Statistics of regulated genes

Genome	Genes	Operons
Haemophilus influenzae Rd KW20	5	5
Aggregatibacter aphrophilus NJ8700	4	4
Pasteurella multocida subsp. multocida str. Pm70	4	4
Mannheimia succiniciproducens MBEL55E	5	5
Actinobacillus succinogenes 130Z	2	2
Haemophilus somnus 2336	3	3
Actinobacillus pleuropneumoniae serovar 7 str. AP76	7	7
Haemophilus ducreyi 35000HP
Haemophilus parasuis SH0165	2	2

Clusters of co-Regulated Orthologous operoNs (CRONs)

Genes										Function
CRON 1.
glyA	* Haemophilus influenzae Rd KW20 Site: position = -109 score = 5.49937 sequence = ATGAATTAATTTCAT Gene: HI0889: Serine hydroxymethyltransferase (EC 2.1.2.1)	* Aggregatibacter aphrophilus NJ8700 Site: position = -114 score = 4.87918 sequence = GTGAAAATTTTTCAT Gene: NT05HA_1325: Serine hydroxymethyltransferase (EC 2.1.2.1)	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -119 score = 5.46053 sequence = ATGAATTTTTTTCAT Gene: PM0225: Serine hydroxymethyltransferase (EC 2.1.2.1)	* Mannheimia succiniciproducens MBEL55E Site: position = -103 score = 4.54964 sequence = CTTAATTAATTTCAT Gene: MS1295: Serine hydroxymethyltransferase (EC 2.1.2.1)	Actinobacillus succinogenes 130Z Gene: Asuc_1360: Serine hydroxymethyltransferase (EC 2.1.2.1)	* Haemophilus somnus 2336 Site: position = -112 score = 5.42558 sequence = ATGAAATTTTTTCAT Gene: HSM_0382: Serine hydroxymethyltransferase (EC 2.1.2.1)	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -153 score = 5.19542 sequence = ATTAATTTTTTTCAT Gene: APP7_0213: Serine hydroxymethyltransferase (EC 2.1.2.1)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165 Gene: HAPS_0379: Serine hydroxymethyltransferase (EC 2.1.2.1)	Serine hydroxymethyltransferase (EC 2.1.2.1)
CRON 2.
metE	* Haemophilus influenzae Rd KW20 Site: position = -128 score = 5.23426 sequence = ATGAATTTATTTAAT Gene: HI1702: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Aggregatibacter aphrophilus NJ8700 Site: position = -122 score = 5.15658 sequence = ATTAAAATTATTCAT Gene: NT05HA_0341: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -132 score = 5.12163 sequence = ATTAAAAATTTTCAT Gene: PM0420: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	* Haemophilus somnus 2336 Site: position = -129 score = 5.19542 sequence = ATTAATTTTTTTCAT Gene: HSM_1293: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -131 score = 4.94346 sequence = ATTAATATGTTTCAT Gene: APP7_1214: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	Haemophilus ducreyi 35000HP	* Haemophilus parasuis SH0165 Site: position = -136 score = 5.38674 sequence = ATGAAAAATTTTCAT Gene: HAPS_1354: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14)
CRON 3.
metR	* Haemophilus influenzae Rd KW20 Site: position = -13 score = 5.19153 sequence = ATGAATATTATTAAT Site: position = -82 score = 4.96527 sequence = ATTAATTTTATTAAT Gene: HI1739: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Aggregatibacter aphrophilus NJ8700 Site: position = -157 score = 5.15658 sequence = ATGAATAATTTTAAT Gene: NT05HA_0342: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -13 score = 4.94346 sequence = ATGAATCTTTTTAAT Site: position = -181 score = 5.12163 sequence = ATGAAAATTTTTAAT Gene: PM0421: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Mannheimia succiniciproducens MBEL55E Site: position = -13 score = 4.51704 sequence = ATGAATTATTCTAAT Gene: MS0763: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	Actinobacillus succinogenes 130Z Gene: Asuc_1680: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	Haemophilus somnus 2336 Gene: HSM_1538: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -13 score = 4.76989 sequence = ATGAATTATTTACAT Gene: APP7_1216: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165 Gene: HAPS_2191: Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family	Homocysteine-responsive transcriptional regulator of methionine metabolism, LysR family
CRON 4.
metE2	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700	Pasteurella multocida subsp. multocida str. Pm70	* Mannheimia succiniciproducens MBEL55E Site: position = -30 score = 5.07657 sequence = ATAAAATTTATTCAT Site: position = -104 score = 4.78233 sequence = ATGAATCCGTTTCAT Gene: MS0941: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	* Actinobacillus succinogenes 130Z Site: position = -30 score = 4.94346 sequence = ATTAAAACTATTCAT Site: position = -105 score = 4.78233 sequence = ATGAATCCGTTTCAT Gene: Asuc_1191: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Haemophilus somnus 2336	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -104 score = 5.49547 sequence = ATGAATATAATTCAT Site: position = -139 score = 4.77739 sequence = ATTATTTTTATTCAT Gene: APP7_0911: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
CRON 5.
HI0736	* Haemophilus influenzae Rd KW20 Site: position = -55 score = 4.79443 sequence = ATGATTAGATTTCAT Gene: HI0736: hypothetical sodium-dependent transporter	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_1978: hypothetical sodium-dependent transporter	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM0718: hypothetical sodium-dependent transporter	* Mannheimia succiniciproducens MBEL55E Site: position = -110 score = 5.07657 sequence = ATAAAAATAATTCAT Gene: MS2382: hypothetical sodium-dependent transporter	Actinobacillus succinogenes 130Z Gene: Asuc_0284: hypothetical sodium-dependent transporter	Haemophilus somnus 2336 Gene: HSM_1866: hypothetical sodium-dependent transporter	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -70 score = 4.85723 sequence = ATGACATATTTTCAT Gene: APP7_1441: hypothetical sodium-dependent transporter	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	hypothetical sodium-dependent transporter
CRON 6.
metE2-2	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700	Pasteurella multocida subsp. multocida str. Pm70	Mannheimia succiniciproducens MBEL55E	* Actinobacillus succinogenes 130Z Site: position = -128 score = 5.32119 sequence = ATGAATTGAATTCAT Gene: Asuc_0713: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Haemophilus somnus 2336	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -121 score = 5.49937 sequence = ATGAATTAATTTCAT Gene: APP7_0324: Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Methionine synthase II, vitamin-B12 independent (EC 2.1.1.14)
CRON 7.
metF	* Haemophilus influenzae Rd KW20 Site: position = -100 score = 4.73855 sequence = ATTAATAATAATCAT Gene: HI1444: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Aggregatibacter aphrophilus NJ8700 Site: position = -106 score = 4.97841 sequence = ATTAATCTTATTCAT Gene: NT05HA_0300: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -109 score = 5.32119 sequence = ATGAATTGAATTCAT Gene: PM0235: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Mannheimia succiniciproducens MBEL55E Site: position = -124 score = 5.26921 sequence = ATTAATTAAATTCAT Gene: MS0787: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Actinobacillus succinogenes 130Z	* Haemophilus somnus 2336 Site: position = -199 score = 4.46704 sequence = ACAAAAAAATTTCAT Site: position = -111 score = 5.53431 sequence = ATGAATTTAATTCAT Gene: HSM_1047: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -139 score = 5.49547 sequence = ATGAATTATATTCAT Site: position = -104 score = 4.77739 sequence = ATGAATAAAAATAAT Gene: APP7_0912: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	Haemophilus ducreyi 35000HP	* Haemophilus parasuis SH0165 Site: position = -154 score = 5.15036 sequence = ATAAATTAAATTCAT Site: position = -186 score = 4.43702 sequence = TTTAAAAATTTTCAT Gene: HAPS_2275: 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)	5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)

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