Regulog NrdR - Frankineae/Propionibacterineae/Pseudonocardiaceae

Properties
Regulator type:	Transcription factor
Regulator family:	NrdR
Regulation mode:	repressor
Biological process:	Deoxyribonucleotide biosynthesis
Effector:	Deoxyribonucleotides
Phylum:	Actinobacteria
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 17 sites [see more]

Member of regulog collections

By trascription factor - NrdR
By taxonomy - Frankineae/Propionibacterineae/Pseudonocardiaceae
By TF family - NrdR
By effector - Deoxyribonucleotides
By pathway - Deoxyribonucleotide biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Acidothermus cellulolyticus 11B	2	1
Frankia sp. CcI3	2	1
Frankia sp. EAN1pec	2	1
Nakamurella multipartita DSM 44233	2	1
Nocardioides sp. JS614	2	1
Propionibacterium acnes KPA171202	6	3
Actinosynnema mirum DSM 43827	4	2
Saccharomonospora viridis DSM 43017	4	2
Saccharopolyspora erythraea NRRL 2338	4	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes										Function

CRON 1.
nrdA	Acidothermus cellulolyticus 11B	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Nocardioides sp. JS614	* Propionibacterium acnes KPA171202 Site: position = -321 score = 4.15452 sequence = GCCCTTCATATAGTGA Gene: PPA2121: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Actinosynnema mirum DSM 43827 Site: position = -373 score = 5.3048 sequence = CCACAACATGTAGTGT Gene: Amir_3157: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Saccharomonospora viridis DSM 43017 Site: position = -149 score = 3.89164 sequence = CGCCCATATCTTGGGT Site: position = -117 score = 4.23629 sequence = CCACTACATGTAGACT Gene: Svir_16410: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	* Saccharopolyspora erythraea NRRL 2338 Site: position = -438 score = 4.96349 sequence = ACCCAAGATGTAGTGT Gene: SACE_1283: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)	Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
nrdB	Acidothermus cellulolyticus 11B	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Nocardioides sp. JS614	Propionibacterium acnes KPA171202 Gene: PPA2122: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Actinosynnema mirum DSM 43827 Gene: Amir_3158: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Saccharomonospora viridis DSM 43017 Gene: Svir_16400: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_1282: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)	Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)

CRON 2.
nrdR	* Acidothermus cellulolyticus 11B Site: position = -122 score = 4.94487 sequence = CCCCAACATGTAGTAG Gene: Acel_1477: Ribonucleotide reductase transcriptional regulator NrdR	* Frankia sp. CcI3 Site: position = -182 score = 4.87448 sequence = ACACAACATCTGGTGC Gene: Francci3_3508: Ribonucleotide reductase transcriptional regulator NrdR	* Frankia sp. EAN1pec Site: position = -171 score = 4.7747 sequence = ACACAACATCTTGTAG Gene: Franean1_1234: Ribonucleotide reductase transcriptional regulator NrdR	* Nakamurella multipartita DSM 44233 Site: position = -223 score = 4.85251 sequence = CCCCTACATCTAGTAC Gene: Namu_3977: Ribonucleotide reductase transcriptional regulator NrdR	* Nocardioides sp. JS614 Site: position = -201 score = 5.01293 sequence = CCACTACATCTAGTAC Gene: Noca_3812: Ribonucleotide reductase transcriptional regulator NrdR	* Propionibacterium acnes KPA171202 Site: position = -128 score = 4.73615 sequence = ATACCAGATGTTGTGG Site: position = -97 score = 3.99216 sequence = TCCCTATAAGTTGTGT Gene: PPA1025: Ribonucleotide reductase transcriptional regulator NrdR	* Actinosynnema mirum DSM 43827 Site: position = -105 score = 5.22436 sequence = CCCCCACATCTAGTGG Gene: Amir_1432: Ribonucleotide reductase transcriptional regulator NrdR	* Saccharomonospora viridis DSM 43017 Site: position = -224 score = 5.03556 sequence = CCACCACATCTAGTAG Gene: Svir_27580: Ribonucleotide reductase transcriptional regulator NrdR	* Saccharopolyspora erythraea NRRL 2338 Site: position = -139 score = 5.07411 sequence = CCACAACATCTAGTAG Gene: SACE_1763: Ribonucleotide reductase transcriptional regulator NrdR	Ribonucleotide reductase transcriptional regulator NrdR
nrdJ	Acidothermus cellulolyticus 11B Gene: Acel_1476: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	Frankia sp. CcI3 Gene: Francci3_3507: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	Frankia sp. EAN1pec Gene: Franean1_1235: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	Nakamurella multipartita DSM 44233 Gene: Namu_3976: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	Nocardioides sp. JS614 Gene: Noca_3811: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	Propionibacterium acnes KPA171202 Gene: PPA1026: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	Actinosynnema mirum DSM 43827 Gene: Amir_1431: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	Saccharomonospora viridis DSM 43017 Gene: Svir_27570: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_1764: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing

CRON 3.
nrdD	Acidothermus cellulolyticus 11B	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Nocardioides sp. JS614	* Propionibacterium acnes KPA171202 Site: position = -285 score = 5.01347 sequence = GCACCAGATGTAGGGG Site: position = -317 score = 4.22382 sequence = ACCCTTTATCTTGTGC Gene: PPA2137: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
nrdG	Acidothermus cellulolyticus 11B	Frankia sp. CcI3	Frankia sp. EAN1pec	Nakamurella multipartita DSM 44233	Nocardioides sp. JS614	Propionibacterium acnes KPA171202 Gene: PPA2136: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Actinosynnema mirum DSM 43827	Saccharomonospora viridis DSM 43017	Saccharopolyspora erythraea NRRL 2338	Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog NrdR - Frankineae/Propionibacterineae/Pseudonocardiaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --