Regulog HrcA - Thermotogales

Properties
Regulator type:	Transcription factor
Regulator family:	HrcA
Regulation mode:	repressor
Biological process:	Heat shock response
Effector:	Heat shock
Phylum:	Thermotogae
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 50 sites [see more]

Member of regulog collections

By taxonomy - Thermotogales
By trascription factor - HrcA
By TF family - HrcA
By effector - Heat shock
By pathway - Heat shock response

Statistics of regulated genes
Genome	Genes	Operons
Thermotoga maritima MSB8	9	4
Thermotoga sp. RQ2	8	4
Thermotoga neapolitana DSM 4359	11	5
Thermotoga petrophila RKU-1	10	5
Thermotoga naphthophila RKU-10	10	5
Thermotoga lettingae TMO	8	3
Thermosipho africanus TCF52B	8	4
Thermosipho melanesiensis BI429	8	4
Fervidobacterium nodosum Rt17-B1	10	6
Petrotoga mobilis SJ95	8	4
Thermotogales bacterium TBF 19.5.1	8	3

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes												Function

CRON 1.
groS	* Thermotoga maritima MSB8 Site: position = -48 score = 6.61133 sequence = TTAGCAGTCGAATGATGAGAGTGCTAA Gene: TM0505: GroES chaperonin	* Thermotoga sp. RQ2 Site: position = -48 score = 6.43529 sequence = TTAGCAGTCGAACGATGAGAGTGCTAA Gene: TRQ2_0431: GroES chaperonin	2 Thermotoga neapolitana DSM 4359* Site: position = -52 score = 6.24123 sequence = TTAGCAGTCATGAGTCGAGAGTGCTAA Gene: CTN_0166: GroES chaperonin Gene: CTN_0165: GroES chaperonin	* Thermotoga petrophila RKU-1 Site: position = -48 score = 6.43529 sequence = TTAGCAGTCGAACGATGAGAGTGCTAA Gene: Tpet_0416: GroES chaperonin	* Thermotoga naphthophila RKU-10 Site: position = -48 score = 6.08443 sequence = TTAGCAGTCAGACGATGAGAGTGCTAA Gene: Tnap_0286: GroES chaperonin	* Thermotoga lettingae TMO Site: position = -57 score = 6.50601 sequence = TTAGCACTCAAACAGTTCGAGTGATAA Gene: Tlet_0318: GroES chaperonin	* Thermosipho africanus TCF52B Site: position = -53 score = 5.86469 sequence = TTAGCAGTCAATGAATTAGAGTGACAA Gene: THA_270: GroES chaperonin	* Thermosipho melanesiensis BI429 Site: position = -54 score = 5.82558 sequence = TTAGCAGTCGATGATTAAGAGTGACAA Gene: Tmel_0053: GroES chaperonin	* Fervidobacterium nodosum Rt17-B1 Site: position = -61 score = 5.80433 sequence = TTAACAAACGGAATATTAGAGTGATAA Gene: Fnod_1544: GroES chaperonin	* Petrotoga mobilis SJ95 Site: position = -85 score = 6.85445 sequence = TTAGCACTCTTAATATTTGATTGCTAA Gene: Pmob_1157: GroES chaperonin	* Thermotogales bacterium TBF 19.5.1 Site: position = -71 score = 6.2951 sequence = TTAGCAGACTCATATAAAGAGTGCTAA Gene: Kole_1626: GroES chaperonin	GroES chaperonin
groL	Thermotoga maritima MSB8 Gene: TM0506: GroEL chaperonin	Thermotoga sp. RQ2 Gene: TRQ2_0430: GroEL chaperonin	Thermotoga neapolitana DSM 4359 Gene: CTN_0164: GroEL chaperonin	Thermotoga petrophila RKU-1 Gene: Tpet_0415: GroEL chaperonin	Thermotoga naphthophila RKU-10 Gene: Tnap_0287: GroEL chaperonin	Thermotoga lettingae TMO Gene: Tlet_0317: GroEL chaperonin	Thermosipho africanus TCF52B Gene: THA_269: GroEL chaperonin	Thermosipho melanesiensis BI429 Gene: Tmel_0052: GroEL chaperonin	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_1543: GroEL chaperonin	Petrotoga mobilis SJ95 Gene: Pmob_1158: GroEL chaperonin	Thermotogales bacterium TBF 19.5.1 Gene: Kole_1627: GroEL chaperonin	GroEL chaperonin

CRON 2.
hrcA	* Thermotoga maritima MSB8 Site: position = -30 score = 6.54111 sequence = TTAGCACTCAAAAGAAGGGAGTGCTAA Gene: TM0851: Heat shock response regulator, HrcA family	* Thermotoga sp. RQ2 Site: position = -30 score = 6.54111 sequence = TTAGCACTCAAAAGAAGGGAGTGCTAA Gene: TRQ2_0076: Heat shock response regulator, HrcA family	* Thermotoga neapolitana DSM 4359 Site: position = -28 score = 6.64654 sequence = TTAGCACTCAAAAGAAAGGAGTGCTAA Gene: CTN_1724: Heat shock response regulator, HrcA family	* Thermotoga petrophila RKU-1 Site: position = -30 score = 6.54111 sequence = TTAGCACTCAAAAGAAGGGAGTGCTAA Gene: Tpet_0076: Heat shock response regulator, HrcA family	* Thermotoga naphthophila RKU-10 Site: position = -30 score = 6.54111 sequence = TTAGCACTCAAAAGAAGGGAGTGCTAA Gene: Tnap_0076: Heat shock response regulator, HrcA family	* Thermotoga lettingae TMO Site: position = -29 score = 6.751 sequence = TTAGCACTCAAATGATGAGAGTGATAA Gene: Tlet_1782: Heat shock response regulator, HrcA family	* Thermosipho africanus TCF52B Site: position = -28 score = 5.83476 sequence = TTATCAGACAAGGATAAAGAGTGATAA Gene: THA_306: Heat shock response regulator, HrcA family	* Thermosipho melanesiensis BI429 Site: position = -51 score = 6.12726 sequence = TTATCAGACATAGCATAAGAGTGATAA Gene: Tmel_0089: Heat shock response regulator, HrcA family	* Fervidobacterium nodosum Rt17-B1 Site: position = -103 score = 5.1343 sequence = TTGGCAGATGGATAATAAGTTTGCTAA Gene: Fnod_1242: Heat shock response regulator, HrcA family	* Petrotoga mobilis SJ95 Site: position = -28 score = 5.79694 sequence = TTAGCACTTAATATGCGGGAGTGATAA Gene: Pmob_1823: Heat shock response regulator, HrcA family	* Thermotogales bacterium TBF 19.5.1 Site: position = -28 score = 5.60512 sequence = TTAGCAGTCTCCAGGGAGGAGTGCTAA Gene: Kole_1384: Heat shock response regulator, HrcA family	Heat shock response regulator, HrcA family
grpE	Thermotoga maritima MSB8 Gene: TM0850: Heat shock protein	Thermotoga sp. RQ2 Gene: TRQ2_0077: Heat shock protein	Thermotoga neapolitana DSM 4359 Gene: CTN_1725: Heat shock protein	Thermotoga petrophila RKU-1 Gene: Tpet_0077: Heat shock protein	Thermotoga naphthophila RKU-10 Gene: Tnap_0077: Heat shock protein	Thermotoga lettingae TMO Gene: Tlet_1781: Heat shock protein	Thermosipho africanus TCF52B Gene: THA_305: Heat shock protein	Thermosipho melanesiensis BI429 Gene: Tmel_0088: Heat shock protein	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_1243: Heat shock protein	Petrotoga mobilis SJ95 Gene: Pmob_1824: Heat shock protein	Thermotogales bacterium TBF 19.5.1 Gene: Kole_1385: Heat shock protein	Heat shock protein
dnaJ	Thermotoga maritima MSB8 Gene: TM0849: Chaperone Hsp40	Thermotoga sp. RQ2 Gene: TRQ2_0078: Chaperone Hsp40	Thermotoga neapolitana DSM 4359 Gene: CTN_1726: Chaperone Hsp40	Thermotoga petrophila RKU-1 Gene: Tpet_0078: Chaperone Hsp40	Thermotoga naphthophila RKU-10 Gene: Tnap_0078: Chaperone Hsp40	Thermotoga lettingae TMO Gene: Tlet_1780: Chaperone Hsp40	Thermosipho africanus TCF52B Gene: THA_304: Chaperone Hsp40	Thermosipho melanesiensis BI429 Gene: Tmel_0087: Chaperone Hsp40	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_1244: Chaperone Hsp40	Petrotoga mobilis SJ95 Gene: Pmob_1825: Chaperone Hsp40	Thermotogales bacterium TBF 19.5.1 Gene: Kole_1386: Chaperone Hsp40	Chaperone Hsp40

CRON 3.
recF	Thermotoga maritima MSB8	Thermotoga sp. RQ2	Thermotoga neapolitana DSM 4359	Thermotoga petrophila RKU-1	Thermotoga naphthophila RKU-10	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	* Fervidobacterium nodosum Rt17-B1 Site: position = -93 score = 5.75024 sequence = TTATCACTCCATCTTGTCAAGTGATAA Gene: Fnod_1362: DNA replication and repair protein RecF	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	DNA replication and repair protein RecF
rgyR	Thermotoga maritima MSB8	Thermotoga sp. RQ2	Thermotoga neapolitana DSM 4359	Thermotoga petrophila RKU-1	Thermotoga naphthophila RKU-10	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_1363: Reverse gyrase	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	Reverse gyrase

CRON 4.
TM0370	* Thermotoga maritima MSB8 Site: position = -16 score = 5.90504 sequence = TTATCAAAAGAAAAAAATGATTGCTAA Gene: TM0370: Predicted RecA-like ATPase, COG0467	Thermotoga sp. RQ2 Gene: TRQ2_0561: Predicted RecA-like ATPase, COG0467	* Thermotoga neapolitana DSM 4359 Site: position = -20 score = 6.35876 sequence = TTATCAATCGATATTGATGAGTGCTAA Gene: CTN_0301: Predicted RecA-like ATPase, COG0467	* Thermotoga petrophila RKU-1 Site: position = -49 score = 6.3797 sequence = TTATCAAACGAAAAAAATGATTGCTAA Gene: Tpet_0547: Predicted RecA-like ATPase, COG0467	* Thermotoga naphthophila RKU-10 Site: position = -49 score = 6.3797 sequence = TTATCAAACGAAAAAAATGATTGCTAA Gene: Tnap_0165: Predicted RecA-like ATPase, COG0467	Thermotoga lettingae TMO	Thermosipho africanus TCF52B Gene: THA_115: Predicted RecA-like ATPase, COG0467	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	Predicted RecA-like ATPase, COG0467
TM0369	Thermotoga maritima MSB8 Gene: TM0369: Conserved hypothetical protein	Thermotoga sp. RQ2 Gene: TRQ2_0562: Conserved hypothetical protein	Thermotoga neapolitana DSM 4359 Gene: CTN_0300: Conserved hypothetical protein	Thermotoga petrophila RKU-1 Gene: Tpet_0548: Conserved hypothetical protein	Thermotoga naphthophila RKU-10 Gene: Tnap_0164: Conserved hypothetical protein	Thermotoga lettingae TMO	Thermosipho africanus TCF52B Gene: THA_116: Conserved hypothetical protein	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	Conserved hypothetical protein

CRON 5.
clpA	Thermotoga maritima MSB8	* Thermotoga sp. RQ2 Site: position = -51 score = 6.34661 sequence = TTATCAAACGTAAGATTTAAGTGCTAA Gene: TRQ2_0054: Chaperone protein	* Thermotoga neapolitana DSM 4359 Site: position = -42 score = 6.25257 sequence = TTATCATTCTTAATAATTAAGTGCTAA Gene: CTN_1702: Chaperone protein	* Thermotoga petrophila RKU-1 Site: position = -51 score = 6.59266 sequence = TTATCAAACGTAATATTTGAGTGCTAA Gene: Tpet_0054: Chaperone protein	* Thermotoga naphthophila RKU-10 Site: position = -51 score = 6.59266 sequence = TTATCAAACGTAATATTTGAGTGCTAA Gene: Tnap_0054: Chaperone protein	Thermotoga lettingae TMO	* Thermosipho africanus TCF52B Site: position = -54 score = 6.55914 sequence = TTATCAGTCTAAATATATGACTGATAA Gene: THA_711: Chaperone protein	* Thermosipho melanesiensis BI429 Site: position = -55 score = 6.31991 sequence = TTATCAGTCTATATATGTGACTGATAA Gene: Tmel_0413: Chaperone protein	Fervidobacterium nodosum Rt17-B1	* Petrotoga mobilis SJ95 Site: position = -68 score = 6.26411 sequence = TTAGCAAATAAAAGTAACGAGTGATAA Gene: Pmob_1629: Chaperone protein	Thermotogales bacterium TBF 19.5.1	Chaperone protein

CRON 6.
dnaK	* Thermotoga maritima MSB8 Site: position = -179 score = 5.69509 sequence = TTATCATTCAAACATTTCATTTGCTAT Gene: TM0373: Chaperone Hsp70	* Thermotoga sp. RQ2 Site: position = -179 score = 5.94261 sequence = TTATCATTCAAAAGTTTCATTTGCTAT Gene: TRQ2_0558: Chaperone Hsp70	* Thermotoga neapolitana DSM 4359 Site: position = -174 score = 6.16296 sequence = TTATCATTCATAAGTTTCGTTTGCTAT Gene: CTN_0304: Chaperone Hsp70	* Thermotoga petrophila RKU-1 Site: position = -179 score = 5.94261 sequence = TTATCATTCAAAAGTTTCATTTGCTAT Gene: Tpet_0544: Chaperone Hsp70	* Thermotoga naphthophila RKU-10 Site: position = -179 score = 5.94261 sequence = TTATCATTCAAAAGTTTCATTTGCTAT Gene: Tnap_0168: Chaperone Hsp70	* Thermotoga lettingae TMO Site: position = -169 score = 5.87844 sequence = GTATCAGTCTATAATTACGAGTGCTAT Gene: Tlet_0014: Chaperone Hsp70	* Thermosipho africanus TCF52B Site: position = -59 score = 6.33068 sequence = TTATCACTCTTGACAAAAGACTGCTAA Site: position = -159 score = 5.16258 sequence = ATAACAAACTTATGTAACAATTGCTAT Gene: THA_1433: Chaperone Hsp70	* Thermosipho melanesiensis BI429 Site: position = -157 score = 5.58445 sequence = ATAACAAACGAATGTTACGATTGCTAT Site: position = -57 score = 6.47169 sequence = TTATCACTCTTGACAATAGAGTGATAA Gene: Tmel_1128: Chaperone Hsp70	* Fervidobacterium nodosum Rt17-B1 Site: position = -82 score = 6.41321 sequence = TTATCACTCTTGACAAATGATTGCTAA Gene: Fnod_1209: Chaperone Hsp70	* Petrotoga mobilis SJ95 Site: position = -205 score = 5.71644 sequence = TTTTCACTCTTAGATTAAGAGTGATAT Gene: Pmob_1649: Chaperone Hsp70	* Thermotogales bacterium TBF 19.5.1 Site: position = -82 score = 5.61923 sequence = ATGGCAAACTTGACATTCGATTGCTAA Gene: Kole_0886: Chaperone Hsp70	Chaperone Hsp70
hsp20	Thermotoga maritima MSB8 Gene: TM0374: Chaperone Hsp20	Thermotoga sp. RQ2 Gene: TRQ2_0557: Chaperone Hsp20	Thermotoga neapolitana DSM 4359 Gene: CTN_0305: Chaperone Hsp20	Thermotoga petrophila RKU-1 Gene: Tpet_0543: Chaperone Hsp20	Thermotoga naphthophila RKU-10 Gene: Tnap_0169: Chaperone Hsp20	Thermotoga lettingae TMO Gene: Tlet_0015: Chaperone Hsp20	Thermosipho africanus TCF52B Gene: THA_1432: Chaperone Hsp20	Thermosipho melanesiensis BI429 Gene: Tmel_1127: Chaperone Hsp20	* Fervidobacterium nodosum Rt17-B1 Site: position = -244 score = 5.70555 sequence = TTATCATTATTAAGTTACAACTGATAA Site: position = -141 score = 6.49219 sequence = TTATCACTCTTGACAATTGAGTGATAA Gene: Fnod_0102: Chaperone Hsp20	Petrotoga mobilis SJ95 Gene: Pmob_1650: Chaperone Hsp20	Thermotogales bacterium TBF 19.5.1 Gene: Kole_0885: Chaperone Hsp20	Chaperone Hsp20
clpB	Thermotoga maritima MSB8 Gene: TM1391: Chaperone protein	Thermotoga sp. RQ2 Gene: TRQ2_1438: Chaperone protein	Thermotoga neapolitana DSM 4359 Gene: CTN_1200: Chaperone protein	Thermotoga petrophila RKU-1 Gene: Tpet_1392: Chaperone protein	Thermotoga naphthophila RKU-10 Gene: Tnap_1412: Chaperone protein	Thermotoga lettingae TMO Gene: Tlet_0016: Chaperone protein	Thermosipho africanus TCF52B Gene: THA_686: Chaperone protein	Thermosipho melanesiensis BI429 Gene: Tmel_0597: Chaperone protein	* Fervidobacterium nodosum Rt17-B1 Site: position = -85 score = 6.04768 sequence = ATATCACTCTTGACATATAAGTGATAA Gene: Fnod_0310: Chaperone protein	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1 Gene: Kole_0884: Chaperone protein	Chaperone protein

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog HrcA - Thermotogales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --