris ATCC 29176	Acetyl-CoA acetyltransferase (EC 2.3.1.9)
yhfT	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA Gene: Cbac1_010100014211: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_00886: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Clostridium nexile DSM 1787	Clostridium scindens ATCC 35704	Dorea formicigenerans ATCC 27755	Dorea longicatena DSM 13814	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82	Ruminococcus gnavus ATCC 29149	Ruminococcus lactaris ATCC 29176	Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog BirA - Clostridia-3

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --