Regulog NrdR - Lactobacillaceae

Properties
Regulator type:	Transcription factor
Regulator family:	NrdR
Regulation mode:	repressor
Biological process:	Deoxyribonucleotide biosynthesis
Effector:	Deoxyribonucleotides
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 81 sites [see more]

Member of regulog collections

By trascription factor - NrdR
By taxonomy - Lactobacillaceae
By TF family - NrdR
By effector - Deoxyribonucleotides
By pathway - Deoxyribonucleotide biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Lactobacillus acidophilus NCFM	9	4
Lactobacillus brevis ATCC 367	8	5
Lactobacillus casei ATCC 334	11	5
Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	8	3
Lactobacillus fermentum IFO 3956	9	3
Lactobacillus helveticus DPC 4571	9	4
Lactobacillus johnsonii NCC 533	5	3
Lactobacillus plantarum WCFS1	8	5
Lactobacillus reuteri JCM 1112	7	4
Lactobacillus rhamnosus GG	11	5
Lactobacillus sakei subsp. sakei 23K	5	3
Lactobacillus salivarius subsp. salivarius UCC118	6	2
Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
Oenococcus oeni PSU-1
Pediococcus pentosaceus ATCC 25745	8	4

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes																Function

CRON 1.
nrdI	Lactobacillus acidophilus NCFM Gene: LBA1749: Ribonucleotide reduction protein NrdI	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	* Lactobacillus fermentum IFO 3956 Site: position = -30 score = 4.69808 sequence = CCACAACATCTTGTGA Gene: LAF_1675: Ribonucleotide reduction protein NrdI	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533 Gene: LJ0592: Ribonucleotide reduction protein NrdI	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_1231: Ribonucleotide reduction protein NrdI	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0255: Ribonucleotide reduction protein NrdI	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Ribonucleotide reduction protein NrdI
nrdE	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367 Gene: LVIS_0596: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Lactobacillus casei ATCC 334 Gene: LSEI_1468: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	2 Lactobacillus fermentum IFO 3956 Gene: LAF_0280: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1) Gene: LAF_1674: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1 Gene: lp_0693: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Lactobacillus reuteri JCM 1112 Gene: LAR_0312: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Lactobacillus rhamnosus GG Gene: LGG_01474: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Lactobacillus sakei subsp. sakei 23K Gene: LSA0941: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_1232: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0254: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Oenococcus oeni PSU-1 Gene: OEOE_0140: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_1488: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)
nrdF	Lactobacillus acidophilus NCFM Gene: LBA1750: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Lactobacillus brevis ATCC 367 Gene: LVIS_0595: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Lactobacillus casei ATCC 334 Gene: LSEI_1469: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	3 Lactobacillus fermentum IFO 3956 Gene: LAF_0279: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1) Gene: LAF_1673: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1) Gene: LAF_1672: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533 Gene: LJ0591: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Lactobacillus plantarum WCFS1 Gene: lp_0692: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Lactobacillus reuteri JCM 1112 Gene: LAR_0311: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Lactobacillus rhamnosus GG Gene: LGG_01475: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Lactobacillus sakei subsp. sakei 23K Gene: LSA0940: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_1233: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0256: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Oenococcus oeni PSU-1 Gene: OEOE_0141: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_1489: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)
nrdH	Lactobacillus acidophilus NCFM	* Lactobacillus brevis ATCC 367 Site: position = -94 score = 4.57309 sequence = CTACCAAATATGGTGT Site: position = -126 score = 4.48345 sequence = ACACCATATTTGGTAG Gene: LVIS_0597: Glutaredoxin-like protein NrdH	* Lactobacillus casei ATCC 334 Site: position = -85 score = 4.58184 sequence = CCCCAAGATATGGTAT Gene: LSEI_1467: Glutaredoxin-like protein NrdH	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	* Lactobacillus fermentum IFO 3956 Site: position = -109 score = 5.42504 sequence = CCACCATATCTTGTGT Site: position = -78 score = 4.40774 sequence = GCACGAGATATGGTGG Gene: LAF_0281: Glutaredoxin-like protein NrdH	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	* Lactobacillus plantarum WCFS1 Site: position = -86 score = 4.64879 sequence = ACCCTAGATGTTGTGT Site: position = -54 score = 4.67018 sequence = TCACCACATGTTGTAT Gene: lp_0694: Glutaredoxin-like protein NrdH	* Lactobacillus reuteri JCM 1112 Site: position = -115 score = 5.58782 sequence = GTACTATATATTGTGT Gene: LAR_0313: Glutaredoxin-like protein NrdH	* Lactobacillus rhamnosus GG Site: position = -85 score = 4.60327 sequence = CCCCAAGATATGGTGT Gene: LGG_01473: Glutaredoxin-like protein NrdH	* Lactobacillus sakei subsp. sakei 23K Site: position = -89 score = 4.95512 sequence = CTACCATATCTGGTAT Gene: LSA0942: Glutaredoxin-like protein NrdH	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -84 score = 5.52267 sequence = CCACAATATATGGTGT Site: position = -51 score = 4.89121 sequence = TCTCTATATATTGTAT Gene: LSL_1230: Glutaredoxin-like protein NrdH	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0253: Glutaredoxin-like protein NrdH	Oenococcus oeni PSU-1 Gene: OEOE_0139: Glutaredoxin-like protein NrdH	* Pediococcus pentosaceus ATCC 25745 Site: position = -122 score = 5.26303 sequence = GCACAATATATAGTGG Gene: PEPE_1487: Glutaredoxin-like protein NrdH	Glutaredoxin-like protein NrdH

CRON 2.
pnuN	* Lactobacillus acidophilus NCFM Site: position = -53 score = 5.46652 sequence = GCACAATATATAGTAT Gene: LBA1653: NrdR-regulated deoxyribonucleotide transporter, PnuC-like	* Lactobacillus brevis ATCC 367 Site: position = -41 score = 3.49626 sequence = GTACTAAATATAGAAA Site: position = -82 score = 5.82932 sequence = CCACAATATATTGTGT Gene: LVIS_0311: NrdR-regulated deoxyribonucleotide transporter, PnuC-like	* Lactobacillus casei ATCC 334 Site: position = -105 score = 3.58663 sequence = CCAATATATTGTATAT Site: position = -107 score = 4.85659 sequence = CACCAATATATTGTAT Gene: LSEI_1204: NrdR-regulated deoxyribonucleotide transporter, PnuC-like	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956 Gene: LAF_1803: NrdR-regulated deoxyribonucleotide transporter, PnuC-like	* Lactobacillus helveticus DPC 4571 Site: position = -172 score = 3.69038 sequence = ACACAACATATAGATA Site: position = -140 score = 4.46445 sequence = GCACAATATTTTGTAA Site: position = -50 score = 4.90158 sequence = ACACAAAATGTTGTAT Gene: lhv_1757: NrdR-regulated deoxyribonucleotide transporter, PnuC-like	* Lactobacillus johnsonii NCC 533 Site: position = -46 score = 5.68414 sequence = GCACAATATATTGTGT Gene: LJ0643: NrdR-regulated deoxyribonucleotide transporter, PnuC-like	* Lactobacillus plantarum WCFS1 Site: position = -108 score = 5.68748 sequence = ATACAATATATTGTGT Site: position = -78 score = 4.80409 sequence = ACACTACATGTAGTAG Gene: lp_0259: NrdR-regulated deoxyribonucleotide transporter, PnuC-like	* Lactobacillus reuteri JCM 1112 Site: position = -72 score = 5.63313 sequence = CCACAATATCTTGTGT Site: position = -30 score = 4.92004 sequence = GCACAACATATAGTAG Gene: LAR_1670: NrdR-regulated deoxyribonucleotide transporter, PnuC-like	* Lactobacillus rhamnosus GG Site: position = -107 score = 4.85659 sequence = CACCAATATATTGTAT Site: position = -139 score = 3.91768 sequence = TTAGTACATGTTGTGG Gene: LGG_01221: NrdR-regulated deoxyribonucleotide transporter, PnuC-like	* Lactobacillus sakei subsp. sakei 23K Site: position = -155 score = 4.21242 sequence = CTACCATATTTTGAAT Site: position = -105 score = 5.39164 sequence = GTACTATATATAGTGT Gene: LSA1189: NrdR-regulated deoxyribonucleotide transporter, PnuC-like	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1445: NrdR-regulated deoxyribonucleotide transporter, PnuC-like	Oenococcus oeni PSU-1 Gene: OEOE_1395: NrdR-regulated deoxyribonucleotide transporter, PnuC-like	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0058: NrdR-regulated deoxyribonucleotide transporter, PnuC-like	NrdR-regulated deoxyribonucleotide transporter, PnuC-like
dgk2	Lactobacillus acidophilus NCFM Gene: LBA1950: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	* Lactobacillus brevis ATCC 367 Site: position = -41 score = 3.636 sequence = GTACACTATATCTTGT Site: position = -39 score = 5.65721 sequence = ACACTATATCTTGTAT Gene: LVIS_1520: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Lactobacillus casei ATCC 334 Gene: LSEI_1205: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_2018: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Lactobacillus fermentum IFO 3956 Gene: LAF_1345: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Lactobacillus helveticus DPC 4571 Gene: lhv_2080: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Lactobacillus johnsonii NCC 533 Gene: LJ1825: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	* Lactobacillus plantarum WCFS1 Site: position = -72 score = 3.93469 sequence = AAAGTCTATATGGTAT Site: position = -40 score = 5.07398 sequence = ATACAATATATTGTGC Gene: lp_1329: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	* Lactobacillus reuteri JCM 1112 Site: position = -88 score = 4.38663 sequence = CCACCAAATATTGTAA Site: position = -56 score = 4.99819 sequence = CCACAATATTTTGTAG Gene: LAR_1221: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Lactobacillus rhamnosus GG Gene: LGG_01222: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0617: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Oenococcus oeni PSU-1 Gene: OEOE_0849: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	* Pediococcus pentosaceus ATCC 25745 Site: position = -83 score = 5.1559 sequence = ATACAATATGTTGTGG Gene: PEPE_0650: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)
dgk1	* Lactobacillus acidophilus NCFM Site: position = -53 score = 4.02826 sequence = CTACCAGATATTGACT Site: position = -23 score = 4.66104 sequence = ACCCTATATATGGTAG Gene: LBA1949: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	* Lactobacillus brevis ATCC 367 Site: position = -100 score = 4.81139 sequence = CCACGATATATTGTCT Site: position = -68 score = 4.92902 sequence = GTACAATATGTGGTGT Gene: LVIS_1711: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Lactobacillus casei ATCC 334	* Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Site: position = -34 score = 3.59034 sequence = AACGTAGATCTAGTAT Site: position = -64 score = 4.23776 sequence = GCACTATATCTTGCAA Gene: LBUL_2017: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Lactobacillus fermentum IFO 3956 Gene: LAF_1535: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	* Lactobacillus helveticus DPC 4571 Site: position = -28 score = 5.02694 sequence = CCACAATATCTCGTAT Site: position = -45 score = 3.76244 sequence = AAAAAAGAGCTTGTGT Site: position = 2 score = 4.35726 sequence = GTCCAATATCTGGTAT Gene: lhv_2079: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	* Lactobacillus johnsonii NCC 533 Site: position = -56 score = 4.53855 sequence = CTACCAGATATTGAAT Site: position = -26 score = 5.33795 sequence = AAACTATATATTGTAG Gene: LJ1824: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	* Lactobacillus plantarum WCFS1 Site: position = -99 score = 4.37897 sequence = TCACCAGATATTGCAT Site: position = -67 score = 5.03948 sequence = GTACAATATGTAGTGT Gene: lp_1011: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Lactobacillus reuteri JCM 1112 Gene: LAR_1408: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_0293: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Oenococcus oeni PSU-1 Gene: OEOE_0437: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	* Pediococcus pentosaceus ATCC 25745 Site: position = -77 score = 4.11974 sequence = TTTCAAGATATTGTTT Site: position = -46 score = 4.42598 sequence = GTACAATATGTAGTGC Gene: PEPE_1437: Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)	Deoxyadenosine kinase (EC 2.7.1.76) / Deoxyguanosine kinase (EC 2.7.1.113)

CRON 3.
mntH2	Lactobacillus acidophilus NCFM	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112	Lactobacillus rhamnosus GG	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1 Gene: OEOE_0827: Predicted manganese transport protein	* Pediococcus pentosaceus ATCC 25745 Site: position = -133 score = 5.71156 sequence = ATACTATATATTGTAT Gene: PEPE_0483: Predicted manganese transport protein	Predicted manganese transport protein
nrdD	* Lactobacillus acidophilus NCFM Site: position = -58 score = 4.50871 sequence = ATACAAGATGTTGTGC Gene: LBA0160: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Lactobacillus brevis ATCC 367	* Lactobacillus casei ATCC 334 Site: position = -131 score = 5.49294 sequence = ACACTATATAGTGTAT Site: position = -133 score = 4.97235 sequence = ACACACTATATAGTGT Gene: LSEI_0131: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Site: position = -173 score = 5.30505 sequence = CCACAATATCTGGTAT Site: position = -131 score = 4.55242 sequence = AAACAAGATGTAGTGG Gene: LBUL_0185: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Lactobacillus fermentum IFO 3956 Site: position = -99 score = 4.73957 sequence = CCACAAGATCTTGTAA Site: position = -68 score = 5.27768 sequence = AAACTATATGTTGTGT Gene: LAF_1376: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Lactobacillus helveticus DPC 4571 Site: position = -56 score = 5.10078 sequence = ATACAAGATGTTGTAT Gene: lhv_0169: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Lactobacillus johnsonii NCC 533 Site: position = -63 score = 4.60636 sequence = CTACAATATCATGTAG Gene: LJ0137: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Lactobacillus plantarum WCFS1 Site: position = -49 score = 4.38667 sequence = GCACTATCAATTGTAT Site: position = -80 score = 5.51537 sequence = CTACTATATATAGTAT Gene: lp_2932: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Lactobacillus reuteri JCM 1112 Site: position = -92 score = 5.31159 sequence = CCACAACATATAGTGT Gene: LAR_1249: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Lactobacillus rhamnosus GG Site: position = -131 score = 5.49294 sequence = CCACTATATAGTGTAT Gene: LGG_00138: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Lactobacillus sakei subsp. sakei 23K Site: position = -75 score = 5.10679 sequence = ACACTATATATAGTTG Gene: LSA1459: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Lactobacillus salivarius subsp. salivarius UCC118 Site: position = -108 score = 5.53681 sequence = ATACTATATATAGTGT Site: position = -76 score = 5.8534 sequence = ACACTATATATTGTAT Gene: LSL_1332: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1539: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Oenococcus oeni PSU-1 Gene: OEOE_1116: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0484: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
nrdG	Lactobacillus acidophilus NCFM Gene: LBA0161: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Lactobacillus brevis ATCC 367	* Lactobacillus casei ATCC 334 Site: position = -113 score = 4.32955 sequence = ATACTACATCTTGGGG Gene: LSEI_1742: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0186: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Lactobacillus fermentum IFO 3956 Gene: LAF_1375: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Lactobacillus helveticus DPC 4571 Gene: lhv_0170: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Lactobacillus johnsonii NCC 533 Gene: LJ0138: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Lactobacillus plantarum WCFS1 Gene: lp_2931: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Lactobacillus reuteri JCM 1112 Gene: LAR_1248: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	* Lactobacillus rhamnosus GG Site: position = -145 score = 4.96889 sequence = ATACTACATCTTGTAG Gene: LGG_01800: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Lactobacillus sakei subsp. sakei 23K Gene: LSA1458: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Lactobacillus salivarius subsp. salivarius UCC118 Gene: LSL_1331: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Gene: LEUM_1538: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Oenococcus oeni PSU-1 Gene: OEOE_1115: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Pediococcus pentosaceus ATCC 25745 Gene: PEPE_0485: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)

CRON 4.
nrdJ	* Lactobacillus acidophilus NCFM Site: position = -52 score = 3.45133 sequence = ATCATACATAATGTGT Site: position = -83 score = 5.05875 sequence = GTACAAGATATTGTGG Gene: LBA0041: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	* Lactobacillus brevis ATCC 367 Site: position = -45 score = 4.60099 sequence = CTACCATATATAGCAT Site: position = -77 score = 5.26147 sequence = TAACTATATATTGTAT Gene: LVIS_1898: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	* Lactobacillus casei ATCC 334 Site: position = -31 score = 5.26176 sequence = ATACCATATCTTGTAT Gene: LSEI_2287: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	* Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Site: position = -138 score = 3.72682 sequence = ACACAGTTTCTCGTGT Site: position = -107 score = 5.3571 sequence = ACACTACATCTTGTGT Gene: LBUL_0079: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	Lactobacillus fermentum IFO 3956	* Lactobacillus helveticus DPC 4571 Site: position = -85 score = 5.34576 sequence = CCACAAGATATTGTGG Gene: lhv_0042: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112	* Lactobacillus rhamnosus GG Site: position = -31 score = 5.26176 sequence = ATACCATATCTTGTAT Gene: LGG_02296: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)
cbrX	Lactobacillus acidophilus NCFM Gene: LBA0040: Additional lipoprotein component of predicted cobalamin ECF transporter	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334 Gene: LSEI_2286: Additional lipoprotein component of predicted cobalamin ECF transporter	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0080: Additional lipoprotein component of predicted cobalamin ECF transporter	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571 Gene: lhv_0041: Additional lipoprotein component of predicted cobalamin ECF transporter	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112 Gene: LAR_1582: Additional lipoprotein component of predicted cobalamin ECF transporter	Lactobacillus rhamnosus GG Gene: LGG_02295: Additional lipoprotein component of predicted cobalamin ECF transporter	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Additional lipoprotein component of predicted cobalamin ECF transporter
cbrT	Lactobacillus acidophilus NCFM Gene: LBA0039: Substrate-specific component CbrT of predicted cobalamin ECF transporter	Lactobacillus brevis ATCC 367	Lactobacillus casei ATCC 334 Gene: LSEI_2285: Substrate-specific component CbrT of predicted cobalamin ECF transporter	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0081: Substrate-specific component CbrT of predicted cobalamin ECF transporter	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571 Gene: lhv_0040: Substrate-specific component CbrT of predicted cobalamin ECF transporter	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112 Gene: LAR_1581: Substrate-specific component CbrT of predicted cobalamin ECF transporter	Lactobacillus rhamnosus GG Gene: LGG_02294: Substrate-specific component CbrT of predicted cobalamin ECF transporter	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Substrate-specific component CbrT of predicted cobalamin ECF transporter
pduO	Lactobacillus acidophilus NCFM Gene: LBA0038: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17)	Lactobacillus brevis ATCC 367 Gene: LVIS_1897: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17)	Lactobacillus casei ATCC 334 Gene: LSEI_2284: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17)	Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 Gene: LBUL_0082: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17)	Lactobacillus fermentum IFO 3956	Lactobacillus helveticus DPC 4571 Gene: lhv_0039: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17)	Lactobacillus johnsonii NCC 533	Lactobacillus plantarum WCFS1	Lactobacillus reuteri JCM 1112 Gene: LAR_1613: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17)	Lactobacillus rhamnosus GG Gene: LGG_02293: Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17)	Lactobacillus sakei subsp. sakei 23K	Lactobacillus salivarius subsp. salivarius UCC118	Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293	Oenococcus oeni PSU-1	Pediococcus pentosaceus ATCC 25745	Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

Export
	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog NrdR - Lactobacillaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --