Regulog PaaR2 - Deinococcus-Thermus

Properties
Regulator type:	Transcription factor
Regulator family:	TetR
Regulation mode:	repressor
Biological process:	Phenylacetic acid degradation
Effector:	Phenylacetyl-CoA
Phylum:	Deinococcus-Thermus
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 26 sites [see more]

Member of regulog collections

By trascription factor - PaaR
By taxonomy - Deinococcus-Thermus
By TF family - TetR
By effector - Phenylacetyl-CoA
By pathway - Phenylacetic acid degradation

Statistics of regulated genes
Genome	Genes	Operons
Deinococcus deserti VCD115	14	8
Deinococcus geothermalis DSM 11300	14	8
Deinococcus radiodurans R1	17	10
Thermus aquaticus Y51MC23
Thermus thermophilus HB27

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes						Function

CRON 1.
paaR	* Deinococcus deserti VCD115 Site: position = -95 score = 4.84557 sequence = CAAACGAGCGTTAGGTGA Gene: Deide_02390: Transcriptional regulator of phenylacetic acid degradation, TetR family	* Deinococcus geothermalis DSM 11300 Site: position = -61 score = 4.84451 sequence = CAAACGGACGTTCACTTG Gene: Dgeo_0117: Transcriptional regulator of phenylacetic acid degradation, TetR family	* Deinococcus radiodurans R1 Site: position = -68 score = 5.37927 sequence = CAAACGCCCGTTTGGTTG Gene: DR2376: Transcriptional regulator of phenylacetic acid degradation, TetR family	Thermus aquaticus Y51MC23	Thermus thermophilus HB27	Transcriptional regulator of phenylacetic acid degradation, TetR family

CRON 2.
pccB	* Deinococcus deserti VCD115 Site: position = -31 score = 6.23732 sequence = CAAACGAGCGTTTGTTAG Gene: Deide_14880: Propionyl-CoA carboxylase (EC 6.4.1.3)	* Deinococcus geothermalis DSM 11300 Site: position = -31 score = 6.38515 sequence = CTAACGGGCGTTTGTTAG Gene: Dgeo_0811: Propionyl-CoA carboxylase (EC 6.4.1.3)	* Deinococcus radiodurans R1 Site: position = -31 score = 6.38515 sequence = CTAACGGGCGTTTGTTAG Gene: DR1542: Propionyl-CoA carboxylase (EC 6.4.1.3)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_4494: Propionyl-CoA carboxylase (EC 6.4.1.3)	Thermus thermophilus HB27 Gene: TTC1192: Propionyl-CoA carboxylase (EC 6.4.1.3)	Propionyl-CoA carboxylase (EC 6.4.1.3)
DR1543	Deinococcus deserti VCD115	Deinococcus geothermalis DSM 11300	Deinococcus radiodurans R1 Gene: DR1543: hypothetical protein	Thermus aquaticus Y51MC23	Thermus thermophilus HB27	hypothetical protein
bcd	Deinococcus deserti VCD115 Gene: Deide_14890: Butyryl-CoA dehydrogenase (EC 1.3.8.1)	Deinococcus geothermalis DSM 11300 Gene: Dgeo_0812: Butyryl-CoA dehydrogenase (EC 1.3.8.1)	Deinococcus radiodurans R1 Gene: DR1544: Butyryl-CoA dehydrogenase (EC 1.3.8.1)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_3905: Butyryl-CoA dehydrogenase (EC 1.3.8.1)	Thermus thermophilus HB27 Gene: TTC1575: Butyryl-CoA dehydrogenase (EC 1.3.8.1)	Butyryl-CoA dehydrogenase (EC 1.3.8.1)

CRON 3.
bkdA1	* Deinococcus deserti VCD115 Site: position = -87 score = 5.97311 sequence = CTAACGAACGTTAGATAG Gene: Deide_23440: Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4)	* Deinococcus geothermalis DSM 11300 Site: position = -90 score = 6.18017 sequence = CTAACGAGCGTTAGCTAG Gene: Dgeo_2338: Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4)	* Deinococcus radiodurans R1 Site: position = -49 score = 5.64397 sequence = CTAACGCTCGTTAGCTAG Gene: DR0029: Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_4725: Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4)	Thermus thermophilus HB27	Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4)
bkdA2	Deinococcus deserti VCD115 Gene: Deide_23450: Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4)	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2339: Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4)	Deinococcus radiodurans R1 Gene: DR0030: Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_4724: Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4)	Thermus thermophilus HB27	Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4)
DR0031	Deinococcus deserti VCD115 Gene: Deide_23460: hypothetical protein	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2340: hypothetical protein	Deinococcus radiodurans R1 Gene: DR0031: hypothetical protein	Thermus aquaticus Y51MC23	Thermus thermophilus HB27	hypothetical protein
bkdB	Deinococcus deserti VCD115 Gene: Deide_23470: Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168)	Deinococcus geothermalis DSM 11300 Gene: Dgeo_2341: Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168)	Deinococcus radiodurans R1 Gene: DR0032: Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_4722: Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168)	Thermus thermophilus HB27 Gene: TTC1754: Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168)	Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168)

CRON 4.
bcd2	* Deinococcus deserti VCD115 Site: position = -27 score = 5.95407 sequence = CTAACGGTCGTTTGGTAG Gene: Deide_10580: Butyryl-CoA dehydrogenase (EC 1.3.99.2)	* Deinococcus geothermalis DSM 11300 Site: position = -27 score = 6.17109 sequence = CTAACAAGCGTTTGGTAG Gene: Dgeo_1179: Butyryl-CoA dehydrogenase (EC 1.3.99.2)	* Deinococcus radiodurans R1 Site: position = -27 score = 5.76015 sequence = CTAACGCCCGTTTGGTAG Gene: DR1255: Butyryl-CoA dehydrogenase (EC 1.3.99.2)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_4675: Butyryl-CoA dehydrogenase (EC 1.3.99.2)	Thermus thermophilus HB27 Gene: TTC1552: Butyryl-CoA dehydrogenase (EC 1.3.99.2)	Butyryl-CoA dehydrogenase (EC 1.3.99.2)

CRON 5.
mcm	* Deinococcus deserti VCD115 Site: position = -71 score = 5.8921 sequence = CTAACGGGCGTTAGTTTT Gene: Deide_11350: Methylmalonyl-CoA mutase (EC 5.4.99.2)	* Deinococcus geothermalis DSM 11300 Site: position = -38 score = 6.07451 sequence = CTAACGAGCGTTTGTTTC Gene: Dgeo_0862: Methylmalonyl-CoA mutase (EC 5.4.99.2)	* Deinococcus radiodurans R1 Site: position = -11 score = 5.63008 sequence = CAAACAAGCGTTTGTTTT Gene: DR1189: Methylmalonyl-CoA mutase (EC 5.4.99.2)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_3869: Methylmalonyl-CoA mutase (EC 5.4.99.2)	Thermus thermophilus HB27 Gene: TTC0677: Methylmalonyl-CoA mutase (EC 5.4.99.2)	Methylmalonyl-CoA mutase (EC 5.4.99.2)

CRON 6.
hmgcL	* Deinococcus deserti VCD115 Site: position = 6 score = 5.79762 sequence = GTAACGAACGTTCGTTTG Gene: Deide_10010: Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)	* Deinococcus geothermalis DSM 11300 Site: position = -35 score = 5.61467 sequence = CCAACGAACGCTTGTTTG Gene: Dgeo_1253: Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)	* Deinococcus radiodurans R1 Site: position = -32 score = 5.70708 sequence = CCAACAAACGTTCGTTTG Gene: DR1240: Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)	Thermus aquaticus Y51MC23	Thermus thermophilus HB27	Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)
maoC	Deinococcus deserti VCD115 Gene: Deide_10000: enoyl-CoA hydratase-like enzyme	Deinococcus geothermalis DSM 11300 Gene: Dgeo_1254: enoyl-CoA hydratase-like enzyme	Deinococcus radiodurans R1 Gene: DR1239: enoyl-CoA hydratase-like enzyme	Thermus aquaticus Y51MC23	Thermus thermophilus HB27	enoyl-CoA hydratase-like enzyme

CRON 7.
accB	* Deinococcus deserti VCD115 Site: position = -95 score = 4.49704 sequence = CAAACGACCGTTAGGTGA Gene: Deide_03290: Biotin carboxyl carrier protein of acetyl-CoA carboxylase	* Deinococcus geothermalis DSM 11300 Site: position = -89 score = 5.27155 sequence = CTAACGACCGTTCGGGAG Gene: Dgeo_0467: Biotin carboxyl carrier protein of acetyl-CoA carboxylase	* Deinococcus radiodurans R1 Site: position = -133 score = 5.73306 sequence = CAAACGGGCGTTAGGTTG Gene: DR0118: Biotin carboxyl carrier protein of acetyl-CoA carboxylase	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_3437: Biotin carboxyl carrier protein of acetyl-CoA carboxylase	Thermus thermophilus HB27 Gene: TTC0759: Biotin carboxyl carrier protein of acetyl-CoA carboxylase	Biotin carboxyl carrier protein of acetyl-CoA carboxylase
accC	Deinococcus deserti VCD115 Gene: Deide_03280: Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14)	Deinococcus geothermalis DSM 11300 Gene: Dgeo_0466: Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14)	Deinococcus radiodurans R1 Gene: DR0117: Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_3438: Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14)	Thermus thermophilus HB27 Gene: TTC0758: Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14)	Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14)

CRON 8.
phbA	* Deinococcus deserti VCD115 Site: position = -37 score = 6.22358 sequence = CTAACGAGCGTTAGGTTG Gene: Deide_01560: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Deinococcus geothermalis DSM 11300 Gene: Dgeo_1441: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	* Deinococcus radiodurans R1 Site: position = -37 score = 4.80962 sequence = CTAACGCTCGTTAGTCTC Gene: DR1072: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Thermus aquaticus Y51MC23 Gene: TaqDRAFT_4092: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Thermus thermophilus HB27 Gene: TTC0191: Acetyl-CoA acetyltransferase (EC 2.3.1.9)	Acetyl-CoA acetyltransferase (EC 2.3.1.9)

CRON 9.
mcm2	Deinococcus deserti VCD115 Gene: Deide_08100: Methylmalonyl-CoA mutase (EC 5.4.99.2)	* Deinococcus geothermalis DSM 11300 Site: position = -55 score = 5.70646 sequence = CTAACGTGCGTTCGTTCG Gene: Dgeo_1320: Methylmalonyl-CoA mutase (EC 5.4.99.2)	* Deinococcus radiodurans R1 Site: position = -55 score = 4.6469 sequence = CGAACGCTCGTTCGGTTC Gene: DR1084: Methylmalonyl-CoA mutase (EC 5.4.99.2)	Thermus aquaticus Y51MC23	Thermus thermophilus HB27	Methylmalonyl-CoA mutase (EC 5.4.99.2)

CRON 10.
acsA	Deinococcus deserti VCD115	Deinococcus geothermalis DSM 11300 Gene: Dgeo_1750: Acetyl-coenzyme A synthetase (EC 6.2.1.1)	* Deinococcus radiodurans R1 Site: position = -69 score = 5.64526 sequence = CTCACAAACGTTCGTTAG Gene: DR0460: Acetyl-coenzyme A synthetase (EC 6.2.1.1)	Thermus aquaticus Y51MC23	Thermus thermophilus HB27	Acetyl-coenzyme A synthetase (EC 6.2.1.1)

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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	Regulatory Sites	[ FASTA format ]	DOWNLOAD

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog PaaR2 - Deinococcus-Thermus

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --