Regulog Rex - Clostridia-2

Properties
Regulator type:	Transcription factor
Regulator family:	Rex
Regulation mode:	repressor
Biological process:	Energy metabolism
Effector:	NADH
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 34 sites [see more]

Member of regulog collections

By taxonomy - Clostridia-2
By TF family - Rex
By effector - NADH
By pathway - Energy metabolism

Statistics of regulated genes
Genome	Genes	Operons
Clostridium bartlettii DSM 16795	19	9
Clostridium difficile 630	23	9
Clostridium hiranonis DSM 13275	6	4

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes				Function

CRON 1.
grdE	Clostridium bartlettii DSM 16795	* Clostridium difficile 630 Site: position = -264 score = 5.46615 sequence = TTGATAAATTATTAACAT Site: position = -187 score = 4.53735 sequence = TTGTTAAAAAAATAATTT Gene: CD2354: Glycine reductase component B beta subunit (EC 1.21.4.2) / Glycine reductase component B alpha subunit (EC 1.21.4.2)	Clostridium hiranonis DSM 13275	Glycine reductase component B beta subunit (EC 1.21.4.2) / Glycine reductase component B alpha subunit (EC 1.21.4.2)

CRON 2.
glcA	* Clostridium bartlettii DSM 16795 Site: position = -119 score = 5.17027 sequence = ATGTTAATAAATAAACAA Site: position = -138 score = 4.26725 sequence = TTTTTATTAATTTAAAAT Gene: CLOBAR_02282: Glycolate permease	Clostridium difficile 630	Clostridium hiranonis DSM 13275	Glycolate permease
PF09861	Clostridium bartlettii DSM 16795 Gene: CLOBAR_02281: Protein of unknown function DUF2088	* Clostridium difficile 630 Site: position = -113 score = 4.04182 sequence = TTGTTATAAAATAAATTA Gene: CD1170: Protein of unknown function DUF2088	Clostridium hiranonis DSM 13275	Protein of unknown function DUF2088
etfB	2 Clostridium bartlettii DSM 16795 Gene: CLOBAR_02279: Electron transfer flavoprotein beta-subunit Gene: CLOBAR_02280: Electron transfer flavoprotein beta-subunit	Clostridium difficile 630 Gene: CD1171: Electron transfer flavoprotein beta-subunit	Clostridium hiranonis DSM 13275	Electron transfer flavoprotein beta-subunit
etfA	Clostridium bartlettii DSM 16795 Gene: CLOBAR_02278: Electron transfer flavoprotein alpha-subunit	Clostridium difficile 630 Gene: CD1172: Electron transfer flavoprotein alpha-subunit	Clostridium hiranonis DSM 13275	Electron transfer flavoprotein alpha-subunit
glcD	Clostridium bartlettii DSM 16795 Gene: CLOBAR_02277: Glycolate oxidase (EC 1.1.99.14), FAD/FMN-containing	Clostridium difficile 630 Gene: CD1173: Glycolate oxidase (EC 1.1.99.14), FAD/FMN-containing	Clostridium hiranonis DSM 13275	Glycolate oxidase (EC 1.1.99.14), FAD/FMN-containing

CRON 3.
rex	2 Clostridium bartlettii DSM 16795* Site: position = -37 score = 3.98978 sequence = TTGTTATGAAAATATTAA Site: position = -99 score = 4.10187 sequence = TTGGTATAATATAATCAA Gene: CLOBAR_00711: Redox-sensitive transcriptional regulator Rex Site: position = -156 score = 4.34683 sequence = ATAATATATTATTAACTA Gene: CLOBAR_01830: Redox-sensitive transcriptional regulator Rex	* Clostridium difficile 630 Site: position = -96 score = 4.5729 sequence = TTGATATAATATAATCAA Gene: CD0171: Redox-sensitive transcriptional regulator Rex	* Clostridium hiranonis DSM 13275 Site: position = -55 score = 4.33113 sequence = ATGTTATATAATAAACCA Site: position = -101 score = 4.01189 sequence = TTGATATAATATATTCAA Gene: CLOHIR_00042: Redox-sensitive transcriptional regulator Rex	Redox-sensitive transcriptional regulator Rex

CRON 4.
bcd2	Clostridium bartlettii DSM 16795	* Clostridium difficile 630 Site: position = -193 score = 5.04578 sequence = TTGATTTTAAATTAACAA Gene: CD1054: Butyryl-CoA dehydrogenase (EC 1.3.99.2)	Clostridium hiranonis DSM 13275	Butyryl-CoA dehydrogenase (EC 1.3.99.2)
etfB2	Clostridium bartlettii DSM 16795	Clostridium difficile 630 Gene: CD1055: Electron transfer flavoprotein, beta subunit	Clostridium hiranonis DSM 13275	Electron transfer flavoprotein, beta subunit
etfA2	Clostridium bartlettii DSM 16795	Clostridium difficile 630 Gene: CD1056: Electron transfer flavoprotein, alpha subunit	Clostridium hiranonis DSM 13275	Electron transfer flavoprotein, alpha subunit
crt2	Clostridium bartlettii DSM 16795	Clostridium difficile 630 Gene: CD1057: 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55)	Clostridium hiranonis DSM 13275	3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55)
hbd	Clostridium bartlettii DSM 16795	Clostridium difficile 630 Gene: CD1058: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)	Clostridium hiranonis DSM 13275	3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)
thlA1	Clostridium bartlettii DSM 16795	Clostridium difficile 630 Gene: CD1059: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Clostridium hiranonis DSM 13275	Acetyl-CoA acetyltransferase (EC 2.3.1.9)

CRON 5.
fprA	Clostridium bartlettii DSM 16795	* Clostridium difficile 630 Site: position = -63 score = 5.39866 sequence = TTGTTTAAAATATAACAA Gene: CD1623: H(2)O-forming NADH oxidase (EC 1.6.3.-)	Clostridium hiranonis DSM 13275	H(2)O-forming NADH oxidase (EC 1.6.3.-)

CRON 6.
CD2344	Clostridium bartlettii DSM 16795	* Clostridium difficile 630 Site: position = -190 score = 4.56384 sequence = TTGTTAATTAAATCATAA Site: position = -129 score = 5.40604 sequence = ATGTTAATTTAATAACAA Site: position = -66 score = 5.21897 sequence = TTGTTAATTTAATAACGA Gene: CD2344: putative transport protein	Clostridium hiranonis DSM 13275	putative transport protein
cat1	Clostridium bartlettii DSM 16795	Clostridium difficile 630 Gene: CD2343: Succinyl-CoA:coenzyme A transferase (EC 2.8.3.-)	Clostridium hiranonis DSM 13275	Succinyl-CoA:coenzyme A transferase (EC 2.8.3.-)
sucD	Clostridium bartlettii DSM 16795	Clostridium difficile 630 Gene: CD2342: Succinate-semialdehyde dehydrogenase, CoA-dependent	Clostridium hiranonis DSM 13275	Succinate-semialdehyde dehydrogenase, CoA-dependent
abfD	Clostridium bartlettii DSM 16795	Clostridium difficile 630 Gene: CD2341: 4-hydroxybutanoyl-CoA dehydratase (EC 4.2.1.-)	Clostridium hiranonis DSM 13275	4-hydroxybutanoyl-CoA dehydratase (EC 4.2.1.-)
CD2340	Clostridium bartlettii DSM 16795	Clostridium difficile 630 Gene: CD2340: hypothetical protein	Clostridium hiranonis DSM 13275	hypothetical protein
abfT	Clostridium bartlettii DSM 16795	Clostridium difficile 630 Gene: CD2339: 4-hydroxybutyrate:acetyl-CoA CoA transferase (EC 2.3.1.-)	Clostridium hiranonis DSM 13275	4-hydroxybutyrate:acetyl-CoA CoA transferase (EC 2.3.1.-)
4hbd	Clostridium bartlettii DSM 16795	Clostridium difficile 630 Gene: CD2338: NAD-dependent 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61)	Clostridium hiranonis DSM 13275	NAD-dependent 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61)

CRON 7.
nadA	* Clostridium bartlettii DSM 16795 Site: position = -113 score = 4.68854 sequence = AAATTAAAAATTTAACTA Gene: CLOBAR_00531: Quinolinate synthetase (EC 4.1.99.-)	Clostridium difficile 630 Gene: CD2372: Quinolinate synthetase (EC 4.1.99.-)	* Clostridium hiranonis DSM 13275 Site: position = -210 score = 5.53742 sequence = ATGATAAAAAAATAACAA Site: position = -38 score = 5.40536 sequence = TAGATAAAAAAATAACAA Gene: CLOHIR_00157: Quinolinate synthetase (EC 4.1.99.-)	Quinolinate synthetase (EC 4.1.99.-)
nadB	Clostridium bartlettii DSM 16795 Gene: CLOBAR_00532: L-aspartate oxidase (EC 1.4.3.16)	Clostridium difficile 630 Gene: CD2371: L-aspartate oxidase (EC 1.4.3.16)	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00158: L-aspartate oxidase (EC 1.4.3.16)	L-aspartate oxidase (EC 1.4.3.16)
nadC	Clostridium bartlettii DSM 16795 Gene: CLOBAR_00533: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Clostridium difficile 630 Gene: CD2370: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00159: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)

CRON 8.
hydC	2 Clostridium bartlettii DSM 16795* Site: position = -125 score = 4.40824 sequence = TATTTAAATTTTTAAAAA Site: position = -169 score = 4.8771 sequence = ATGTTAAAAAAGTATCAT Gene: CLOBAR_00902: NAD-reducing Fe-hydrogenase, subunit HydC (EC 1.12.7.2) Site: position = -128 score = 4.69586 sequence = TAGATAATTAAATAAAAA Gene: CLOBAR_00255: NAD-reducing Fe-hydrogenase, subunit HydC (EC 1.12.7.2)	Clostridium difficile 630	Clostridium hiranonis DSM 13275	NAD-reducing Fe-hydrogenase, subunit HydC (EC 1.12.7.2)
hydB	2 Clostridium bartlettii DSM 16795 Gene: CLOBAR_00256: NAD-reducing Fe-hydrogenase, subunit HydB (EC 1.12.7.2) Gene: CLOBAR_00901: NAD-reducing Fe-hydrogenase, subunit HydB (EC 1.12.7.2)	Clostridium difficile 630	Clostridium hiranonis DSM 13275	NAD-reducing Fe-hydrogenase, subunit HydB (EC 1.12.7.2)
hydA	Clostridium bartlettii DSM 16795 Gene: CLOBAR_00900: NAD-reducing Fe-hydrogenase, subunit HydA (EC 1.12.7.2)	Clostridium difficile 630	Clostridium hiranonis DSM 13275	NAD-reducing Fe-hydrogenase, subunit HydA (EC 1.12.7.2)

CRON 9.
phf1	Clostridium bartlettii DSM 16795	Clostridium difficile 630	* Clostridium hiranonis DSM 13275 Site: position = -107 score = 4.81147 sequence = ATGTTAAAAATATAAAGA Site: position = -87 score = 5.08872 sequence = TTGATAAAAAAATGACAA Gene: CLOHIR_00139: Fe-hydrogenase (EC 1.12.7.2)	Fe-hydrogenase (EC 1.12.7.2)

CRON 10.
CD2707	* Clostridium bartlettii DSM 16795 Site: position = -91 score = 4.90725 sequence = ACGTTAAGAATTTAACAA Gene: CLOBAR_02221: Transport protein, MFS family	* Clostridium difficile 630 Site: position = -34 score = 5.74236 sequence = ATGTTAATAAATTAACAA Gene: CD2707: Transport protein, MFS family	Clostridium hiranonis DSM 13275 Gene: CLOHIR_00106: Transport protein, MFS family	Transport protein, MFS family

CRON 11.
adhE	* Clostridium bartlettii DSM 16795 Site: position = -130 score = 5.26195 sequence = ATGTTAAACAAATAACAA Site: position = -106 score = 4.77526 sequence = AGGTTAATAATATAACAT Site: position = -188 score = 5.53742 sequence = ATGATAAAAAAATAACAA Gene: CLOBAR_00502: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)	2 Clostridium difficile 630* Gene: CD0334: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10) Site: position = -146 score = 5.09002 sequence = ATGTTAAAAAAATAACTT Site: position = -103 score = 5.56157 sequence = ATGTTAATAAATTAACAT Gene: CD2966: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)	* Clostridium hiranonis DSM 13275 Site: position = -209 score = 5.27221 sequence = ATGATAAAAAAATATCAA Gene: CLOHIR_00687: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)	Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)

CRON 12.
lldD	* Clostridium bartlettii DSM 16795 Site: position = -94 score = 5.49793 sequence = ATGTTAAAAAAATAACAT Gene: CLOBAR_01995: L-lactate dehydrogenase	Clostridium difficile 630	Clostridium hiranonis DSM 13275	L-lactate dehydrogenase

CRON 13.
noxE	Clostridium bartlettii DSM 16795 Gene: CLOBAR_01035: NADH oxidase (EC 1.6.99.3)	* Clostridium difficile 630 Site: position = -112 score = 5.23654 sequence = ATGTTAAATAAATAACTA Gene: CD2540: NADH oxidase (EC 1.6.99.3)	Clostridium hiranonis DSM 13275	NADH oxidase (EC 1.6.99.3)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog Rex - Clostridia-2

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --