Regulog BirA - Bacillales

Properties
Regulator type:	Transcription factor
Regulator family:	BirA
Regulation mode:	repressor
Biological process:	Biotin biosynthesis
Effector:	Biotin
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 36 sites [see more]

Member of regulog collections

By taxonomy - Bacillales
By trascription factor - BirA
By TF family - BirA
By effector - Biotin
By pathway - Biotin biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Bacillus subtilis subsp. subtilis str. 168	10	3
Bacillus amyloliquefaciens FZB42	10	3
Bacillus pumilus SAFR-032	5	3
Bacillus licheniformis DSM 13	7	2
Anoxybacillus flavithermus WK1	7	4
Geobacillus kaustophilus HTA426	7	5
Bacillus cereus ATCC 14579	10	3
Bacillus halodurans C-125	7	4
Bacillus clausii KSM-K16	3	2
Oceanobacillus iheyensis HTE831	2	2
Paenibacillus sp. JDR-2	7	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes												Function

CRON 1.
bioY2	* Bacillus subtilis subsp. subtilis str. 168 Site: position = -88 score = 8.45358 sequence = ATGTAAAC-(15)-GTTGACAT Gene: BSU10370: Substrate-specific component BioY of biotin ECF transporter	* Bacillus amyloliquefaciens FZB42 Site: position = -87 score = 8.61757 sequence = ATGTTAAC-(15)-GTTGACAT Gene: RBAM_010550: Substrate-specific component BioY of biotin ECF transporter	* Bacillus pumilus SAFR-032 Site: position = -88 score = 8.61757 sequence = ATGTTAAC-(15)-GTTGACAT Gene: BPUM_2376: Substrate-specific component BioY of biotin ECF transporter	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	* Bacillus cereus ATCC 14579 Site: position = -46 score = 7.74646 sequence = ATGTTACC-(15)-GTTTACAA Site: position = -111 score = 8.57717 sequence = TTGTAAAC-(15)-GTTGACAA Gene: BC3629: Substrate-specific component BioY of biotin ECF transporter	Bacillus halodurans C-125	* Bacillus clausii KSM-K16 Site: position = -82 score = 8.74116 sequence = TTGTTAAC-(15)-GTTGACAA Gene: ABC2607: Substrate-specific component BioY of biotin ECF transporter	* Oceanobacillus iheyensis HTE831 Site: position = -81 score = 8.57717 sequence = TTGTAAAC-(15)-GTTGACAA Gene: OB1717: Substrate-specific component BioY of biotin ECF transporter	* Paenibacillus sp. JDR-2 Site: position = -158 score = 8.77913 sequence = TTGTTAAC-(18)-GTTAACAt Gene: Pjdr2_3366: Substrate-specific component BioY of biotin ECF transporter	Substrate-specific component BioY of biotin ECF transporter
yhfT	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU10360: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_010540: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Bacillus pumilus SAFR-032 Gene: BPUM_2375: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579 Gene: BC3628: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Bacillus halodurans C-125	* Bacillus clausii KSM-K16 Site: position = -87 score = 8.51537 sequence = ATGTAAAC-(15)-GTTGACAA Gene: ABC0344: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
yhfS	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU10350: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_010530: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Bacillus pumilus SAFR-032 Gene: BPUM_2374: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579 Gene: BC3627: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Bacillus halodurans C-125	Bacillus clausii KSM-K16 Gene: ABC0345: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Acetyl-CoA acetyltransferase (EC 2.3.1.9)

CRON 2.
bioY1	* Bacillus subtilis subsp. subtilis str. 168 Site: position = -87 score = 8.74116 sequence = TTGTTAAC-(15)-GTTGACAA Gene: BSU32030: Substrate-specific component BioY of biotin ECF transporter	* Bacillus amyloliquefaciens FZB42 Site: position = -84 score = 7.86636 sequence = TAGTAAAC-(15)-GTTGACAA Gene: RBAM_029080: Substrate-specific component BioY of biotin ECF transporter	* Bacillus pumilus SAFR-032 Site: position = -83 score = 8.74116 sequence = TTGTTAAC-(15)-GTTGACAA Gene: BPUM_2863: Substrate-specific component BioY of biotin ECF transporter	* Bacillus licheniformis DSM 13 Site: position = -89 score = 8.74116 sequence = TTGTTAAC-(15)-GTTGACAA Gene: BLi03385: Substrate-specific component BioY of biotin ECF transporter	* Anoxybacillus flavithermus WK1 Site: position = -31 score = 8.13012 sequence = TCGTTAAC-(15)-GTTAACAA Gene: Aflv_2398: Substrate-specific component BioY of biotin ECF transporter	* Geobacillus kaustophilus HTA426 Site: position = -31 score = 8.61514 sequence = TTGTTAAC-(15)-GTTTACAT Gene: GK2944: Substrate-specific component BioY of biotin ECF transporter	* Bacillus cereus ATCC 14579 Site: position = 107 score = 8.71733 sequence = ATGTTAAC-(16)-GTTAACAT Gene: BC4917: Substrate-specific component BioY of biotin ECF transporter	* Bacillus halodurans C-125 Site: position = -33 score = 7.84865 sequence = ATGTTAAC-(15)-GTAAACAT Site: position = -87 score = 8.5796 sequence = ATGTCAAC-(15)-GTTGACAA Gene: BH3358: Substrate-specific component BioY of biotin ECF transporter	Bacillus clausii KSM-K16	* Oceanobacillus iheyensis HTE831 Site: position = -81 score = 8.64139 sequence = TTGTCAAC-(15)-GTTGACAA Gene: OB2346: Substrate-specific component BioY of biotin ECF transporter	Paenibacillus sp. JDR-2	Substrate-specific component BioY of biotin ECF transporter

CRON 3.
bioW	* Bacillus subtilis subsp. subtilis str. 168 Site: position = -85 score = 8.84092 sequence = TTGTTAAC-(15)-GTTAACAA Gene: BSU30240: Pimeloyl-CoA synthase (EC 6.2.1.14)	* Bacillus amyloliquefaciens FZB42 Site: position = -64 score = 8.18574 sequence = GTGTTAAC-(15)-GTTAACAT Site: position = -126 score = 7.22626 sequence = CAGTTAAC-(15)-GTTGACAT Gene: RBAM_018290: Pimeloyl-CoA synthase (EC 6.2.1.14)	Bacillus pumilus SAFR-032	* Bacillus licheniformis DSM 13 Site: position = -55 score = 8.71733 sequence = ATGTTAAC-(15)-GTTAACAT Gene: BLi00766: Pimeloyl-CoA synthase (EC 6.2.1.14)	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Pimeloyl-CoA synthase (EC 6.2.1.14)
bioA	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU30230: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_018280: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi00767: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Anoxybacillus flavithermus WK1 Gene: Aflv_1071: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Geobacillus kaustophilus HTA426 Gene: GK3016: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	* Bacillus cereus ATCC 14579 Site: position = -45 score = 8.71733 sequence = ATGTTAAC-(15)-GTTAACAT Gene: BC4119: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Bacillus halodurans C-125 Gene: BH0782: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	* Paenibacillus sp. JDR-2 Site: position = 40 score = 8.84092 sequence = TTGTTAAC-(18)-GTTAACAA Gene: Pjdr2_1461: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
bioF	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU30220: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_018270: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi00768: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	* Anoxybacillus flavithermus WK1 Site: position = -45 score = 8.45115 sequence = ATGTAAAC-(15)-GTTTACAA Gene: Aflv_1163: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	* Geobacillus kaustophilus HTA426 Site: position = -46 score = 8.38936 sequence = ATGTAAAC-(15)-GTTTACAT Gene: GK2128: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Bacillus cereus ATCC 14579 Gene: BC4117: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	* Bacillus halodurans C-125 Site: position = -66 score = 8.77913 sequence = ATGTTAAC-(15)-GTTAACAA Gene: BH3907: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_1464: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	8-amino-7-oxononanoate synthase (EC 2.3.1.47)
bioD	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU30210: Dethiobiotin synthetase (EC 6.3.3.3)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_018260: Dethiobiotin synthetase (EC 6.3.3.3)	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi00769: Dethiobiotin synthetase (EC 6.3.3.3)	* Anoxybacillus flavithermus WK1 Site: position = -52 score = 8.74116 sequence = TTGTTAAC-(15)-GTTGACAA Gene: Aflv_1070: Dethiobiotin synthetase (EC 6.3.3.3)	Geobacillus kaustophilus HTA426 Gene: GK3017: Dethiobiotin synthetase (EC 6.3.3.3)	Bacillus cereus ATCC 14579 Gene: BC4118: Dethiobiotin synthetase (EC 6.3.3.3)	* Bacillus halodurans C-125 Site: position = -42 score = 8.71733 sequence = ATGTTAAC-(15)-GTTAACAT Gene: BH0783: Dethiobiotin synthetase (EC 6.3.3.3)	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_1462: Dethiobiotin synthetase (EC 6.3.3.3)	Dethiobiotin synthetase (EC 6.3.3.3)
bioB	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU30200: Biotin synthase (EC 2.8.1.6)	Bacillus amyloliquefaciens FZB42 Gene: RBAM_018250: Biotin synthase (EC 2.8.1.6)	* Bacillus pumilus SAFR-032 Site: position = -48 score = 8.71733 sequence = ATGTTAAC-(15)-GTTAACAT Gene: BPUM_2779: Biotin synthase (EC 2.8.1.6)	Bacillus licheniformis DSM 13 Gene: BLi00770: Biotin synthase (EC 2.8.1.6)	* Anoxybacillus flavithermus WK1 Site: position = -55 score = 8.67936 sequence = TTGTTAAC-(15)-GTTGACAT Gene: Aflv_1376: Biotin synthase (EC 2.8.1.6)	* Geobacillus kaustophilus HTA426 Site: position = -86 score = 7.80457 sequence = AAGTAAAC-(15)-GTTGACAA Gene: GK1570: Biotin synthase (EC 2.8.1.6)	Bacillus cereus ATCC 14579 Gene: BC4114: Biotin synthase (EC 2.8.1.6)	* Bacillus halodurans C-125 Site: position = -56 score = 8.67693 sequence = TTGTTAAC-(15)-GTTTACAA Gene: BH1748: Biotin synthase (EC 2.8.1.6)	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_1463: Biotin synthase (EC 2.8.1.6)	Biotin synthase (EC 2.8.1.6)
bioI	Bacillus subtilis subsp. subtilis str. 168 Gene: BSU30190: Biotin biosynthesis protein BioI of cytochrome P450 family, pimeloyl-ACP producing	Bacillus amyloliquefaciens FZB42 Gene: RBAM_018240: Biotin biosynthesis protein BioI of cytochrome P450 family, pimeloyl-ACP producing	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13 Gene: BLi00771: Biotin biosynthesis protein BioI of cytochrome P450 family, pimeloyl-ACP producing	Anoxybacillus flavithermus WK1	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Biotin biosynthesis protein BioI of cytochrome P450 family, pimeloyl-ACP producing
bioH	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1 Gene: Aflv_1164: Biotin synthesis protein bioH	* Geobacillus kaustophilus HTA426 Site: position = -330 score = 8.45115 sequence = ATGTAAAC-(15)-GTTTACAA Gene: GK3098: Biotin synthesis protein bioH	Bacillus cereus ATCC 14579 Gene: BC4116: Biotin synthesis protein bioH	Bacillus halodurans C-125 Gene: BH3908: Biotin synthesis protein bioH	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_1465: Biotin synthesis protein bioH	Biotin synthesis protein bioH
bioC	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1 Gene: Aflv_1165: SAM-dependent methyltransferase	Geobacillus kaustophilus HTA426	Bacillus cereus ATCC 14579 Gene: BC4115: SAM-dependent methyltransferase	Bacillus halodurans C-125 Gene: BH3909: SAM-dependent methyltransferase	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2 Gene: Pjdr2_1466: SAM-dependent methyltransferase	SAM-dependent methyltransferase
bioY	Bacillus subtilis subsp. subtilis str. 168	Bacillus amyloliquefaciens FZB42	Bacillus pumilus SAFR-032	Bacillus licheniformis DSM 13	Anoxybacillus flavithermus WK1	* Geobacillus kaustophilus HTA426 Site: position = -84 score = 8.51537 sequence = ATGTAAAC-(15)-GTTGACAA Gene: GK3018: Substrate-specific component BioY of biotin ECF transporter	Bacillus cereus ATCC 14579	Bacillus halodurans C-125	Bacillus clausii KSM-K16	Oceanobacillus iheyensis HTE831	Paenibacillus sp. JDR-2	Substrate-specific component BioY of biotin ECF transporter

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog BirA - Bacillales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --