Regulog NrdR - Clostridia-3

Properties
Regulator type:	Transcription factor
Regulator family:	NrdR
Regulation mode:	repressor
Biological process:	Deoxyribonucleotide biosynthesis
Effector:	Deoxyribonucleotides
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 49 sites [see more]

Member of regulog collections

By trascription factor - NrdR
By TF family - NrdR
By effector - Deoxyribonucleotides
By pathway - Deoxyribonucleotide biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Bacteroides pectinophilus ATCC 43243	3	2
Blautia hansenii DSM 20583	3	2
Bryantella formatexigens DSM 14469	1	1
Clostridiales bacterium 1_7_47_FAA	4	2
Clostridium bolteae ATCC BAA-613	2	1
Clostridium nexile DSM 1787	4	2
Clostridium scindens ATCC 35704	6	3
Dorea formicigenerans ATCC 27755	1	1
Dorea longicatena DSM 13814	2	2
Eubacterium eligens ATCC 27750	1	1
Eubacterium rectale ATCC 33656	1	1
Roseburia intestinalis L1-82	2	1
Ruminococcus gnavus ATCC 29149	5	3
Ruminococcus lactaris ATCC 29176	2	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes															Function

CRON 1.
nrdD	2 Bacteroides pectinophilus ATCC 43243* Site: position = -147 score = 5.11295 sequence = GCACAATATATTGTTT Site: position = -116 score = 3.88826 sequence = TTTCTATATTTGGTAG Gene: BACPEC_00926: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Site: position = -159 score = 4.12183 sequence = ACGCAATATTTGGTAA Site: position = -128 score = 4.47345 sequence = TATCTATATATTGTGG Gene: BACPEC_00140: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Blautia hansenii DSM 20583	Bryantella formatexigens DSM 14469	* Clostridiales bacterium 1_7_47_FAA Site: position = -141 score = 4.80858 sequence = ACACAACATTTAGTGC Site: position = -173 score = 3.83212 sequence = ATACATCCTATCGTAT Gene: Cbac1_010100006828: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Clostridium bolteae ATCC BAA-613 Site: position = -171 score = 3.96011 sequence = ATACATCTTATCGTAT Site: position = -140 score = 4.98145 sequence = ACACAACATTTAGTGG Gene: CLOBOL_02823: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Clostridium nexile DSM 1787	* Clostridium scindens ATCC 35704 Site: position = -67 score = 4.58667 sequence = GTGCTAGATATTGTAT Site: position = -35 score = 4.08906 sequence = AACCAACATTTAGTGG Site: position = -135 score = 4.44694 sequence = AAAGTAAATATTGTAT Gene: CLOSCI_01031: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Dorea formicigenerans ATCC 27755 Site: position = -162 score = 4.21833 sequence = ACGCCATATTTTGTAG Site: position = -129 score = 5.03846 sequence = ACACAATATCTTGTGA Site: position = -64 score = 4.8777 sequence = ACACAAGATGTTGTGG Gene: DORFOR_02443: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Dorea longicatena DSM 13814 Site: position = -102 score = 4.56888 sequence = GCACAATATCTTGTGC Site: position = -70 score = 4.9584 sequence = AAACAATATTTAGTAG Gene: DORLON_00953: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Eubacterium eligens ATCC 27750 Site: position = -178 score = 5.07151 sequence = TTACAAGATATTGTGT Site: position = -146 score = 4.58088 sequence = AGCCTATATGTTGTAT Gene: EUBELI_01571: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Eubacterium rectale ATCC 33656 Site: position = -284 score = 4.73032 sequence = CTACAAAATATTGTTG Site: position = -253 score = 4.85465 sequence = CAACAATATCTTGTAT Site: position = -26 score = 5.50789 sequence = ATACTATATATAGTAC Gene: EUBREC_2400: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	2 Roseburia intestinalis L1-82* Gene: ROSINTL182_03098: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2) Site: position = -95 score = 5.85257 sequence = ACACAATATATTGTAT Gene: ROSINTL182_03097: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Ruminococcus gnavus ATCC 29149 Gene: RUMGNA_00011: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Ruminococcus lactaris ATCC 29176 Site: position = 19 score = 5.52515 sequence = ATACTATATTTTGTAT Site: position = 48 score = 4.12511 sequence = AGACAATATCTTGAAA Gene: RUMLAC_00868: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
nrdG	Bacteroides pectinophilus ATCC 43243 Gene: BACPEC_00927: anaerobic ribonucleoside-triphosphate reductase activating protein	Blautia hansenii DSM 20583	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA Gene: Cbac1_010100006823: anaerobic ribonucleoside-triphosphate reductase activating protein	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_02822: anaerobic ribonucleoside-triphosphate reductase activating protein	Clostridium nexile DSM 1787	Clostridium scindens ATCC 35704 Gene: CLOSCI_01030: anaerobic ribonucleoside-triphosphate reductase activating protein	Dorea formicigenerans ATCC 27755 Gene: DORFOR_02441: anaerobic ribonucleoside-triphosphate reductase activating protein	Dorea longicatena DSM 13814 Gene: DORLON_00951: anaerobic ribonucleoside-triphosphate reductase activating protein	Eubacterium eligens ATCC 27750 Gene: EUBELI_20493: anaerobic ribonucleoside-triphosphate reductase activating protein	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82	Ruminococcus gnavus ATCC 29149 Gene: RUMGNA_00010: anaerobic ribonucleoside-triphosphate reductase activating protein	Ruminococcus lactaris ATCC 29176 Gene: RUMLAC_00869: anaerobic ribonucleoside-triphosphate reductase activating protein	anaerobic ribonucleoside-triphosphate reductase activating protein

CRON 2.
ligA	Bacteroides pectinophilus ATCC 43243	* Blautia hansenii DSM 20583 Site: position = -123 score = 5.04546 sequence = ACACTATATATCGTTT Site: position = -153 score = 5.61079 sequence = ACACTATATGTAGTAT Site: position = -92 score = 4.8276 sequence = TTACTATATATAGAGG Gene: BLAHAN_00802: NAD-dependent DNA ligase	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613	Clostridium nexile DSM 1787	Clostridium scindens ATCC 35704 Gene: CLOSCI_03783: NAD-dependent DNA ligase	Dorea formicigenerans ATCC 27755	Dorea longicatena DSM 13814	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82	* Ruminococcus gnavus ATCC 29149 Site: position = -153 score = 5.61079 sequence = ACACTATATGTAGTAT Site: position = -123 score = 5.04546 sequence = ACACTATATATCGTTT Site: position = -92 score = 4.8276 sequence = TTACTATATATAGAGG Gene: RUMGNA_01429: NAD-dependent DNA ligase	Ruminococcus lactaris ATCC 29176	NAD-dependent DNA ligase

CRON 3.
nrdE	Bacteroides pectinophilus ATCC 43243	* Blautia hansenii DSM 20583 Site: position = -41 score = 5.42914 sequence = ATACAAGATATAGTAT Gene: BLAHAN_01704: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA Gene: Cbac1_010100012710: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_02577: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	* Clostridium nexile DSM 1787 Site: position = -60 score = 5.07322 sequence = CAACTATATATTGTGG Site: position = -28 score = 4.98436 sequence = ATACTATAAATAGTAA Gene: CLONEX_03145: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	* Clostridium scindens ATCC 35704 Site: position = -64 score = 5.06548 sequence = CAACAATATATTGTGG Site: position = -33 score = 4.43605 sequence = AATCAATAAATTGTAT Gene: CLOSCI_02889: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Dorea formicigenerans ATCC 27755	Dorea longicatena DSM 13814	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82	* Ruminococcus gnavus ATCC 29149 Site: position = -78 score = 4.80932 sequence = ATCCAATATCTTGTGT Site: position = -48 score = 5.27176 sequence = CCACTATATTTTGTAT Gene: RUMGNA_02624: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Ruminococcus lactaris ATCC 29176	Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)
nrdF	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583 Gene: BLAHAN_01705: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA Gene: Cbac1_010100012705: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_02576: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Clostridium nexile DSM 1787 Gene: CLONEX_03144: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Clostridium scindens ATCC 35704 Gene: CLOSCI_02888: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Dorea formicigenerans ATCC 27755	Dorea longicatena DSM 13814	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82	Ruminococcus gnavus ATCC 29149 Gene: RUMGNA_02625: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Ruminococcus lactaris ATCC 29176	Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)

CRON 4.
nrdD2	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583	* Bryantella formatexigens DSM 14469 Site: position = -110 score = 4.7903 sequence = ACACTATATATTGATG Site: position = -142 score = 4.41178 sequence = ATACTCTATTTAGTAC Gene: BRYFOR_03555: Oxygen-sensitive ribonucleoside-triphosphate reductase (EC 1.17.4.2)	* Clostridiales bacterium 1_7_47_FAA Site: position = -144 score = 5.04969 sequence = ACACAATATCTAGTTT Site: position = -127 score = 4.10208 sequence = ACACAAAATGTTATAC Gene: Cbac1_010100017114: Oxygen-sensitive ribonucleoside-triphosphate reductase (EC 1.17.4.2)	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_06849: Oxygen-sensitive ribonucleoside-triphosphate reductase (EC 1.17.4.2)	* Clostridium nexile DSM 1787 Site: position = -122 score = 4.33424 sequence = TAACAATATATAGGAA Site: position = -91 score = 4.90973 sequence = ACACAATATATGGTTT Gene: CLONEX_02838: Oxygen-sensitive ribonucleoside-triphosphate reductase (EC 1.17.4.2)	* Clostridium scindens ATCC 35704 Site: position = -96 score = 4.39897 sequence = ACACAATAAGTGGTAT Site: position = -129 score = 4.79611 sequence = GCACAATATATTGTTA Site: position = -160 score = 4.79611 sequence = TAACAATATATTGTGC Gene: CLOSCI_01639: Oxygen-sensitive ribonucleoside-triphosphate reductase (EC 1.17.4.2)	Dorea formicigenerans ATCC 27755	Dorea longicatena DSM 13814	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82	* Ruminococcus gnavus ATCC 29149 Site: position = -91 score = 4.0261 sequence = ATACTAGATGTTGGTG Site: position = -44 score = 4.28964 sequence = ACACTAAATACAGCGT Gene: RUMGNA_02734: Oxygen-sensitive ribonucleoside-triphosphate reductase (EC 1.17.4.2)	Ruminococcus lactaris ATCC 29176	Oxygen-sensitive ribonucleoside-triphosphate reductase (EC 1.17.4.2)
COG0345	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583 Gene: BLAHAN_00380: Pyrroline-5-carboxylate reductase (EC 1.5.1.2)	Bryantella formatexigens DSM 14469 Gene: BRYFOR_04808: Pyrroline-5-carboxylate reductase (EC 1.5.1.2)	Clostridiales bacterium 1_7_47_FAA	Clostridium bolteae ATCC BAA-613	Clostridium nexile DSM 1787 Gene: CLONEX_02839: Pyrroline-5-carboxylate reductase (EC 1.5.1.2)	Clostridium scindens ATCC 35704 Gene: CLOSCI_01601: Pyrroline-5-carboxylate reductase (EC 1.5.1.2)	Dorea formicigenerans ATCC 27755 Gene: DORFOR_03282: Pyrroline-5-carboxylate reductase (EC 1.5.1.2)	* Dorea longicatena DSM 13814 Site: position = -74 score = 3.7892 sequence = ACATAACAGATTGTTT Gene: DORLON_01167: Pyrroline-5-carboxylate reductase (EC 1.5.1.2)	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656 Gene: EUBREC_1178: Pyrroline-5-carboxylate reductase (EC 1.5.1.2)	Roseburia intestinalis L1-82	Ruminococcus gnavus ATCC 29149 Gene: RUMGNA_02726: Pyrroline-5-carboxylate reductase (EC 1.5.1.2)	Ruminococcus lactaris ATCC 29176 Gene: RUMLAC_01681: Pyrroline-5-carboxylate reductase (EC 1.5.1.2)	Pyrroline-5-carboxylate reductase (EC 1.5.1.2)
Cbac1_010100017119	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583	Bryantella formatexigens DSM 14469	Clostridiales bacterium 1_7_47_FAA Gene: Cbac1_010100017119: hypothetical protein	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_06848: hypothetical protein	Clostridium nexile DSM 1787	Clostridium scindens ATCC 35704	Dorea formicigenerans ATCC 27755	Dorea longicatena DSM 13814	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82	Ruminococcus gnavus ATCC 29149	Ruminococcus lactaris ATCC 29176	hypothetical protein
COG0492	Bacteroides pectinophilus ATCC 43243	Blautia hansenii DSM 20583	Bryantella formatexigens DSM 14469 Gene: BRYFOR_01585: thioredoxin reductase	Clostridiales bacterium 1_7_47_FAA Gene: Cbac1_010100029421: thioredoxin reductase	Clostridium bolteae ATCC BAA-613 Gene: CLOBOL_05920: thioredoxin reductase	Clostridium nexile DSM 1787 Gene: CLONEX_03825: thioredoxin reductase	Clostridium scindens ATCC 35704 Gene: CLOSCI_01638: thioredoxin reductase	Dorea formicigenerans ATCC 27755 Gene: DORFOR_00179: thioredoxin reductase	Dorea longicatena DSM 13814	Eubacterium eligens ATCC 27750	Eubacterium rectale ATCC 33656	Roseburia intestinalis L1-82	Ruminococcus gnavus ATCC 29149 Gene: RUMGNA_02735: thioredoxin reductase	Ruminococcus lactaris ATCC 29176 Gene: RUMLAC_01680: thioredoxin reductase	thioredoxin reductase

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog NrdR - Clostridia-3

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --