Regulog NrdR - Various betaproteobacteria

Properties
Regulator type:	Transcription factor
Regulator family:	NrdR
Regulation mode:	repressor
Biological process:	Deoxyribonucleotide biosynthesis
Effector:	Deoxyribonucleotides
Phylum:	Proteobacteria/beta
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 20 sites [see more]

Member of regulog collections

By taxonomy - Various betaproteobacteria
By trascription factor - NrdR
By TF family - NrdR
By effector - Deoxyribonucleotides
By pathway - Deoxyribonucleotide biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Azoarcus sp. EbN1	1	1
Thauera sp. MZ1T	1	1
Dechloromonas aromatica RCB	1	1
Nitrosomonas europaea ATCC 19718	2	1
Nitrosospira multiformis ATCC 25196	2	1
Thiobacillus denitrificans	2	1
Chromobacterium violaceum ATCC 12472	7	3
Neisseria meningitidis MC58	5	1
Laribacter hongkongensis HLHK9	6	3
Methylobacillus flagellatus KT	5	2
Methylotenera mobilis JLW8	4	2
Methylophilales bacterium HTCC2181	1	1

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes													Function

CRON 1.
nrdA	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	* Neisseria meningitidis MC58 Site: position = -72 score = 4.10309 sequence = ATCCACTATATTGTCT Gene: NMB1291: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Laribacter hongkongensis HLHK9	* Methylobacillus flagellatus KT Site: position = -376 score = 5.29873 sequence = GAACAATATATAGTGT Gene: Mfla_1223: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
NMB1290	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58 Gene: NMB1290: C-5 cytosine-specific DNA-methylase	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	C-5 cytosine-specific DNA-methylase
NMB1289	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58 Gene: NMB1289: type II restriction enzyme, putative	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	type II restriction enzyme, putative
nrdB	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58 Gene: NMB1288: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT Gene: Mfla_1224: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
yfaE	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58 Gene: NMB1287: Ferredoxin	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT Gene: Mfla_1225: Ferredoxin	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Ferredoxin

CRON 2.
nrdD	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	* Chromobacterium violaceum ATCC 12472 Site: position = -162 score = 4.4603 sequence = GCACAATATATTGATC Gene: CV2412: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Neisseria meningitidis MC58	* Laribacter hongkongensis HLHK9 Site: position = -80 score = 5.56687 sequence = ACACAACATCTTGTGT Gene: LHK_02258: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
nrdG	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV2413: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_02259: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)

CRON 3.
nrdJa	* Azoarcus sp. EbN1 Site: position = -140 score = 4.83809 sequence = CTACTACATATAGTAC Gene: ebA4850: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	* Thauera sp. MZ1T Site: position = -149 score = 4.89862 sequence = CTACTACATGTAGTGC Gene: Tmz1t_1360: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	* Dechloromonas aromatica RCB Site: position = -75 score = 4.80233 sequence = GCACTATATCTAGTAG Gene: Daro_0964: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans Gene: Tbd_0058: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	* Chromobacterium violaceum ATCC 12472 Site: position = -121 score = 4.56469 sequence = ACACAACAACTTGCGT Site: position = -88 score = 5.328 sequence = TAACAACATATAGTGT Gene: CV1446: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	Neisseria meningitidis MC58	* Laribacter hongkongensis HLHK9 Site: position = -158 score = 5.34018 sequence = AAACAACATCTAGTGT Gene: LHK_01596: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	* Methylobacillus flagellatus KT Site: position = -95 score = 5.06584 sequence = TCACTATATGTTGTGG Gene: Mfla_2541: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	* Methylotenera mobilis JLW8 Site: position = -148 score = 5.55372 sequence = ACACAATATATAGTGG Gene: Mmol_0049: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	* Methylophilales bacterium HTCC2181 Site: position = -82 score = 5.44506 sequence = TCACAACATATTGTGG Gene: MB2181_01310: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)
nrdJb	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT Gene: Mfla_2542: Ribonucleotide reductase of class II (coenzyme B12-dependent), alpha subunit (EC 1.17.4.1)	Methylotenera mobilis JLW8 Gene: Mmol_0050: Ribonucleotide reductase of class II (coenzyme B12-dependent), alpha subunit (EC 1.17.4.1)	Methylophilales bacterium HTCC2181	Ribonucleotide reductase of class II (coenzyme B12-dependent), alpha subunit (EC 1.17.4.1)

CRON 4.
nrdA	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	* Nitrosomonas europaea ATCC 19718 Site: position = -116 score = 5.70196 sequence = ACACAATATATTGTGT Gene: NE2423: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Nitrosospira multiformis ATCC 25196 Site: position = -112 score = 4.8583 sequence = CTACTATATATAGTAG Gene: Nmul_A2468: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Thiobacillus denitrificans Site: position = -88 score = 4.63574 sequence = CCACAAGATGTTGTGA Gene: Tbd_1976: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Chromobacterium violaceum ATCC 12472 Site: position = -283 score = 5.18318 sequence = CTACAACATCTAGTGC Site: position = -50 score = 4.54922 sequence = ACGGTATATATTGTGT Gene: CV2287: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Neisseria meningitidis MC58	* Laribacter hongkongensis HLHK9 Site: position = -69 score = 5.45724 sequence = ACACAACATCTTGTGC Gene: LHK_01803: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Methylobacillus flagellatus KT	* Methylotenera mobilis JLW8 Site: position = -442 score = 4.90239 sequence = TATCAATATATTGTGT Gene: Mmol_1920: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Methylophilales bacterium HTCC2181	Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
CV2286	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV2286: hypothetical protein	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	hypothetical protein
CV2285	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472 Gene: CV2285: hypothetical protein	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	hypothetical protein
nrdB	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718 Gene: NE2422: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Nitrosospira multiformis ATCC 25196 Gene: Nmul_A2469: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Thiobacillus denitrificans Gene: Tbd_1975: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Chromobacterium violaceum ATCC 12472 Gene: CV2284: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_01801: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8 Gene: Mmol_1921: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Methylophilales bacterium HTCC2181	Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
CV3202	Azoarcus sp. EbN1	Thauera sp. MZ1T	Dechloromonas aromatica RCB	Nitrosomonas europaea ATCC 19718	Nitrosospira multiformis ATCC 25196	Thiobacillus denitrificans	Chromobacterium violaceum ATCC 12472	Neisseria meningitidis MC58	Laribacter hongkongensis HLHK9 Gene: LHK_01802: hypothetical protein	Methylobacillus flagellatus KT	Methylotenera mobilis JLW8	Methylophilales bacterium HTCC2181	hypothetical protein

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog NrdR - Various betaproteobacteria

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --