Regulog NrdR - Thermotogales

Properties
Regulator type:	Transcription factor
Regulator family:	NrdR
Regulation mode:	repressor
Biological process:	Deoxyribonucleotide biosynthesis
Effector:	Deoxyribonucleotides
Phylum:	Thermotogae
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 60 sites [see more]

Member of regulog collections

By trascription factor - NrdR
By taxonomy - Thermotogales
By TF family - NrdR
By effector - Deoxyribonucleotides
By pathway - Deoxyribonucleotide biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Thermotoga maritima MSB8	7	4
Thermotoga sp. RQ2	7	4
Thermotoga neapolitana DSM 4359	7	4
Thermotoga petrophila RKU-1	7	4
Thermotoga naphthophila RKU-10	7	4
Thermotoga lettingae TMO	3	2
Thermosipho africanus TCF52B	3	1
Thermosipho melanesiensis BI429	3	1
Fervidobacterium nodosum Rt17-B1	3	2
Petrotoga mobilis SJ95	3	2
Thermotogales bacterium TBF 19.5.1	3	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes												Function

CRON 1.
metE	* Thermotoga maritima MSB8 Site: position = -25 score = 4.28315 sequence = ATACAACAAATGGAGG Site: position = -55 score = 4.8302 sequence = ACACAACATGTGGTAT Gene: TM1286: 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (EC 2.1.1.14)	* Thermotoga sp. RQ2 Site: position = -25 score = 4.28315 sequence = ATACAACAAATGGAGG Site: position = -55 score = 4.8302 sequence = ACACAACATGTGGTAT Gene: TRQ2_1533: 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (EC 2.1.1.14)	* Thermotoga neapolitana DSM 4359 Site: position = -25 score = 4.28315 sequence = ATACAACAAATGGAGG Site: position = -55 score = 4.8302 sequence = ACACAACATGTGGTAT Gene: CTN_1290: 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (EC 2.1.1.14)	* Thermotoga petrophila RKU-1 Site: position = -55 score = 4.8302 sequence = ACACAACATGTGGTAT Site: position = -25 score = 4.28315 sequence = ATACAACAAATGGAGG Gene: Tpet_1489: 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (EC 2.1.1.14)	* Thermotoga naphthophila RKU-10 Site: position = -55 score = 4.8302 sequence = ACACAACATGTGGTAT Site: position = -25 score = 4.28315 sequence = ATACAACAAATGGAGG Gene: Tnap_1512: 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (EC 2.1.1.14)	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase (EC 2.1.1.14)

CRON 2.
TM0152	* Thermotoga maritima MSB8 Site: position = -109 score = 3.79203 sequence = ATACTACAAAATGTAC Site: position = -140 score = 5.28299 sequence = ATACAATATATGGTAT Gene: TM0152: Conserved hypothetical protein	* Thermotoga sp. RQ2 Site: position = -140 score = 4.57949 sequence = ATACAATATACGGTAT Site: position = -109 score = 4.17095 sequence = ATACTACAAAATGTAT Gene: TRQ2_0796: Conserved hypothetical protein	* Thermotoga neapolitana DSM 4359 Site: position = -141 score = 4.17018 sequence = CTACTTCATGTTGTGT Site: position = -110 score = 4.48855 sequence = ATACCATAAGTAGTGT Gene: CTN_0535: Conserved hypothetical protein	* Thermotoga petrophila RKU-1 Site: position = -109 score = 3.79203 sequence = ATACTACAAAATGTAC Site: position = -140 score = 4.57949 sequence = ATACAATATACGGTAT Gene: Tpet_0773: Conserved hypothetical protein	* Thermotoga naphthophila RKU-10 Site: position = -109 score = 3.79203 sequence = ATACTACAAAATGTAC Site: position = -140 score = 4.57949 sequence = ATACAATATACGGTAT Gene: Tnap_0782: Conserved hypothetical protein	Thermotoga lettingae TMO Gene: Tlet_0268: Conserved hypothetical protein	Thermosipho africanus TCF52B Gene: THA_1698: Conserved hypothetical protein	Thermosipho melanesiensis BI429 Gene: Tmel_1208: Conserved hypothetical protein	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_0424: Conserved hypothetical protein	Petrotoga mobilis SJ95	* Thermotogales bacterium TBF 19.5.1 Site: position = -154 score = 4.46491 sequence = TTTCTATATGTTGTGA Site: position = -126 score = 4.14124 sequence = CTCCAATACATTGTGT Gene: Kole_0584: Conserved hypothetical protein	Conserved hypothetical protein

CRON 3.
nrdJ	* Thermotoga maritima MSB8 Site: position = -34 score = 5.26428 sequence = ACACAATATGTTGTTT Site: position = -64 score = 4.46072 sequence = CTACCACATGTTGAAT Gene: TM0118: B12-dependent ribonucleotide reductase (EC 1.17.4.1)	* Thermotoga sp. RQ2 Site: position = -34 score = 5.01815 sequence = ACACAATATGTTGTTA Site: position = -64 score = 4.30619 sequence = CTACCAAATGTTGAAT Gene: TRQ2_0829: B12-dependent ribonucleotide reductase (EC 1.17.4.1)	* Thermotoga neapolitana DSM 4359 Site: position = -7 score = 5.01815 sequence = AcACAATATgTTGTta Site: position = -37 score = 4.43706 sequence = CCACCACATGTTGAAT Gene: CTN_0571: B12-dependent ribonucleotide reductase (EC 1.17.4.1)	* Thermotoga petrophila RKU-1 Site: position = -34 score = 5.01815 sequence = ACACAATATGTTGTTA Site: position = -64 score = 4.30619 sequence = CTACCAAATGTTGAAT Gene: Tpet_0806: B12-dependent ribonucleotide reductase (EC 1.17.4.1)	* Thermotoga naphthophila RKU-10 Site: position = -64 score = 4.30619 sequence = CTACCAAATGTTGAAT Site: position = -34 score = 5.01815 sequence = ACACAATATGTTGTTA Gene: Tnap_0748: B12-dependent ribonucleotide reductase (EC 1.17.4.1)	* Thermotoga lettingae TMO Site: position = -45 score = 4.65988 sequence = ATACAACTTGTAGTAT Site: position = -75 score = 5.41019 sequence = ACACAATATATAGTGT Gene: Tlet_0333: B12-dependent ribonucleotide reductase (EC 1.17.4.1)	Thermosipho africanus TCF52B Gene: THA_675: B12-dependent ribonucleotide reductase (EC 1.17.4.1)	Thermosipho melanesiensis BI429 Gene: Tmel_0606: B12-dependent ribonucleotide reductase (EC 1.17.4.1)	* Fervidobacterium nodosum Rt17-B1 Site: position = -98 score = 5.09526 sequence = ATACTATATATGGTAT Site: position = -128 score = 4.46193 sequence = TAACTATAAGTTGTGT Gene: Fnod_0421: B12-dependent ribonucleotide reductase (EC 1.17.4.1)	* Petrotoga mobilis SJ95 Site: position = -63 score = 4.59703 sequence = TTTCAATATATTGTCG Site: position = -32 score = 4.86148 sequence = GTACAATATATTGATT Gene: Pmob_1872: B12-dependent ribonucleotide reductase (EC 1.17.4.1)	Thermotogales bacterium TBF 19.5.1	B12-dependent ribonucleotide reductase (EC 1.17.4.1)
TM0119	Thermotoga maritima MSB8 Gene: TM0119: Predicted acetamidase/formamidase	Thermotoga sp. RQ2 Gene: TRQ2_0828: Predicted acetamidase/formamidase	Thermotoga neapolitana DSM 4359 Gene: CTN_0570: Predicted acetamidase/formamidase	Thermotoga petrophila RKU-1 Gene: Tpet_0805: Predicted acetamidase/formamidase	Thermotoga naphthophila RKU-10 Gene: Tnap_0749: Predicted acetamidase/formamidase	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	Predicted acetamidase/formamidase
TM0120	Thermotoga maritima MSB8 Gene: TM0120: Predicted oxidoreductase	Thermotoga sp. RQ2 Gene: TRQ2_0827: Predicted oxidoreductase	Thermotoga neapolitana DSM 4359 Gene: CTN_0569: Predicted oxidoreductase	Thermotoga petrophila RKU-1 Gene: Tpet_0804: Predicted oxidoreductase	Thermotoga naphthophila RKU-10 Gene: Tnap_0750: Predicted oxidoreductase	Thermotoga lettingae TMO	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	Predicted oxidoreductase
nrdD	Thermotoga maritima MSB8 Gene: TM0385: Anaerobic ribonucleoside-triphosphate reductase (EC 1.17.4.2)	Thermotoga sp. RQ2 Gene: TRQ2_0550: Anaerobic ribonucleoside-triphosphate reductase (EC 1.17.4.2)	Thermotoga neapolitana DSM 4359 Gene: CTN_0312: Anaerobic ribonucleoside-triphosphate reductase (EC 1.17.4.2)	Thermotoga petrophila RKU-1 Gene: Tpet_0536: Anaerobic ribonucleoside-triphosphate reductase (EC 1.17.4.2)	Thermotoga naphthophila RKU-10 Gene: Tnap_0176: Anaerobic ribonucleoside-triphosphate reductase (EC 1.17.4.2)	* Thermotoga lettingae TMO Site: position = -28 score = 5.26977 sequence = ATACTATATATAGTAT Site: position = -58 score = 4.7913 sequence = ATCCTATATATTGTAT Gene: Tlet_0432: Anaerobic ribonucleoside-triphosphate reductase (EC 1.17.4.2)	* Thermosipho africanus TCF52B Site: position = -91 score = 5.31477 sequence = AAACTATATATTGTAT Site: position = -59 score = 5.49055 sequence = ATACAATATATTGTGG Gene: THA_677: Anaerobic ribonucleoside-triphosphate reductase (EC 1.17.4.2)	* Thermosipho melanesiensis BI429 Site: position = -103 score = 5.43385 sequence = ACACAATATATAGTAT Site: position = -71 score = 5.49055 sequence = ATACAATATATTGTGG Gene: Tmel_0604: Anaerobic ribonucleoside-triphosphate reductase (EC 1.17.4.2)	Fervidobacterium nodosum Rt17-B1 Gene: Fnod_1249: Anaerobic ribonucleoside-triphosphate reductase (EC 1.17.4.2)	* Petrotoga mobilis SJ95 Site: position = -62 score = 4.96734 sequence = ACACAATAAATTGAGT Site: position = -94 score = 4.59932 sequence = ATACAATATACAGTGG Gene: Pmob_0978: Anaerobic ribonucleoside-triphosphate reductase (EC 1.17.4.2)	* Thermotogales bacterium TBF 19.5.1 Site: position = -35 score = 3.71916 sequence = TTACTATTTATAGGGA Site: position = -66 score = 4.89085 sequence = ATACTATATATAGTAC Gene: Kole_0530: Anaerobic ribonucleoside-triphosphate reductase (EC 1.17.4.2)	Anaerobic ribonucleoside-triphosphate reductase (EC 1.17.4.2)
nrdG	* Thermotoga maritima MSB8 Site: position = -55 score = 5.33586 sequence = CCACAATATATTGTGG Site: position = -85 score = 4.10199 sequence = CAACAATTTTTTGAGA Gene: TM0384: Anaerobic ribonucleoside-triphosphate reductase-activating protein	* Thermotoga sp. RQ2 Site: position = -85 score = 4.10199 sequence = CAACAATTTTTTGAGA Site: position = -55 score = 5.33586 sequence = CCACAATATATTGTGG Gene: TRQ2_0549: Anaerobic ribonucleoside-triphosphate reductase-activating protein	* Thermotoga neapolitana DSM 4359 Site: position = -54 score = 5.12129 sequence = CCACAACATATTGTGG Site: position = -84 score = 4.4711 sequence = CAACAATTTATTGAGA Gene: CTN_0313: Anaerobic ribonucleoside-triphosphate reductase-activating protein	* Thermotoga petrophila RKU-1 Site: position = -61 score = 5.33586 sequence = CCACAATATATTGTGG Site: position = -91 score = 4.10199 sequence = CAACAATTTTTTGAGA Gene: Tpet_0535: Anaerobic ribonucleoside-triphosphate reductase-activating protein	* Thermotoga naphthophila RKU-10 Site: position = -85 score = 4.10199 sequence = CAACAATTTTTTGAGA Site: position = -55 score = 5.33586 sequence = CCACAATATATTGTGG Gene: Tnap_0177: Anaerobic ribonucleoside-triphosphate reductase-activating protein	Thermotoga lettingae TMO	Thermosipho africanus TCF52B Gene: THA_676: Anaerobic ribonucleoside-triphosphate reductase-activating protein	Thermosipho melanesiensis BI429 Gene: Tmel_0605: Anaerobic ribonucleoside-triphosphate reductase-activating protein	* Fervidobacterium nodosum Rt17-B1 Site: position = -91 score = 5.24612 sequence = ATACTATATATAGTGT Site: position = -61 score = 5.2404 sequence = ATTCAATATATTGTTT Gene: Fnod_1248: Anaerobic ribonucleoside-triphosphate reductase-activating protein	Petrotoga mobilis SJ95	Thermotogales bacterium TBF 19.5.1	Anaerobic ribonucleoside-triphosphate reductase-activating protein
nrdX	Thermotoga maritima MSB8	Thermotoga sp. RQ2	Thermotoga neapolitana DSM 4359	Thermotoga petrophila RKU-1	Thermotoga naphthophila RKU-10	Thermotoga lettingae TMO Gene: Tlet_0433: Anaerobic ribonucleoside-triphosphate reductase-activating protein	Thermosipho africanus TCF52B	Thermosipho melanesiensis BI429	Fervidobacterium nodosum Rt17-B1	Petrotoga mobilis SJ95 Gene: Pmob_0979: Anaerobic ribonucleoside-triphosphate reductase-activating protein	Thermotogales bacterium TBF 19.5.1 Gene: Kole_0529: Anaerobic ribonucleoside-triphosphate reductase-activating protein	Anaerobic ribonucleoside-triphosphate reductase-activating protein

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog NrdR - Thermotogales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --