Collection of regulogs in Pasteurellales taxonomic group
Genomes | 9 |
TF regulogs | 31 |
TF regulons | 181 |
TF binding sites | 950 |
RNA regulogs | 11 |
RNA regulons | 82 |
RNA sites | 112 |
This collection involves all regulons that were tentatively predicted by applying integrative comparative genomic approach to a single taxonomic group of closely-related genomes. To infer the regulons operated by transcription factors (TFs), we combined the identification of TF binding sites and cross-genome comparison of regulons with the analysis of the genomic and functional context of candidate target genes. To infer the regulons operated by regulatory RNAs such as riboswitches, we identified candidate RNA regulatory elements using HMM profiles and further analyzed their genomic and functional context.
TF | RNA | Total | ||||
---|---|---|---|---|---|---|
Genomes | Regulons | Sites | Regulons | Sites | Regulons | Sites |
Actinobacillus pleuropneumoniae serovar 7 str. AP76 | 18 | 117 | 9 | 13 | 27 | 130 |
Actinobacillus succinogenes 130Z | 21 | 107 | 8 | 11 | 29 | 118 |
Aggregatibacter aphrophilus NJ8700 | 21 | 113 | 10 | 16 | 31 | 129 |
Haemophilus ducreyi 35000HP | 13 | 63 | 7 | 10 | 20 | 73 |
Haemophilus influenzae Rd KW20 | 21 | 110 | 11 | 16 | 32 | 126 |
Haemophilus parasuis SH0165 | 19 | 79 | 9 | 11 | 28 | 90 |
Haemophilus somnus 2336 | 20 | 98 | 8 | 10 | 28 | 108 |
Mannheimia succiniciproducens MBEL55E | 25 | 125 | 10 | 13 | 35 | 138 |
Pasteurella multocida subsp. multocida str. Pm70 | 23 | 138 | 10 | 12 | 33 | 150 |
Family | Type | Regulator | Function | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
AraC | TF | RhaS |
1
RhaS
Mannheimia succiniciproducens MBEL55E |
Rhamnose utilization | ||||||||
ArgR | TF | ArgR |
3
ArgR
Haemophilus influenzae Rd KW20 |
2
ArgR
Aggregatibacter aphrophilus NJ8700 |
6
ArgR
Pasteurella multocida subsp. multocida str. Pm70 |
6
ArgR
Mannheimia succiniciproducens MBEL55E |
7
ArgR
Actinobacillus succinogenes 130Z |
2
ArgR
Haemophilus somnus 2336 |
5
ArgR
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
4
ArgR
Haemophilus ducreyi 35000HP |
3
ArgR
Haemophilus parasuis SH0165 |
Arginine biosynthesis |
DeoR | TF | AgaR |
1
AgaR
Haemophilus parasuis SH0165 |
N-acetylgalactosamine utilization | ||||||||
FUR | TF | Fur |
12
Fur
Haemophilus influenzae Rd KW20 |
12
Fur
Aggregatibacter aphrophilus NJ8700 |
16
Fur
Pasteurella multocida subsp. multocida str. Pm70 |
5
Fur
Mannheimia succiniciproducens MBEL55E |
4
Fur
Actinobacillus succinogenes 130Z |
8
Fur
Haemophilus somnus 2336 |
16
Fur
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
7
Fur
Haemophilus ducreyi 35000HP |
6
Fur
Haemophilus parasuis SH0165 |
Iron homeostasis |
GntR/MocR | TF | PdxR |
1
PdxR
Pasteurella multocida subsp. multocida str. Pm70 |
1
PdxR
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
1
PdxR
Haemophilus ducreyi 35000HP |
Pyridoxine biosynthesis | ||||||
GntR/Others | TF | FadR |
1
FadR
Haemophilus influenzae Rd KW20 |
2
FadR
Aggregatibacter aphrophilus NJ8700 |
2
FadR
Pasteurella multocida subsp. multocida str. Pm70 |
2
FadR
Mannheimia succiniciproducens MBEL55E |
2
FadR
Actinobacillus succinogenes 130Z |
3
FadR
Haemophilus somnus 2336 |
2
FadR
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
2
FadR
Haemophilus ducreyi 35000HP |
1
FadR
Haemophilus parasuis SH0165 |
Fatty acid degradation |
TF | UxuR |
2
UxuR
Haemophilus influenzae Rd KW20 |
2
UxuR
Mannheimia succiniciproducens MBEL55E |
3
UxuR
Actinobacillus succinogenes 130Z |
5
UxuR
Haemophilus somnus 2336 |
Glucuronate utilization | ||||||
IclR | TF | KdgR |
6
KdgR
Mannheimia succiniciproducens MBEL55E |
6
KdgR
Actinobacillus succinogenes 130Z |
Pectin and polygalacturonate utlization | |||||||
LacI | TF | FruR |
1
FruR
Aggregatibacter aphrophilus NJ8700 |
1
FruR
Mannheimia succiniciproducens MBEL55E |
1
FruR
Actinobacillus succinogenes 130Z |
Fructose utilization | ||||||
TF | GalR |
3
GalR
Haemophilus influenzae Rd KW20 |
3
GalR
Aggregatibacter aphrophilus NJ8700 |
3
GalR
Pasteurella multocida subsp. multocida str. Pm70 |
3
GalR
Mannheimia succiniciproducens MBEL55E |
2
GalR
Haemophilus somnus 2336 |
Galactose utilization | |||||
TF | GntR |
2
GntR
Aggregatibacter aphrophilus NJ8700 |
2
GntR
Pasteurella multocida subsp. multocida str. Pm70 |
2
GntR
Mannheimia succiniciproducens MBEL55E |
2
GntR
Actinobacillus succinogenes 130Z |
2
GntR
Haemophilus somnus 2336 |
2
GntR
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
2
GntR
Haemophilus parasuis SH0165 |
Gluconate utilization | |||
TF | PurR |
8
PurR
Haemophilus influenzae Rd KW20 |
9
PurR
Aggregatibacter aphrophilus NJ8700 |
9
PurR
Pasteurella multocida subsp. multocida str. Pm70 |
10
PurR
Mannheimia succiniciproducens MBEL55E |
9
PurR
Actinobacillus succinogenes 130Z |
7
PurR
Haemophilus somnus 2336 |
10
PurR
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
5
PurR
Haemophilus ducreyi 35000HP |
10
PurR
Haemophilus parasuis SH0165 |
Purine metabolism | |
TF | RbsR |
1
RbsR
Haemophilus influenzae Rd KW20 |
1
RbsR
Pasteurella multocida subsp. multocida str. Pm70 |
1
RbsR
Actinobacillus succinogenes 130Z |
1
RbsR
Haemophilus somnus 2336 |
1
RbsR
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
1
RbsR
Haemophilus parasuis SH0165 |
Ribose utilization | ||||
TF | SgaR |
2
SgaR
Mannheimia succiniciproducens MBEL55E |
Ascorbate utilization | |||||||||
LexA | TF | LexA |
9
LexA
Haemophilus influenzae Rd KW20 |
9
LexA
Aggregatibacter aphrophilus NJ8700 |
9
LexA
Pasteurella multocida subsp. multocida str. Pm70 |
8
LexA
Mannheimia succiniciproducens MBEL55E |
8
LexA
Actinobacillus succinogenes 130Z |
8
LexA
Haemophilus somnus 2336 |
7
LexA
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
8
LexA
Haemophilus ducreyi 35000HP |
7
LexA
Haemophilus parasuis SH0165 |
SOS response |
LuxR | TF | NarP |
9
NarP
Haemophilus influenzae Rd KW20 |
14
NarP
Aggregatibacter aphrophilus NJ8700 |
10
NarP
Pasteurella multocida subsp. multocida str. Pm70 |
17
NarP
Mannheimia succiniciproducens MBEL55E |
14
NarP
Actinobacillus succinogenes 130Z |
7
NarP
Haemophilus somnus 2336 |
18
NarP
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
10
NarP
Haemophilus ducreyi 35000HP |
Nitrate and nitrite respiration | |
TF | TtrR |
2
TtrR
Pasteurella multocida subsp. multocida str. Pm70 |
2
TtrR
Haemophilus somnus 2336 |
Tetrathionate reduction | ||||||||
LysR | TF | MetR |
5
MetR
Haemophilus influenzae Rd KW20 |
4
MetR
Aggregatibacter aphrophilus NJ8700 |
4
MetR
Pasteurella multocida subsp. multocida str. Pm70 |
5
MetR
Mannheimia succiniciproducens MBEL55E |
2
MetR
Actinobacillus succinogenes 130Z |
3
MetR
Haemophilus somnus 2336 |
7
MetR
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
2
MetR
Haemophilus parasuis SH0165 |
Methionine biosynthesis | |
MerR | TF | CadR-PbrR |
1
CadR-PbrR
Pasteurella multocida subsp. multocida str. Pm70 |
1
CadR-PbrR
Mannheimia succiniciproducens MBEL55E |
1
CadR-PbrR
Haemophilus somnus 2336 |
1
CadR-PbrR
Haemophilus parasuis SH0165 |
Lead resistance; Cadmium resistance | |||||
TF | CueR |
2
CueR
Haemophilus influenzae Rd KW20 |
2
CueR
Aggregatibacter aphrophilus NJ8700 |
1
CueR
Pasteurella multocida subsp. multocida str. Pm70 |
2
CueR
Mannheimia succiniciproducens MBEL55E |
2
CueR
Actinobacillus succinogenes 130Z |
2
CueR
Haemophilus somnus 2336 |
2
CueR
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
1
CueR
Haemophilus parasuis SH0165 |
Copper resistance | ||
TF | NimR |
2
NimR
Haemophilus influenzae Rd KW20 |
1
NimR
Aggregatibacter aphrophilus NJ8700 |
2
NimR
Mannheimia succiniciproducens MBEL55E |
2
NimR
Actinobacillus succinogenes 130Z |
Nickel homeostasis | ||||||
TF | NmlR |
2
NmlR
Haemophilus influenzae Rd KW20 |
2
NmlR
Mannheimia succiniciproducens MBEL55E |
Carbonyl stress response | ||||||||
MetJ | TF | MetJ |
5
MetJ
Haemophilus influenzae Rd KW20 |
4
MetJ
Aggregatibacter aphrophilus NJ8700 |
6
MetJ
Pasteurella multocida subsp. multocida str. Pm70 |
5
MetJ
Mannheimia succiniciproducens MBEL55E |
4
MetJ
Actinobacillus succinogenes 130Z |
5
MetJ
Haemophilus somnus 2336 |
3
MetJ
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
2
MetJ
Haemophilus ducreyi 35000HP |
5
MetJ
Haemophilus parasuis SH0165 |
Methionine metabolism; Methionine biosynthesis |
ModE | TF | ModE |
5
ModE
Haemophilus influenzae Rd KW20 |
4
ModE
Aggregatibacter aphrophilus NJ8700 |
4
ModE
Pasteurella multocida subsp. multocida str. Pm70 |
3
ModE
Mannheimia succiniciproducens MBEL55E |
3
ModE
Actinobacillus succinogenes 130Z |
2
ModE
Haemophilus parasuis SH0165 |
Molybdenum homeostasis | |||
NrdR | TF | NrdR |
2
NrdR
Haemophilus influenzae Rd KW20 |
2
NrdR
Aggregatibacter aphrophilus NJ8700 |
2
NrdR
Pasteurella multocida subsp. multocida str. Pm70 |
2
NrdR
Mannheimia succiniciproducens MBEL55E |
2
NrdR
Actinobacillus succinogenes 130Z |
2
NrdR
Haemophilus somnus 2336 |
3
NrdR
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
2
NrdR
Haemophilus ducreyi 35000HP |
2
NrdR
Haemophilus parasuis SH0165 |
Deoxyribonucleotide biosynthesis |
ROK | TF | NagC |
5
NagC
Aggregatibacter aphrophilus NJ8700 |
9
NagC
Pasteurella multocida subsp. multocida str. Pm70 |
N-acetylglucosamine utilization | |||||||
RpiR | TF | SiaR |
2
SiaR
Haemophilus influenzae Rd KW20 |
2
SiaR
Aggregatibacter aphrophilus NJ8700 |
3
SiaR
Pasteurella multocida subsp. multocida str. Pm70 |
3
SiaR
Haemophilus somnus 2336 |
2
SiaR
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
2
SiaR
Haemophilus ducreyi 35000HP |
3
SiaR
Haemophilus parasuis SH0165 |
Sialic acid utilization | ||
Rrf2 | TF | IscR |
2
IscR
Haemophilus influenzae Rd KW20 |
3
IscR
Aggregatibacter aphrophilus NJ8700 |
3
IscR
Pasteurella multocida subsp. multocida str. Pm70 |
3
IscR
Mannheimia succiniciproducens MBEL55E |
3
IscR
Actinobacillus succinogenes 130Z |
3
IscR
Haemophilus somnus 2336 |
2
IscR
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
2
IscR
Haemophilus ducreyi 35000HP |
1
IscR
Haemophilus parasuis SH0165 |
Iron-sulfur cluster biogenesis |
TetR | TF | FabR |
2
FabR
Haemophilus influenzae Rd KW20 |
3
FabR
Aggregatibacter aphrophilus NJ8700 |
2
FabR
Pasteurella multocida subsp. multocida str. Pm70 |
3
FabR
Mannheimia succiniciproducens MBEL55E |
2
FabR
Actinobacillus succinogenes 130Z |
2
FabR
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
2
FabR
Haemophilus ducreyi 35000HP |
2
FabR
Haemophilus parasuis SH0165 |
Fatty acid biosynthesis | |
TrpR | TF | TrpR |
5
TrpR
Haemophilus influenzae Rd KW20 |
4
TrpR
Aggregatibacter aphrophilus NJ8700 |
5
TrpR
Pasteurella multocida subsp. multocida str. Pm70 |
5
TrpR
Mannheimia succiniciproducens MBEL55E |
5
TrpR
Actinobacillus succinogenes 130Z |
4
TrpR
Haemophilus somnus 2336 |
3
TrpR
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
3
TrpR
Haemophilus parasuis SH0165 |
Tryptophan biosynthesis | |
TyrR | TF | TyrR |
2
TyrR
Haemophilus influenzae Rd KW20 |
2
TyrR
Aggregatibacter aphrophilus NJ8700 |
4
TyrR
Pasteurella multocida subsp. multocida str. Pm70 |
3
TyrR
Mannheimia succiniciproducens MBEL55E |
2
TyrR
Actinobacillus succinogenes 130Z |
2
TyrR
Haemophilus somnus 2336 |
3
TyrR
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
2
TyrR
Haemophilus ducreyi 35000HP |
4
TyrR
Haemophilus parasuis SH0165 |
Aromatic amino acid metabolism |
RF00050 | RNA | FMN |
1
FMN
Haemophilus influenzae Rd KW20 |
1
FMN
Aggregatibacter aphrophilus NJ8700 |
1
FMN
Pasteurella multocida subsp. multocida str. Pm70 |
1
FMN
Mannheimia succiniciproducens MBEL55E |
1
FMN
Actinobacillus succinogenes 130Z |
1
FMN
Haemophilus somnus 2336 |
1
FMN
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
1
FMN
Haemophilus ducreyi 35000HP |
1
FMN
Haemophilus parasuis SH0165 |
Riboflavin biosynthesis |
RF00059 | RNA | TPP |
3
TPP
Haemophilus influenzae Rd KW20 |
3
TPP
Aggregatibacter aphrophilus NJ8700 |
2
TPP
Pasteurella multocida subsp. multocida str. Pm70 |
3
TPP
Mannheimia succiniciproducens MBEL55E |
3
TPP
Actinobacillus succinogenes 130Z |
1
TPP
Haemophilus somnus 2336 |
2
TPP
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
1
TPP
Haemophilus ducreyi 35000HP |
2
TPP
Haemophilus parasuis SH0165 |
Thiamine biosynthesis |
RF00114 | RNA | S15 |
2
S15
Haemophilus influenzae Rd KW20 |
1
S15
Aggregatibacter aphrophilus NJ8700 |
1
S15
Pasteurella multocida subsp. multocida str. Pm70 |
1
S15
Mannheimia succiniciproducens MBEL55E |
1
S15
Actinobacillus succinogenes 130Z |
1
S15
Haemophilus somnus 2336 |
1
S15
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
1
S15
Haemophilus ducreyi 35000HP |
1
S15
Haemophilus parasuis SH0165 |
Ribosome biogenesis |
RF00168 | RNA | Lysine |
1
Lysine
Haemophilus influenzae Rd KW20 |
1
Lysine
Aggregatibacter aphrophilus NJ8700 |
1
Lysine
Pasteurella multocida subsp. multocida str. Pm70 |
1
Lysine
Mannheimia succiniciproducens MBEL55E |
1
Lysine
Haemophilus somnus 2336 |
2
Lysine
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
2
Lysine
Haemophilus ducreyi 35000HP |
1
Lysine
Haemophilus parasuis SH0165 |
Lysine biosynthesis | |
RF00504 | RNA | Glycine |
1
Glycine
Haemophilus influenzae Rd KW20 |
1
Glycine
Aggregatibacter aphrophilus NJ8700 |
1
Glycine
Pasteurella multocida subsp. multocida str. Pm70 |
1
Glycine
Mannheimia succiniciproducens MBEL55E |
1
Glycine
Actinobacillus succinogenes 130Z |
1
Glycine
Haemophilus somnus 2336 |
1
Glycine
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
1
Glycine
Haemophilus ducreyi 35000HP |
1
Glycine
Haemophilus parasuis SH0165 |
Glycine metabolism |
RF00506 | RNA | Thr_leader |
1
Thr_leader
Haemophilus influenzae Rd KW20 |
1
Thr_leader
Pasteurella multocida subsp. multocida str. Pm70 |
1
Thr_leader
Mannheimia succiniciproducens MBEL55E |
1
Thr_leader
Actinobacillus succinogenes 130Z |
1
Thr_leader
Haemophilus somnus 2336 |
1
Thr_leader
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
1
Thr_leader
Haemophilus parasuis SH0165 |
Threonine biosynthesis | ||
RF00512 | RNA | Leu_leader |
1
Leu_leader
Haemophilus influenzae Rd KW20 |
2
Leu_leader
Aggregatibacter aphrophilus NJ8700 |
1
Leu_leader
Pasteurella multocida subsp. multocida str. Pm70 |
1
Leu_leader
Mannheimia succiniciproducens MBEL55E |
Branched-chain amino acid biosynthesis | |||||
RF00514 | RNA | His_leader |
2
His_leader
Haemophilus influenzae Rd KW20 |
2
His_leader
Aggregatibacter aphrophilus NJ8700 |
1
His_leader
Pasteurella multocida subsp. multocida str. Pm70 |
1
His_leader
Mannheimia succiniciproducens MBEL55E |
1
His_leader
Actinobacillus succinogenes 130Z |
1
His_leader
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
1
His_leader
Haemophilus parasuis SH0165 |
Histidine biosynthesis | ||
RF00522 | RNA | PreQ1 |
1
PreQ1
Haemophilus influenzae Rd KW20 |
2
PreQ1
Aggregatibacter aphrophilus NJ8700 |
1
PreQ1
Pasteurella multocida subsp. multocida str. Pm70 |
1
PreQ1
Mannheimia succiniciproducens MBEL55E |
1
PreQ1
Actinobacillus succinogenes 130Z |
1
PreQ1
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
1
PreQ1
Haemophilus ducreyi 35000HP |
1
PreQ1
Haemophilus parasuis SH0165 |
Queuosine biosynthesis | |
RF00557 | RNA | L10_leader |
1
L10_leader
Haemophilus influenzae Rd KW20 |
1
L10_leader
Aggregatibacter aphrophilus NJ8700 |
1
L10_leader
Haemophilus somnus 2336 |
Ribosome biogenesis | ||||||
RF01055 | RNA | MOCO_RNA_motif |
1
MOCO_RNA_motif
Haemophilus influenzae Rd KW20 |
1
MOCO_RNA_motif
Aggregatibacter aphrophilus NJ8700 |
1
MOCO_RNA_motif
Pasteurella multocida subsp. multocida str. Pm70 |
1
MOCO_RNA_motif
Mannheimia succiniciproducens MBEL55E |
1
MOCO_RNA_motif
Actinobacillus succinogenes 130Z |
2
MOCO_RNA_motif
Haemophilus somnus 2336 |
2
MOCO_RNA_motif
Actinobacillus pleuropneumoniae serovar 7 str. AP76 |
2
MOCO_RNA_motif
Haemophilus ducreyi 35000HP |
1
MOCO_RNA_motif
Haemophilus parasuis SH0165 |
Molybdopterin biosynthesis; Molybdenum homeostasis |