Collection of regulogs for TetR transcription factor family

TetR family of transcription factors is the third most frequently occurring regulator family in Bacteria [20595046]. This family includes diverse transcriptional repressors that control genes involved in multidrug resistance, different catabolic pathways, biosynthesis of antibiotics, osmotic stress, and pathogenicity [15944459]. TetR proteins serve as chemical sensors to monitor the cellular environment and are particularly abundant in microbes exposed to environmental changes, e.g. in soil microorganisms and methanogenic bacteria, but not in intracellular pathogens [15944459]. In general, members of the TetR family bind their target operators upstream of regulated genes and thus block their expression. more

When effector binds to the regulator, this binding causes conformational change that renders the protein unable to bind DNA [15944459]. TetR-family regulators are composed of an N-terminal HTH DNA binding domain (PF00440) and a C-terminal ligand binding domain. Diversity of ligand binding domains corresponds to a variety of effectors of TetR-family proteins [19130905]. TetR-family proteins are known to respond to tetracycline, resorcinol, multidrug efflux related-compounds [21559286], bile acids [21328631] etc, and were crystalized in complexes with stearic acid, phloretin, ethidium, hexadecyl octanoate etc [20595046].