Statistics of regulated genes

Genome	Genes	Operons
Haemophilus influenzae Rd KW20	5	5
Aggregatibacter aphrophilus NJ8700	6	4
Pasteurella multocida subsp. multocida str. Pm70	8	6
Mannheimia succiniciproducens MBEL55E	7	5
Actinobacillus succinogenes 130Z	6	4
Haemophilus somnus 2336	7	5
Actinobacillus pleuropneumoniae serovar 7 str. AP76	6	3
Haemophilus ducreyi 35000HP	4	2
Haemophilus parasuis SH0165	8	5

Clusters of co-Regulated Orthologous operoNs (CRONs)

Genes										Function
CRON 1.
metB	Haemophilus influenzae Rd KW20 Gene: HI0086: Cystathionine gamma-synthase (EC 2.5.1.48)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_1400: Cystathionine gamma-synthase (EC 2.5.1.48)	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -61 score = 6.69574 sequence = AGACATCT-(0)-AGATAGCT Gene: PM0995: Cystathionine gamma-synthase (EC 2.5.1.48)	* Mannheimia succiniciproducens MBEL55E Site: position = -121 score = 6.0394 sequence = AGAAATTA-(0)-AGATGTTT Gene: MS1627: Cystathionine gamma-synthase (EC 2.5.1.48)	Actinobacillus succinogenes 130Z Gene: Asuc_1846: Cystathionine gamma-synthase (EC 2.5.1.48)	Haemophilus somnus 2336 Gene: HSM_0277: Cystathionine gamma-synthase (EC 2.5.1.48)	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_0723: Cystathionine gamma-synthase (EC 2.5.1.48)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165 Gene: HAPS_2273: Cystathionine gamma-synthase (EC 2.5.1.48)	Cystathionine gamma-synthase (EC 2.5.1.48)
CRON 2.
metK	* Haemophilus influenzae Rd KW20 Site: position = -50 score = 6.67509 sequence = AGCCGTCT-(0)-ATACGTCA Gene: HI1172: S-adenosylmethionine synthetase (EC 2.5.1.6)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_2370: S-adenosylmethionine synthetase (EC 2.5.1.6)	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1027: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Mannheimia succiniciproducens MBEL55E Site: position = -46 score = 6.18043 sequence = AGCCGTCC-(0)-ATACGTCC Gene: MS0669: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Actinobacillus succinogenes 130Z Site: position = -38 score = 6.80421 sequence = GGCCGTCT-(0)-AAACGGCT Gene: Asuc_0835: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Haemophilus somnus 2336 Site: position = -66 score = 6.93657 sequence = AGCCGTCT-(0)-AGACGTTA Site: position = -58 score = 6.45841 sequence = AGACGTTA-(0)-AAACATCT Gene: HSM_0387: S-adenosylmethionine synthetase (EC 2.5.1.6)	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_1138: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Haemophilus ducreyi 35000HP Site: position = -162 score = 6.24015 sequence = AGACGTCT-(0)-AGATGTAC Gene: HD0569: S-adenosylmethionine synthetase (EC 2.5.1.6)	* Haemophilus parasuis SH0165 Site: position = -161 score = 5.8083 sequence = AGCCATCT-(0)-AGACGGAA Gene: HAPS_0500: S-adenosylmethionine synthetase (EC 2.5.1.6)	S-adenosylmethionine synthetase (EC 2.5.1.6)
CRON 3.
metN	* Haemophilus influenzae Rd KW20 Site: position = -61 score = 7.34702 sequence = AGCAATCT-(0)-AGACATCT Gene: HI0621: Methionine ABC transporter ATP-binding protein	* Aggregatibacter aphrophilus NJ8700 Site: position = -65 score = 6.82024 sequence = GGCATTCT-(0)-AGACGTCT Gene: NT05HA_2130: Methionine ABC transporter ATP-binding protein	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -62 score = 7.28636 sequence = GGAAATCT-(0)-AGACGTCT Gene: PM1728: Methionine ABC transporter ATP-binding protein	* Mannheimia succiniciproducens MBEL55E Site: position = -68 score = 7.32491 sequence = AAACGTCT-(0)-AGACATCT Gene: MS0434: Methionine ABC transporter ATP-binding protein	* Actinobacillus succinogenes 130Z Site: position = -51 score = 7.13012 sequence = AGCCATAT-(0)-AGCCGTCT Gene: Asuc_0032: Methionine ABC transporter ATP-binding protein	* Haemophilus somnus 2336 Site: position = -61 score = 7.8321 sequence = AGCAATCT-(0)-AGACGTCT Gene: HSM_0571: Methionine ABC transporter ATP-binding protein	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -62 score = 7.8321 sequence = AGCAATCT-(0)-AGACGTCT Gene: APP7_0972: Methionine ABC transporter ATP-binding protein	* Haemophilus ducreyi 35000HP Site: position = -56 score = 7.40479 sequence = AGCATTCT-(0)-AGACGTCT Gene: HD1098: Methionine ABC transporter ATP-binding protein	* Haemophilus parasuis SH0165 Site: position = -61 score = 7.8321 sequence = AGCAATCT-(0)-AGACGTCT Gene: HAPS_0448: Methionine ABC transporter ATP-binding protein	Methionine ABC transporter ATP-binding protein
metI	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_2129: Methionine ABC transporter permease protein	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1729 (deprecated): Methionine ABC transporter permease protein	Mannheimia succiniciproducens MBEL55E Gene: MS0433: Methionine ABC transporter permease protein	Actinobacillus succinogenes 130Z Gene: Asuc_0033: Methionine ABC transporter permease protein	Haemophilus somnus 2336 Gene: HSM_0570: Methionine ABC transporter permease protein	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_0971: Methionine ABC transporter permease protein	Haemophilus ducreyi 35000HP Gene: HD1099: Methionine ABC transporter permease protein	Haemophilus parasuis SH0165 Gene: HAPS_0447: Methionine ABC transporter permease protein	Methionine ABC transporter permease protein
metQ	Haemophilus influenzae Rd KW20 Gene: HI0620: Methionine ABC transporter substrate-binding protein	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_2128: Methionine ABC transporter substrate-binding protein	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1730: Methionine ABC transporter substrate-binding protein	Mannheimia succiniciproducens MBEL55E Gene: MS0432: Methionine ABC transporter substrate-binding protein	Actinobacillus succinogenes 130Z Gene: Asuc_0034: Methionine ABC transporter substrate-binding protein	Haemophilus somnus 2336 Gene: HSM_0569: Methionine ABC transporter substrate-binding protein	2 Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_0970: Methionine ABC transporter substrate-binding protein Gene: APP7_0969: Methionine ABC transporter substrate-binding protein	Haemophilus ducreyi 35000HP Gene: HD1100: Methionine ABC transporter substrate-binding protein	2 Haemophilus parasuis SH0165 Gene: HAPS_0446: Methionine ABC transporter substrate-binding protein Gene: HAPS_0445: Methionine ABC transporter substrate-binding protein	Methionine ABC transporter substrate-binding protein
CRON 4.
metE	* Haemophilus influenzae Rd KW20 Site: position = -52 score = 7.86939 sequence = AGACGTTT-(0)-AGCCGTCT Gene: HI1702: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	* Aggregatibacter aphrophilus NJ8700 Site: position = -46 score = 7.86939 sequence = AGACGTTT-(0)-AGCCGTCT Gene: NT05HA_0341: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -56 score = 7.86939 sequence = AGACGTTT-(0)-AGCCGTCT Gene: PM0420: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	* Haemophilus somnus 2336 Site: position = -52 score = 8.28113 sequence = AGACGTTT-(0)-AGACGTCT Gene: HSM_1293: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_1214: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	Haemophilus ducreyi 35000HP	* Haemophilus parasuis SH0165 Site: position = -64 score = 7.59565 sequence = AGCCATTT-(0)-AGACGGCT Site: position = -56 score = 7.31677 sequence = AGACGGCT-(0)-AAACGTCT Gene: HAPS_1354: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase
CRON 5.
metX	* Haemophilus influenzae Rd KW20 Site: position = -87 score = 7.76856 sequence = AGCCGTTT-(0)-AGACGGCT Gene: HI1263: Homoserine O-acetyltransferase (EC 2.3.1.31)	* Aggregatibacter aphrophilus NJ8700 Site: position = -163 score = 7.86746 sequence = AGATGTTT-(0)-AGACGTCT Gene: NT05HA_0899: Homoserine O-acetyltransferase (EC 2.3.1.31)	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -70 score = 7.16165 sequence = AGATGTTT-(0)-AGACGTCC Gene: PM0866: Homoserine O-acetyltransferase (EC 2.3.1.31)	* Mannheimia succiniciproducens MBEL55E Site: position = -94 score = 8.24232 sequence = AGCCGTTT-(0)-AGACGTCT Gene: MS0924: Homoserine O-acetyltransferase (EC 2.3.1.31)	* Actinobacillus succinogenes 130Z Site: position = -100 score = 8.24232 sequence = AGCCGTTT-(0)-AGACGTCT Gene: Asuc_1733: Homoserine O-acetyltransferase (EC 2.3.1.31)	* Haemophilus somnus 2336 Site: position = -119 score = 6.39054 sequence = GGCTGTCT-(0)-AGATGTTT Site: position = -111 score = 6.21414 sequence = AGATGTTT-(0)-GGATGGCT Gene: HSM_1561: Homoserine O-acetyltransferase (EC 2.3.1.31)	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -147 score = 7.04368 sequence = AGAACTCT-(0)-AGACGTTT Site: position = -74 score = 7.49184 sequence = AGGCGTTT-(0)-AGACGTCT Site: position = -139 score = 7.80737 sequence = AGACGTTT-(0)-AGACGGCT Gene: APP7_0516: Homoserine O-acetyltransferase (EC 2.3.1.31)	Haemophilus ducreyi 35000HP	* Haemophilus parasuis SH0165 Site: position = -107 score = 7.80737 sequence = AGACGTTT-(0)-AGATGTCT Site: position = -123 score = 6.5112 sequence = AGCCATTT-(0)-AAAAATCT Gene: HAPS_0134: Homoserine O-acetyltransferase (EC 2.3.1.31)	Homoserine O-acetyltransferase (EC 2.3.1.31)
CRON 6.
metJ	* Haemophilus influenzae Rd KW20 Site: position = -83 score = 6.01034 sequence = AGCCGTCT-(0)-AGATTGTT Site: position = -91 score = 7.02742 sequence = GGAAGTTT-(0)-AGCCGTCT Gene: HI0294: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Aggregatibacter aphrophilus NJ8700 Site: position = -85 score = 5.72379 sequence = AGCAGTCT-(0)-TCACGGCT Site: position = -93 score = 6.78595 sequence = AGAAATCT-(0)-AGCAGTCT Gene: NT05HA_1785: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -97 score = 5.56007 sequence = GGATATCT-(0)-AGCAATCT Site: position = -89 score = 6.50624 sequence = AGCAATCT-(0)-TAACGTCT Gene: PM1290: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Mannheimia succiniciproducens MBEL55E Site: position = -26 score = 6.19755 sequence = AGCAGTCT-(0)-TCACGTCT Site: position = -34 score = 5.82751 sequence = ACCTGTTT-(0)-AGCAGTCT Gene: MS1966: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Actinobacillus succinogenes 130Z Site: position = -80 score = 5.33846 sequence = GGCAGTCC-(0)-ATACGTCC Gene: Asuc_0407: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Haemophilus somnus 2336 Site: position = -83 score = 7.00263 sequence = AGCTATCT-(0)-AGAAGTCT Site: position = -75 score = 5.79173 sequence = AGAAGTCT-(0)-AGATTGTT Gene: HSM_0768: S-adenosylmethionine-responsive transcriptional repressor MetJ	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -82 score = 7.1651 sequence = AGAAATCT-(0)-AGACGTCC Gene: APP7_2006: S-adenosylmethionine-responsive transcriptional repressor MetJ	Haemophilus ducreyi 35000HP Gene: HD0675: S-adenosylmethionine-responsive transcriptional repressor MetJ	Haemophilus parasuis SH0165 Gene: HAPS_2077: S-adenosylmethionine-responsive transcriptional repressor MetJ	S-adenosylmethionine-responsive transcriptional repressor MetJ
CRON 7.
metF	Haemophilus influenzae Rd KW20 Gene: HI1444: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_0300: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -43 score = 7.05679 sequence = AGCCATAT-(0)-AGACATCT Gene: PM0235: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Mannheimia succiniciproducens MBEL55E Gene: MS0787: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336 Gene: HSM_1047: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_0912: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Haemophilus ducreyi 35000HP	* Haemophilus parasuis SH0165 Site: position = -86 score = 7.6896 sequence = AGCCATCT-(0)-AAACGTCT Gene: HAPS_2275: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)

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