Collection of regulogs for GntR/MocR transcription factor family

Transcription factors from the GntR family possess a conserved N-terminal HTH DNA binding domain (PF00392). C-terminal domains (responsible for effector-binding and oligomerization) are diverse and heterogeneous within the GntR family and were used to define the FadR, HutC, MocR, and YtrA subfamilies [11756427]. The MocR subfamily is characterized by a C-terminal domain that is homologous to the class I aminotransferase (PF00155). The class I aminotransferases catalyze transamination of amino acids to alpha-keto acids and use pyridoxal 5?-phosphate (PLP) as a cofactor. A similar requirement for PLP was shown for some MocR-subfamily proteins (TauR, GabR) [17981966, 15223311]. more

PdxR in Listeria and Corynebacterium spp. is directly involved in the regulation of the pyridoxal phosphate synthesis [24730374, 20847010]. Aminotransferases are known to form head-to-tail dimers and such dimerization may likely occur in MocR-subfamily proteins as well.