Regulog NrdR - Enterobacteriales

Properties
Regulator type:	Transcription factor
Regulator family:	NrdR
Regulation mode:	repressor
Biological process:	Ribonucleotide reductases
Effector:	Deoxyribonucleotides
Phylum:	Proteobacteria/gamma
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 70 sites [see more]

Member of regulog collections

By trascription factor - NrdR
By taxonomy - Enterobacteriales
By TF family - NrdR
By effector - Deoxyribonucleotides
By pathway - Ribonucleotide reductases

Statistics of regulated genes
Genome	Genes	Operons
Escherichia coli str. K-12 substr. MG1655	9	3
Salmonella typhimurium LT2	9	3
Citrobacter koseri ATCC BAA-895	9	3
Klebsiella pneumoniae subsp. pneumoniae MGH 78578	8	3
Enterobacter sp. 638	9	3
Erwinia amylovora ATCC 49946	8	3
Yersinia pestis KIM	5	3
Serratia proteamaculans 568	9	3
Erwinia carotovora subsp. atroseptica SCRI1043	9	3
Edwardsiella tarda EIB202	5	2
Proteus mirabilis HI4320	9	3
Photorhabdus luminescens subsp. laumondii TTO1	9	3

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes													Function

CRON 1.
nrdA	* Escherichia coli str. K-12 substr. MG1655 Site: position = -93 score = 5.73596 sequence = CCCCTATATATAGTGT Site: position = -62 score = 3.52449 sequence = GTACTACAGGTAGTCT Gene: b2234: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Salmonella typhimurium LT2 Site: position = -136 score = 3.68962 sequence = ACTCACCATATAGCGT Site: position = -104 score = 5.82924 sequence = CCCCTATATATAGTAT Gene: STM2277: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Citrobacter koseri ATCC BAA-895 Site: position = -127 score = 3.68962 sequence = ACTCACCATATAGCGT Site: position = -95 score = 5.82924 sequence = CCCCTATATATAGTAT Gene: CKO_00541: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -125 score = 3.68962 sequence = ACTCACCATATAGCGT Site: position = -93 score = 5.77825 sequence = CCCCTACATATAGTAT Gene: KPN_02642: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Enterobacter sp. 638 Site: position = -130 score = 3.68962 sequence = ACTCACCATATAGCGT Site: position = -98 score = 5.61466 sequence = CCCCTATATGTAGTAT Gene: Ent638_2801: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Erwinia amylovora ATCC 49946 Site: position = -96 score = 3.22852 sequence = ACCCCCTATATGTTGT Site: position = -94 score = 5.40602 sequence = CCCCTATATGTTGTGT Gene: EAM_2266: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Yersinia pestis KIM Site: position = -132 score = 5.52356 sequence = CCACTATATATTGTGT Site: position = -165 score = 3.03789 sequence = ACTCACTATCTTGTTA Gene: y2974: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Serratia proteamaculans 568 Site: position = -83 score = 3.22376 sequence = AACCCCTATATATAGT Site: position = -81 score = 5.73596 sequence = CCCCTATATATAGTGT Gene: Spro_3271: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Erwinia carotovora subsp. atroseptica SCRI1043 Site: position = -129 score = 3.57936 sequence = ACTCACCATGTAGTAG Site: position = -98 score = 5.62973 sequence = CACCTATATCTAGTAT Gene: ECA1199: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Edwardsiella tarda EIB202 Site: position = -126 score = 3.26091 sequence = CAACACTATCTTGTTG Site: position = -94 score = 5.62059 sequence = CCCCTATATATTGTGT Gene: ETAE_2338: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Proteus mirabilis HI4320 Site: position = -169 score = 3.28062 sequence = TACCATTATCTTGTTA Site: position = -137 score = 5.62059 sequence = CCCCTATATATTGTGT Gene: PMI1734: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Photorhabdus luminescens subsp. laumondii TTO1 Site: position = -178 score = 3.18358 sequence = TAACATTATCTTGTTG Site: position = -146 score = 5.5696 sequence = CCCCTACATATTGTGT Gene: plu3052: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
nrdB	Escherichia coli str. K-12 substr. MG1655 Gene: b2235: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Salmonella typhimurium LT2 Gene: STM2278: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Citrobacter koseri ATCC BAA-895 Gene: CKO_00540: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_02643: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Enterobacter sp. 638 Gene: Ent638_2802: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Erwinia amylovora ATCC 49946 Gene: EAM_2267: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Yersinia pestis KIM Gene: y2975: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Serratia proteamaculans 568 Gene: Spro_3272: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Erwinia carotovora subsp. atroseptica SCRI1043 Gene: ECA1198: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Edwardsiella tarda EIB202 Gene: ETAE_2339: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Proteus mirabilis HI4320 Gene: PMI1735: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu3053: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
yfaE	Escherichia coli str. K-12 substr. MG1655 Gene: b2236: ferredoxin	Salmonella typhimurium LT2 Gene: STM2279: ferredoxin	Citrobacter koseri ATCC BAA-895 Gene: CKO_00539: ferredoxin	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_02644: ferredoxin	Enterobacter sp. 638 Gene: Ent638_2803: ferredoxin	Erwinia amylovora ATCC 49946 Gene: EAM_2268: ferredoxin	Yersinia pestis KIM Gene: y2976: ferredoxin	Serratia proteamaculans 568 Gene: Spro_3273: ferredoxin	Erwinia carotovora subsp. atroseptica SCRI1043 Gene: ECA1197: ferredoxin	Edwardsiella tarda EIB202 Gene: ETAE_2340: ferredoxin	Proteus mirabilis HI4320 Gene: PMI1736: ferredoxin	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu3054: ferredoxin	ferredoxin

CRON 2.
nrdD	* Escherichia coli str. K-12 substr. MG1655 Site: position = -208 score = 4.27142 sequence = GCACTATATATAGACT Site: position = -177 score = 5.02804 sequence = ACCCAATATGTTGTAT Gene: b4238: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Salmonella typhimurium LT2 Site: position = -177 score = 5.02804 sequence = ACCCAATATGTTGTAT Site: position = -207 score = 4.53055 sequence = TCACTACATATAGACT Gene: STM4452: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Citrobacter koseri ATCC BAA-895 Site: position = -225 score = 4.73366 sequence = TCACTACATATAGAAC Site: position = -194 score = 5.02804 sequence = ACCCAATATGTTGTAT Gene: CKO_03580: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -207 score = 4.73366 sequence = TCACTACATATAGAAC Site: position = -176 score = 4.96225 sequence = GCCCAACATATTGTAT Gene: KPN_04646: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Enterobacter sp. 638 Site: position = -203 score = 4.73366 sequence = TCACTACATATAGAAC Site: position = -172 score = 5.06851 sequence = ACCCAACATCTTGTAT Gene: Ent638_0437: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Erwinia amylovora ATCC 49946 Site: position = -67 score = 3.049 sequence = ATACCATATATAGATA Site: position = -36 score = 3.38075 sequence = GGACTATATGTAGTTG Gene: EAM_3059: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Yersinia pestis KIM Site: position = -142 score = 5.10028 sequence = TACCCATATATAGTGT Site: position = -111 score = 4.6707 sequence = CATCTATATGTAGTAG Gene: y0733: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Serratia proteamaculans 568 Site: position = -189 score = 4.97841 sequence = TATCTATATATAGTGC Site: position = -158 score = 4.90908 sequence = CACCTATATGTAGTAG Gene: Spro_0525: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Erwinia carotovora subsp. atroseptica SCRI1043 Site: position = -132 score = 4.40099 sequence = TTTCAATATATAGTGC Site: position = -101 score = 5.53124 sequence = TACCTACATATAGTGT Gene: ECA0375: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Edwardsiella tarda EIB202 Site: position = -156 score = 4.83603 sequence = TTCCCATATATAGTGT Site: position = -124 score = 5.12365 sequence = CACCTATATATAGTAG Gene: ETAE_0423: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Proteus mirabilis HI4320 Site: position = -143 score = 4.74013 sequence = TTACTATATATTGTGC Site: position = -111 score = 4.24012 sequence = ATACAACATATAGTAA Gene: PMI3451: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Photorhabdus luminescens subsp. laumondii TTO1 Site: position = -119 score = 5.10558 sequence = TTACTATATATTGTGT Site: position = -88 score = 3.75302 sequence = AGACTATATATAGCAA Gene: plu4499: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
nrdG	Escherichia coli str. K-12 substr. MG1655 Gene: b4237: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Salmonella typhimurium LT2 Gene: STM4451: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Citrobacter koseri ATCC BAA-895 Gene: CKO_03582: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_04645: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Enterobacter sp. 638 Gene: Ent638_0436: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Erwinia amylovora ATCC 49946 Gene: EAM_3060: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Yersinia pestis KIM Gene: y0732: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Serratia proteamaculans 568 Gene: Spro_0524: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Erwinia carotovora subsp. atroseptica SCRI1043 Gene: ECA0374: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Edwardsiella tarda EIB202 Gene: ETAE_0422: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Proteus mirabilis HI4320 Gene: PMI3450: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu4500: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)

CRON 3.
nrdH	* Escherichia coli str. K-12 substr. MG1655 Site: position = -120 score = 4.79546 sequence = TTGCTATATATTGTGT Site: position = -89 score = 5.4817 sequence = CAACTACATCTAGTAT Gene: b2673: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Salmonella typhimurium LT2 Site: position = -89 score = 5.4817 sequence = CAACTACATCTAGTAT Site: position = -121 score = 4.69084 sequence = TTCCCATATCTTGTAT Gene: STM2805: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Citrobacter koseri ATCC BAA-895 Site: position = -106 score = 4.59756 sequence = TTCCCATATCTTGTGT Site: position = -75 score = 5.34036 sequence = CATCTACATCTAGTAT Gene: CKO_04022: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Site: position = -182 score = 4.55058 sequence = ACGCTATATATTGAGT Site: position = -151 score = 5.40437 sequence = TAACTACATCTAGTAT Gene: KPN_03004: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Enterobacter sp. 638 Site: position = -106 score = 4.59756 sequence = TTCCCATATCTTGTGT Site: position = -75 score = 5.4817 sequence = CAACTACATCTAGTAT Gene: Ent638_3153: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Erwinia amylovora ATCC 49946 Site: position = -121 score = 5.14089 sequence = ACGCTATATCTAGTAT Site: position = -89 score = 4.19528 sequence = ACGCTATATGGTGTGT Gene: EAM_2594: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Yersinia pestis KIM Site: position = -171 score = 5.21963 sequence = TAACTACATGTAGTGT Site: position = -140 score = 5.29376 sequence = GCACTACATATAGTAT Gene: y1225: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Serratia proteamaculans 568 Site: position = -164 score = 4.35867 sequence = ACACCATATATAGCGT Site: position = -133 score = 5.38613 sequence = TATCTACATATAGTAT Gene: Spro_3721: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Erwinia carotovora subsp. atroseptica SCRI1043 Site: position = -162 score = 4.35326 sequence = ATCATATATCTTGTGT Site: position = -131 score = 5.26303 sequence = TATCTACATCTAGTAT Gene: ECA3335: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	Edwardsiella tarda EIB202	* Proteus mirabilis HI4320 Site: position = -107 score = 4.87578 sequence = ACACCATATCTAGTGT Site: position = -76 score = 5.59475 sequence = AACCTATATATAGTAT Gene: PMI0416: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	* Photorhabdus luminescens subsp. laumondii TTO1 Site: position = -133 score = 4.63344 sequence = ACACCATATATAGTGC Site: position = -102 score = 5.60388 sequence = TCACTACATATAGTAT Gene: plu1287: Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib	Glutaredoxin-like protein NrdH, required for reduction of Ribonucleotide reductase class Ib
nrdI	Escherichia coli str. K-12 substr. MG1655 Gene: b2674: Ribonucleotide reductase stimulatory protein NrdI	Salmonella typhimurium LT2 Gene: STM2806: Ribonucleotide reductase stimulatory protein NrdI	Citrobacter koseri ATCC BAA-895 Gene: CKO_04023: Ribonucleotide reductase stimulatory protein NrdI	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_03005: Ribonucleotide reductase stimulatory protein NrdI	Enterobacter sp. 638 Gene: Ent638_3154: Ribonucleotide reductase stimulatory protein NrdI	Erwinia amylovora ATCC 49946 Gene: EAM_2595: Ribonucleotide reductase stimulatory protein NrdI	Yersinia pestis KIM	Serratia proteamaculans 568 Gene: Spro_3722: Ribonucleotide reductase stimulatory protein NrdI	Erwinia carotovora subsp. atroseptica SCRI1043 Gene: ECA3336: Ribonucleotide reductase stimulatory protein NrdI	Edwardsiella tarda EIB202	Proteus mirabilis HI4320 Gene: PMI0415: Ribonucleotide reductase stimulatory protein NrdI	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu1286: Ribonucleotide reductase stimulatory protein NrdI	Ribonucleotide reductase stimulatory protein NrdI
nrdE	Escherichia coli str. K-12 substr. MG1655 Gene: b2675: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Salmonella typhimurium LT2 Gene: STM2807: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Citrobacter koseri ATCC BAA-895 Gene: CKO_04024: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_03006: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Enterobacter sp. 638 Gene: Ent638_3155: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Erwinia amylovora ATCC 49946 Gene: EAM_2596: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Yersinia pestis KIM Gene: y1223: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Serratia proteamaculans 568 Gene: Spro_3723: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Erwinia carotovora subsp. atroseptica SCRI1043 Gene: ECA3337: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Edwardsiella tarda EIB202	Proteus mirabilis HI4320 Gene: PMI0414: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu1285: Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)	Ribonucleotide reductase of class Ib (aerobic), alpha subunit (EC 1.17.4.1)
nrdF	Escherichia coli str. K-12 substr. MG1655 Gene: b2676: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Salmonella typhimurium LT2 Gene: STM2808: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Citrobacter koseri ATCC BAA-895 Gene: CKO_04025: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Gene: KPN_03007: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Enterobacter sp. 638 Gene: Ent638_3156: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Erwinia amylovora ATCC 49946 Gene: EAM_2597: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Yersinia pestis KIM Gene: y1222: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Serratia proteamaculans 568 Gene: Spro_3724: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Erwinia carotovora subsp. atroseptica SCRI1043 Gene: ECA3338: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Edwardsiella tarda EIB202	Proteus mirabilis HI4320 Gene: PMI0413: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Photorhabdus luminescens subsp. laumondii TTO1 Gene: plu1284: Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)	Ribonucleotide reductase of class Ib (aerobic), beta subunit (EC 1.17.4.1)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog NrdR - Enterobacteriales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --