Regulog BioQ - Frankineae/Propionibacterineae/Pseudonocardiaceae

Properties
Regulator type:	Transcription factor
Regulator family:	TetR
Regulation mode:	repressor
Biological process:	Biotin biosynthesis
Effector:	Biotin
Phylum:	Actinobacteria
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 11 sites [see more]

Member of regulog collections

By trascription factor - BioQ
By taxonomy - Frankineae/Propionibacterineae/Pseudonocardiaceae
By TF family - TetR
By effector - Biotin
By pathway - Biotin biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Actinosynnema mirum DSM 43827
Saccharopolyspora erythraea NRRL 2338	4	2
Saccharomonospora viridis DSM 43017
Nakamurella multipartita DSM 44233
Frankia sp. EAN1pec
Frankia sp. CcI3
Acidothermus cellulolyticus 11B
Propionibacterium acnes KPA171202	8	5
Nocardioides sp. JS614	8	3

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes										Function

CRON 1.
bioB	Actinosynnema mirum DSM 43827	* Saccharopolyspora erythraea NRRL 2338 Site: position = -63 score = 6.25966 sequence = CCTGAACGGCGTTCAGG Gene: SACE_4683: Biotin synthase (EC 2.8.1.6)	Saccharomonospora viridis DSM 43017	Nakamurella multipartita DSM 44233	Frankia sp. EAN1pec	Frankia sp. CcI3	Acidothermus cellulolyticus 11B	* Propionibacterium acnes KPA171202 Site: position = 9 score = 4.63055 sequence = ATTGAATCCCGTTCAAT Site: position = 26 score = 6.25966 sequence = CCTGAACGGCGTTCAGG Gene: PPA1407: Biotin synthase (EC 2.8.1.6)	* Nocardioides sp. JS614 Site: position = -36 score = 6.17558 sequence = CCTGAACGCTGTTCAGG Gene: Noca_3415: Biotin synthase (EC 2.8.1.6)	Biotin synthase (EC 2.8.1.6)
bioA	Actinosynnema mirum DSM 43827	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_4684: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Saccharomonospora viridis DSM 43017	Nakamurella multipartita DSM 44233	Frankia sp. EAN1pec	Frankia sp. CcI3	Acidothermus cellulolyticus 11B	* Propionibacterium acnes KPA171202 Site: position = -121 score = 5.91266 sequence = CCTGAACACTGTTCAAG Gene: PPA0967: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Nocardioides sp. JS614 Gene: Noca_3414: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
bioF	Actinosynnema mirum DSM 43827	Saccharopolyspora erythraea NRRL 2338 Gene: SACE_4685: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Saccharomonospora viridis DSM 43017	Nakamurella multipartita DSM 44233	Frankia sp. EAN1pec	Frankia sp. CcI3	Acidothermus cellulolyticus 11B	Propionibacterium acnes KPA171202	Nocardioides sp. JS614 Gene: Noca_3413: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	8-amino-7-oxononanoate synthase (EC 2.3.1.47)
bioD	Actinosynnema mirum DSM 43827	Saccharopolyspora erythraea NRRL 2338	Saccharomonospora viridis DSM 43017	Nakamurella multipartita DSM 44233	Frankia sp. EAN1pec	Frankia sp. CcI3	Acidothermus cellulolyticus 11B	Propionibacterium acnes KPA171202 Gene: PPA0968: Dethiobiotin synthetase (EC 6.3.3.3)	Nocardioides sp. JS614 Gene: Noca_3412: Dethiobiotin synthetase (EC 6.3.3.3)	Dethiobiotin synthetase (EC 6.3.3.3)
bioY	Actinosynnema mirum DSM 43827	Saccharopolyspora erythraea NRRL 2338	Saccharomonospora viridis DSM 43017	Nakamurella multipartita DSM 44233	Frankia sp. EAN1pec	Frankia sp. CcI3	Acidothermus cellulolyticus 11B	* Propionibacterium acnes KPA171202 Site: position = -75 score = 5.63909 sequence = ACTGAACGGTGTTCAAT Gene: PPA1400: Substrate-specific component BioY of biotin ECF transporter	* Nocardioides sp. JS614 Site: position = -39 score = 5.77142 sequence = CCTGACCACCGTTCAGG Gene: Noca_3349: Substrate-specific component BioY of biotin ECF transporter	Substrate-specific component BioY of biotin ECF transporter
bioM	Actinosynnema mirum DSM 43827	Saccharopolyspora erythraea NRRL 2338	Saccharomonospora viridis DSM 43017	Nakamurella multipartita DSM 44233	Frankia sp. EAN1pec	Frankia sp. CcI3	Acidothermus cellulolyticus 11B	Propionibacterium acnes KPA171202 Gene: PPA1399: ATPase component BioM of energizing module of biotin ECF transporter	Nocardioides sp. JS614 Gene: Noca_3350: ATPase component BioM of energizing module of biotin ECF transporter	ATPase component BioM of energizing module of biotin ECF transporter
bioN	Actinosynnema mirum DSM 43827	Saccharopolyspora erythraea NRRL 2338	Saccharomonospora viridis DSM 43017	Nakamurella multipartita DSM 44233	Frankia sp. EAN1pec	Frankia sp. CcI3	Acidothermus cellulolyticus 11B	Propionibacterium acnes KPA171202 Gene: PPA1398: Transmembrane component BioN of energizing module of biotin ECF transporter	Nocardioides sp. JS614 Gene: Noca_3351: Transmembrane component BioN of energizing module of biotin ECF transporter	Transmembrane component BioN of energizing module of biotin ECF transporter

CRON 2.
bioWF	Actinosynnema mirum DSM 43827	Saccharopolyspora erythraea NRRL 2338	Saccharomonospora viridis DSM 43017	Nakamurella multipartita DSM 44233	Frankia sp. EAN1pec	Frankia sp. CcI3	Acidothermus cellulolyticus 11B	* Propionibacterium acnes KPA171202 Site: position = -50 score = 5.05611 sequence = ATTGAATGGTGTTCAAT Gene: PPA1866: Pimeloyl-CoA synthase (EC 6.2.1.14) / 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Nocardioides sp. JS614	Pimeloyl-CoA synthase (EC 6.2.1.14) / 8-amino-7-oxononanoate synthase (EC 2.3.1.47)

CRON 3.
bioQ	Actinosynnema mirum DSM 43827	* Saccharopolyspora erythraea NRRL 2338 Site: position = -58 score = 6.25966 sequence = CCTGAACGCCGTTCAGG Gene: SACE_4682: Biotin repressor, TetR family	Saccharomonospora viridis DSM 43017	Nakamurella multipartita DSM 44233	Frankia sp. EAN1pec	Frankia sp. CcI3	Acidothermus cellulolyticus 11B	* Propionibacterium acnes KPA171202 Site: position = -55 score = 6.25966 sequence = CCTGAACGCCGTTCAGG Gene: PPA1406: Biotin repressor, TetR family	* Nocardioides sp. JS614 Site: position = -95 score = 5.77142 sequence = CCTGAACGGTGGTCAGG Gene: Noca_3348: Biotin repressor, TetR family	Biotin repressor, TetR family

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulated Genes	[ Tab delimited format ]	DOWNLOAD
	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog BioQ - Frankineae/Propionibacterineae/Pseudonocardiaceae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --