Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --

Regulog BioQ - Nocardiaceae

Properties
Regulator type: Transcription factor
Regulator family: TetR
Regulation mode: repressor
Biological process: Biotin biosynthesis
Effector: Biotin
Phylum: Actinobacteria
Visualization:
Allows to visualize regulog content in the context of metabolic pathways
Built upon 25 sites [see more]
Member of regulog collections
Statistics of regulated genes
Genome Genes Operons
Nocardia farcinica IFM 10152 5 4
Rhodococcus erythropolis PR4 5 4
Rhodococcus opacus B4 14 6
Rhodococcus sp. RHA1 11 5
Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes Function
 
CRON 1.
bioF
*
Nocardia farcinica IFM 10152

Site:
position = -31
score = 5.94964
sequence = CCTGAACGGTGTTCAAG

Gene: nfa18190: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
*
Rhodococcus erythropolis PR4

Site:
position = -18
score = 6.12375
sequence = GTTGAACGGTGTTCAAG

Gene: RER_35040: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
*
Rhodococcus opacus B4

Site:
position = -24
score = 6.14621
sequence = GTTGAACACCGTTCAAG

Gene: ROP_07820: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
*
Rhodococcus sp. RHA1

Site:
position = -26
score = 6.14621
sequence = GTTGAACACCGTTCAAG

Gene: RHA1_ro01054: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)
8-amino-7-oxononanoate synthase (EC 2.3.1.47)
bioD
 
Nocardia farcinica IFM 10152

Gene: nfa18200: Dethiobiotin synthetase (EC 6.3.3.3)
 
Rhodococcus erythropolis PR4

Gene: RER_35030: Dethiobiotin synthetase (EC 6.3.3.3)
 
Rhodococcus opacus B4

Gene: ROP_07810: Dethiobiotin synthetase (EC 6.3.3.3)
 
Rhodococcus sp. RHA1

Gene: RHA1_ro01053: Dethiobiotin synthetase (EC 6.3.3.3)
Dethiobiotin synthetase (EC 6.3.3.3)
 
CRON 2.
bioA
*
Nocardia farcinica IFM 10152

Site:
position = -60
score = 6.2666
sequence = CTTGAACACTGTTCAAG

Gene: nfa18180: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Rhodococcus erythropolis PR4

Site:
position = -37
score = 6.12822
sequence = CTTGAACACCGTTCAAC

Gene: RER_35050: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Rhodococcus opacus B4

Site:
position = -41
score = 6.10576
sequence = CTTGAACGGTGTTCAAC

Gene: ROP_07830: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
*
Rhodococcus sp. RHA1

Site:
position = -59
score = 6.10576
sequence = CTTGAACGGTGTTCAAC

Gene: RHA1_ro01055: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
 
CRON 3.
bioB
*
Nocardia farcinica IFM 10152

Site:
position = -85
score = 5.97209
sequence = CCTGAACACCGTTCAAG

Gene: nfa18320: Biotin synthase (EC 2.8.1.6)
*
Rhodococcus erythropolis PR4

Site:
position = -58
score = 5.85617
sequence = CGTGAACACCGTTCAAC

Site:
position = -42
score = 5.09969
sequence = CTTGTACGGTGTTCAAT

Gene: RER_34880: Biotin synthase (EC 2.8.1.6)
*
Rhodococcus opacus B4

Site:
position = -88
score = 5.85617
sequence = CGTGAACACCGTTCAAC

Site:
position = -72
score = 5.09969
sequence = CTTGTACGGTGTTCAAT

Gene: ROP_07700: Biotin synthase (EC 2.8.1.6)
*
Rhodococcus sp. RHA1

Site:
position = -1
score = 5.85617
sequence = CGTGAACACCGTTCAAC

Site:
position = 15
score = 5.09969
sequence = CTTGTACGGTGTTCAAT

Gene: RHA1_ro01043: Biotin synthase (EC 2.8.1.6)
Biotin synthase (EC 2.8.1.6)
 
CRON 4.
bioQ
*
Nocardia farcinica IFM 10152

Site:
position = -65
score = 5.84581
sequence = CTTGAACGGTGTTCAGG

Gene: nfa18310: Biotin repressor, TetR family
*
Rhodococcus erythropolis PR4

Site:
position = -124
score = 5.51501
sequence = ATTGAACACCGTACAAG

Site:
position = -108
score = 5.83669
sequence = GTTGAACGGTGTTCACG

Gene: RER_34890: Biotin repressor, TetR family
*
Rhodococcus opacus B4

Site:
position = -99
score = 5.51501
sequence = ATTGAACACCGTACAAG

Site:
position = -83
score = 5.83669
sequence = GTTGAACGGTGTTCACG

Gene: ROP_07710: Biotin repressor, TetR family
*
Rhodococcus sp. RHA1

Site:
position = -24
score = 5.51501
sequence = ATTGAACACCGTACAAG

Site:
position = -8
score = 5.83669
sequence = GTTGAACGGTGTTCACG

Gene: RHA1_ro01044: Biotin repressor, TetR family
Biotin repressor, TetR family
 
CRON 5.
bioY
 
Nocardia farcinica IFM 10152
 
Rhodococcus erythropolis PR4

Gene: RER_27460: Substrate-specific component BioY of biotin ECF transporter
*2
Rhodococcus opacus B4

Site:
position = -38
score = 5.73372
sequence = CTTGAACGTCGTTCAAG

Gene: ROP_53000: Substrate-specific component BioY of biotin ECF transporter

Site:
position = -38
score = 5.73372
sequence = CTTGAACGTCGTTCAAG

Gene: ROP_52960: Substrate-specific component BioY of biotin ECF transporter
*
Rhodococcus sp. RHA1

Site:
position = -38
score = 5.73372
sequence = CTTGAACGTCGTTCAAG

Gene: RHA1_ro05255: Substrate-specific component BioY of biotin ECF transporter
Substrate-specific component BioY of biotin ECF transporter
yhfT
 
Nocardia farcinica IFM 10152
 
Rhodococcus erythropolis PR4
 3
Rhodococcus opacus B4

Gene: ROP_53050: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)

Gene: ROP_53010: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)

Gene: ROP_52970: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
 2
Rhodococcus sp. RHA1

Gene: RHA1_ro05260: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)

Gene: RHA1_ro05256: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
yhfS
 
Nocardia farcinica IFM 10152
 
Rhodococcus erythropolis PR4
 2
Rhodococcus opacus B4

Gene: ROP_53020: acetyl-CoA acetyltransferase

Gene: ROP_52980: acetyl-CoA acetyltransferase
 
Rhodococcus sp. RHA1

Gene: RHA1_ro05257: acetyl-CoA acetyltransferase
acetyl-CoA acetyltransferase
bioM
 
Nocardia farcinica IFM 10152
 
Rhodococcus erythropolis PR4

Gene: RER_27450: ATPase component BioM of energizing module of biotin ECF transporter
 
Rhodococcus opacus B4

Gene: ROP_53030: ATPase component BioM of energizing module of biotin ECF transporter
 
Rhodococcus sp. RHA1

Gene: RHA1_ro05258: ATPase component BioM of energizing module of biotin ECF transporter
ATPase component BioM of energizing module of biotin ECF transporter
bioN
 
Nocardia farcinica IFM 10152
 
Rhodococcus erythropolis PR4

Gene: RER_27440: Transmembrane component BioN of energizing module of biotin ECF transporter
 
Rhodococcus opacus B4

Gene: ROP_53040: Transmembrane component BioN of energizing module of biotin ECF transporter
 
Rhodococcus sp. RHA1

Gene: RHA1_ro05259: Transmembrane component BioN of energizing module of biotin ECF transporter
Transmembrane component BioN of energizing module of biotin ECF transporter
Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.
Red color - the gene is in non-regulated operon.
Gray color - the orthologous gene is absent.
The star symbol - the TFBS is located in upstream region of this gene.
The number - the numeber of homologs (shown only if it is greater than one).
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