Statistics of regulated genes

Genome	Genes	Operons
Thermotoga maritima MSB8	39	12
Thermotoga sp. RQ2	32	13
Thermotoga neapolitana DSM 4359	32	11
Thermotoga petrophila RKU-1	40	13
Thermotoga naphthophila RKU-10	30	12
Thermotoga lettingae TMO	23	5
Thermosipho africanus TCF52B	16	7
Thermosipho melanesiensis BI429	19	7
Fervidobacterium nodosum Rt17-B1	18	7
Petrotoga mobilis SJ95	11	4
Thermotogales bacterium TBF 19.5.1	12	4

Clusters of co-Regulated Orthologous operoNs (CRONs)

Genes												Function
CRON 1.
TM1586	* Thermotoga maritima MSB8 Site: position = -177 score = 4.8716 sequence = GAGTAAAATATTTCACAA Gene: TM1586: Putative oxidoreductase, COG0778	* Thermotoga sp. RQ2 Site: position = -177 score = 4.8716 sequence = GAGTAAAATATTTCACAA Gene: TRQ2_1249: Putative oxidoreductase, COG0778	Thermotoga neapolitana DSM 4359	* Thermotoga petrophila RKU-1 Site: position = -177 score = 4.8716 sequence = GAGTAAAATATTTCACAA Gene: Tpet_1206: Putative oxidoreductase, COG0778	* Thermotoga naphthophila RKU-10 Site: position = -177 score = 4.8716 sequence = GAGTAAAATATTTCACAA Gene: Tnap_1222: Putative oxidoreductase, COG0778	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	Putative oxidoreductase, COG0778
gckA	Thermotoga maritima MSB8 Gene: TM1585: D-glycerate 2-kinase (EC 2.7.1.-), GK-II family	Thermotoga sp. RQ2 Gene: TRQ2_1248: D-glycerate 2-kinase (EC 2.7.1.-), GK-II family	Thermotoga neapolitana DSM 4359 Gene: CTN_1169: D-glycerate 2-kinase (EC 2.7.1.-), GK-II family	Thermotoga petrophila RKU-1 Gene: Tpet_1207: D-glycerate 2-kinase (EC 2.7.1.-), GK-II family	Thermotoga naphthophila RKU-10 Gene: Tnap_1223: D-glycerate 2-kinase (EC 2.7.1.-), GK-II family	Thermotoga lettingae TMO Gene: Tlet_1724: D-glycerate 2-kinase (EC 2.7.1.-), GK-II family	Thermosipho africanus TCF52B Gene: THA_302: D-glycerate 2-kinase (EC 2.7.1.-), GK-II family	Thermosipho melanesiensis BI429 Gene: Tmel_0085: D-glycerate 2-kinase (EC 2.7.1.-), GK-II family	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_1253: D-glycerate 2-kinase (EC 2.7.1.-), GK-II family	Petrotoga mobilis SJ95 Gene: Pmob_0534: D-glycerate 2-kinase (EC 2.7.1.-), GK-II family	Thermotogales bacterium TBF 19.5.1 Gene: Kole_1768: D-glycerate 2-kinase (EC 2.7.1.-), GK-II family	D-glycerate 2-kinase (EC 2.7.1.-), GK-II family
CRON 2.
TM0179	* Thermotoga maritima MSB8 Site: position = -30 score = 4.62536 sequence = TTGTTATAATAGTAACAA Gene: TM0179: hypothetical protein	* Thermotoga sp. RQ2 Site: position = -30 score = 4.62536 sequence = TTGTTATAATAGTAACAA Gene: TRQ2_0769: hypothetical protein	* Thermotoga neapolitana DSM 4359 Site: position = -30 score = 4.39653 sequence = TTGTTATAATGATATCAA Gene: CTN_0508: hypothetical protein	* Thermotoga petrophila RKU-1 Site: position = -30 score = 4.62536 sequence = TTGTTATAATAGTAACAA Gene: Tpet_0745: hypothetical protein	* Thermotoga naphthophila RKU-10 Site: position = -30 score = 4.62536 sequence = TTGTTATAATAGTAACAA Gene: Tnap_0810: hypothetical protein	Thermotoga lettingae TMO Gene: Tlet_0873: hypothetical protein	* Thermosipho africanus TCF52B Site: position = -35 score = 4.88149 sequence = TTGTGAATTTTTGCACTA Gene: THA_713: hypothetical protein	Thermosipho melanesiensis BI429 Gene: Tmel_0415: hypothetical protein	* Fervidobacterium nodosum Rt17-B1 Site: position = -86 score = 4.60494 sequence = TAGTGAAAAACTTGACAA Gene: Fnod_0241: hypothetical protein	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1 Gene: Kole_0974: hypothetical protein	hypothetical protein
CRON 3.
cas6	* Thermotoga maritima MSB8 Site: position = -40 score = 4.90924 sequence = ATGATAAAATTATCACAA Gene: TM1814: CRISPR/Cas system-associated RAMP superfamily protein Cas6	* Thermotoga sp. RQ2 Site: position = -40 score = 4.90924 sequence = ATGATAAAATTATCACAA Gene: TRQ2_1007: CRISPR/Cas system-associated RAMP superfamily protein Cas6	* Thermotoga neapolitana DSM 4359 Site: position = 117 score = 4.90924 sequence = aTGatAAAATTaTCACAA Gene: CTN_0700: CRISPR/Cas system-associated RAMP superfamily protein Cas6	* Thermotoga petrophila RKU-1 Site: position = -40 score = 4.90924 sequence = ATGATAAAATTATCACAA Gene: Tpet_1099: CRISPR/Cas system-associated RAMP superfamily protein Cas6	* Thermotoga naphthophila RKU-10 Site: position = -40 score = 4.90924 sequence = ATGATAAAATTATCACAA Gene: Tnap_1013: CRISPR/Cas system-associated RAMP superfamily protein Cas6	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	CRISPR/Cas system-associated RAMP superfamily protein Cas6
TM1813	Thermotoga maritima MSB8 Gene: TM1813: hypothetical protein	Thermotoga sp. RQ2	Thermotoga neapolitana DSM 4359	Thermotoga petrophila RKU-1	Thermotoga naphthophila RKU-10	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	hypothetical protein
csx1	Thermotoga maritima MSB8 Gene: TM1812: CRISPR/Cas system-associated protein Csx1	Thermotoga sp. RQ2 Gene: TRQ2_1008: CRISPR/Cas system-associated protein Csx1	Thermotoga neapolitana DSM 4359 Gene: CTN_0701: CRISPR/Cas system-associated protein Csx1	Thermotoga petrophila RKU-1 Gene: Tpet_1098: CRISPR/Cas system-associated protein Csx1	Thermotoga naphthophila RKU-10 Gene: Tnap_1014: CRISPR/Cas system-associated protein Csx1	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	CRISPR/Cas system-associated protein Csx1
cas10	Thermotoga maritima MSB8 Gene: TM1811: CRISPR/Cas system-associated protein Cas10	Thermotoga sp. RQ2 Gene: TRQ2_1009: CRISPR/Cas system-associated protein Cas10	Thermotoga neapolitana DSM 4359 Gene: CTN_0702: CRISPR/Cas system-associated protein Cas10	Thermotoga petrophila RKU-1 Gene: Tpet_1097: CRISPR/Cas system-associated protein Cas10	Thermotoga naphthophila RKU-10 Gene: Tnap_1015: CRISPR/Cas system-associated protein Cas10	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	CRISPR/Cas system-associated protein Cas10
csm2	Thermotoga maritima MSB8 Gene: TM1810: CRISPR/Cas system-associated protein Csm2	Thermotoga sp. RQ2 Gene: TRQ2_1010: CRISPR/Cas system-associated protein Csm2	Thermotoga neapolitana DSM 4359	Thermotoga petrophila RKU-1 Gene: Tpet_1096: CRISPR/Cas system-associated protein Csm2	Thermotoga naphthophila RKU-10 Gene: Tnap_1016: CRISPR/Cas system-associated protein Csm2	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	CRISPR/Cas system-associated protein Csm2
csm3	Thermotoga maritima MSB8 Gene: TM1809: CRISPR/Cas system-associated RAMP superfamily protein Csm3	Thermotoga sp. RQ2 Gene: TRQ2_1011: CRISPR/Cas system-associated RAMP superfamily protein Csm3	Thermotoga neapolitana DSM 4359	Thermotoga petrophila RKU-1 Gene: Tpet_1095: CRISPR/Cas system-associated RAMP superfamily protein Csm3	Thermotoga naphthophila RKU-10 Gene: Tnap_1017: CRISPR/Cas system-associated RAMP superfamily protein Csm3	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	CRISPR/Cas system-associated RAMP superfamily protein Csm3
csm4	Thermotoga maritima MSB8 Gene: TM1808: CRISPR/Cas system-associated RAMP superfamily protein Csm4	Thermotoga sp. RQ2 Gene: TRQ2_1012: CRISPR/Cas system-associated RAMP superfamily protein Csm4	Thermotoga neapolitana DSM 4359	Thermotoga petrophila RKU-1 Gene: Tpet_1094: CRISPR/Cas system-associated RAMP superfamily protein Csm4	Thermotoga naphthophila RKU-10 Gene: Tnap_1018: CRISPR/Cas system-associated RAMP superfamily protein Csm4	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	CRISPR/Cas system-associated RAMP superfamily protein Csm4
csm5	Thermotoga maritima MSB8 Gene: TM1807: CRISPR/Cas system-associated RAMP superfamily protein Csm5	Thermotoga sp. RQ2 Gene: TRQ2_1013: CRISPR/Cas system-associated RAMP superfamily protein Csm5	Thermotoga neapolitana DSM 4359	Thermotoga petrophila RKU-1 Gene: Tpet_1093: CRISPR/Cas system-associated RAMP superfamily protein Csm5	Thermotoga naphthophila RKU-10 Gene: Tnap_1019: CRISPR/Cas system-associated RAMP superfamily protein Csm5	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	CRISPR/Cas system-associated RAMP superfamily protein Csm5
TM1806	Thermotoga maritima MSB8 Gene: TM1806: hypothetical protein	Thermotoga sp. RQ2 Gene: TRQ2_1014: hypothetical protein	Thermotoga neapolitana DSM 4359	Thermotoga petrophila RKU-1 Gene: Tpet_1092: hypothetical protein	Thermotoga naphthophila RKU-10 Gene: Tnap_1020: hypothetical protein	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	hypothetical protein
CRON 4.
TM0983	* Thermotoga maritima MSB8 Site: position = -41 score = 5.13954 sequence = TTGAGATTTTTTTCACAA Gene: TM0983: conserved hypothetical protein, SirA family	* Thermotoga sp. RQ2 Site: position = -62 score = 4.67089 sequence = ATGTTATCATTTTCACAA Site: position = -41 score = 5.13954 sequence = TTGAGATTTTTTTCACAA Gene: TRQ2_1812: conserved hypothetical protein, SirA family	* Thermotoga neapolitana DSM 4359 Site: position = -32 score = 5.13954 sequence = TTGAGATTTTTTTCACAA Gene: CTN_1595: conserved hypothetical protein, SirA family	* Thermotoga petrophila RKU-1 Site: position = -41 score = 5.13954 sequence = TTGAGATTTTTTTCACAA Site: position = -62 score = 4.67089 sequence = ATGTTATCATTTTCACAA Gene: Tpet_1758: conserved hypothetical protein, SirA family	* Thermotoga naphthophila RKU-10 Site: position = -63 score = 4.67089 sequence = ATGTTATCATTTTCACAA Gene: Tnap_1770: conserved hypothetical protein, SirA family	* Thermotoga lettingae TMO Site: position = -34 score = 4.8774 sequence = TcGatAtttTTTTCACgA Gene: Tlet_1312: conserved hypothetical protein, SirA family	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	conserved hypothetical protein, SirA family
TM0982	Thermotoga maritima MSB8 Gene: TM0982: protein of unknown function DUF395 YeeE/YedE	Thermotoga sp. RQ2	Thermotoga neapolitana DSM 4359 Gene: CTN_1596: protein of unknown function DUF395 YeeE/YedE	Thermotoga petrophila RKU-1 Gene: Tpet_1759: protein of unknown function DUF395 YeeE/YedE	Thermotoga naphthophila RKU-10	Thermotoga lettingae TMO Gene: Tlet_1313: protein of unknown function DUF395 YeeE/YedE	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	protein of unknown function DUF395 YeeE/YedE
TM0981	Thermotoga maritima MSB8 Gene: TM0981: DsrE family protein	Thermotoga sp. RQ2 Gene: TRQ2_1814: DsrE family protein	Thermotoga neapolitana DSM 4359 Gene: CTN_1597: DsrE family protein	Thermotoga petrophila RKU-1 Gene: Tpet_1760: DsrE family protein	Thermotoga naphthophila RKU-10 Gene: Tnap_1772: DsrE family protein	Thermotoga lettingae TMO Gene: Tlet_1314: DsrE family protein	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	DsrE family protein
TM0980	Thermotoga maritima MSB8 Gene: TM0980: uncharacterized protein involved in the oxidation of intracellular sulfur-like protein	Thermotoga sp. RQ2 Gene: TRQ2_1815: uncharacterized protein involved in the oxidation of intracellular sulfur-like protein	Thermotoga neapolitana DSM 4359 Gene: CTN_1598: uncharacterized protein involved in the oxidation of intracellular sulfur-like protein	Thermotoga petrophila RKU-1 Gene: Tpet_1761: uncharacterized protein involved in the oxidation of intracellular sulfur-like protein	Thermotoga naphthophila RKU-10 Gene: Tnap_1773: uncharacterized protein involved in the oxidation of intracellular sulfur-like protein	Thermotoga lettingae TMO Gene: Tlet_1315: uncharacterized protein involved in the oxidation of intracellular sulfur-like protein	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	uncharacterized protein involved in the oxidation of intracellular sulfur-like protein
TM0979	Thermotoga maritima MSB8 Gene: TM0979: DsrH family protein	Thermotoga sp. RQ2 Gene: TRQ2_1816: DsrH family protein	Thermotoga neapolitana DSM 4359 Gene: CTN_1599: DsrH family protein	Thermotoga petrophila RKU-1 Gene: Tpet_1762: DsrH family protein	Thermotoga naphthophila RKU-10 Gene: Tnap_1774: DsrH family protein	Thermotoga lettingae TMO Gene: Tlet_1316: DsrH family protein	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	DsrH family protein
CRON 5.
Pmob_0727	Thermotoga maritima MSB8	Thermotoga sp. RQ2	Thermotoga neapolitana DSM 4359	Thermotoga petrophila RKU-1	Thermotoga naphthophila RKU-10	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	*2 Petrotoga mobilis SJ95 Site: position = -133 score = 5.31639 sequence = ATGTGAATATTTTCACAA Gene: Pmob_0728: oxidoreductase domain protein Gene: Pmob_0727: oxidoreductase domain protein	Thermotogales bacterium TBF 19.5.1	oxidoreductase domain protein
hycA	* Thermotoga maritima MSB8 Site: position = -27 score = 4.26228 sequence = aTGTGAAAAaaaTatCAg Site: position = -2 score = 5.03107 sequence = TTGTGAAAAaaTTCcCgA Gene: TM0012: NAD-reducing Fe-hydrogenase, subunit HycA (EC 1.12.7.2)	* Thermotoga sp. RQ2 Site: position = -44 score = 5.03107 sequence = TTGTGAAAAAATTCCCGA Site: position = -69 score = 4.26228 sequence = ATGTGAAAAAAATATCAG Gene: TRQ2_0933: NAD-reducing Fe-hydrogenase, subunit HycA (EC 1.12.7.2)	* Thermotoga neapolitana DSM 4359 Site: position = -61 score = 4.26228 sequence = ATGTGAAAAAAATATCAG Site: position = -36 score = 5.21271 sequence = TTGTGAAAAAATTCTCGA Gene: CTN_0686: NAD-reducing Fe-hydrogenase, subunit HycA (EC 1.12.7.2)	* Thermotoga petrophila RKU-1 Site: position = -69 score = 4.26228 sequence = ATGTGAAAAAAATATCAG Site: position = -44 score = 5.03107 sequence = TTGTGAAAAAATTCCCGA Gene: Tpet_0911: NAD-reducing Fe-hydrogenase, subunit HycA (EC 1.12.7.2)	* Thermotoga naphthophila RKU-10 Site: position = -44 score = 5.03107 sequence = TTGTGAAAAAATTCCCGA Site: position = -69 score = 4.26228 sequence = ATGTGAAAAAAATATCAG Gene: Tnap_0643: NAD-reducing Fe-hydrogenase, subunit HycA (EC 1.12.7.2)	* Thermotoga lettingae TMO Site: position = -30 score = 4.83756 sequence = TTGTGAATTTATTAACAG Gene: Tlet_1522: NAD-reducing Fe-hydrogenase, subunit HycA (EC 1.12.7.2)	* Thermosipho africanus TCF52B Site: position = 12 score = 4.20874 sequence = TTGTGAAAAacaTgtCgA Site: position = -65 score = 4.59739 sequence = aaGTGAAAtTTTTtACtt Gene: THA_1559: NAD-reducing Fe-hydrogenase, subunit HycA (EC 1.12.7.2)	* Thermosipho melanesiensis BI429 Site: position = 9 score = 4.20874 sequence = TTGTGAAAAacaTgtCgA Site: position = -68 score = 4.45741 sequence = aaGTGAAttTTTTtACtt Gene: Tmel_1172: NAD-reducing Fe-hydrogenase, subunit HycA (EC 1.12.7.2)	* Fervidobacterium nodosum Rt17-B1 Site: position = -38 score = 4.82917 sequence = ATGTTATAATAATCACGA Gene: Fnod_0995: NAD-reducing Fe-hydrogenase, subunit HycA (EC 1.12.7.2)	*2 Petrotoga mobilis SJ95 Gene: Pmob_0726: NAD-reducing Fe-hydrogenase, subunit HycA (EC 1.12.7.2) Site: position = -36 score = 5.35947 sequence = TAGTGAAAATATTAACAA Gene: Pmob_1151: NAD-reducing Fe-hydrogenase, subunit HycA (EC 1.12.7.2)	* Thermotogales bacterium TBF 19.5.1 Site: position = -71 score = 4.64776 sequence = aaGTGAAAtaaaTaACAt Gene: Kole_0180: NAD-reducing Fe-hydrogenase, subunit HycA (EC 1.12.7.2)	NAD-reducing Fe-hydrogenase, subunit HycA (EC 1.12.7.2)
hycB	Thermotoga maritima MSB8 Gene: TM0011: NAD-reducing Fe-hydrogenase, subunit HycB (EC 1.12.7.2)	Thermotoga sp. RQ2 Gene: TRQ2_0934: NAD-reducing Fe-hydrogenase, subunit HycB (EC 1.12.7.2)	Thermotoga neapolitana DSM 4359 Gene: CTN_0687: NAD-reducing Fe-hydrogenase, subunit HycB (EC 1.12.7.2)	Thermotoga petrophila RKU-1 Gene: Tpet_0912: NAD-reducing Fe-hydrogenase, subunit HycB (EC 1.12.7.2)	Thermotoga naphthophila RKU-10 Gene: Tnap_0642: NAD-reducing Fe-hydrogenase, subunit HycB (EC 1.12.7.2)	Thermotoga lettingae TMO Gene: Tlet_1521: NAD-reducing Fe-hydrogenase, subunit HycB (EC 1.12.7.2)	Thermosipho africanus TCF52B Gene: THA_1558: NAD-reducing Fe-hydrogenase, subunit HycB (EC 1.12.7.2)	Thermosipho melanesiensis BI429 Gene: Tmel_1171: NAD-reducing Fe-hydrogenase, subunit HycB (EC 1.12.7.2)	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0994: NAD-reducing Fe-hydrogenase, subunit HycB (EC 1.12.7.2)	Petrotoga mobilis SJ95 Gene: Pmob_0725: NAD-reducing Fe-hydrogenase, subunit HycB (EC 1.12.7.2)	Thermotogales bacterium TBF 19.5.1 Gene: Kole_0181: NAD-reducing Fe-hydrogenase, subunit HycB (EC 1.12.7.2)	NAD-reducing Fe-hydrogenase, subunit HycB (EC 1.12.7.2)
hycC	Thermotoga maritima MSB8 Gene: TM0010: NAD-reducing Fe-hydrogenase, subunit HycC (EC 1.12.7.2)	Thermotoga sp. RQ2 Gene: TRQ2_0935: NAD-reducing Fe-hydrogenase, subunit HycC (EC 1.12.7.2)	Thermotoga neapolitana DSM 4359 Gene: CTN_0688: NAD-reducing Fe-hydrogenase, subunit HycC (EC 1.12.7.2)	Thermotoga petrophila RKU-1 Gene: Tpet_0913: NAD-reducing Fe-hydrogenase, subunit HycC (EC 1.12.7.2)	Thermotoga naphthophila RKU-10 Gene: Tnap_0641: NAD-reducing Fe-hydrogenase, subunit HycC (EC 1.12.7.2)	Thermotoga lettingae TMO Gene: Tlet_1520: NAD-reducing Fe-hydrogenase, subunit HycC (EC 1.12.7.2)	Thermosipho africanus TCF52B Gene: THA_1556: NAD-reducing Fe-hydrogenase, subunit HycC (EC 1.12.7.2)	Thermosipho melanesiensis BI429 Gene: Tmel_1170: NAD-reducing Fe-hydrogenase, subunit HycC (EC 1.12.7.2)	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0993: NAD-reducing Fe-hydrogenase, subunit HycC (EC 1.12.7.2)	2 Petrotoga mobilis SJ95 Gene: Pmob_0724: NAD-reducing Fe-hydrogenase, subunit HycC (EC 1.12.7.2) Gene: Pmob_1150: NAD-reducing Fe-hydrogenase, subunit HycC (EC 1.12.7.2)	Thermotogales bacterium TBF 19.5.1 Gene: Kole_0182: NAD-reducing Fe-hydrogenase, subunit HycC (EC 1.12.7.2)	NAD-reducing Fe-hydrogenase, subunit HycC (EC 1.12.7.2)
hycD	* Thermotoga maritima MSB8 Site: position = 24 score = 5.27953 sequence = TTGAGAAATTTATCACAA Gene: TM0201: NAD-reducing Fe-hydrogenase, subunit HycD (EC 1.12.7.2)	* Thermotoga sp. RQ2 Site: position = -54 score = 5.27953 sequence = TTGAGAAATTTATCACAA Gene: TRQ2_0747: NAD-reducing Fe-hydrogenase, subunit HycD (EC 1.12.7.2)	* Thermotoga neapolitana DSM 4359 Site: position = 0 score = 5.13954 sequence = TTGAGAATTTTATCACAA Gene: CTN_0485: NAD-reducing Fe-hydrogenase, subunit HycD (EC 1.12.7.2)	* Thermotoga petrophila RKU-1 Site: position = -54 score = 5.27953 sequence = TTGAGAAATTTATCACAA Gene: Tpet_0723: NAD-reducing Fe-hydrogenase, subunit HycD (EC 1.12.7.2)	* Thermotoga naphthophila RKU-10 Site: position = -54 score = 5.27953 sequence = TTGAGAAATTTATCACAA Gene: Tnap_0831: NAD-reducing Fe-hydrogenase, subunit HycD (EC 1.12.7.2)	* Thermotoga lettingae TMO Site: position = -42 score = 4.73353 sequence = ATGTGAATACTTTAACAA Gene: Tlet_1350: NAD-reducing Fe-hydrogenase, subunit HycD (EC 1.12.7.2)	* Thermosipho africanus TCF52B Site: position = -106 score = 4.69619 sequence = TTGTGAtAtaaTTtACtt Gene: THA_1808: NAD-reducing Fe-hydrogenase, subunit HycD (EC 1.12.7.2)	* Thermosipho melanesiensis BI429 Site: position = -108 score = 4.69619 sequence = TTGTGAtAtaaTTtACtt Gene: Tmel_1601: NAD-reducing Fe-hydrogenase, subunit HycD (EC 1.12.7.2)	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0236: NAD-reducing Fe-hydrogenase, subunit HycD (EC 1.12.7.2)	*2 Petrotoga mobilis SJ95 Gene: Pmob_0723: NAD-reducing Fe-hydrogenase, subunit HycD (EC 1.12.7.2) Site: position = -31 score = 4.85594 sequence = TTGAGAAATTTTACACAA Gene: Pmob_1149: NAD-reducing Fe-hydrogenase, subunit HycD (EC 1.12.7.2)	* Thermotogales bacterium TBF 19.5.1 Site: position = -57 score = 4.65462 sequence = TTGATAGAAAATTCACAA Gene: Kole_0172: NAD-reducing Fe-hydrogenase, subunit HycD (EC 1.12.7.2)	NAD-reducing Fe-hydrogenase, subunit HycD (EC 1.12.7.2)
hycE	Thermotoga maritima MSB8	* Thermotoga sp. RQ2 Site: position = -30 score = 5.25055 sequence = TTGTGAAATTTTTGACGA Gene: TRQ2_0721: NAD-reducing Fe-hydrogenase, subunit HycE (EC 1.12.7.2)	* Thermotoga neapolitana DSM 4359 Site: position = 8 score = 5.25055 sequence = TTGTGAAATTTTTGACGA Gene: CTN_0459: NAD-reducing Fe-hydrogenase, subunit HycE (EC 1.12.7.2)	* Thermotoga petrophila RKU-1 Site: position = -30 score = 5.25055 sequence = TTGTGAAATTTTTGACGA Gene: Tpet_0697: NAD-reducing Fe-hydrogenase, subunit HycE (EC 1.12.7.2)	* Thermotoga naphthophila RKU-10 Site: position = -30 score = 5.25055 sequence = TTGTGAAATTTTTGACGA Gene: Tnap_0857: NAD-reducing Fe-hydrogenase, subunit HycE (EC 1.12.7.2)	Thermotoga lettingae TMO Gene: Tlet_1519: NAD-reducing Fe-hydrogenase, subunit HycE (EC 1.12.7.2)	Thermosipho africanus TCF52B Gene: THA_1555: NAD-reducing Fe-hydrogenase, subunit HycE (EC 1.12.7.2)	Thermosipho melanesiensis BI429 Gene: Tmel_1169: NAD-reducing Fe-hydrogenase, subunit HycE (EC 1.12.7.2)	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0992: NAD-reducing Fe-hydrogenase, subunit HycE (EC 1.12.7.2)	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1 Gene: Kole_0183: NAD-reducing Fe-hydrogenase, subunit HycE (EC 1.12.7.2)	NAD-reducing Fe-hydrogenase, subunit HycE (EC 1.12.7.2)
hycF	* Thermotoga maritima MSB8 Site: position = -499 score = 5.25055 sequence = TTGTGAAATTTTTGACGA Gene: TM0228: NAD-reducing Fe-hydrogenase, subunit HycF (EC 1.12.7.2)	Thermotoga sp. RQ2 Gene: TRQ2_0720: NAD-reducing Fe-hydrogenase, subunit HycF (EC 1.12.7.2)	Thermotoga neapolitana DSM 4359 Gene: CTN_0458: NAD-reducing Fe-hydrogenase, subunit HycF (EC 1.12.7.2)	Thermotoga petrophila RKU-1 Gene: Tpet_0696: NAD-reducing Fe-hydrogenase, subunit HycF (EC 1.12.7.2)	Thermotoga naphthophila RKU-10 Gene: Tnap_0858: NAD-reducing Fe-hydrogenase, subunit HycF (EC 1.12.7.2)	Thermotoga lettingae TMO Gene: Tlet_1518: NAD-reducing Fe-hydrogenase, subunit HycF (EC 1.12.7.2)	Thermosipho africanus TCF52B Gene: THA_1554: NAD-reducing Fe-hydrogenase, subunit HycF (EC 1.12.7.2)	Thermosipho melanesiensis BI429 Gene: Tmel_1168: NAD-reducing Fe-hydrogenase, subunit HycF (EC 1.12.7.2)	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0991: NAD-reducing Fe-hydrogenase, subunit HycF (EC 1.12.7.2)	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1 Gene: Kole_0184: NAD-reducing Fe-hydrogenase, subunit HycF (EC 1.12.7.2)	NAD-reducing Fe-hydrogenase, subunit HycF (EC 1.12.7.2)
TM0009	Thermotoga maritima MSB8 Gene: TM0009: rubrerythrin	Thermotoga sp. RQ2 Gene: TRQ2_0936: rubrerythrin	Thermotoga neapolitana DSM 4359 Gene: CTN_0689: rubrerythrin	Thermotoga petrophila RKU-1 Gene: Tpet_0914: rubrerythrin	Thermotoga naphthophila RKU-10 Gene: Tnap_0640: rubrerythrin	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	rubrerythrin
CRON 6.
dnaX	* Thermotoga maritima MSB8 Site: position = -104 score = 5.12168 sequence = TaGTtAtttTTTTCACgA Gene: TM0686: DNA polymerase III subunits gamma and tau	* Thermotoga sp. RQ2 Site: position = -104 score = 5.12168 sequence = TAGTTATTTTTTTCACGA Gene: TRQ2_0243: DNA polymerase III subunits gamma and tau	* Thermotoga neapolitana DSM 4359 Site: position = -103 score = 5.12168 sequence = TAGTTATTTTTTTCACGA Gene: CTN_1900: DNA polymerase III subunits gamma and tau	* Thermotoga petrophila RKU-1 Site: position = -104 score = 5.12168 sequence = TAGTTATTTTTTTCACGA Gene: Tpet_0245: DNA polymerase III subunits gamma and tau	* Thermotoga naphthophila RKU-10 Site: position = -104 score = 5.12168 sequence = TAGTTATTTTTTTCACGA Gene: Tnap_0482: DNA polymerase III subunits gamma and tau	* Thermotoga lettingae TMO Site: position = -29 score = 4.00202 sequence = cTGTtAtAATTTaatCAA Gene: Tlet_1000: DNA polymerase III subunits gamma and tau	Thermosipho africanus TCF52B Gene: THA_1713: DNA polymerase III subunits gamma and tau	Thermosipho melanesiensis BI429 Gene: Tmel_1397: DNA polymerase III subunits gamma and tau	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0277: DNA polymerase III subunits gamma and tau	Petrotoga mobilis SJ95 Gene: Pmob_1414: DNA polymerase III subunits gamma and tau	* Thermotogales bacterium TBF 19.5.1 Site: position = -90 score = 5.35235 sequence = TaGTtAAtAaTTTCACAA Gene: Kole_2018: DNA polymerase III subunits gamma and tau	DNA polymerase III subunits gamma and tau
TM0687	Thermotoga maritima MSB8 Gene: TM0687: conserved probable DNA binding protein, similar to YbaB family	Thermotoga sp. RQ2	Thermotoga neapolitana DSM 4359 Gene: CTN_1899: conserved probable DNA binding protein, similar to YbaB family	Thermotoga petrophila RKU-1 Gene: Tpet_0244: conserved probable DNA binding protein, similar to YbaB family	Thermotoga naphthophila RKU-10 Gene: Tnap_0483: conserved probable DNA binding protein, similar to YbaB family	Thermotoga lettingae TMO Gene: Tlet_0999: conserved probable DNA binding protein, similar to YbaB family	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1 Gene: Kole_2019: conserved probable DNA binding protein, similar to YbaB family	conserved probable DNA binding protein, similar to YbaB family
gap	Thermotoga maritima MSB8 Gene: TM0688: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	Thermotoga sp. RQ2 Gene: TRQ2_0241: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	Thermotoga neapolitana DSM 4359 Gene: CTN_1898: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	Thermotoga petrophila RKU-1 Gene: Tpet_0243: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	Thermotoga naphthophila RKU-10 Gene: Tnap_0484: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	Thermotoga lettingae TMO Gene: Tlet_0998: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	* Thermosipho africanus TCF52B Site: position = -44 score = 5.18923 sequence = TaGTaAAAtTTTTCACgA Gene: THA_1607: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	* Thermosipho melanesiensis BI429 Site: position = -45 score = 5.18923 sequence = TaGTaAAAtTTTTCACgA Gene: Tmel_1266: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	* Fervidobacterium nodosum Rt17-B1 Site: position = -77 score = 4.73878 sequence = TTGTacAAtTTTTCACgA Gene: Fnod_0740: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	* Petrotoga mobilis SJ95 Site: position = -43 score = 4.63709 sequence = aaGaGAAAAaaaTaACAA Gene: Pmob_1445: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	Thermotogales bacterium TBF 19.5.1 Gene: Kole_2020: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)	NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12)
pgk	Thermotoga maritima MSB8 Gene: TM0689: Phosphoglycerate kinase (EC 2.7.2.3)	Thermotoga sp. RQ2 Gene: TRQ2_0240: Phosphoglycerate kinase (EC 2.7.2.3)	Thermotoga neapolitana DSM 4359 Gene: CTN_1897: Phosphoglycerate kinase (EC 2.7.2.3)	Thermotoga petrophila RKU-1 Gene: Tpet_0242: Phosphoglycerate kinase (EC 2.7.2.3)	Thermotoga naphthophila RKU-10 Gene: Tnap_0485: Phosphoglycerate kinase (EC 2.7.2.3)	Thermotoga lettingae TMO Gene: Tlet_0997: Phosphoglycerate kinase (EC 2.7.2.3)	Thermosipho africanus TCF52B Gene: THA_1606: Phosphoglycerate kinase (EC 2.7.2.3)	Thermosipho melanesiensis BI429 Gene: Tmel_1265: Phosphoglycerate kinase (EC 2.7.2.3)	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0739: Phosphoglycerate kinase (EC 2.7.2.3)	Petrotoga mobilis SJ95 Gene: Pmob_1444: Phosphoglycerate kinase (EC 2.7.2.3)	Thermotogales bacterium TBF 19.5.1 Gene: Kole_2021: Phosphoglycerate kinase (EC 2.7.2.3)	Phosphoglycerate kinase (EC 2.7.2.3)
tpi	Thermotoga maritima MSB8	Thermotoga sp. RQ2 Gene: TRQ2_0239: Triosephosphate isomerase (EC 5.3.1.1)	Thermotoga neapolitana DSM 4359 Gene: CTN_1896: Triosephosphate isomerase (EC 5.3.1.1)	Thermotoga petrophila RKU-1 Gene: Tpet_0241: Triosephosphate isomerase (EC 5.3.1.1)	Thermotoga naphthophila RKU-10 Gene: Tnap_0486: Triosephosphate isomerase (EC 5.3.1.1)	Thermotoga lettingae TMO Gene: Tlet_0996: Triosephosphate isomerase (EC 5.3.1.1)	Thermosipho africanus TCF52B Gene: THA_1605: Triosephosphate isomerase (EC 5.3.1.1)	Thermosipho melanesiensis BI429 Gene: Tmel_1264: Triosephosphate isomerase (EC 5.3.1.1)	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0738: Triosephosphate isomerase (EC 5.3.1.1)	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1 Gene: Kole_2022: Triosephosphate isomerase (EC 5.3.1.1)	Triosephosphate isomerase (EC 5.3.1.1)
CRON 7.
sat	* Thermotoga maritima MSB8 Site: position = -47 score = 5.09579 sequence = TAGTTAAAAAAATAACAA Gene: TM1400: Serine aminotransferase (EC 2.6.5.1)	* Thermotoga sp. RQ2 Site: position = -47 score = 5.09579 sequence = TAGTTAAAAAAATAACAA Gene: TRQ2_1429: Serine aminotransferase (EC 2.6.5.1)	* Thermotoga neapolitana DSM 4359 Site: position = -47 score = 5.09579 sequence = TAGTTAAAAAAATAACAA Gene: CTN_1191: Serine aminotransferase (EC 2.6.5.1)	* Thermotoga petrophila RKU-1 Site: position = -47 score = 5.09579 sequence = TAGTTAAAAAAATAACAA Gene: Tpet_1383: Serine aminotransferase (EC 2.6.5.1)	* Thermotoga naphthophila RKU-10 Site: position = -47 score = 5.09579 sequence = TAGTTAAAAAAATAACAA Gene: Tnap_1403: Serine aminotransferase (EC 2.6.5.1)	Thermotoga lettingae TMO Gene: Tlet_1767: Serine aminotransferase (EC 2.6.5.1)	Thermosipho africanus TCF52B Gene: THA_344: Serine aminotransferase (EC 2.6.5.1)	Thermosipho melanesiensis BI429 Gene: Tmel_0111: Serine aminotransferase (EC 2.6.5.1)	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0104: Serine aminotransferase (EC 2.6.5.1)	Petrotoga mobilis SJ95 Gene: Pmob_0257: Serine aminotransferase (EC 2.6.5.1)	Thermotogales bacterium TBF 19.5.1 Gene: Kole_2168: Serine aminotransferase (EC 2.6.5.1)	Serine aminotransferase (EC 2.6.5.1)
hpr	Thermotoga maritima MSB8 Gene: TM1401: Hydroxypyruvate reductase (EC 1.1.1.81)	Thermotoga sp. RQ2 Gene: TRQ2_1428: Hydroxypyruvate reductase (EC 1.1.1.81)	Thermotoga neapolitana DSM 4359 Gene: CTN_1190: Hydroxypyruvate reductase (EC 1.1.1.81)	Thermotoga petrophila RKU-1 Gene: Tpet_1382: Hydroxypyruvate reductase (EC 1.1.1.81)	Thermotoga naphthophila RKU-10 Gene: Tnap_1402: Hydroxypyruvate reductase (EC 1.1.1.81)	Thermotoga lettingae TMO Gene: Tlet_1768: Hydroxypyruvate reductase (EC 1.1.1.81)	Thermosipho africanus TCF52B Gene: THA_345: Hydroxypyruvate reductase (EC 1.1.1.81)	Thermosipho melanesiensis BI429 Gene: Tmel_0112: Hydroxypyruvate reductase (EC 1.1.1.81)	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0103: Hydroxypyruvate reductase (EC 1.1.1.81)	Petrotoga mobilis SJ95 Gene: Pmob_0258: Hydroxypyruvate reductase (EC 1.1.1.81)	Thermotogales bacterium TBF 19.5.1 Gene: Kole_2169: Hydroxypyruvate reductase (EC 1.1.1.81)	Hydroxypyruvate reductase (EC 1.1.1.81)
CRON 8.
adhA	Thermotoga maritima MSB8	* Thermotoga sp. RQ2 Site: position = -85 score = 5.04932 sequence = GTGAGAAAATTTTCACAA Site: position = -61 score = 4.72615 sequence = TTGTTATGAAATTCACAA Gene: TRQ2_0578: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent	Thermotoga neapolitana DSM 4359	* Thermotoga petrophila RKU-1 Site: position = -193 score = 4.72615 sequence = TTGTTATGAAATTCACAA Site: position = -217 score = 5.04932 sequence = GTGAGAAAATTTTCACAA Gene: Tpet_0563: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent	* Thermotoga naphthophila RKU-10 Site: position = -100 score = 5.04932 sequence = GTGAGAAAATTTTCACAA Site: position = -76 score = 4.72615 sequence = TTGTTATGAAATTCACAA Gene: Tnap_0992: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent	Thermotoga lettingae TMO	* Thermosipho africanus TCF52B Site: position = -95 score = 5.31989 sequence = TcGTGAAAAaaTTaACgA Site: position = -29 score = 5.08931 sequence = TTGTGAAAATATTCACAG Gene: THA_374: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent	* Thermosipho melanesiensis BI429 Site: position = -95 score = 4.66813 sequence = ccGTGAAAAaaaTaACgA Site: position = -29 score = 5.08931 sequence = TTGTGAAAATATTCACAG Gene: Tmel_0139: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent	* Fervidobacterium nodosum Rt17-B1 Site: position = -78 score = 5.03231 sequence = AAGTGATTTTTTTCACAA Gene: Fnod_1174: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent	Petrotoga mobilis SJ95 Gene: Pmob_1193: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent	* Thermotogales bacterium TBF 19.5.1 Site: position = -111 score = 4.80942 sequence = cTGTGAAAAaaTTCACAt Site: position = -33 score = 5.18422 sequence = AAGTGAAAAAATTCACAA Gene: Kole_0742: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent	Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent
CRON 9.
gldA	* Thermotoga maritima MSB8 Site: position = -52 score = 5.53862 sequence = TCGTGAAAAATTTAACAA Gene: TM0423: Glycerol dehydrogenase (EC 1.1.1.6)	* Thermotoga sp. RQ2 Site: position = -52 score = 5.53862 sequence = TCGTGAAAAATTTAACAA Gene: TRQ2_0522: Glycerol dehydrogenase (EC 1.1.1.6)	* Thermotoga neapolitana DSM 4359 Site: position = -30 score = 4.13555 sequence = TTGTGAAATACGTAACAT Gene: CTN_0247: Glycerol dehydrogenase (EC 1.1.1.6)	* Thermotoga petrophila RKU-1 Site: position = -52 score = 5.53862 sequence = TCGTGAAAAATTTAACAA Gene: Tpet_0498: Glycerol dehydrogenase (EC 1.1.1.6)	Thermotoga naphthophila RKU-10	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1 Gene: Kole_0505: Glycerol dehydrogenase (EC 1.1.1.6)	Glycerol dehydrogenase (EC 1.1.1.6)
CRON 10.
TM1420	* Thermotoga maritima MSB8 Site: position = -45 score = 4.98889 sequence = TaGTGAAAAaTaTaACgt Gene: TM1420: Fe-hydrogenase, thioredoxin subunit, 2Fe-2S cluster binding protein	* Thermotoga sp. RQ2 Site: position = -51 score = 4.98889 sequence = TaGTGAAAAaTaTaACgt Gene: TRQ2_1314: Fe-hydrogenase, thioredoxin subunit, 2Fe-2S cluster binding protein	* Thermotoga neapolitana DSM 4359 Site: position = -51 score = 4.98889 sequence = TaGTGAAAAaTaTaACgt Gene: CTN_1072: Fe-hydrogenase, thioredoxin subunit, 2Fe-2S cluster binding protein	* Thermotoga petrophila RKU-1 Site: position = -69 score = 4.98889 sequence = TaGTGAAAAaTaTaACgt Gene: Tpet_1372: Fe-hydrogenase, thioredoxin subunit, 2Fe-2S cluster binding protein	* Thermotoga naphthophila RKU-10 Site: position = -51 score = 4.98889 sequence = TaGTGAAAAaTaTaACgt Gene: Tnap_1390: Fe-hydrogenase, thioredoxin subunit, 2Fe-2S cluster binding protein	* Thermotoga lettingae TMO Site: position = 32 score = 5.16085 sequence = TcGTGAAAtaaaTaACgA Site: position = 46 score = 4.74461 sequence = acGatAAAAaTaTCACgA Gene: Tlet_0957: Fe-hydrogenase, thioredoxin subunit, 2Fe-2S cluster binding protein	* Thermosipho africanus TCF52B Site: position = -35 score = 5.03518 sequence = acGTtAtAtTTTTCACgA Site: position = -49 score = 4.90233 sequence = TcGTGAAAATaaTaACgt Gene: THA_782: Fe-hydrogenase, thioredoxin subunit, 2Fe-2S cluster binding protein	* Thermosipho melanesiensis BI429 Site: position = -43 score = 5.03518 sequence = TcGTGAAAAaTaTaACgt Site: position = -29 score = 4.88807 sequence = acGTtAtttaTTTCACgA Gene: Tmel_0495: Fe-hydrogenase, thioredoxin subunit, 2Fe-2S cluster binding protein	* Fervidobacterium nodosum Rt17-B1 Site: position = -52 score = 5.31276 sequence = TcGTGAAAtaaTTaACgA Gene: Fnod_0319: Fe-hydrogenase, thioredoxin subunit, 2Fe-2S cluster binding protein	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	Fe-hydrogenase, thioredoxin subunit, 2Fe-2S cluster binding protein
TM1421	2 Thermotoga maritima MSB8 Gene: TM1422: Fe-hydrogenase, 2Fe-2S iron-sulfur cluster binding protein Gene: TM1421: Fe-hydrogenase, 2Fe-2S iron-sulfur cluster binding protein	Thermotoga sp. RQ2 Gene: TRQ2_1315: Fe-hydrogenase, 2Fe-2S iron-sulfur cluster binding protein	Thermotoga neapolitana DSM 4359 Gene: CTN_1071: Fe-hydrogenase, 2Fe-2S iron-sulfur cluster binding protein	Thermotoga petrophila RKU-1 Gene: Tpet_1371: Fe-hydrogenase, 2Fe-2S iron-sulfur cluster binding protein	Thermotoga naphthophila RKU-10 Gene: Tnap_1389: Fe-hydrogenase, 2Fe-2S iron-sulfur cluster binding protein	Thermotoga lettingae TMO Gene: Tlet_0956: Fe-hydrogenase, 2Fe-2S iron-sulfur cluster binding protein	Thermosipho africanus TCF52B Gene: THA_783: Fe-hydrogenase, 2Fe-2S iron-sulfur cluster binding protein	Thermosipho melanesiensis BI429 Gene: Tmel_0494: Fe-hydrogenase, 2Fe-2S iron-sulfur cluster binding protein	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0318: Fe-hydrogenase, 2Fe-2S iron-sulfur cluster binding protein	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	Fe-hydrogenase, 2Fe-2S iron-sulfur cluster binding protein
TM1423	Thermotoga maritima MSB8 Gene: TM1423: predicted protein serine/threonine phosphatase	Thermotoga sp. RQ2 Gene: TRQ2_1316: predicted protein serine/threonine phosphatase	Thermotoga neapolitana DSM 4359 Gene: CTN_1070: predicted protein serine/threonine phosphatase	Thermotoga petrophila RKU-1 Gene: Tpet_1370: predicted protein serine/threonine phosphatase	Thermotoga naphthophila RKU-10	Thermotoga lettingae TMO Gene: Tlet_0955: predicted protein serine/threonine phosphatase	Thermosipho africanus TCF52B Gene: THA_784: predicted protein serine/threonine phosphatase	Thermosipho melanesiensis BI429 Gene: Tmel_0493: predicted protein serine/threonine phosphatase	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0317: predicted protein serine/threonine phosphatase	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	predicted protein serine/threonine phosphatase
hydC	Thermotoga maritima MSB8 Gene: TM1424: Fe-hydrogenase, gamma subunit, FeS cluster containing	Thermotoga sp. RQ2 Gene: TRQ2_1317: Fe-hydrogenase, gamma subunit, FeS cluster containing	Thermotoga neapolitana DSM 4359 Gene: CTN_1069: Fe-hydrogenase, gamma subunit, FeS cluster containing	Thermotoga petrophila RKU-1 Gene: Tpet_1369: Fe-hydrogenase, gamma subunit, FeS cluster containing	Thermotoga naphthophila RKU-10 Gene: Tnap_1387: Fe-hydrogenase, gamma subunit, FeS cluster containing	Thermotoga lettingae TMO Gene: Tlet_0954: Fe-hydrogenase, gamma subunit, FeS cluster containing	Thermosipho africanus TCF52B Gene: THA_785: Fe-hydrogenase, gamma subunit, FeS cluster containing	Thermosipho melanesiensis BI429 Gene: Tmel_0492: Fe-hydrogenase, gamma subunit, FeS cluster containing	* Fervidobacterium nodosum Rt17-B1 Site: position = -125 score = 4.97395 sequence = TTGTGAAAAaaaTaACgt Site: position = -111 score = 4.7174 sequence = acGTtAtAAaaaTaACAA Gene: Fnod_0227: Fe-hydrogenase, gamma subunit, FeS cluster containing	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	Fe-hydrogenase, gamma subunit, FeS cluster containing
hydB	Thermotoga maritima MSB8 Gene: TM1425: Fe-hydrogenase, beta subunit, FeS cluster, FMN, NAD(P)H dehydrogenase activity	Thermotoga sp. RQ2 Gene: TRQ2_1318: Fe-hydrogenase, beta subunit, FeS cluster, FMN, NAD(P)H dehydrogenase activity	Thermotoga neapolitana DSM 4359 Gene: CTN_1068: Fe-hydrogenase, beta subunit, FeS cluster, FMN, NAD(P)H dehydrogenase activity	Thermotoga petrophila RKU-1 Gene: Tpet_1368: Fe-hydrogenase, beta subunit, FeS cluster, FMN, NAD(P)H dehydrogenase activity	Thermotoga naphthophila RKU-10 Gene: Tnap_1386: Fe-hydrogenase, beta subunit, FeS cluster, FMN, NAD(P)H dehydrogenase activity	Thermotoga lettingae TMO Gene: Tlet_0953: Fe-hydrogenase, beta subunit, FeS cluster, FMN, NAD(P)H dehydrogenase activity	Thermosipho africanus TCF52B Gene: THA_786: Fe-hydrogenase, beta subunit, FeS cluster, FMN, NAD(P)H dehydrogenase activity	Thermosipho melanesiensis BI429 Gene: Tmel_0491: Fe-hydrogenase, beta subunit, FeS cluster, FMN, NAD(P)H dehydrogenase activity	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0226: Fe-hydrogenase, beta subunit, FeS cluster, FMN, NAD(P)H dehydrogenase activity	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	Fe-hydrogenase, beta subunit, FeS cluster, FMN, NAD(P)H dehydrogenase activity
hydA	Thermotoga maritima MSB8 Gene: TM1426: Fe-hydrogenase, alpha subunit, FeS cluster, hydrogenase activity	Thermotoga sp. RQ2 Gene: TRQ2_1319: Fe-hydrogenase, alpha subunit, FeS cluster, hydrogenase activity	Thermotoga neapolitana DSM 4359 Gene: CTN_1067: Fe-hydrogenase, alpha subunit, FeS cluster, hydrogenase activity	Thermotoga petrophila RKU-1 Gene: Tpet_1367: Fe-hydrogenase, alpha subunit, FeS cluster, hydrogenase activity	Thermotoga naphthophila RKU-10 Gene: Tnap_1385: Fe-hydrogenase, alpha subunit, FeS cluster, hydrogenase activity	Thermotoga lettingae TMO Gene: Tlet_0952: Fe-hydrogenase, alpha subunit, FeS cluster, hydrogenase activity	Thermosipho africanus TCF52B Gene: THA_787: Fe-hydrogenase, alpha subunit, FeS cluster, hydrogenase activity	Thermosipho melanesiensis BI429 Gene: Tmel_0490: Fe-hydrogenase, alpha subunit, FeS cluster, hydrogenase activity	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0225: Fe-hydrogenase, alpha subunit, FeS cluster, hydrogenase activity	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	Fe-hydrogenase, alpha subunit, FeS cluster, hydrogenase activity
rex1	Thermotoga maritima MSB8 Gene: TM1427: Redox sensitive transcriptional regulator paralog, Rex family	Thermotoga sp. RQ2 Gene: TRQ2_1320: Redox sensitive transcriptional regulator paralog, Rex family	Thermotoga neapolitana DSM 4359 Gene: CTN_1066: Redox sensitive transcriptional regulator paralog, Rex family	Thermotoga petrophila RKU-1 Gene: Tpet_1366: Redox sensitive transcriptional regulator paralog, Rex family	Thermotoga naphthophila RKU-10 Gene: Tnap_1384: Redox sensitive transcriptional regulator paralog, Rex family	Thermotoga lettingae TMO Gene: Tlet_0951: Redox sensitive transcriptional regulator paralog, Rex family	Thermosipho africanus TCF52B Gene: THA_788: Redox sensitive transcriptional regulator paralog, Rex family	Thermosipho melanesiensis BI429 Gene: Tmel_0489: Redox sensitive transcriptional regulator paralog, Rex family	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0224: Redox sensitive transcriptional regulator paralog, Rex family	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	Redox sensitive transcriptional regulator paralog, Rex family
CRON 11.
noxE2	Thermotoga maritima MSB8	Thermotoga sp. RQ2	Thermotoga neapolitana DSM 4359	Thermotoga petrophila RKU-1	Thermotoga naphthophila RKU-10	Thermotoga lettingae TMO	* Thermosipho africanus TCF52B Site: position = -38 score = 4.789 sequence = AAGTTAAATTATTCTCAA Gene: THA_982: NADH oxidase (EC 1.6.99.3)	* Thermosipho melanesiensis BI429 Site: position = -31 score = 5.20043 sequence = TAGTTAAAAAAATCACAA Gene: Tmel_0141: NADH oxidase (EC 1.6.99.3)	* Fervidobacterium nodosum Rt17-B1 Site: position = -65 score = 4.52985 sequence = aaGTGAAAAaaaTaACtt Gene: Fnod_0587: NADH oxidase (EC 1.6.99.3)	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	NADH oxidase (EC 1.6.99.3)
noxE	* Thermotoga maritima MSB8 Site: position = -32 score = 4.95487 sequence = TCGTGAAAAATTTCTCTT Gene: TM0379: NADH oxidase (EC 1.6.99.3)	* Thermotoga sp. RQ2 Site: position = -32 score = 4.95487 sequence = TCGTGAAAAATTTCTCTT Gene: TRQ2_0544: NADH oxidase (EC 1.6.99.3)	* Thermotoga neapolitana DSM 4359 Site: position = -34 score = 4.55541 sequence = TTGTGAAATCTTTCTCTT Gene: CTN_0317: NADH oxidase (EC 1.6.99.3)	* Thermotoga petrophila RKU-1 Site: position = -32 score = 4.81489 sequence = TCGTGAAAAAATTCTCTT Gene: Tpet_0530: NADH oxidase (EC 1.6.99.3)	* Thermotoga naphthophila RKU-10 Site: position = -32 score = 4.81489 sequence = TCGTGAAAAAATTCTCTT Gene: Tnap_0182: NADH oxidase (EC 1.6.99.3)	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	* Thermosipho melanesiensis BI429 Site: position = -59 score = 4.90211 sequence = TTGTGAAAAATATATCAT Gene: Tmel_1229: NADH oxidase (EC 1.6.99.3)	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1 Gene: Kole_1123: NADH oxidase (EC 1.6.99.3)	NADH oxidase (EC 1.6.99.3)

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD