Regulog NrdR - Micrococcineae

Properties
Regulator type:	Transcription factor
Regulator family:	NrdR
Regulation mode:	repressor
Biological process:	Deoxyribonucleotide biosynthesis
Effector:	Deoxyribonucleotides
Phylum:	Actinobacteria
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 44 sites [see more]

Member of regulog collections

By trascription factor - NrdR
By taxonomy - Micrococcineae
By TF family - NrdR
By effector - Deoxyribonucleotides
By pathway - Deoxyribonucleotide biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Arthrobacter aurescens TC1	5	2
Arthrobacter chlorophenolicus A6	5	2
Arthrobacter sp. FB24	5	2
Beutenbergia cavernae DSM 12333	6	2
Brachybacterium faecium DSM 4810	5	2
Brevibacterium linens BL2	4	1
Clavibacter michiganensis subsp. michiganensis NCPPB 382	2	1
Janibacter sp. HTCC2649	2	1
Jonesia denitrificans DSM 20603	3	1
Kocuria rhizophila DC2201	5	2
Kytococcus sedentarius DSM 20547	4	2
Leifsonia xyli subsp. xyli str. CTCB07	2	1
Renibacterium salmoninarum ATCC 33209	6	3
Tropheryma whipplei str. Twist	2	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes															Function

CRON 1.
nrdI2	Arthrobacter aurescens TC1	Arthrobacter chlorophenolicus A6	Arthrobacter sp. FB24	Beutenbergia cavernae DSM 12333	* Brachybacterium faecium DSM 4810 Site: position = -73 score = 4.0989 sequence = CTACTAGATGTGCTGC Site: position = -42 score = 5.24362 sequence = GCACAACATGTAGTGG Gene: Bfae_28110: Ribonucleotide reduction protein NrdI	Brevibacterium linens BL2	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	* Kocuria rhizophila DC2201 Site: position = -193 score = 4.82332 sequence = CAACCAGATGTAGTGG Gene: KRH_00590: Ribonucleotide reduction protein NrdI	Kytococcus sedentarius DSM 20547	Leifsonia xyli subsp. xyli str. CTCB07	* Renibacterium salmoninarum ATCC 33209 Site: position = -39 score = 3.87223 sequence = ACACATCATCTTGTAA Site: position = -71 score = 4.48779 sequence = CTACTAGATATAGTAC Gene: RSal33209_0419: Ribonucleotide reduction protein NrdI	Tropheryma whipplei str. Twist	Ribonucleotide reduction protein NrdI
nrdE2	Arthrobacter aurescens TC1	Arthrobacter chlorophenolicus A6	Arthrobacter sp. FB24	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810 Gene: Bfae_28100: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Brevibacterium linens BL2 Gene: BlinB01000966: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	Kocuria rhizophila DC2201	Kytococcus sedentarius DSM 20547	Leifsonia xyli subsp. xyli str. CTCB07	Renibacterium salmoninarum ATCC 33209	Tropheryma whipplei str. Twist	Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)

CRON 2.
nrdR	* Arthrobacter aurescens TC1 Site: position = -143 score = 4.8551 sequence = CCACTACATGTAGTAA Site: position = -165 score = 4.5421 sequence = CCACTACATATATGGG Gene: AAur_1725: Ribonucleotide reductase transcriptional regulator NrdR	* Arthrobacter chlorophenolicus A6 Site: position = -156 score = 4.66685 sequence = CCACTACATGTGGTAA Site: position = -178 score = 4.54383 sequence = ATACTACATGTAGTTG Gene: Achl_1586: Ribonucleotide reductase transcriptional regulator NrdR	* Arthrobacter sp. FB24 Site: position = -104 score = 3.68903 sequence = CAGCTACATGTAGTCG Site: position = -136 score = 4.8551 sequence = CCACTACATGTAGTAA Gene: Arth_1586: Ribonucleotide reductase transcriptional regulator NrdR	* Beutenbergia cavernae DSM 12333 Site: position = -127 score = 3.68184 sequence = CGGCCACATCTAGTAG Site: position = -95 score = 4.16605 sequence = CGCCTACATCTTGTGA Gene: Bcav_2431: Ribonucleotide reductase transcriptional regulator NrdR	Brachybacterium faecium DSM 4810 Gene: Bfae_10640: Ribonucleotide reductase transcriptional regulator NrdR	Brevibacterium linens BL2 Gene: BlinB01002775: Ribonucleotide reductase transcriptional regulator NrdR	Clavibacter michiganensis subsp. michiganensis NCPPB 382 Gene: CMM_1847: Ribonucleotide reductase transcriptional regulator NrdR	* Janibacter sp. HTCC2649 Site: position = -148 score = 3.37264 sequence = CATCCACATGTGGTTC Site: position = -180 score = 5.22382 sequence = CTACTACATCTAGTGG Gene: JNB_00230: Ribonucleotide reductase transcriptional regulator NrdR	Jonesia denitrificans DSM 20603 Gene: Jden_1056: Ribonucleotide reductase transcriptional regulator NrdR	Kocuria rhizophila DC2201 Gene: KRH_14690: Ribonucleotide reductase transcriptional regulator NrdR	* Kytococcus sedentarius DSM 20547 Site: position = -72 score = 4.65189 sequence = TCTCTACATCTAGTGG Gene: Ksed_17180: Ribonucleotide reductase transcriptional regulator NrdR	Leifsonia xyli subsp. xyli str. CTCB07 Gene: Lxx15110: Ribonucleotide reductase transcriptional regulator NrdR	* Renibacterium salmoninarum ATCC 33209 Site: position = -90 score = 4.82393 sequence = CCACTACATCTAGTAA Site: position = -58 score = 3.78412 sequence = CATCTATATGTAGTTG Gene: RSal33209_2478: Ribonucleotide reductase transcriptional regulator NrdR	Tropheryma whipplei str. Twist Gene: TW237: Ribonucleotide reductase transcriptional regulator NrdR	Ribonucleotide reductase transcriptional regulator NrdR
nrdJ	Arthrobacter aurescens TC1	Arthrobacter chlorophenolicus A6	Arthrobacter sp. FB24	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649 Gene: JNB_00235: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	Jonesia denitrificans DSM 20603	Kocuria rhizophila DC2201	Kytococcus sedentarius DSM 20547 Gene: Ksed_17170: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	Leifsonia xyli subsp. xyli str. CTCB07	Renibacterium salmoninarum ATCC 33209	Tropheryma whipplei str. Twist	Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)

CRON 3.
nrdA	Arthrobacter aurescens TC1	Arthrobacter chlorophenolicus A6	Arthrobacter sp. FB24	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2	* Clavibacter michiganensis subsp. michiganensis NCPPB 382 Site: position = -207 score = 3.77803 sequence = CCCGCATATATAGTGA Site: position = -239 score = 4.92991 sequence = CCACTACATATGGGGT Gene: CMM_2429: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	Kocuria rhizophila DC2201	* Kytococcus sedentarius DSM 20547 Site: position = -498 score = 5.05536 sequence = CCACAACATGTGGTGC Site: position = -466 score = 3.54843 sequence = TCACCGTATATGGTGC Gene: Ksed_21940: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Leifsonia xyli subsp. xyli str. CTCB07 Site: position = 66 score = 3.89684 sequence = CCCCGCTATATAGTGG Site: position = 34 score = 5.22436 sequence = CCACTAGATGTGGGGG Gene: Lxx17790: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Renibacterium salmoninarum ATCC 33209	* Tropheryma whipplei str. Twist Site: position = -60 score = 4.27498 sequence = ACACGATATATAGTAG Site: position = -92 score = 4.47449 sequence = ACACTATATATCGTGT Gene: TW683: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
nrdB	Arthrobacter aurescens TC1	Arthrobacter chlorophenolicus A6	Arthrobacter sp. FB24	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2	Clavibacter michiganensis subsp. michiganensis NCPPB 382 Gene: CMM_2428: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	Kocuria rhizophila DC2201	Kytococcus sedentarius DSM 20547 Gene: Ksed_21930: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Leifsonia xyli subsp. xyli str. CTCB07 Gene: Lxx17770: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Renibacterium salmoninarum ATCC 33209	Tropheryma whipplei str. Twist Gene: TW682: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)

CRON 4.
nrdH	* Arthrobacter aurescens TC1 Site: position = -169 score = 4.8944 sequence = GCACTACATGTAGTAT Site: position = -201 score = 4.11171 sequence = ATACATCATCTTGGGG Gene: AAur_2341: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Arthrobacter chlorophenolicus A6 Site: position = -78 score = 4.8944 sequence = GCACTACATGTAGTAT Site: position = -110 score = 4.26141 sequence = ATACATCATCTAGGGG Gene: Achl_2119: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Arthrobacter sp. FB24 Site: position = -141 score = 4.8944 sequence = GCACTACATGTAGTAT Site: position = -173 score = 4.11171 sequence = ATACATCATCTTGGGG Gene: Arth_2358: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Beutenbergia cavernae DSM 12333 Site: position = -134 score = 4.43448 sequence = ACACAAGGTCTTGGGG Site: position = -102 score = 4.9255 sequence = CCACTAGGTGTAGTGT Gene: Bcav_0095: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Brachybacterium faecium DSM 4810 Site: position = -190 score = 4.44737 sequence = TCAGTACATCTAGTGG Site: position = -158 score = 4.9255 sequence = CCACTAGGTGTAGTGT Gene: Bfae_24930: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Brevibacterium linens BL2 Site: position = -151 score = 4.37034 sequence = ACACTGGATATAGGGG Site: position = -120 score = 5.27362 sequence = ACACAACATCTAGTGG Gene: BlinB01000654: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	* Jonesia denitrificans DSM 20603 Site: position = -171 score = 4.74957 sequence = ACACTAGGTATAGTGG Site: position = -202 score = 3.94311 sequence = ACGCTAGGTATTGTGG Gene: Jden_1753: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Kocuria rhizophila DC2201 Site: position = -116 score = 5.07411 sequence = CCACTAGATGTAGTAT Site: position = -148 score = 4.4921 sequence = CCACATCATGTTGGGT Gene: KRH_11580: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	Kytococcus sedentarius DSM 20547	Leifsonia xyli subsp. xyli str. CTCB07	* Renibacterium salmoninarum ATCC 33209 Site: position = -74 score = 4.71848 sequence = GCACTATATGTAGTAT Site: position = -106 score = 4.11171 sequence = ATACATCATCTTGGGG Gene: RSal33209_3481: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	Tropheryma whipplei str. Twist	Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib
nrdI	Arthrobacter aurescens TC1 Gene: AAur_2340: Ribonucleotide reduction protein NrdI	Arthrobacter chlorophenolicus A6 Gene: Achl_2118: Ribonucleotide reduction protein NrdI	Arthrobacter sp. FB24 Gene: Arth_2357: Ribonucleotide reduction protein NrdI	Beutenbergia cavernae DSM 12333 Gene: Bcav_0096: Ribonucleotide reduction protein NrdI	Brachybacterium faecium DSM 4810 Gene: Bfae_24920: Ribonucleotide reduction protein NrdI	Brevibacterium linens BL2 Gene: BlinB01000655: Ribonucleotide reduction protein NrdI	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	Kocuria rhizophila DC2201 Gene: KRH_11590: Ribonucleotide reduction protein NrdI	Kytococcus sedentarius DSM 20547	Leifsonia xyli subsp. xyli str. CTCB07	Renibacterium salmoninarum ATCC 33209 Gene: RSal33209_3482: Ribonucleotide reduction protein NrdI	Tropheryma whipplei str. Twist	Ribonucleotide reduction protein NrdI
nrdE	Arthrobacter aurescens TC1 Gene: AAur_2339: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Arthrobacter chlorophenolicus A6 Gene: Achl_2117: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Arthrobacter sp. FB24 Gene: Arth_2356: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Beutenbergia cavernae DSM 12333 Gene: Bcav_0097: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Brachybacterium faecium DSM 4810 Gene: Bfae_24910: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Brevibacterium linens BL2 Gene: BlinB01000656: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603 Gene: Jden_1752: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Kocuria rhizophila DC2201 Gene: KRH_11600: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Kytococcus sedentarius DSM 20547	Leifsonia xyli subsp. xyli str. CTCB07	Renibacterium salmoninarum ATCC 33209 Gene: RSal33209_3483: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Tropheryma whipplei str. Twist	Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)
Bcav_0098	Arthrobacter aurescens TC1	Arthrobacter chlorophenolicus A6	Arthrobacter sp. FB24	Beutenbergia cavernae DSM 12333 Gene: Bcav_0098: hypothetical protein	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	Kocuria rhizophila DC2201	Kytococcus sedentarius DSM 20547	Leifsonia xyli subsp. xyli str. CTCB07	Renibacterium salmoninarum ATCC 33209	Tropheryma whipplei str. Twist	hypothetical protein
nrdF	Arthrobacter aurescens TC1 Gene: AAur_2338: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Arthrobacter chlorophenolicus A6 Gene: Achl_2116: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Arthrobacter sp. FB24 Gene: Arth_2355: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Beutenbergia cavernae DSM 12333 Gene: Bcav_0099: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2 Gene: BlinB01000657: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603 Gene: Jden_1751: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Kocuria rhizophila DC2201 Gene: KRH_11610: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Kytococcus sedentarius DSM 20547	Leifsonia xyli subsp. xyli str. CTCB07	Renibacterium salmoninarum ATCC 33209 Gene: RSal33209_3484: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Tropheryma whipplei str. Twist	Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog NrdR - Micrococcineae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --