Collection of regulogs in Thermotogales taxonomic group
Genomes | 11 |
TF regulogs | 34 |
TF regulons | 245 |
TF binding sites | 648 |
RNA regulogs | 13 |
RNA regulons | 74 |
RNA sites | 88 |
This collection involves all regulons that were tentatively predicted by applying integrative comparative genomic approach to a single taxonomic group of closely-related genomes. To infer the regulons operated by transcription factors (TFs), we combined the identification of TF binding sites and cross-genome comparison of regulons with the analysis of the genomic and functional context of candidate target genes. To infer the regulons operated by regulatory RNAs such as riboswitches, we identified candidate RNA regulatory elements using HMM profiles and further analyzed their genomic and functional context.
TF | RNA | Total | ||||
---|---|---|---|---|---|---|
Genomes | Regulons | Sites | Regulons | Sites | Regulons | Sites |
Fervidobacterium nodosum Rt17-B1 | 14 | 34 | 5 | 8 | 19 | 42 |
Petrotoga mobilis SJ95 | 11 | 23 | 9 | 9 | 20 | 32 |
Thermosipho africanus TCF52B | 17 | 40 | 7 | 10 | 24 | 50 |
Thermosipho melanesiensis BI429 | 15 | 30 | 8 | 13 | 23 | 43 |
Thermotoga lettingae TMO | 23 | 42 | 9 | 12 | 32 | 54 |
Thermotoga maritima MSB8 | 31 | 92 | 6 | 6 | 37 | 98 |
Thermotoga naphthophila RKU-10 | 33 | 92 | 6 | 6 | 39 | 98 |
Thermotoga neapolitana DSM 4359 | 31 | 83 | 7 | 7 | 38 | 90 |
Thermotoga petrophila RKU-1 | 31 | 95 | 6 | 6 | 37 | 101 |
Thermotoga sp. RQ2 | 29 | 95 | 6 | 6 | 35 | 101 |
Thermotogales bacterium TBF 19.5.1 | 10 | 22 | 5 | 5 | 15 | 27 |
Family | Type | Regulator | Function | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ArgR | TF | ArgR |
2
ArgR
Thermotoga maritima MSB8 |
2
ArgR
Thermotoga sp. RQ2 |
2
ArgR
Thermotoga neapolitana DSM 4359 |
2
ArgR
Thermotoga petrophila RKU-1 |
2
ArgR
Thermotoga naphthophila RKU-10 |
Arginine biosynthesis | ||||||
CRP | TF | HcpR |
2
HcpR
Thermotoga maritima MSB8 |
2
HcpR
Thermotoga sp. RQ2 |
1
HcpR
Thermotoga neapolitana DSM 4359 |
2
HcpR
Thermotoga petrophila RKU-1 |
2
HcpR
Thermotoga naphthophila RKU-10 |
2
HcpR
Thermotoga lettingae TMO |
2
HcpR
Thermosipho africanus TCF52B |
1
HcpR
Thermosipho melanesiensis BI429 |
2
HcpR
Fervidobacterium nodosum Rt17-B1 |
2
HcpR
Petrotoga mobilis SJ95 |
2
HcpR
Thermotogales bacterium TBF 19.5.1 |
Nitrosative stress response |
DeoR | TF | FruR |
1
FruR
Thermotoga sp. RQ2 |
1
FruR
Thermotoga naphthophila RKU-10 |
Fructose utilization | |||||||||
TF | RhaR |
3
RhaR
Thermotoga maritima MSB8 |
3
RhaR
Thermotoga neapolitana DSM 4359 |
3
RhaR
Thermotoga petrophila RKU-1 |
3
RhaR
Thermotoga naphthophila RKU-10 |
Rhamnose utilization; Rhamnose oligosaccharides utilization | ||||||||
FUR | TF | Fur |
5
Fur
Thermotoga maritima MSB8 |
4
Fur
Thermotoga sp. RQ2 |
2
Fur
Thermotoga neapolitana DSM 4359 |
4
Fur
Thermotoga petrophila RKU-1 |
3
Fur
Thermotoga naphthophila RKU-10 |
1
Fur
Thermotoga lettingae TMO |
3
Fur
Thermosipho africanus TCF52B |
1
Fur
Thermosipho melanesiensis BI429 |
1
Fur
Fervidobacterium nodosum Rt17-B1 |
1
Fur
Thermotogales bacterium TBF 19.5.1 |
Iron homeostasis | |
TF | Zur |
1
Zur
Thermotoga maritima MSB8 |
1
Zur
Thermotoga sp. RQ2 |
1
Zur
Thermotoga neapolitana DSM 4359 |
1
Zur
Thermotoga petrophila RKU-1 |
1
Zur
Thermotoga naphthophila RKU-10 |
1
Zur
Thermosipho africanus TCF52B |
1
Zur
Thermosipho melanesiensis BI429 |
1
Zur
Fervidobacterium nodosum Rt17-B1 |
1
Zur
Petrotoga mobilis SJ95 |
Zinc homeostasis | |||
GntR/Others | TF | AraR |
3
AraR
Thermotoga maritima MSB8 |
5
AraR
Thermotoga sp. RQ2 |
2
AraR
Thermotoga neapolitana DSM 4359 |
5
AraR
Thermotoga petrophila RKU-1 |
3
AraR
Thermotoga naphthophila RKU-10 |
2
AraR
Thermotoga lettingae TMO |
Arabinose utilization | |||||
TF | THA_1503 |
1
THA_1503
Thermotoga lettingae TMO |
1
THA_1503
Thermosipho africanus TCF52B |
1
THA_1503
Thermosipho melanesiensis BI429 |
1
THA_1503
Fervidobacterium nodosum Rt17-B1 |
1
THA_1503
Petrotoga mobilis SJ95 |
1
THA_1503
Thermotogales bacterium TBF 19.5.1 |
Multidrug resistance; Multidrug efflux | ||||||
TF | TM0766 |
1
TM0766
Thermotoga maritima MSB8 |
1
TM0766
Thermotoga sp. RQ2 |
1
TM0766
Thermotoga neapolitana DSM 4359 |
1
TM0766
Thermotoga petrophila RKU-1 |
1
TM0766
Thermotoga naphthophila RKU-10 |
1
TM0766
Thermotoga lettingae TMO |
1
TM0766
Thermosipho africanus TCF52B |
1
TM0766
Thermosipho melanesiensis BI429 |
1
TM0766
Fervidobacterium nodosum Rt17-B1 |
Hypothetical ABC transporter | |||
TF | UxaR |
4
UxaR
Thermotoga maritima MSB8 |
5
UxaR
Thermotoga sp. RQ2 |
3
UxaR
Thermotoga neapolitana DSM 4359 |
3
UxaR
Thermotoga petrophila RKU-1 |
3
UxaR
Thermotoga naphthophila RKU-10 |
Galacturonate utilization; Pectin utilization | |||||||
HrcA | TF | HrcA |
4
HrcA
Thermotoga maritima MSB8 |
4
HrcA
Thermotoga sp. RQ2 |
5
HrcA
Thermotoga neapolitana DSM 4359 |
5
HrcA
Thermotoga petrophila RKU-1 |
5
HrcA
Thermotoga naphthophila RKU-10 |
3
HrcA
Thermotoga lettingae TMO |
4
HrcA
Thermosipho africanus TCF52B |
4
HrcA
Thermosipho melanesiensis BI429 |
6
HrcA
Fervidobacterium nodosum Rt17-B1 |
4
HrcA
Petrotoga mobilis SJ95 |
3
HrcA
Thermotogales bacterium TBF 19.5.1 |
Heat shock response |
IclR | TF | KdgR |
6
KdgR
Thermotoga maritima MSB8 |
4
KdgR
Thermotoga sp. RQ2 |
4
KdgR
Thermotoga neapolitana DSM 4359 |
6
KdgR
Thermotoga petrophila RKU-1 |
6
KdgR
Thermotoga naphthophila RKU-10 |
Glucuronate utilization | ||||||
LacI | TF | CelR |
7
CelR
Thermotoga maritima MSB8 |
7
CelR
Thermotoga sp. RQ2 |
5
CelR
Thermotoga neapolitana DSM 4359 |
5
CelR
Thermotoga petrophila RKU-1 |
5
CelR
Thermotoga naphthophila RKU-10 |
1
CelR
Thermotoga lettingae TMO |
1
CelR
Fervidobacterium nodosum Rt17-B1 |
Cellobiose utilization | ||||
TF | GalR |
2
GalR
Thermotoga maritima MSB8 |
2
GalR
Thermotoga sp. RQ2 |
1
GalR
Thermotoga neapolitana DSM 4359 |
2
GalR
Thermotoga petrophila RKU-1 |
2
GalR
Thermotoga naphthophila RKU-10 |
3
GalR
Thermotoga lettingae TMO |
1
GalR
Thermosipho africanus TCF52B |
2
GalR
Fervidobacterium nodosum Rt17-B1 |
1
GalR
Petrotoga mobilis SJ95 |
Galactosides utilization | |||
TF | GloR |
2
GloR
Thermotoga maritima MSB8 |
2
GloR
Thermotoga sp. RQ2 |
2
GloR
Thermotoga naphthophila RKU-10 |
1
GloR
Thermotoga lettingae TMO |
1
GloR
Petrotoga mobilis SJ95 |
Fucose-glucose oligosaccharide utilization | |||||||
TF | RbsR |
1
RbsR
Thermotoga maritima MSB8 |
1
RbsR
Thermotoga neapolitana DSM 4359 |
1
RbsR
Thermotoga petrophila RKU-1 |
1
RbsR
Thermotoga naphthophila RKU-10 |
1
RbsR
Thermotoga lettingae TMO |
1
RbsR
Thermosipho africanus TCF52B |
1
RbsR
Petrotoga mobilis SJ95 |
1
RbsR
Thermotogales bacterium TBF 19.5.1 |
Ribose utilization | ||||
TF | UgpR |
1
UgpR
Thermotoga maritima MSB8 |
1
UgpR
Thermotoga neapolitana DSM 4359 |
1
UgpR
Thermotoga petrophila RKU-1 |
1
UgpR
Thermotoga naphthophila RKU-10 |
1
UgpR
Thermotoga lettingae TMO |
1
UgpR
Thermosipho africanus TCF52B |
1
UgpR
Thermosipho melanesiensis BI429 |
Possibly alpha-mannosides utilization | |||||
NiaR | TF | NiaR |
2
NiaR
Thermotoga maritima MSB8 |
2
NiaR
Thermotoga sp. RQ2 |
2
NiaR
Thermotoga neapolitana DSM 4359 |
2
NiaR
Thermotoga petrophila RKU-1 |
2
NiaR
Thermotoga naphthophila RKU-10 |
1
NiaR
Thermotoga lettingae TMO |
1
NiaR
Thermosipho africanus TCF52B |
1
NiaR
Thermosipho melanesiensis BI429 |
NAD biosynthesis | |||
NrdR | TF | NrdR |
4
NrdR
Thermotoga maritima MSB8 |
4
NrdR
Thermotoga sp. RQ2 |
4
NrdR
Thermotoga neapolitana DSM 4359 |
4
NrdR
Thermotoga petrophila RKU-1 |
4
NrdR
Thermotoga naphthophila RKU-10 |
2
NrdR
Thermotoga lettingae TMO |
1
NrdR
Thermosipho africanus TCF52B |
1
NrdR
Thermosipho melanesiensis BI429 |
2
NrdR
Fervidobacterium nodosum Rt17-B1 |
2
NrdR
Petrotoga mobilis SJ95 |
2
NrdR
Thermotogales bacterium TBF 19.5.1 |
Deoxyribonucleotide biosynthesis |
OmpR | TF | PhoB |
1
PhoB
Thermotoga maritima MSB8 |
1
PhoB
Thermotoga sp. RQ2 |
1
PhoB
Thermotoga neapolitana DSM 4359 |
1
PhoB
Thermotoga petrophila RKU-1 |
1
PhoB
Thermotoga naphthophila RKU-10 |
1
PhoB
Thermotoga lettingae TMO |
1
PhoB
Thermosipho africanus TCF52B |
1
PhoB
Thermosipho melanesiensis BI429 |
1
PhoB
Fervidobacterium nodosum Rt17-B1 |
1
PhoB
Petrotoga mobilis SJ95 |
1
PhoB
Thermotogales bacterium TBF 19.5.1 |
Phosphate metabolism |
TF | ZnuR |
1
ZnuR
Thermotoga maritima MSB8 |
1
ZnuR
Thermotoga sp. RQ2 |
1
ZnuR
Thermotoga neapolitana DSM 4359 |
1
ZnuR
Thermotoga petrophila RKU-1 |
1
ZnuR
Thermotoga naphthophila RKU-10 |
Zinc homeostasis | |||||||
ROK | TF | BglR |
1
BglR
Thermotoga maritima MSB8 |
1
BglR
Thermotoga sp. RQ2 |
1
BglR
Thermotoga neapolitana DSM 4359 |
1
BglR
Thermotoga petrophila RKU-1 |
1
BglR
Thermotoga naphthophila RKU-10 |
2
BglR
Thermotoga lettingae TMO |
Beta-glucosides utilization | |||||
TF | ChiR |
1
ChiR
Thermotoga maritima MSB8 |
1
ChiR
Thermotoga sp. RQ2 |
1
ChiR
Thermotoga neapolitana DSM 4359 |
1
ChiR
Thermotoga petrophila RKU-1 |
1
ChiR
Thermotoga naphthophila RKU-10 |
1
ChiR
Thermotoga lettingae TMO |
1
ChiR
Thermosipho africanus TCF52B |
1
ChiR
Thermosipho melanesiensis BI429 |
Chitobiose utilization | ||||
TF | GluR |
2
GluR
Thermotoga sp. RQ2 |
2
GluR
Thermotoga neapolitana DSM 4359 |
1
GluR
Thermotoga petrophila RKU-1 |
2
GluR
Thermotoga naphthophila RKU-10 |
Glucose utilization; Trehalose utilization | ||||||||
TF | IolR |
1
IolR
Thermotoga maritima MSB8 |
1
IolR
Thermotoga neapolitana DSM 4359 |
1
IolR
Thermotoga petrophila RKU-1 |
1
IolR
Thermotoga naphthophila RKU-10 |
Inositol utilization | ||||||||
TF | ManR |
2
ManR
Thermotoga maritima MSB8 |
2
ManR
Thermotoga sp. RQ2 |
1
ManR
Thermotoga neapolitana DSM 4359 |
1
ManR
Thermotoga petrophila RKU-1 |
1
ManR
Thermotoga naphthophila RKU-10 |
Mannan and beta-mannosides utilization | |||||||
TF | TreR |
1
TreR
Thermotoga maritima MSB8 |
2
TreR
Thermotoga sp. RQ2 |
2
TreR
Thermotoga neapolitana DSM 4359 |
2
TreR
Thermotoga petrophila RKU-1 |
2
TreR
Thermotoga naphthophila RKU-10 |
1
TreR
Thermotoga lettingae TMO |
2
TreR
Thermosipho africanus TCF52B |
2
TreR
Thermosipho melanesiensis BI429 |
2
TreR
Fervidobacterium nodosum Rt17-B1 |
2
TreR
Thermotogales bacterium TBF 19.5.1 |
Trehalose utilization | ||
TF | XylR |
7
XylR
Thermotoga maritima MSB8 |
8
XylR
Thermotoga sp. RQ2 |
8
XylR
Thermotoga neapolitana DSM 4359 |
7
XylR
Thermotoga petrophila RKU-1 |
7
XylR
Thermotoga naphthophila RKU-10 |
2
XylR
Thermotoga lettingae TMO |
Xylose utilization | ||||||
Rex | TF | Rex |
12
Rex
Thermotoga maritima MSB8 |
13
Rex
Thermotoga sp. RQ2 |
11
Rex
Thermotoga neapolitana DSM 4359 |
13
Rex
Thermotoga petrophila RKU-1 |
12
Rex
Thermotoga naphthophila RKU-10 |
5
Rex
Thermotoga lettingae TMO |
7
Rex
Thermosipho africanus TCF52B |
7
Rex
Thermosipho melanesiensis BI429 |
7
Rex
Fervidobacterium nodosum Rt17-B1 |
4
Rex
Petrotoga mobilis SJ95 |
4
Rex
Thermotogales bacterium TBF 19.5.1 |
Energy metabolism |
TF | Rex1 |
1
Rex1
Thermotoga maritima MSB8 |
1
Rex1
Thermotoga sp. RQ2 |
1
Rex1
Thermotoga neapolitana DSM 4359 |
1
Rex1
Thermotoga petrophila RKU-1 |
1
Rex1
Thermotoga naphthophila RKU-10 |
1
Rex1
Thermotoga lettingae TMO |
1
Rex1
Thermosipho africanus TCF52B |
1
Rex1
Thermosipho melanesiensis BI429 |
2
Rex1
Fervidobacterium nodosum Rt17-B1 |
Energy metabolism | |||
RpiR | TF | UctR |
1
UctR
Thermotoga maritima MSB8 |
1
UctR
Thermotoga sp. RQ2 |
1
UctR
Thermotoga neapolitana DSM 4359 |
1
UctR
Thermotoga petrophila RKU-1 |
1
UctR
Thermotoga naphthophila RKU-10 |
Sugar utilization | ||||||
TF | UgtR |
1
UgtR
Thermotoga maritima MSB8 |
1
UgtR
Thermotoga sp. RQ2 |
1
UgtR
Thermotoga neapolitana DSM 4359 |
1
UgtR
Thermotoga petrophila RKU-1 |
1
UgtR
Thermotoga naphthophila RKU-10 |
1
UgtR
Thermotoga lettingae TMO |
1
UgtR
Petrotoga mobilis SJ95 |
1
UgtR
Thermotogales bacterium TBF 19.5.1 |
Sugar utilization | ||||
TetR | TF | TM1030 |
1
TM1030
Thermotoga maritima MSB8 |
1
TM1030
Thermotoga sp. RQ2 |
1
TM1030
Thermotoga neapolitana DSM 4359 |
1
TM1030
Thermotoga petrophila RKU-1 |
1
TM1030
Thermotoga naphthophila RKU-10 |
1
TM1030
Thermotoga lettingae TMO |
Multidrug resistance | |||||
XRE | TF | PuuR |
1
PuuR
Thermotoga maritima MSB8 |
1
PuuR
Thermotoga sp. RQ2 |
1
PuuR
Thermotoga neapolitana DSM 4359 |
1
PuuR
Thermotoga petrophila RKU-1 |
1
PuuR
Thermotoga naphthophila RKU-10 |
1
PuuR
Thermotoga lettingae TMO |
1
PuuR
Thermosipho africanus TCF52B |
1
PuuR
Thermosipho melanesiensis BI429 |
1
PuuR
Fervidobacterium nodosum Rt17-B1 |
Spermidine biosynthesis | ||
RF00050 | RNA | FMN |
1
FMN
Thermotoga maritima MSB8 |
1
FMN
Thermotoga sp. RQ2 |
1
FMN
Thermotoga neapolitana DSM 4359 |
1
FMN
Thermotoga petrophila RKU-1 |
1
FMN
Thermotoga naphthophila RKU-10 |
1
FMN
Thermosipho melanesiensis BI429 |
1
FMN
Fervidobacterium nodosum Rt17-B1 |
1
FMN
Thermotogales bacterium TBF 19.5.1 |
Riboflavin biosynthesis | |||
RF00059 | RNA | TPP |
1
TPP
Thermotoga maritima MSB8 |
1
TPP
Thermotoga sp. RQ2 |
1
TPP
Thermotoga neapolitana DSM 4359 |
1
TPP
Thermotoga petrophila RKU-1 |
1
TPP
Thermotoga naphthophila RKU-10 |
2
TPP
Thermotoga lettingae TMO |
2
TPP
Thermosipho africanus TCF52B |
3
TPP
Thermosipho melanesiensis BI429 |
2
TPP
Fervidobacterium nodosum Rt17-B1 |
1
TPP
Petrotoga mobilis SJ95 |
1
TPP
Thermotogales bacterium TBF 19.5.1 |
Thiamine biosynthesis |
RF00080 | RNA | yybP-ykoY |
1
yybP-ykoY
Petrotoga mobilis SJ95 |
|||||||||||
RF00162 | RNA | SAM |
1
SAM
Petrotoga mobilis SJ95 |
Methionine biosynthesis | ||||||||||
RF00167 | RNA | Purine |
1
Purine
Thermotoga lettingae TMO |
1
Purine
Petrotoga mobilis SJ95 |
Purine metabolism | |||||||||
RF00168 | RNA | Lysine |
1
Lysine
Thermotoga maritima MSB8 |
1
Lysine
Thermotoga sp. RQ2 |
1
Lysine
Thermotoga neapolitana DSM 4359 |
1
Lysine
Thermotoga petrophila RKU-1 |
1
Lysine
Thermotoga naphthophila RKU-10 |
1
Lysine
Thermosipho africanus TCF52B |
1
Lysine
Thermosipho melanesiensis BI429 |
1
Lysine
Petrotoga mobilis SJ95 |
1
Lysine
Thermotogales bacterium TBF 19.5.1 |
Lysine biosynthesis | ||
RF00174 | RNA | Cobalamin |
1
Cobalamin
Thermotoga maritima MSB8 |
1
Cobalamin
Thermotoga sp. RQ2 |
1
Cobalamin
Thermotoga neapolitana DSM 4359 |
1
Cobalamin
Thermotoga petrophila RKU-1 |
1
Cobalamin
Thermotoga naphthophila RKU-10 |
3
Cobalamin
Thermotoga lettingae TMO |
3
Cobalamin
Thermosipho africanus TCF52B |
4
Cobalamin
Thermosipho melanesiensis BI429 |
3
Cobalamin
Fervidobacterium nodosum Rt17-B1 |
1
Cobalamin
Petrotoga mobilis SJ95 |
1
Cobalamin
Thermotogales bacterium TBF 19.5.1 |
Cobalamin biosynthesis |
RF00513 | RNA | Trp_leader |
1
Trp_leader
Thermotoga lettingae TMO |
1
Trp_leader
Thermosipho africanus TCF52B |
1
Trp_leader
Thermosipho melanesiensis BI429 |
Tryptophan biosynthesis | ||||||||
RF00514 | RNA | His_leader |
1
His_leader
Thermotoga lettingae TMO |
Histidine biosynthesis | ||||||||||
RF00557 | RNA | L10_leader |
1
L10_leader
Thermotoga maritima MSB8 |
1
L10_leader
Thermotoga sp. RQ2 |
1
L10_leader
Thermotoga neapolitana DSM 4359 |
1
L10_leader
Thermotoga petrophila RKU-1 |
1
L10_leader
Thermotoga naphthophila RKU-10 |
1
L10_leader
Thermotoga lettingae TMO |
1
L10_leader
Thermosipho africanus TCF52B |
1
L10_leader
Thermosipho melanesiensis BI429 |
1
L10_leader
Fervidobacterium nodosum Rt17-B1 |
1
L10_leader
Petrotoga mobilis SJ95 |
1
L10_leader
Thermotogales bacterium TBF 19.5.1 |
Ribosome biogenesis |
RF00558 | RNA | L20_leader |
1
L20_leader
Thermotoga maritima MSB8 |
1
L20_leader
Thermotoga sp. RQ2 |
1
L20_leader
Thermotoga neapolitana DSM 4359 |
1
L20_leader
Thermotoga petrophila RKU-1 |
1
L20_leader
Thermotoga naphthophila RKU-10 |
1
L20_leader
Thermotoga lettingae TMO |
1
L20_leader
Thermosipho africanus TCF52B |
1
L20_leader
Thermosipho melanesiensis BI429 |
1
L20_leader
Fervidobacterium nodosum Rt17-B1 |
1
L20_leader
Petrotoga mobilis SJ95 |
Ribosome biogenesis | |
RF00559 | RNA | L21_leader |
1
L21_leader
Thermotoga neapolitana DSM 4359 |
1
L21_leader
Thermotoga lettingae TMO |
1
L21_leader
Thermosipho africanus TCF52B |
1
L21_leader
Thermosipho melanesiensis BI429 |
Ribosome biogenesis | |||||||
RF01055 | RNA | MOCO_RNA_motif |
1
MOCO_RNA_motif
Thermotoga lettingae TMO |
1
MOCO_RNA_motif
Petrotoga mobilis SJ95 |
Molybdopterin biosynthesis; Molybdenum homeostasis |