Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulon of Cobalamin in Thermosipho melanesiensis BI429

Properties
Regulator type: RNA regulatory element
Name: Cobalamin
RFAM: RF00174
Regulation mode:
Biological process: Cobalamin biosynthesis
Effector: Adenosylcobalamin
Regulog: Cobalamin - Thermotogales
Under regulation:
- Genes 35
- Operons 4
Member of regulog collections
Regulated operons
Locus Tag Name Function
Position: -242
Score: 99.4
Sequence: TGATATAATTATGTT...
Locus tag: Tmel_0038
Name: btuF
Funciton: Vitamin B12 ABC transporter, B12-binding component BtuF
Locus tag: Tmel_0039
Name: btuC
Funciton: Vitamin B12 ABC transporter, permease component BtuC
Tmel_0038
btuF
Vitamin B12 ABC transporter, B12-binding component BtuF
Tmel_0039
btuC
Vitamin B12 ABC transporter, permease component BtuC
Position: -242
Score: 132.1
Sequence: ATAACCAATGGAATA...
Locus tag: Tmel_1870
Name: sucC
Funciton: Succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5)
Locus tag: Tmel_1871
Name: sucD
Funciton: Succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
Locus tag: Tmel_1872
Name: null
Funciton: Predicted permease
Tmel_1870
sucC
Succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5)
Tmel_1871
sucD
Succinyl-CoA ligase [ADP-forming] alpha chain (EC 6.2.1.5)
Tmel_1872
Predicted permease
Position: -233
Score: 134.7
Sequence: AATAATAAAACATCT...
Locus tag: Tmel_0695
Name: cobT
Funciton: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
Locus tag: Tmel_0696
Name: cbiX
Funciton: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)
Locus tag: Tmel_0697
Name: cbiC
Funciton: Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
Locus tag: Tmel_0698
Name: cbiD
Funciton: Cobalt-precorrin-6 synthase, anaerobic
Locus tag: Tmel_0699
Name: cbiE
Funciton: Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)
Locus tag: Tmel_0700
Name: cbiT
Funciton: Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
Locus tag: Tmel_0701
Name: cbiL
Funciton: Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
Locus tag: Tmel_0702
Name: cbiF
Funciton: Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
Locus tag: Tmel_0703
Name: cbiG
Funciton: Cobalamin biosynthesis protein CbiG
Locus tag: Tmel_0704
Name: cbiH
Funciton: Cobalt-precorrin-3b C17-methyltransferase
Locus tag: Tmel_0705
Name: cbiJ
Funciton: Cobalt-precorrin-6x reductase (EC 1.3.1.54)
Locus tag: Tmel_0706
Name: null
Funciton: Glutamyl-tRNA reductase (EC 1.2.1.70)
Locus tag: Tmel_0707
Name: null
Funciton: Porphobilinogen deaminase (EC 2.5.1.61)
Locus tag: Tmel_0708
Name: cysG
Funciton: cobA
Locus tag: Tmel_0709
Name: hemB
Funciton: Porphobilinogen synthase (EC 4.2.1.24)
Locus tag: Tmel_0710
Name: cysG1
Funciton: Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4)
Locus tag: Tmel_0711
Name: hemL
Funciton: Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)
Locus tag: Tmel_0712
Name: cbiM
Funciton: Substrate-specific component CbiM of cobalt ECF transporter
Locus tag: Tmel_0713
Name: cbiN
Funciton: Additional substrate-specific component CbiN of cobalt ECF transporter
Locus tag: Tmel_0714
Name: cbiQ
Funciton: Transmembrane component CbiQ of energizing module of cobalt ECF transporter
Locus tag: Tmel_0715
Name: cbiO
Funciton: ATPase component CbiO of energizing module of cobalt ECF transporter
Locus tag: Tmel_0716
Name: Tmel_0716
Funciton: Putative ATP binding protein
Tmel_0695
cobT
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
Tmel_0696
cbiX
Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)
Tmel_0697
cbiC
Cobalt-precorrin-8x methylmutase (EC 5.4.1.2)
Tmel_0698
cbiD
Cobalt-precorrin-6 synthase, anaerobic
Tmel_0699
cbiE
Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-)
Tmel_0700
cbiT
Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
Tmel_0701
cbiL
Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130)
Tmel_0702
cbiF
Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133)
Tmel_0703
cbiG
Cobalamin biosynthesis protein CbiG
Tmel_0704
cbiH
Cobalt-precorrin-3b C17-methyltransferase
Tmel_0705
cbiJ
Cobalt-precorrin-6x reductase (EC 1.3.1.54)
Tmel_0706
Glutamyl-tRNA reductase (EC 1.2.1.70)
Tmel_0707
Porphobilinogen deaminase (EC 2.5.1.61)
Tmel_0708
cysG
cobA
Tmel_0709
hemB
Porphobilinogen synthase (EC 4.2.1.24)
Tmel_0710
cysG1
Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4)
Tmel_0711
hemL
Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)
Tmel_0712
cbiM
Substrate-specific component CbiM of cobalt ECF transporter
Tmel_0713
cbiN
Additional substrate-specific component CbiN of cobalt ECF transporter
Tmel_0714
cbiQ
Transmembrane component CbiQ of energizing module of cobalt ECF transporter
Tmel_0715
cbiO
ATPase component CbiO of energizing module of cobalt ECF transporter
Tmel_0716
Tmel_0716
Putative ATP binding protein
Position: -219
Score: 113.9
Sequence: TATAAATTGTTACTA...
Locus tag: Tmel_0854
Name: cobT
Funciton: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
Locus tag: Tmel_0855
Name: cobU
Funciton: Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
Locus tag: Tmel_0856
Name: null
Funciton: Putative xylose isomerase domain protein
Locus tag: Tmel_0857
Name: cobS
Funciton: Cobalamin synthase
Locus tag: Tmel_0858
Name: cbiP
Funciton: Cobyric acid synthase
Locus tag: Tmel_0859
Name: cbiB
Funciton: Adenosylcobinamide-phosphate synthase
Locus tag: Tmel_0860
Name: cobD
Funciton: L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
Locus tag: Tmel_0861
Name: btuR
Funciton: Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
Tmel_0854
cobT
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21)
Tmel_0855
cobU
Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62)
Tmel_0856
Putative xylose isomerase domain protein
Tmel_0857
cobS
Cobalamin synthase
Tmel_0858
cbiP
Cobyric acid synthase
Tmel_0859
cbiB
Adenosylcobinamide-phosphate synthase
Tmel_0860
cobD
L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)
Tmel_0861
btuR
Cob(I)alamin adenosyltransferase (EC 2.5.1.17)
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