Regulog Cobalamin - Thermotogales
| Regulator type: | RNA regulatory element |
| Name: | Cobalamin |
| RFAM: | RF00174 |
| Regulation mode: | |
| Biological process: | Cobalamin biosynthesis |
| Effector: | Adenosylcobalamin |
| Phylum: | Thermotogae |
Member of regulog collections
- By taxonomy - Thermotogales
- By RNA motif - Cobalamin
- By effector - Adenosylcobalamin
- By pathway - Cobalamin biosynthesis
| Genome | Genes | Operons |
|---|---|---|
| Thermotoga maritima MSB8 | 3 | 1 |
| Thermotoga sp. RQ2 | 3 | 1 |
| Thermotoga neapolitana DSM 4359 | 3 | 1 |
| Thermotoga petrophila RKU-1 | 3 | 1 |
| Thermotoga naphthophila RKU-10 | 3 | 1 |
| Thermotoga lettingae TMO | 12 | 3 |
| Thermosipho africanus TCF52B | 32 | 3 |
| Thermosipho melanesiensis BI429 | 35 | 4 |
| Fervidobacterium nodosum Rt17-B1 | 14 | 3 |
| Petrotoga mobilis SJ95 | 3 | 1 |
| Thermotogales bacterium TBF 19.5.1 | 3 | 1 |
| Genes | Function | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CRON 1. | ||||||||||||
| btuF |
*
Thermotoga maritima MSB8 Site: position = -158 score = 95.04 sequence = GTATGATTTTCAAAT... Gene: TM0080: Vitamin B12 ABC transporter, B12-binding component BtuF |
*
Thermotoga sp. RQ2 Site: position = -253 score = 96.92 sequence = TATGATCTTCAAATA... Gene: TRQ2_0867: Vitamin B12 ABC transporter, B12-binding component BtuF |
*
Thermotoga neapolitana DSM 4359 Site: position = -219 score = 105.34 sequence = AACCTCCCTCACCGT... Gene: CTN_0612: Vitamin B12 ABC transporter, B12-binding component BtuF |
*
Thermotoga petrophila RKU-1 Site: position = -230 score = 93.04 sequence = AGCCTCCCTCACCGT... Gene: Tpet_0844: Vitamin B12 ABC transporter, B12-binding component BtuF |
*
Thermotoga naphthophila RKU-10 Site: position = -238 score = 93.04 sequence = GAAGCCTCCCTCACC... Gene: Tnap_0710: Vitamin B12 ABC transporter, B12-binding component BtuF |
*
Thermotoga lettingae TMO Site: position = -234 score = 113.23 sequence = TGAATAAGAAGCGTC... Gene: Tlet_1275: Vitamin B12 ABC transporter, B12-binding component BtuF |
*
Thermosipho africanus TCF52B Site: position = -241 score = 96.62 sequence = CTATTTGCAGCAACT... Gene: THA_254: Vitamin B12 ABC transporter, B12-binding component BtuF |
*
Thermosipho melanesiensis BI429 Site: position = -242 score = 99.39 sequence = TGATATAATTATGTT... Gene: Tmel_0038: Vitamin B12 ABC transporter, B12-binding component BtuF |
*
Fervidobacterium nodosum Rt17-B1 Site: position = -231 score = 96.84 sequence = AATAAACCTCCCTTT... Gene: Fnod_0257: Vitamin B12 ABC transporter, B12-binding component BtuF |
*
Petrotoga mobilis SJ95 Site: position = -232 score = 101.5 sequence = TAATATTTACTGCAT... Gene: Pmob_0038: Vitamin B12 ABC transporter, B12-binding component BtuF |
*
Thermotogales bacterium TBF 19.5.1 Site: position = -268 score = 100.27 sequence = TGATCCGATTTAAAG... Gene: Kole_1602: Vitamin B12 ABC transporter, B12-binding component BtuF |
Vitamin B12 ABC transporter, B12-binding component BtuF |
| btuC |
Gene: TM0079: Vitamin B12 ABC transporter, permease component BtuC |
Gene: TRQ2_0868: Vitamin B12 ABC transporter, permease component BtuC |
Gene: CTN_0613: Vitamin B12 ABC transporter, permease component BtuC |
Gene: Tpet_0845: Vitamin B12 ABC transporter, permease component BtuC |
Gene: Tnap_0709: Vitamin B12 ABC transporter, permease component BtuC |
Gene: Tlet_1274: Vitamin B12 ABC transporter, permease component BtuC |
Gene: THA_255: Vitamin B12 ABC transporter, permease component BtuC |
Gene: Tmel_0039: Vitamin B12 ABC transporter, permease component BtuC |
Gene: Fnod_0256: Vitamin B12 ABC transporter, permease component BtuC |
Gene: Pmob_0039: Vitamin B12 ABC transporter, permease component BtuC |
Gene: Kole_1601: Vitamin B12 ABC transporter, permease component BtuC |
Vitamin B12 ABC transporter, permease component BtuC |
| btuD |
Gene: TM0078: Vitamin B12 ABC transporter, ATPase component BtuD |
Gene: TRQ2_0869: Vitamin B12 ABC transporter, ATPase component BtuD |
Gene: CTN_0614: Vitamin B12 ABC transporter, ATPase component BtuD |
Gene: Tpet_0846: Vitamin B12 ABC transporter, ATPase component BtuD |
Gene: Tnap_0708: Vitamin B12 ABC transporter, ATPase component BtuD |
Gene: Tlet_1273: Vitamin B12 ABC transporter, ATPase component BtuD |
Gene: THA_1650: Vitamin B12 ABC transporter, ATPase component BtuD |
Gene: Tmel_1310: Vitamin B12 ABC transporter, ATPase component BtuD |
Gene: Fnod_1090: Vitamin B12 ABC transporter, ATPase component BtuD |
Gene: Pmob_0040: Vitamin B12 ABC transporter, ATPase component BtuD |
Gene: Kole_1600: Vitamin B12 ABC transporter, ATPase component BtuD |
Vitamin B12 ABC transporter, ATPase component BtuD |
| CRON 2. | ||||||||||||
| sucC |
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|
*
Thermotoga lettingae TMO Site: position = -167 score = 133.29 sequence = TATGATTTTCCACCT... Gene: Tlet_1461: Succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5) |
|
*
Thermosipho melanesiensis BI429 Site: position = -242 score = 132.08 sequence = ATAACCAATGGAATA... Gene: Tmel_1870: Succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5) |
*
Fervidobacterium nodosum Rt17-B1 Site: position = -261 score = 122.17 sequence = ATATTCCAAACTGCG... Gene: Fnod_1378: Succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5) |
|
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Succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5) |
| sucD |
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Gene: Tlet_1462: Succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5) |
|
Gene: Tmel_1871: Succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5) |
Gene: Fnod_1379: Succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5) |
|
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Succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5) |
| THA_169 |
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Gene: THA_169: Predicted permease |
Gene: Tmel_1872: Predicted permease |
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Predicted permease |
| TM0177 |
Gene: TM0177: Predicted transmembrane protein |
Gene: TRQ2_0771: Predicted transmembrane protein |
Gene: CTN_0510: Predicted transmembrane protein |
Gene: Tpet_0748: Predicted transmembrane protein |
Gene: Tnap_0807: Predicted transmembrane protein |
Gene: Tlet_0319: Predicted transmembrane protein |
Gene: THA_289: Predicted transmembrane protein |
Gene: Tmel_0072: Predicted transmembrane protein |
Gene: Fnod_1380: Predicted transmembrane protein |
|
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Predicted transmembrane protein |
| CRON 3. | ||||||||||||
| cobT |
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*
Thermotoga lettingae TMO Site: position = -582 score = 105.26 sequence = TGATAAAATAAATAT... Gene: Tlet_1236: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
*2
Thermosipho africanus TCF52B Site: position = -602 score = 112.02 sequence = AATATAGAAAACCAT... Gene: THA_1046: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Site: position = -244 score = 131.17 sequence = ATAATGTTAACACCT... Gene: THA_1065: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
*2
Thermosipho melanesiensis BI429 Site: position = -219 score = 113.91 sequence = TATAAATTGTTACTA... Gene: Tmel_0854: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) Site: position = -233 score = 134.7 sequence = AATAATAAAACATCT... Gene: Tmel_0695: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
*
Fervidobacterium nodosum Rt17-B1 Site: position = -265 score = 99.56 sequence = AAAAACAAACCGAAT... Gene: Fnod_1365: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
|
Gene: Kole_0453: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) |
| cbiX |
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Gene: THA_1066: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) |
Gene: Tmel_0696: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) |
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Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) |
| cbiC |
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Gene: THA_1067: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) |
Gene: Tmel_0697: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) |
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Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) |
| cbiD |
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Gene: THA_1068: Cobalt-precorrin-6 synthase, anaerobic |
Gene: Tmel_0698: Cobalt-precorrin-6 synthase, anaerobic |
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Cobalt-precorrin-6 synthase, anaerobic |
| cbiE |
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Gene: THA_1069: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) |
Gene: Tmel_0699: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) |
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Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) |
| cbiT |
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Gene: THA_1070: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) |
Gene: Tmel_0700: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) |
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Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) |
| cbiL |
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Gene: THA_1071: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) |
Gene: Tmel_0701: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) |
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Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) |
| cbiF |
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Gene: THA_1072: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) |
Gene: Tmel_0702: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) |
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Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) |
| cbiG |
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Gene: THA_1073: Cobalamin biosynthesis protein CbiG |
Gene: Tmel_0703: Cobalamin biosynthesis protein CbiG |
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Cobalamin biosynthesis protein CbiG |
| cbiH |
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Gene: THA_1074: Cobalt-precorrin-3b C17-methyltransferase |
Gene: Tmel_0704: Cobalt-precorrin-3b C17-methyltransferase |
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Cobalt-precorrin-3b C17-methyltransferase |
| cbiJ |
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Gene: THA_1075: Cobalt-precorrin-6x reductase (EC 1.3.1.54) |
Gene: Tmel_0705: Cobalt-precorrin-6x reductase (EC 1.3.1.54) |
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Cobalt-precorrin-6x reductase (EC 1.3.1.54) |
| hemA |
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Gene: THA_1076: Glutamyl-tRNA reductase (EC 1.2.1.70) |
Gene: Tmel_0706: Glutamyl-tRNA reductase (EC 1.2.1.70) |
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Glutamyl-tRNA reductase (EC 1.2.1.70) |
| hemC |
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Gene: THA_1077: Porphobilinogen deaminase (EC 2.5.1.61) |
Gene: Tmel_0707: Porphobilinogen deaminase (EC 2.5.1.61) |
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Porphobilinogen deaminase (EC 2.5.1.61) |
| cysG |
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Gene: THA_1078: cobA |
Gene: Tmel_0708: cobA |
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cobA |
| hemB |
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Gene: THA_1079: Porphobilinogen synthase (EC 4.2.1.24) |
Gene: Tmel_0709: Porphobilinogen synthase (EC 4.2.1.24) |
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Porphobilinogen synthase (EC 4.2.1.24) |
| cysG1 |
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Gene: THA_1080: Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) |
Gene: Tmel_0710: Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) |
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Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4) |
| hemL |
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Gene: THA_1081: Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) |
Gene: Tmel_0711: Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) |
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Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8) |
| cbiM |
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Gene: THA_1082: Substrate-specific component CbiM of cobalt ECF transporter |
Gene: Tmel_0712: Substrate-specific component CbiM of cobalt ECF transporter |
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Substrate-specific component CbiM of cobalt ECF transporter |
| cbiN |
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Gene: THA_1083: Additional substrate-specific component CbiN of cobalt ECF transporter |
Gene: Tmel_0713: Additional substrate-specific component CbiN of cobalt ECF transporter |
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Additional substrate-specific component CbiN of cobalt ECF transporter |
| cbiQ |
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Gene: THA_1084: Transmembrane component CbiQ of energizing module of cobalt ECF transporter |
Gene: Tmel_0714: Transmembrane component CbiQ of energizing module of cobalt ECF transporter |
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Transmembrane component CbiQ of energizing module of cobalt ECF transporter |
| cbiO |
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Gene: THA_1085: ATPase component CbiO of energizing module of cobalt ECF transporter |
Gene: Tmel_0715: ATPase component CbiO of energizing module of cobalt ECF transporter |
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ATPase component CbiO of energizing module of cobalt ECF transporter |
| Fnod_1372 |
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Gene: THA_1086: Putative ATP binding protein |
Gene: Tmel_0716: Putative ATP binding protein |
Gene: Fnod_1372: Putative ATP binding protein |
|
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Putative ATP binding protein |
| cobU |
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Gene: Tlet_1237: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: THA_1045: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: Tmel_0855: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Gene: Fnod_1366: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
|
Gene: Kole_0454: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) |
| Tlet_1238 |
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Gene: Tlet_1238: Putative xylose isomerase domain protein |
Gene: THA_1044: Putative xylose isomerase domain protein |
Gene: Tmel_0856: Putative xylose isomerase domain protein |
Gene: Fnod_1367: Putative xylose isomerase domain protein |
|
Gene: Kole_0455: Putative xylose isomerase domain protein |
Putative xylose isomerase domain protein |
| cobS |
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Gene: Tlet_1239: Cobalamin synthase |
Gene: THA_1043: Cobalamin synthase |
Gene: Tmel_0857: Cobalamin synthase |
Gene: Fnod_1368: Cobalamin synthase |
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Gene: Kole_0456: Cobalamin synthase |
Cobalamin synthase |
| cbiP |
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Gene: THA_1042: Cobyric acid synthase |
Gene: Tmel_0858: Cobyric acid synthase |
Gene: Fnod_1369: Cobyric acid synthase |
|
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Cobyric acid synthase |
| cbiB |
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Gene: Tlet_1240: Adenosylcobinamide-phosphate synthase |
Gene: THA_1041: Adenosylcobinamide-phosphate synthase |
Gene: Tmel_0859: Adenosylcobinamide-phosphate synthase |
Gene: Fnod_1370: Adenosylcobinamide-phosphate synthase |
|
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Adenosylcobinamide-phosphate synthase |
| cobD |
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Gene: Tlet_1241: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
Gene: THA_1040: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
Gene: Tmel_0860: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
Gene: Fnod_1371: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
|
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L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) |
| btuR |
Gene: TM1465: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
Gene: TRQ2_1358: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
Gene: CTN_1028: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
Gene: Tpet_1328: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
Gene: Tnap_1345: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
Gene: Tlet_1242: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
Gene: THA_1039: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
Gene: Tmel_0861: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
Gene: Fnod_1373: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
Gene: Pmob_1886: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
Gene: Kole_0599: Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
Cob(I)alamin adenosyltransferase (EC 2.5.1.17) |
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
|
Regulated Genes | [ Tab delimited format ] | DOWNLOAD |
|
Regulatory Sites | [ FASTA format ] | DOWNLOAD |