Regulog BioQ - Micrococcineae

Properties
Regulator type:	Transcription factor
Regulator family:	TetR
Regulation mode:	repressor
Biological process:	Biotin biosynthesis
Effector:	Biotin
Phylum:	Actinobacteria
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 17 sites [see more]

Member of regulog collections

By taxonomy - Micrococcineae
By trascription factor - BioQ
By TF family - TetR
By effector - Biotin
By pathway - Biotin biosynthesis

Statistics of regulated genes
Genome	Genes	Operons
Arthrobacter aurescens TC1
Arthrobacter chlorophenolicus A6
Arthrobacter sp. FB24
Beutenbergia cavernae DSM 12333
Brachybacterium faecium DSM 4810
Brevibacterium linens BL2	8	3
Clavibacter michiganensis subsp. michiganensis NCPPB 382	4	2
Janibacter sp. HTCC2649
Jonesia denitrificans DSM 20603
Kocuria rhizophila DC2201	5	2
Kytococcus sedentarius DSM 20547
Leifsonia xyli subsp. xyli str. CTCB07	7	2
Renibacterium salmoninarum ATCC 33209	9	2
Tropheryma whipplei str. Twist

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes															Function

CRON 1.
bioY	Arthrobacter aurescens TC1 Gene: AAur_2114: Substrate-specific component BioY of biotin ECF transporter	Arthrobacter chlorophenolicus A6 Gene: Achl_1855: Substrate-specific component BioY of biotin ECF transporter	Arthrobacter sp. FB24 Gene: Arth_2113: Substrate-specific component BioY of biotin ECF transporter	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	* Brevibacterium linens BL2 Site: position = -21 score = 5.97442 sequence = CCTGAACAGTGTTCAGT Gene: BlinB01002267: Substrate-specific component BioY of biotin ECF transporter	* Clavibacter michiganensis subsp. michiganensis NCPPB 382 Site: position = -65 score = 5.78156 sequence = AGTGAACGCCGTTCAGG Site: position = -50 score = 5.45395 sequence = GGTGAACATCGTTCAGG Gene: CMM_1625: Substrate-specific component BioY of biotin ECF transporter	Janibacter sp. HTCC2649 Gene: JNB_15728: Substrate-specific component BioY of biotin ECF transporter	Jonesia denitrificans DSM 20603 Gene: Jden_1159: Substrate-specific component BioY of biotin ECF transporter	Kocuria rhizophila DC2201 Gene: KRH_12340: Substrate-specific component BioY of biotin ECF transporter	Kytococcus sedentarius DSM 20547 Gene: Ksed_01740: Substrate-specific component BioY of biotin ECF transporter	* Leifsonia xyli subsp. xyli str. CTCB07 Site: position = -44 score = 5.84457 sequence = AGTGAACGCTGTTCAGG Site: position = -29 score = 5.69988 sequence = GGTGAACACCGTTCAGT Gene: Lxx20880: Substrate-specific component BioY of biotin ECF transporter	* Renibacterium salmoninarum ATCC 33209 Site: position = -113 score = 5.48572 sequence = ATTGAACCCTGTTCAAT Gene: RSal33209_2106: Substrate-specific component BioY of biotin ECF transporter	Tropheryma whipplei str. Twist Gene: TW211: Substrate-specific component BioY of biotin ECF transporter	Substrate-specific component BioY of biotin ECF transporter
yhfT	Arthrobacter aurescens TC1	Arthrobacter chlorophenolicus A6	Arthrobacter sp. FB24	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	Kocuria rhizophila DC2201	Kytococcus sedentarius DSM 20547	Leifsonia xyli subsp. xyli str. CTCB07 Gene: Lxx20870: Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)	Renibacterium salmoninarum ATCC 33209	Tropheryma whipplei str. Twist	Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
yhfS	Arthrobacter aurescens TC1	Arthrobacter chlorophenolicus A6	Arthrobacter sp. FB24	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	Kocuria rhizophila DC2201	Kytococcus sedentarius DSM 20547	Leifsonia xyli subsp. xyli str. CTCB07 Gene: Lxx20900: acetyl-coA acyltransferase	Renibacterium salmoninarum ATCC 33209	Tropheryma whipplei str. Twist	acetyl-coA acyltransferase
bioM	Arthrobacter aurescens TC1 Gene: AAur_2113: ATPase component BioM of energizing module of biotin ECF transporter	Arthrobacter chlorophenolicus A6 Gene: Achl_1854: ATPase component BioM of energizing module of biotin ECF transporter	Arthrobacter sp. FB24 Gene: Arth_2112: ATPase component BioM of energizing module of biotin ECF transporter	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2 Gene: BlinB01002268: ATPase component BioM of energizing module of biotin ECF transporter	Clavibacter michiganensis subsp. michiganensis NCPPB 382 Gene: CMM_1626: ATPase component BioM of energizing module of biotin ECF transporter	Janibacter sp. HTCC2649 Gene: JNB_15723: ATPase component BioM of energizing module of biotin ECF transporter	Jonesia denitrificans DSM 20603 Gene: Jden_1158: ATPase component BioM of energizing module of biotin ECF transporter	Kocuria rhizophila DC2201 Gene: KRH_12330: ATPase component BioM of energizing module of biotin ECF transporter	Kytococcus sedentarius DSM 20547 Gene: Ksed_01750: ATPase component BioM of energizing module of biotin ECF transporter	Leifsonia xyli subsp. xyli str. CTCB07 Gene: Lxx20910: ATPase component BioM of energizing module of biotin ECF transporter	Renibacterium salmoninarum ATCC 33209 Gene: RSal33209_2107: ATPase component BioM of energizing module of biotin ECF transporter	Tropheryma whipplei str. Twist	ATPase component BioM of energizing module of biotin ECF transporter
bioN	Arthrobacter aurescens TC1 Gene: AAur_2111: Transmembrane component BioN of energizing module of biotin ECF transporter	Arthrobacter chlorophenolicus A6 Gene: Achl_1853: Transmembrane component BioN of energizing module of biotin ECF transporter	Arthrobacter sp. FB24 Gene: Arth_2111: Transmembrane component BioN of energizing module of biotin ECF transporter	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2 Gene: BlinB01002269: Transmembrane component BioN of energizing module of biotin ECF transporter	Clavibacter michiganensis subsp. michiganensis NCPPB 382 Gene: CMM_1627: Transmembrane component BioN of energizing module of biotin ECF transporter	Janibacter sp. HTCC2649 Gene: JNB_15718: Transmembrane component BioN of energizing module of biotin ECF transporter	Jonesia denitrificans DSM 20603 Gene: Jden_1157: Transmembrane component BioN of energizing module of biotin ECF transporter	Kocuria rhizophila DC2201 Gene: KRH_12320: Transmembrane component BioN of energizing module of biotin ECF transporter	Kytococcus sedentarius DSM 20547 Gene: Ksed_01760: Transmembrane component BioN of energizing module of biotin ECF transporter	Leifsonia xyli subsp. xyli str. CTCB07 Gene: Lxx20920: Transmembrane component BioN of energizing module of biotin ECF transporter	Renibacterium salmoninarum ATCC 33209 Gene: RSal33209_2108: Transmembrane component BioN of energizing module of biotin ECF transporter	Tropheryma whipplei str. Twist	Transmembrane component BioN of energizing module of biotin ECF transporter
CMM_2958	Arthrobacter aurescens TC1	Arthrobacter chlorophenolicus A6	Arthrobacter sp. FB24	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	Kocuria rhizophila DC2201	Kytococcus sedentarius DSM 20547	Leifsonia xyli subsp. xyli str. CTCB07 Gene: Lxx20930: hypothetical protein	Renibacterium salmoninarum ATCC 33209	Tropheryma whipplei str. Twist	hypothetical protein

CRON 2.
bioB	Arthrobacter aurescens TC1 Gene: AAur_1091: Biotin synthase (EC 2.8.1.6)	Arthrobacter chlorophenolicus A6 Gene: Achl_0984: Biotin synthase (EC 2.8.1.6)	Arthrobacter sp. FB24 Gene: Arth_0875: Biotin synthase (EC 2.8.1.6)	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	2 Brevibacterium linens BL2* Site: position = -23 score = 5.90758 sequence = CCTGAACAGTGTTCAAT Gene: BlinB01003681: Biotin synthase (EC 2.8.1.6) Site: position = -68 score = 5.90758 sequence = ATTGAACACTGTTCAGG Gene: BlinB01003562: Biotin synthase (EC 2.8.1.6)	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	* Kocuria rhizophila DC2201 Site: position = -8 score = 5.63854 sequence = ATTGAACAATGTTCAAG Site: position = -26 score = 5.84457 sequence = CCTGAACACCGTTCAAT Gene: KRH_02440: Biotin synthase (EC 2.8.1.6)	Kytococcus sedentarius DSM 20547 Gene: Ksed_26490: Biotin synthase (EC 2.8.1.6)	Leifsonia xyli subsp. xyli str. CTCB07	* Renibacterium salmoninarum ATCC 33209 Site: position = -8 score = 5.5208 sequence = TTTGAACAGTGTTCAAT Gene: RSal33209_0557: Biotin synthase (EC 2.8.1.6)	Tropheryma whipplei str. Twist	Biotin synthase (EC 2.8.1.6)
bioA	Arthrobacter aurescens TC1 Gene: AAur_1089: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Arthrobacter chlorophenolicus A6	Arthrobacter sp. FB24	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2 Gene: BlinB01003680: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	Kocuria rhizophila DC2201 Gene: KRH_02450: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Kytococcus sedentarius DSM 20547	Leifsonia xyli subsp. xyli str. CTCB07	Renibacterium salmoninarum ATCC 33209 Gene: RSal33209_0558: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)	Tropheryma whipplei str. Twist	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)
RSal33209_0559	Arthrobacter aurescens TC1	Arthrobacter chlorophenolicus A6	Arthrobacter sp. FB24	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	Kocuria rhizophila DC2201	Kytococcus sedentarius DSM 20547	Leifsonia xyli subsp. xyli str. CTCB07	Renibacterium salmoninarum ATCC 33209 Gene: RSal33209_0559: hypothetical membrane protein	Tropheryma whipplei str. Twist	hypothetical membrane protein
bioF	Arthrobacter aurescens TC1 Gene: AAur_1088: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Arthrobacter chlorophenolicus A6	Arthrobacter sp. FB24	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2 Gene: BlinB01003679: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	Kocuria rhizophila DC2201 Gene: KRH_02460: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Kytococcus sedentarius DSM 20547	Leifsonia xyli subsp. xyli str. CTCB07	2 Renibacterium salmoninarum ATCC 33209 Gene: RSal33209_0560: 8-amino-7-oxononanoate synthase (EC 2.3.1.47) Gene: RSal33209_0561: 8-amino-7-oxononanoate synthase (EC 2.3.1.47)	Tropheryma whipplei str. Twist	8-amino-7-oxononanoate synthase (EC 2.3.1.47)
bioD	Arthrobacter aurescens TC1 Gene: AAur_1087: Dethiobiotin synthetase (EC 6.3.3.3)	Arthrobacter chlorophenolicus A6	Arthrobacter sp. FB24	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2 Gene: BlinB01003678: Dethiobiotin synthetase (EC 6.3.3.3)	Clavibacter michiganensis subsp. michiganensis NCPPB 382	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	Kocuria rhizophila DC2201 Gene: KRH_02470: Dethiobiotin synthetase (EC 6.3.3.3)	Kytococcus sedentarius DSM 20547	Leifsonia xyli subsp. xyli str. CTCB07	Renibacterium salmoninarum ATCC 33209 Gene: RSal33209_0562: Dethiobiotin synthetase (EC 6.3.3.3)	Tropheryma whipplei str. Twist	Dethiobiotin synthetase (EC 6.3.3.3)

CRON 3.
bioQ	Arthrobacter aurescens TC1	Arthrobacter chlorophenolicus A6	Arthrobacter sp. FB24	Beutenbergia cavernae DSM 12333	Brachybacterium faecium DSM 4810	Brevibacterium linens BL2	* Clavibacter michiganensis subsp. michiganensis NCPPB 382 Site: position = -47 score = 5.45395 sequence = CCTGAACGATGTTCACC Site: position = -32 score = 5.78156 sequence = CCTGAACGGCGTTCACT Gene: CMM_1624: Biotin repressor, TetR family	Janibacter sp. HTCC2649	Jonesia denitrificans DSM 20603	* Kocuria rhizophila DC2201 Site: position = -253 score = 5.84457 sequence = ATTGAACGGTGTTCAGG Site: position = -271 score = 5.63854 sequence = CTTGAACATTGTTCAAT Gene: KRH_02430: Biotin repressor, TetR family	Kytococcus sedentarius DSM 20547	* Leifsonia xyli subsp. xyli str. CTCB07 Site: position = -43 score = 5.69988 sequence = ACTGAACGGTGTTCACC Site: position = -28 score = 5.84457 sequence = CCTGAACAGCGTTCACT Gene: Lxx20890: Biotin repressor, TetR family	Renibacterium salmoninarum ATCC 33209	Tropheryma whipplei str. Twist	Biotin repressor, TetR family

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog BioQ - Micrococcineae

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --