Collection of regulogs for NrdR transcription factor family

NrdR repressor controls expression of genes for deoxyribonucleotide reductases (nrd) of all three types in most lineages of Bacteria [15949864]. Novel DNA-binding motif (NrdR-box) was first discovered by application of the comparative genomic approach, and the NrdR transcription factor (previously known as hypothetical protein YbaD in E. coli) was attributed to the identified NrdR-box motif by correlating their occurrence with the phylogenetic distribution of ortholog families. The DNA-binding motifs of NrdR showed significant conservation across diverse bacterial lineages. The predicted regulatory role of NrdR was confirmed in experiments conducted in E. more

coli, Streptomyces and Chlamydia spp. [15522084, 21725017]. It was suggested that NrdR activity is modulated by a deoxyribonucleotide corepressor [21725017]. NrdR proteins constitute a unique family of transcription factors (COG1327) containing a Zn-ribbon DNA binding domain and ATP cone nucleotide binding domain (PF03477).