Regulog NrdR - Thermoanaerobacterales

Properties
Regulator type:	Transcription factor
Regulator family:	NrdR
Regulation mode:	repressor
Biological process:	Deoxyribonucleotide biosynthesis
Effector:	Deoxyribonucleotides
Phylum:	Firmicutes
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 18 sites [see more]

Member of regulog collections

By trascription factor - NrdR
By TF family - NrdR
By effector - Deoxyribonucleotides
By pathway - Deoxyribonucleotide biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Anaerocellum thermophilum DSM 6725	1	1
Caldicellulosiruptor saccharolyticus DSM 8903	1	1
Carboxydothermus hydrogenoformans Z-2901	3	1
Moorella thermoacetica ATCC 39073
Thermoanaerobacter ethanolicus X514	3	2
Thermoanaerobacter italicus Ab9	3	2
Thermoanaerobacter tengcongensis MB4	3	2

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes								Function

CRON 1.
nrdD	* Anaerocellum thermophilum DSM 6725 Site: position = -127 score = 4.72755 sequence = ATATAATATATTGTGC Site: position = -95 score = 5.60692 sequence = ACACAATATATAGTGG Gene: Athe_0548: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Caldicellulosiruptor saccharolyticus DSM 8903 Site: position = -83 score = 5.60692 sequence = ACACAATATATAGTGG Site: position = -115 score = 5.12077 sequence = ATATAATATATTGTGT Gene: Csac_0774: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Carboxydothermus hydrogenoformans Z-2901	Moorella thermoacetica ATCC 39073 Gene: Moth_1449: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Thermoanaerobacter ethanolicus X514 Site: position = -378 score = 4.91307 sequence = ATACTAAATATTGGGT Site: position = -347 score = 5.27176 sequence = ACACTATATTTTGTAG Gene: Teth514_1144: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Thermoanaerobacter italicus Ab9 Site: position = -378 score = 4.91307 sequence = ATACTAAATATTGGGT Site: position = -347 score = 5.27176 sequence = ACACTATATTTTGTAG Gene: Thit_1661: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	* Thermoanaerobacter tengcongensis MB4 Site: position = -88 score = 4.76849 sequence = ATACTAAATATTGAGG Site: position = -57 score = 5.27176 sequence = CTACTATATTTTGTGT Gene: TTE1850: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
nrdG2	Anaerocellum thermophilum DSM 6725 Gene: Athe_0341: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Caldicellulosiruptor saccharolyticus DSM 8903 Gene: Csac_1169: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Carboxydothermus hydrogenoformans Z-2901	Moorella thermoacetica ATCC 39073 Gene: Moth_1448: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Thermoanaerobacter ethanolicus X514 Gene: Teth514_1145: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Thermoanaerobacter italicus Ab9 Gene: Thit_1660: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Thermoanaerobacter tengcongensis MB4 Gene: TTE1849: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)

CRON 2.
nrdR	Anaerocellum thermophilum DSM 6725 Gene: Athe_1510: Ribonucleotide reductase transcriptional regulator NrdR	Caldicellulosiruptor saccharolyticus DSM 8903 Gene: Csac_2057: Ribonucleotide reductase transcriptional regulator NrdR	* Carboxydothermus hydrogenoformans Z-2901 Site: position = -28 score = 4.88002 sequence = ACACAAAATATAGGGT Site: position = -60 score = 5.17575 sequence = ACACAAGATATAGTAG Gene: CHY_2052: Ribonucleotide reductase transcriptional regulator NrdR	Moorella thermoacetica ATCC 39073	Thermoanaerobacter ethanolicus X514 Gene: Teth514_1998: Ribonucleotide reductase transcriptional regulator NrdR	Thermoanaerobacter italicus Ab9 Gene: Thit_1471: Ribonucleotide reductase transcriptional regulator NrdR	Thermoanaerobacter tengcongensis MB4 Gene: TTE1634: Ribonucleotide reductase transcriptional regulator NrdR	Ribonucleotide reductase transcriptional regulator NrdR
nrdD	Anaerocellum thermophilum DSM 6725	Caldicellulosiruptor saccharolyticus DSM 8903	Carboxydothermus hydrogenoformans Z-2901 Gene: CHY_2051: Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)	Moorella thermoacetica ATCC 39073	Thermoanaerobacter ethanolicus X514	Thermoanaerobacter italicus Ab9	Thermoanaerobacter tengcongensis MB4	Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)
nrdG	Anaerocellum thermophilum DSM 6725	Caldicellulosiruptor saccharolyticus DSM 8903	Carboxydothermus hydrogenoformans Z-2901 Gene: CHY_2050: Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)	Moorella thermoacetica ATCC 39073	Thermoanaerobacter ethanolicus X514	Thermoanaerobacter italicus Ab9	Thermoanaerobacter tengcongensis MB4	Ribonucleotide reductase of class III (anaerobic), activating protein (EC 1.97.1.4)

CRON 3.
nrdJ	Anaerocellum thermophilum DSM 6725	Caldicellulosiruptor saccharolyticus DSM 8903	Carboxydothermus hydrogenoformans Z-2901	Moorella thermoacetica ATCC 39073	Thermoanaerobacter ethanolicus X514	Thermoanaerobacter italicus Ab9	* Thermoanaerobacter tengcongensis MB4 Site: position = -139 score = 5.48436 sequence = ATACAAAATATTGTGT Site: position = -171 score = 4.39551 sequence = ACACAACAAAATGTAT Gene: TTE2336: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)	Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)

CRON 4.
nrdJ	Anaerocellum thermophilum DSM 6725	Caldicellulosiruptor saccharolyticus DSM 8903	Carboxydothermus hydrogenoformans Z-2901 Gene: CHY_0676: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	Moorella thermoacetica ATCC 39073 Gene: Moth_1137: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	* Thermoanaerobacter ethanolicus X514 Site: position = -41 score = 5.23097 sequence = ACACAAAATATTGTGG Site: position = -72 score = 4.43243 sequence = CCACAATAAAATGTAT Gene: Teth514_0821: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	* Thermoanaerobacter italicus Ab9 Site: position = -72 score = 4.65277 sequence = ACACAATAAAATGTAT Site: position = -41 score = 5.23097 sequence = CCACAAAATATTGTGT Gene: Thit_2029: Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing	Thermoanaerobacter tengcongensis MB4	Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1) @ intein-containing

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog NrdR - Thermoanaerobacterales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --