Collection of regulogs for Rex transcription factor family

Rex family of transcription factors includes NADH-responsive repressors that control central carbohydrate and energy metabolism and fermentative growth in Gram-positive bacteria [21521360, 22210771, 23417491, 23028612, 22576944] and the Thermotogales [22210771]. Rex regulators act as sensors of the intracellular NADH/NAD(+) redox state through direct binding of effector molecules, NADH or NAD(+) [21402078]. Under the low NADH:NAD(+) ratio, Rex proteins bind to the target sites and blocks expression of downstream genes, while the increase of NADH concentration results in the dissociation of Rex from DNA and derepression of target genes [22210771]. more

Rex-family regulators are composed of an N-terminal winged HTH DNA binding domain (PF06971) and a C-terminal Rossmann-fold domain (PF02629) that is responsible for effector binding and dimerization [20374494].