Regulog Rex - Clostridia-1

Properties
Regulator type:	Transcription factor
Regulator family:	Rex
Regulation mode:	repressor
Biological process:	Energy metabolism
Effector:	NADH
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 83 sites [see more]

Member of regulog collections

By taxonomy - Clostridia-1
By trascription factor - Rex
By TF family - Rex
By effector - NADH
By pathway - Energy metabolism

Statistics of regulated genes
Genome	Genes	Operons
Clostridium acetobutylicum ATCC 824	17	7
Clostridium beijerincki NCIMB 8052	16	11
Clostridium botulinum A str. ATCC 3502	15	8
Clostridium butyricum 5521	20	11
Clostridium kluyveri DSM 555	7	2
Clostridium novyi NT	22	9
Clostridium perfringens ATCC 13124	15	8
Clostridium tetani E88	19	11

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes									Function

CRON 1.
ldh	* Clostridium acetobutylicum ATCC 824 Site: position = -98 score = 5.6103 sequence = TAGTTAATAAATTAACAA Gene: CAC0267: L-lactate dehydrogenase (EC 1.1.1.27)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_1014: L-lactate dehydrogenase (EC 1.1.1.27)	* Clostridium botulinum A str. ATCC 3502 Site: position = -161 score = 5.30017 sequence = ATGTTAATTAATTAACTA Gene: CBO1519: L-lactate dehydrogenase (EC 1.1.1.27)	Clostridium butyricum 5521 Gene: CBY_2757: L-lactate dehydrogenase (EC 1.1.1.27)	Clostridium kluyveri DSM 555 Gene: CKL_1381: L-lactate dehydrogenase (EC 1.1.1.27)	Clostridium novyi NT Gene: NT01CX_0236: L-lactate dehydrogenase (EC 1.1.1.27)	* Clostridium perfringens ATCC 13124 Site: position = -64 score = 5.06382 sequence = TTGTTATATAATTAACTT Gene: CPF_0098: L-lactate dehydrogenase (EC 1.1.1.27)	Clostridium tetani E88 Gene: CTC01998: L-lactate dehydrogenase (EC 1.1.1.27)	L-lactate dehydrogenase (EC 1.1.1.27)

CRON 2.
narK	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	* Clostridium perfringens ATCC 13124 Site: position = -44 score = 5.38052 sequence = GAGTTAAAAAATTAACAA Gene: CPF_2556: Nitrate/nitrite antiporter	Clostridium tetani E88	Nitrate/nitrite antiporter

CRON 3.
narA	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	* Clostridium butyricum 5521 Site: position = -169 score = 5.18045 sequence = TTATTAATTTTTTAACAA Site: position = -148 score = 5.12606 sequence = TTGTTAAAAAAAGAACAA Gene: CBY_3325: Nitrate reductase, catalytic subunit	Clostridium kluyveri DSM 555	Clostridium novyi NT	* Clostridium perfringens ATCC 13124 Site: position = -47 score = 5.53884 sequence = ATGATAAATTTTTAACAA Gene: CPF_2052: Nitrate reductase, catalytic subunit	Clostridium tetani E88	Nitrate reductase, catalytic subunit
narB	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3326: Nitrate reductase, electron transfer subunit	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_2051: Nitrate reductase, electron transfer subunit	Clostridium tetani E88	Nitrate reductase, electron transfer subunit
narD	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502 Gene: CBO1333: Nitrate reductase, NAD/FAD binding subunit	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_2050: Nitrate reductase, NAD/FAD binding subunit	Clostridium tetani E88	Nitrate reductase, NAD/FAD binding subunit

CRON 4.
adhA	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	* Clostridium botulinum A str. ATCC 3502 Site: position = -236 score = 5.02761 sequence = TTGTTAAAAAATTATTAA Site: position = -87 score = 5.38312 sequence = TTGTTAAAAAAATAACTA Gene: CBO1438: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent

CRON 5.
frdA	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	* Clostridium tetani E88 Site: position = -147 score = 5.40479 sequence = TTGACAAAATATTAACAA Gene: CTC01488: Fumarate reductase flavoprotein subunit (EC 1.3.99.1)	Fumarate reductase flavoprotein subunit (EC 1.3.99.1)

CRON 6.
hyd	Clostridium acetobutylicum ATCC 824	* Clostridium beijerincki NCIMB 8052 Site: position = -84 score = 5.55573 sequence = TTGTTATAATTTTAACAA Site: position = -287 score = 5.30057 sequence = ATGTTAATAATTTATCAT Gene: Cbei_0327: Periplasmic [Fe] hydrogenase (EC 1.12.7.2)	Clostridium botulinum A str. ATCC 3502 Gene: CBO3302: Periplasmic [Fe] hydrogenase (EC 1.12.7.2)	Clostridium butyricum 5521 Gene: CBY_3049: Periplasmic [Fe] hydrogenase (EC 1.12.7.2)	Clostridium kluyveri DSM 555	* Clostridium novyi NT Site: position = -97 score = 5.34342 sequence = ATGTTACATATTTAACAA Gene: NT01CX_0464: Periplasmic [Fe] hydrogenase (EC 1.12.7.2)	Clostridium perfringens ATCC 13124 Gene: CPF_2900: Periplasmic [Fe] hydrogenase (EC 1.12.7.2)	* Clostridium tetani E88 Site: position = -84 score = 5.35734 sequence = CTGTTAATAAATTAACAA Gene: CTC02417: Periplasmic [Fe] hydrogenase (EC 1.12.7.2)	Periplasmic [Fe] hydrogenase (EC 1.12.7.2)

CRON 7.
bdh	Clostridium acetobutylicum ATCC 824	2 Clostridium beijerincki NCIMB 8052* Site: position = -99 score = 5.33365 sequence = TTGATAAAATAATAACAT Gene: Cbei_1722: NADPH-dependent butanol dehydrogenase (EC 1.1.1.-) / Butyraldehyde dehydrogenase Site: position = -129 score = 5.08963 sequence = TTGATAAAATAATCACAA Gene: Cbei_2181: NADPH-dependent butanol dehydrogenase (EC 1.1.1.-) / Butyraldehyde dehydrogenase	* Clostridium botulinum A str. ATCC 3502 Site: position = -261 score = 4.76223 sequence = TAGTTATTATTTTATCAT Gene: CBO1643: NADPH-dependent butanol dehydrogenase (EC 1.1.1.-) / Butyraldehyde dehydrogenase	2 Clostridium butyricum 5521* Site: position = -122 score = 4.98062 sequence = ATGATAAAAATATTACAA Gene: CBY_3751: NADPH-dependent butanol dehydrogenase (EC 1.1.1.-) / Butyraldehyde dehydrogenase Site: position = -92 score = 5.3733 sequence = TTGACAAAAAAATAACAA Gene: CBY_3747: NADPH-dependent butanol dehydrogenase (EC 1.1.1.-) / Butyraldehyde dehydrogenase	Clostridium kluyveri DSM 555 Gene: CKL_0543: NADPH-dependent butanol dehydrogenase (EC 1.1.1.-) / Butyraldehyde dehydrogenase	* Clostridium novyi NT Site: position = -61 score = 5.6879 sequence = TTGTTAATAAAATAACAA Gene: NT01CX_0468: NADPH-dependent butanol dehydrogenase (EC 1.1.1.-) / Butyraldehyde dehydrogenase	Clostridium perfringens ATCC 13124 Gene: CPF_1465: NADPH-dependent butanol dehydrogenase (EC 1.1.1.-) / Butyraldehyde dehydrogenase	* Clostridium tetani E88 Site: position = -157 score = 4.8315 sequence = AAGTTAAGTTATTAACAA Site: position = -50 score = 5.41773 sequence = ATGTTAAAAATATATCAA Gene: CTC02422: NADPH-dependent butanol dehydrogenase (EC 1.1.1.-) / Butyraldehyde dehydrogenase	NADPH-dependent butanol dehydrogenase (EC 1.1.1.-) / Butyraldehyde dehydrogenase

CRON 8.
thlA	Clostridium acetobutylicum ATCC 824	* Clostridium beijerincki NCIMB 8052 Site: position = -118 score = 5.43015 sequence = TTGTTTAAATTTTAACAA Site: position = -58 score = 5.74658 sequence = ATGTTAATAATTTAACAA Gene: Cbei_0411: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Clostridium botulinum A str. ATCC 3502	* Clostridium butyricum 5521 Site: position = -81 score = 5.4472 sequence = ATGTTAATAATTTAACGA Site: position = -140 score = 5.28901 sequence = TTGTCTAAAATTTAACAA Gene: CBY_1290: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Clostridium kluyveri DSM 555	Clostridium novyi NT	* Clostridium perfringens ATCC 13124 Site: position = -35 score = 4.70429 sequence = TTGATAAATTTTTACCTA Site: position = -115 score = 5.56543 sequence = TTGTTTAAAATTTAACAA Gene: CPF_2460: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Clostridium tetani E88	Acetyl-CoA acetyltransferase (EC 2.3.1.9)

CRON 9.
ptb	* Clostridium acetobutylicum ATCC 824 Site: position = -52 score = 4.80662 sequence = ACGTTAATCATTTAACAT Gene: CAC3076: Phosphate butyryltransferase (EC 2.3.1.19)	* Clostridium beijerincki NCIMB 8052 Site: position = -74 score = 5.54971 sequence = TTGATATAAATTTAACAA Gene: Cbei_0203: Phosphate butyryltransferase (EC 2.3.1.19)	Clostridium botulinum A str. ATCC 3502 Gene: CBO3427: Phosphate butyryltransferase (EC 2.3.1.19)	* Clostridium butyricum 5521 Site: position = -55 score = 5.41442 sequence = TTGATATAATTTTAACAA Gene: CBY_2919: Phosphate butyryltransferase (EC 2.3.1.19)	Clostridium kluyveri DSM 555	Clostridium novyi NT	* Clostridium perfringens ATCC 13124 Site: position = -190 score = 5.23252 sequence = GTGTTTAAAATTTAACAA Site: position = -43 score = 5.69101 sequence = TTGTTATAAATTTAACAA Gene: CPF_2657: Phosphate butyryltransferase (EC 2.3.1.19)	* Clostridium tetani E88 Site: position = -48 score = 4.82204 sequence = TAGTTAAAAAGATATCAA Gene: CTC02546: Phosphate butyryltransferase (EC 2.3.1.19)	Phosphate butyryltransferase (EC 2.3.1.19)
buk	Clostridium acetobutylicum ATCC 824 Gene: CAC3075: Butyrate kinase (EC 2.7.2.7)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_0204: Butyrate kinase (EC 2.7.2.7)	Clostridium botulinum A str. ATCC 3502 Gene: CBO3426: Butyrate kinase (EC 2.7.2.7)	Clostridium butyricum 5521 Gene: CBY_2920: Butyrate kinase (EC 2.7.2.7)	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_2656: Butyrate kinase (EC 2.7.2.7)	Clostridium tetani E88 Gene: CTC02545: Butyrate kinase (EC 2.7.2.7)	Butyrate kinase (EC 2.7.2.7)

CRON 10.
butA	Clostridium acetobutylicum ATCC 824	* Clostridium beijerincki NCIMB 8052 Site: position = -41 score = 5.27385 sequence = ATGTGAATTAATTAACAA Gene: Cbei_1464: 2,3-butanediol dehydrogenase (EC 1.1.1.4)	* Clostridium botulinum A str. ATCC 3502 Site: position = -51 score = 5.5273 sequence = ATGTTAATTAATTAACAT Gene: CBO2217: 2,3-butanediol dehydrogenase (EC 1.1.1.4)	* Clostridium butyricum 5521 Site: position = -41 score = 5.27385 sequence = ATGTGAATTAATTAACAA Gene: CBY_2472: 2,3-butanediol dehydrogenase (EC 1.1.1.4)	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0344: 2,3-butanediol dehydrogenase (EC 1.1.1.4)	Clostridium perfringens ATCC 13124	Clostridium tetani E88	2,3-butanediol dehydrogenase (EC 1.1.1.4)

CRON 11.
crt	* Clostridium acetobutylicum ATCC 824 Site: position = -45 score = 5.55152 sequence = TTGTTATAATATTAACAA Gene: CAC2712: 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55)	2 Clostridium beijerincki NCIMB 8052* Gene: Cbei_2034: 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) Site: position = -87 score = 5.51724 sequence = TTGTTATATTATTAACAA Gene: Cbei_0321: 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55)	* Clostridium botulinum A str. ATCC 3502 Site: position = -136 score = 4.96078 sequence = TAGATAAATTTTTATCAT Site: position = -93 score = 4.81095 sequence = TTGTTAAAATAATAGCTA Gene: CBO3202: 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55)	* Clostridium butyricum 5521 Site: position = -98 score = 5.55152 sequence = TTGTTATAATATTAACAA Gene: CBY_3041: 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55)	* Clostridium kluyveri DSM 555 Site: position = -64 score = 5.083 sequence = TTGTGATATTATTAACAA Gene: CKL_0454: 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55)	* Clostridium novyi NT Site: position = -69 score = 5.24738 sequence = TTGTTACTATATTAACAA Gene: NT01CX_0474: 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55)	* Clostridium perfringens ATCC 13124 Site: position = -124 score = 5.48579 sequence = TTGTTACAAAATTAACAA Gene: CPF_2585: 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55)	* Clostridium tetani E88 Site: position = -245 score = 5.02604 sequence = TTGTTATAAATTCAACAA Site: position = -104 score = 5.55152 sequence = TTGTTATAATATTAACAA Gene: CTC02427: 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55)	3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55)
hbd	Clostridium acetobutylicum ATCC 824 Gene: CAC2708: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)	2 Clostridium beijerincki NCIMB 8052* Site: position = -146 score = 4.79902 sequence = AAGTTAATAATGTAACAT Site: position = -126 score = 5.32241 sequence = AAGATAATTAATTAACAA Gene: Cbei_0325: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157) Gene: Cbei_2038: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)	Clostridium botulinum A str. ATCC 3502 Gene: CBO3201: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)	Clostridium butyricum 5521 Gene: CBY_3045: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)	Clostridium kluyveri DSM 555 Gene: CKL_0458: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)	2 Clostridium novyi NT* Gene: NT01CX_0470: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157) Site: position = -233 score = 5.40312 sequence = ATGATATATATTTAACAA Site: position = -46 score = 5.60112 sequence = AAGTTAAAAAATTAACAA Gene: NT01CX_0604: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)	Clostridium perfringens ATCC 13124 Gene: CPF_2581: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)	Clostridium tetani E88 Gene: CTC02423: 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)	3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157)
thl	2 Clostridium acetobutylicum ATCC 824* Site: position = -161 score = 4.5875 sequence = TTGTGTTTTTTTTAACAA Gene: CAC2873: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9) Gene: CAP0078: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9)	* Clostridium beijerincki NCIMB 8052 Site: position = -48 score = 5.79103 sequence = TTGTTAAAAAAATAACAA Gene: Cbei_3630: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Clostridium botulinum A str. ATCC 3502 Gene: CBO3200: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0603: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Clostridium perfringens ATCC 13124	* Clostridium tetani E88 Site: position = -64 score = 5.28141 sequence = TTGTTAATTTTTTAACTA Gene: CTC00312: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9)	3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9)
bcd	Clostridium acetobutylicum ATCC 824 Gene: CAC2711: Butyryl-CoA dehydrogenase (EC 1.3.99.2)	2 Clostridium beijerincki NCIMB 8052 Gene: Cbei_2035: Butyryl-CoA dehydrogenase (EC 1.3.99.2) Gene: Cbei_0322: Butyryl-CoA dehydrogenase (EC 1.3.99.2)	Clostridium botulinum A str. ATCC 3502 Gene: CBO3199: Butyryl-CoA dehydrogenase (EC 1.3.99.2)	Clostridium butyricum 5521 Gene: CBY_3042: Butyryl-CoA dehydrogenase (EC 1.3.99.2)	Clostridium kluyveri DSM 555 Gene: CKL_0455: Butyryl-CoA dehydrogenase (EC 1.3.99.2)	2 Clostridium novyi NT* Gene: NT01CX_0473: Butyryl-CoA dehydrogenase (EC 1.3.99.2) Site: position = -114 score = 4.68884 sequence = GTGTTTTTTTTTTAACAA Gene: NT01CX_2324: Butyryl-CoA dehydrogenase (EC 1.3.99.2)	Clostridium perfringens ATCC 13124 Gene: CPF_2584: Butyryl-CoA dehydrogenase (EC 1.3.99.2)	2 Clostridium tetani E88* Gene: CTC02426: Butyryl-CoA dehydrogenase (EC 1.3.99.2) Site: position = -64 score = 5.12554 sequence = AAGTTAGTTATTTAACAA Gene: CTC00710: Butyryl-CoA dehydrogenase (EC 1.3.99.2)	Butyryl-CoA dehydrogenase (EC 1.3.99.2)
etfB	Clostridium acetobutylicum ATCC 824 Gene: CAC2710: Electron transfer flavoprotein, beta subunit	2 Clostridium beijerincki NCIMB 8052 Gene: Cbei_2036: Electron transfer flavoprotein, beta subunit Gene: Cbei_0323: Electron transfer flavoprotein, beta subunit	Clostridium botulinum A str. ATCC 3502 Gene: CBO3198: Electron transfer flavoprotein, beta subunit	Clostridium butyricum 5521 Gene: CBY_3043: Electron transfer flavoprotein, beta subunit	Clostridium kluyveri DSM 555 Gene: CKL_0456: Electron transfer flavoprotein, beta subunit	2 Clostridium novyi NT Gene: NT01CX_0472: Electron transfer flavoprotein, beta subunit Gene: NT01CX_2323: Electron transfer flavoprotein, beta subunit	Clostridium perfringens ATCC 13124 Gene: CPF_2583: Electron transfer flavoprotein, beta subunit	2 Clostridium tetani E88 Gene: CTC02425: Electron transfer flavoprotein, beta subunit Gene: CTC00711: Electron transfer flavoprotein, beta subunit	Electron transfer flavoprotein, beta subunit
etfA	Clostridium acetobutylicum ATCC 824 Gene: CAC2709: Electron transfer flavoprotein, alpha subunit	2 Clostridium beijerincki NCIMB 8052 Gene: Cbei_2037: Electron transfer flavoprotein, alpha subunit Gene: Cbei_0324: Electron transfer flavoprotein, alpha subunit	Clostridium botulinum A str. ATCC 3502 Gene: CBO3197: Electron transfer flavoprotein, alpha subunit	Clostridium butyricum 5521 Gene: CBY_3044: Electron transfer flavoprotein, alpha subunit	Clostridium kluyveri DSM 555 Gene: CKL_0457: Electron transfer flavoprotein, alpha subunit	2 Clostridium novyi NT Gene: NT01CX_0471: Electron transfer flavoprotein, alpha subunit Gene: NT01CX_2322: Electron transfer flavoprotein, alpha subunit	Clostridium perfringens ATCC 13124 Gene: CPF_2582: Electron transfer flavoprotein, alpha subunit	2 Clostridium tetani E88 Gene: CTC02424: Electron transfer flavoprotein, alpha subunit Gene: CTC00712: Electron transfer flavoprotein, alpha subunit	Electron transfer flavoprotein, alpha subunit

CRON 12.
adhE	2 Clostridium acetobutylicum ATCC 824* Gene: CAP0162: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10) Site: position = -262 score = 4.91216 sequence = TTGTTAAATGTTTGACAA Gene: CAP0035: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_0305: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)	* Clostridium botulinum A str. ATCC 3502 Site: position = -178 score = 5.67413 sequence = ATGATAAATATTTAACAA Site: position = -121 score = 5.75676 sequence = TTGTTAAATAAATAACAA Gene: CBO0345: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)	* Clostridium butyricum 5521 Site: position = -104 score = 5.45813 sequence = GTGTTAAAAAAATAACAA Site: position = -146 score = 4.96798 sequence = TTGACAAAAAATAAACAA Gene: CBY_3753: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)	Clostridium kluyveri DSM 555 Gene: CKL_1614: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)	Clostridium novyi NT	* Clostridium perfringens ATCC 13124 Site: position = -286 score = 5.22492 sequence = TTGATAAAAAAATCACAA Site: position = -266 score = 5.24729 sequence = TAGTTAAAAAAATAACGA Gene: CPF_2855: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)	* Clostridium tetani E88 Site: position = -139 score = 5.47173 sequence = TTGTTATATAATTAACAT Gene: CTC01366: Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)	Alcohol dehydrogenase (EC 1.1.1.1), Fe-dependent; Acetaldehyde dehydrogenase (EC 1.2.1.10)

CRON 13.
COG1115	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	* Clostridium botulinum A str. ATCC 3502 Site: position = -144 score = 5.03987 sequence = TTGAGAGAAAATTAACAA Gene: CBO1579: Putative amino-acid transport protein	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	* Clostridium novyi NT Site: position = -30 score = 5.04408 sequence = TTGAGAGAAATTTAACAA Gene: NT01CX_0309: Putative amino-acid transport protein	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Putative amino-acid transport protein
noxE	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_3000: NADH oxidase (EC 1.6.99.3)	Clostridium botulinum A str. ATCC 3502 Gene: CBO1580: NADH oxidase (EC 1.6.99.3)	Clostridium butyricum 5521 Gene: CBY_1874: NADH oxidase (EC 1.6.99.3)	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0308: NADH oxidase (EC 1.6.99.3)	* Clostridium perfringens ATCC 13124 Site: position = -60 score = 5.57634 sequence = TAGATAAAAATTTAACAA Gene: CPF_0728: NADH oxidase (EC 1.6.99.3)	* Clostridium tetani E88 Site: position = -141 score = 5.04408 sequence = TTGAAAGAAATTTAACAA Gene: CTC01178: NADH oxidase (EC 1.6.99.3)	NADH oxidase (EC 1.6.99.3)
PF04143	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502 Gene: CBO1581: Protein of unknown function DUF395, YeeE/YedE	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0307: Protein of unknown function DUF395, YeeE/YedE	Clostridium perfringens ATCC 13124	2 Clostridium tetani E88* Gene: CTC01179: Protein of unknown function DUF395, YeeE/YedE Site: position = -39 score = 5.16341 sequence = TTGACAGATAATTAACAA Gene: CTC00400: Protein of unknown function DUF395, YeeE/YedE	Protein of unknown function DUF395, YeeE/YedE

CRON 14.
pflB	Clostridium acetobutylicum ATCC 824 Gene: CAC0980: Pyruvate formate-lyase (EC 2.3.1.54)	2 Clostridium beijerincki NCIMB 8052* Gene: Cbei_1011: Pyruvate formate-lyase (EC 2.3.1.54) Site: position = -52 score = 5.41991 sequence = TTGATTAAAAATTAACAA Gene: Cbei_1009: Pyruvate formate-lyase (EC 2.3.1.54)	Clostridium botulinum A str. ATCC 3502 Gene: CBO3216: Pyruvate formate-lyase (EC 2.3.1.54)	Clostridium butyricum 5521 Gene: CBY_0465: Pyruvate formate-lyase (EC 2.3.1.54)	Clostridium kluyveri DSM 555 Gene: CKL_1107: Pyruvate formate-lyase (EC 2.3.1.54)	Clostridium novyi NT Gene: NT01CX_0015: Pyruvate formate-lyase (EC 2.3.1.54)	Clostridium perfringens ATCC 13124 Gene: CPF_1356: Pyruvate formate-lyase (EC 2.3.1.54)	Clostridium tetani E88	Pyruvate formate-lyase (EC 2.3.1.54)

CRON 15.
pflD	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_1978: Pyruvate formate-lyase (EC 2.3.1.54)	Clostridium kluyveri DSM 555	* Clostridium novyi NT Site: position = -198 score = 5.35706 sequence = TAGATAAATAATTAACAT Gene: NT01CX_0385: Pyruvate formate-lyase (EC 2.3.1.54)	Clostridium perfringens ATCC 13124	Clostridium tetani E88 Gene: CTC00936: Pyruvate formate-lyase (EC 2.3.1.54)	Pyruvate formate-lyase (EC 2.3.1.54)
pflC	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_1977: Pyruvate formate-lyase activating enzyme (EC 1.97.1.4)	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0384: Pyruvate formate-lyase activating enzyme (EC 1.97.1.4)	Clostridium perfringens ATCC 13124	Clostridium tetani E88 Gene: CTC00937: Pyruvate formate-lyase activating enzyme (EC 1.97.1.4)	Pyruvate formate-lyase activating enzyme (EC 1.97.1.4)

CRON 16.
etfB	Clostridium acetobutylicum ATCC 824 Gene: CAC2544: Electron transfer flavoprotein, beta subunit	Clostridium beijerincki NCIMB 8052 Gene: Cbei_0310: Electron transfer flavoprotein, beta subunit	Clostridium botulinum A str. ATCC 3502	* Clostridium butyricum 5521 Site: position = -198 score = 5.2937 sequence = CTGTTAAAAAAATAACAA Gene: CBY_3016: Electron transfer flavoprotein, beta subunit	Clostridium kluyveri DSM 555	* Clostridium novyi NT Site: position = -70 score = 5.18543 sequence = TTGAAAAATATATAACAA Gene: NT01CX_1610: Electron transfer flavoprotein, beta subunit	Clostridium perfringens ATCC 13124 Gene: CPF_0308: Electron transfer flavoprotein, beta subunit	Clostridium tetani E88 Gene: CTC00973: Electron transfer flavoprotein, beta subunit	Electron transfer flavoprotein, beta subunit
etfA	Clostridium acetobutylicum ATCC 824 Gene: CAC2543: Electron transfer flavoprotein, alpha subunit	Clostridium beijerincki NCIMB 8052 Gene: Cbei_0311: Electron transfer flavoprotein, alpha subunit	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3017: Electron transfer flavoprotein, alpha subunit	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_1611: Electron transfer flavoprotein, alpha subunit	Clostridium perfringens ATCC 13124 Gene: CPF_0309: Electron transfer flavoprotein, alpha subunit	Clostridium tetani E88 Gene: CTC00974: Electron transfer flavoprotein, alpha subunit	Electron transfer flavoprotein, alpha subunit
glcD	Clostridium acetobutylicum ATCC 824 Gene: CAC2542: Glycolate oxidase (EC 1.1.99.14), FAD/FMN-containing	Clostridium beijerincki NCIMB 8052 Gene: Cbei_0312: Glycolate oxidase (EC 1.1.99.14), FAD/FMN-containing	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521 Gene: CBY_3018: Glycolate oxidase (EC 1.1.99.14), FAD/FMN-containing	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_1612: Glycolate oxidase (EC 1.1.99.14), FAD/FMN-containing	Clostridium perfringens ATCC 13124 Gene: CPF_0310: Glycolate oxidase (EC 1.1.99.14), FAD/FMN-containing	Clostridium tetani E88 Gene: CTC00976: Glycolate oxidase (EC 1.1.99.14), FAD/FMN-containing	Glycolate oxidase (EC 1.1.99.14), FAD/FMN-containing

CRON 17.
nadA	* Clostridium acetobutylicum ATCC 824 Site: position = -110 score = 5.26404 sequence = TTGATAAATATCTAACAA Gene: CAC1025: Quinolinate synthetase (EC 4.1.99.-)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_0792: Quinolinate synthetase (EC 4.1.99.-)	Clostridium botulinum A str. ATCC 3502 Gene: CBO1448: Quinolinate synthetase (EC 4.1.99.-)	Clostridium butyricum 5521 Gene: CBY_3922: Quinolinate synthetase (EC 4.1.99.-)	Clostridium kluyveri DSM 555 Gene: CKL_0748: Quinolinate synthetase (EC 4.1.99.-)	Clostridium novyi NT Gene: NT01CX_0090: Quinolinate synthetase (EC 4.1.99.-)	Clostridium perfringens ATCC 13124 Gene: CPF_0382: Quinolinate synthetase (EC 4.1.99.-)	Clostridium tetani E88	Quinolinate synthetase (EC 4.1.99.-)
nadB	Clostridium acetobutylicum ATCC 824 Gene: CAC1024: L-aspartate oxidase (EC 1.4.3.16)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_0793: L-aspartate oxidase (EC 1.4.3.16)	Clostridium botulinum A str. ATCC 3502 Gene: CBO1447A: L-aspartate oxidase (EC 1.4.3.16)	Clostridium butyricum 5521 Gene: CBY_3921: L-aspartate oxidase (EC 1.4.3.16)	Clostridium kluyveri DSM 555 Gene: CKL_0749: L-aspartate oxidase (EC 1.4.3.16)	Clostridium novyi NT Gene: NT01CX_0089: L-aspartate oxidase (EC 1.4.3.16)	Clostridium perfringens ATCC 13124 Gene: CPF_0383: L-aspartate oxidase (EC 1.4.3.16)	Clostridium tetani E88	L-aspartate oxidase (EC 1.4.3.16)
nadC	Clostridium acetobutylicum ATCC 824 Gene: CAC1023: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_0794: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Clostridium botulinum A str. ATCC 3502 Gene: CBO1447: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Clostridium butyricum 5521 Gene: CBY_3920: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Clostridium kluyveri DSM 555 Gene: CKL_0750: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Clostridium novyi NT Gene: NT01CX_0088: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Clostridium perfringens ATCC 13124 Gene: CPF_0384: Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)	Clostridium tetani E88	Quinolinate phosphoribosyltransferase [decarboxylating] (EC 2.4.2.19)

CRON 18.
frdA	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	* Clostridium tetani E88 Site: position = -40 score = 5.47923 sequence = TAGTTAATATTTTAACAA Gene: CTC01847: Fumarate reductase flavoprotein subunit (EC 1.3.99.1)	Fumarate reductase flavoprotein subunit (EC 1.3.99.1)

CRON 19.
asrT	* Clostridium acetobutylicum ATCC 824 Site: position = -42 score = 5.52146 sequence = TTGTTATATTTTTAACAA Gene: CAC1512: Predicted sulfite transporter	Clostridium beijerincki NCIMB 8052 Gene: Cbei_0782: Predicted sulfite transporter	Clostridium botulinum A str. ATCC 3502 Gene: CBO0956: Predicted sulfite transporter	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_1695: Predicted sulfite transporter	Clostridium tetani E88 Gene: CTC02487: Predicted sulfite transporter	Predicted sulfite transporter
asrA	Clostridium acetobutylicum ATCC 824 Gene: CAC1513: Anaerobic sulfite reductase, subunit A (EC 1.8.1.-)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_0783: Anaerobic sulfite reductase, subunit A (EC 1.8.1.-)	Clostridium botulinum A str. ATCC 3502 Gene: CBO0957: Anaerobic sulfite reductase, subunit A (EC 1.8.1.-)	Clostridium butyricum 5521 Gene: CBY_3322: Anaerobic sulfite reductase, subunit A (EC 1.8.1.-)	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0257: Anaerobic sulfite reductase, subunit A (EC 1.8.1.-)	Clostridium perfringens ATCC 13124 Gene: CPF_1693: Anaerobic sulfite reductase, subunit A (EC 1.8.1.-)	Clostridium tetani E88 Gene: CTC02486: Anaerobic sulfite reductase, subunit A (EC 1.8.1.-)	Anaerobic sulfite reductase, subunit A (EC 1.8.1.-)
asrB	Clostridium acetobutylicum ATCC 824 Gene: CAC1514: Anaerobic sulfite reductase, subunit B (EC 1.8.1.-)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_0784: Anaerobic sulfite reductase, subunit B (EC 1.8.1.-)	Clostridium botulinum A str. ATCC 3502 Gene: CBO0958: Anaerobic sulfite reductase, subunit B (EC 1.8.1.-)	Clostridium butyricum 5521 Gene: CBY_3323: Anaerobic sulfite reductase, subunit B (EC 1.8.1.-)	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0256: Anaerobic sulfite reductase, subunit B (EC 1.8.1.-)	Clostridium perfringens ATCC 13124 Gene: CPF_1692: Anaerobic sulfite reductase, subunit B (EC 1.8.1.-)	Clostridium tetani E88 Gene: CTC02485: Anaerobic sulfite reductase, subunit B (EC 1.8.1.-)	Anaerobic sulfite reductase, subunit B (EC 1.8.1.-)
asrC	Clostridium acetobutylicum ATCC 824 Gene: CAC1515: Anaerobic sulfite reductase, subunit C (EC 1.8.1.-)	Clostridium beijerincki NCIMB 8052 Gene: Cbei_0785: Anaerobic sulfite reductase, subunit C (EC 1.8.1.-)	Clostridium botulinum A str. ATCC 3502 Gene: CBO0959: Anaerobic sulfite reductase, subunit C (EC 1.8.1.-)	Clostridium butyricum 5521 Gene: CBY_3324: Anaerobic sulfite reductase, subunit C (EC 1.8.1.-)	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0255: Anaerobic sulfite reductase, subunit C (EC 1.8.1.-)	Clostridium perfringens ATCC 13124 Gene: CPF_1691: Anaerobic sulfite reductase, subunit C (EC 1.8.1.-)	Clostridium tetani E88 Gene: CTC02484: Anaerobic sulfite reductase, subunit C (EC 1.8.1.-)	Anaerobic sulfite reductase, subunit C (EC 1.8.1.-)

CRON 20.
maeB	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_4008: NAD-dependent malic enzyme (EC 1.1.1.38)	* Clostridium botulinum A str. ATCC 3502 Site: position = -145 score = 5.69212 sequence = TTGTTAATAATATAACAA Gene: CBO0246: NAD-dependent malic enzyme (EC 1.1.1.38)	* Clostridium butyricum 5521 Site: position = -145 score = 5.43541 sequence = TTGTTAAAAAAGTAACAA Gene: CBY_2357: NAD-dependent malic enzyme (EC 1.1.1.38)	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	NAD-dependent malic enzyme (EC 1.1.1.38)

CRON 21.
ctfA	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_2654: Butyrate-acetoacetate CoA-transferase subunit A (EC 2.8.3.9)	Clostridium botulinum A str. ATCC 3502 Gene: CBO2847: Butyrate-acetoacetate CoA-transferase subunit A (EC 2.8.3.9)	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	* Clostridium novyi NT Site: position = -90 score = 5.43198 sequence = ATGACAAAAATTTAACAA Gene: NT01CX_0278: Butyrate-acetoacetate CoA-transferase subunit A (EC 2.8.3.9)	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Butyrate-acetoacetate CoA-transferase subunit A (EC 2.8.3.9)
ctfB	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052 Gene: Cbei_2653: Butyrate-acetoacetate CoA-transferase subunit B (EC 2.8.3.9)	Clostridium botulinum A str. ATCC 3502 Gene: CBO2848: Butyrate-acetoacetate CoA-transferase subunit B (EC 2.8.3.9)	Clostridium butyricum 5521	Clostridium kluyveri DSM 555	Clostridium novyi NT Gene: NT01CX_0277: Butyrate-acetoacetate CoA-transferase subunit B (EC 2.8.3.9)	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Butyrate-acetoacetate CoA-transferase subunit B (EC 2.8.3.9)

CRON 22.
nadO	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	* Clostridium kluyveri DSM 555 Site: position = -75 score = 4.71314 sequence = TTGTTTTAATTTTATCAT Site: position = -46 score = 5.41616 sequence = TTGTCAAAAAATTATCAA Gene: CKL_0591: NADH oxidase	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	NADH oxidase
PF07690	Clostridium acetobutylicum ATCC 824	Clostridium beijerincki NCIMB 8052	Clostridium botulinum A str. ATCC 3502	Clostridium butyricum 5521	Clostridium kluyveri DSM 555 Gene: CKL_0592: Predicted transporter protein	Clostridium novyi NT	Clostridium perfringens ATCC 13124	Clostridium tetani E88	Predicted transporter protein

CRON 23.
fld	Clostridium acetobutylicum ATCC 824 Gene: CAC2452: Flavodoxin	* Clostridium beijerincki NCIMB 8052 Site: position = -37 score = 5.46793 sequence = AAGTTAATTATTTAACAA Gene: Cbei_4319: Flavodoxin	Clostridium botulinum A str. ATCC 3502	* Clostridium butyricum 5521 Site: position = -37 score = 5.46793 sequence = AAGTTAATTATTTAACAA Gene: CBY_3643: Flavodoxin	Clostridium kluyveri DSM 555	Clostridium novyi NT	Clostridium perfringens ATCC 13124 Gene: CPF_2319: Flavodoxin	Clostridium tetani E88 Gene: CTC01742: Flavodoxin	Flavodoxin
por	Clostridium acetobutylicum ATCC 824 Gene: CAC2229: Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-)	2 Clostridium beijerincki NCIMB 8052 Gene: Cbei_1853: Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Gene: Cbei_4318: Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-)	Clostridium botulinum A str. ATCC 3502 Gene: CBO2760: Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-)	3 Clostridium butyricum 5521 Gene: CBY_1889: Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Gene: CBY_3642: Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-) Gene: CBY_0233: Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-)	Clostridium kluyveri DSM 555 Gene: CKL_2138: Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-)	Clostridium novyi NT Gene: NT01CX_1854: Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-)	Clostridium perfringens ATCC 13124 Gene: CPF_2318: Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-)	Clostridium tetani E88 Gene: CTC01741: Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-)	Pyruvate-flavodoxin oxidoreductase (EC 1.2.7.-)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog Rex - Clostridia-1

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --