Collection of regulogs for Rex transcription factor

The Rex regulator is a unique transcription factor that respond to intracellular redox potential and negatively control expression of genes involved in energy metabolism and fermentative growth in Gram-positive bacteria including Streptomyces coelicolor, Bacillus subtilis, Staphylococcus aureus, and Thermus aquaticus. Nicotinamide adenine dinucleotides (NAD(H)) play important role in different biological processes, including redox cellular balance. During the catabolism of carbohydrates, NAD+ is reduced to NADH by glycolytic enzymes. The NADH formed is re-oxidized back either by the electron transport chain under aerobic conditions, or by NADH-linked fermentative enzymes under anaerobic conditions. more

The DNA-binding activity of Rex is modulated by the intracellular ratio of NADH:NAD+. Under low NADH:NAD+ ratio, Rex protein binds to the target sites and represses transcription of genes involved in NADH reoxidation, while the increase of the NADH concentration results the dissociation of Rex from DNA and de-repression of its target genes. We used a comparative genomics approach to reconstruct transcriptional regulons controlled by Rex orthologs in diverse bacterial lineages [22210771].