Regulog SiaR - Pasteurellales

Properties
Regulator type:	Transcription factor
Regulator family:	RpiR
Regulation mode:	repressor (activator)
Biological process:	Sialic acid utilization
Effector:	Glucosamine-6-phosphate
Phylum:	Proteobacteria/gamma
Visualization:
	Allows to visualize regulog content in the context of metabolic pathways

Built upon 23 sites [see more]

Member of regulog collections

By taxonomy - Pasteurellales
By trascription factor - SiaR
By TF family - RpiR
By effector - Glucosamine-6-phosphate
By pathway - Sialic acid utilization

Statistics of regulated genes
Genome	Genes	Operons
Haemophilus influenzae Rd KW20	9	2
Aggregatibacter aphrophilus NJ8700	6	2
Pasteurella multocida subsp. multocida str. Pm70	10	3
Mannheimia succiniciproducens MBEL55E
Actinobacillus succinogenes 130Z
Haemophilus somnus 2336	10	3
Actinobacillus pleuropneumoniae serovar 7 str. AP76	8	2
Haemophilus ducreyi 35000HP	6	2
Haemophilus parasuis SH0165	7	3

Clusters of co-Regulated Orthologous operoNs (CRONs)
Genes										Function

CRON 1.
siaP	* Haemophilus influenzae Rd KW20 Site: position = -205 score = 4.76634 sequence = TTTGAAGTGTTTTTTCATA Gene: HI0146: Sialic acid-binding periplasmic protein SiaP (N-acetylneuraminic-binding protein) (Neu5Ac-binding protein)(Extracytoplasmic solute receptor protein siaP)	* Aggregatibacter aphrophilus NJ8700 Site: position = -117 score = 5.29198 sequence = TTTGAAATAAAACTTCATT Site: position = -156 score = 4.76067 sequence = TTTGAAGTGATATTTCAAA Gene: NT05HA_0544: Sialic acid-binding periplasmic protein SiaP (N-acetylneuraminic-binding protein) (Neu5Ac-binding protein)(Extracytoplasmic solute receptor protein siaP)	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -125 score = 5.46746 sequence = TATGAAATAAAACTTCATT Gene: PM1709: Sialic acid-binding periplasmic protein SiaP (N-acetylneuraminic-binding protein) (Neu5Ac-binding protein)(Extracytoplasmic solute receptor protein siaP)	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	* Haemophilus somnus 2336 Site: position = -106 score = 4.41624 sequence = TCTGAAATAAAACTCTATA Site: position = -156 score = 4.1005 sequence = TTTGGTGTTTTACTCCAGA Gene: HSM_1112: Sialic acid-binding periplasmic protein SiaP (N-acetylneuraminic-binding protein) (Neu5Ac-binding protein)(Extracytoplasmic solute receptor protein siaP)	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Sialic acid-binding periplasmic protein SiaP (N-acetylneuraminic-binding protein) (Neu5Ac-binding protein)(Extracytoplasmic solute receptor protein siaP)
siaT	Haemophilus influenzae Rd KW20 Gene: HI0147: TRAP-type transport system, large permease component, N-acetylneuraminate transporter / TRAP-type transport system, small permease component, N-acetylneuraminate transporter	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_0543: TRAP-type transport system, large permease component, N-acetylneuraminate transporter / TRAP-type transport system, small permease component, N-acetylneuraminate transporter	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1708: TRAP-type transport system, large permease component, N-acetylneuraminate transporter / TRAP-type transport system, small permease component, N-acetylneuraminate transporter	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336 Gene: HSM_1113: TRAP-type transport system, large permease component, N-acetylneuraminate transporter / TRAP-type transport system, small permease component, N-acetylneuraminate transporter	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	TRAP-type transport system, large permease component, N-acetylneuraminate transporter / TRAP-type transport system, small permease component, N-acetylneuraminate transporter
nanM	Haemophilus influenzae Rd KW20 Gene: HI0148: Sialic acid-induced transmembrane protein YjhT(NanM), possible mutarotase	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_0541: Sialic acid-induced transmembrane protein YjhT(NanM), possible mutarotase	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1707: Sialic acid-induced transmembrane protein YjhT(NanM), possible mutarotase	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336	Actinobacillus pleuropneumoniae serovar 7 str. AP76	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Sialic acid-induced transmembrane protein YjhT(NanM), possible mutarotase

CRON 2.
nanE	* Haemophilus influenzae Rd KW20 Site: position = -163 score = 4.76634 sequence = TATGAAAAAACACTTCAAA Gene: HI0145: N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)	* Aggregatibacter aphrophilus NJ8700 Site: position = -117 score = 4.76067 sequence = TTTGAAATATCACTTCAAA Site: position = -156 score = 5.29198 sequence = AATGAAGTTTTATTTCAAA Gene: NT05HA_0545: N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -43 score = 4.55186 sequence = ATTGGAGTCAATCTTCTTT Gene: PM1711: N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336 Gene: HSM_1110: N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_1837: N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)	* Haemophilus ducreyi 35000HP Site: position = -125 score = 4.27787 sequence = ACAGAAAATTCACTTCTTT Gene: HD1852: N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)	* Haemophilus parasuis SH0165 Site: position = -43 score = 4.63406 sequence = TTTGGAGTAAATTTTCTTT Site: position = -191 score = 4.10276 sequence = AATCGATTAAAACTCGTTT Gene: HAPS_1216: N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)	N-acetylmannosamine-6-phosphate 2-epimerase (EC 5.1.3.9)
nanK	Haemophilus influenzae Rd KW20 Gene: HI0144: N-acetylmannosamine kinase (EC 2.7.1.60)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_0546: N-acetylmannosamine kinase (EC 2.7.1.60)	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1712: N-acetylmannosamine kinase (EC 2.7.1.60)	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336 Gene: HSM_1109: N-acetylmannosamine kinase (EC 2.7.1.60)	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_1838: N-acetylmannosamine kinase (EC 2.7.1.60)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165 Gene: HAPS_1215: N-acetylmannosamine kinase (EC 2.7.1.60)	N-acetylmannosamine kinase (EC 2.7.1.60)
siaR	Haemophilus influenzae Rd KW20 Gene: HI0143: Sialic acid utilization regulator, RpiR family	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_0547: Sialic acid utilization regulator, RpiR family	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1714: Sialic acid utilization regulator, RpiR family	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336 Gene: HSM_1107: Sialic acid utilization regulator, RpiR family	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_0748: Sialic acid utilization regulator, RpiR family	Haemophilus ducreyi 35000HP Gene: HD1380: Sialic acid utilization regulator, RpiR family	Haemophilus parasuis SH0165 Gene: HAPS_0407: Sialic acid utilization regulator, RpiR family	Sialic acid utilization regulator, RpiR family
nanA	Haemophilus influenzae Rd KW20 Gene: HI0142: N-acetylneuraminate lyase (EC 4.1.3.3)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_0548: N-acetylneuraminate lyase (EC 4.1.3.3)	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1715: N-acetylneuraminate lyase (EC 4.1.3.3)	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	Haemophilus somnus 2336 Gene: HSM_1106: N-acetylneuraminate lyase (EC 4.1.3.3)	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_1839: N-acetylneuraminate lyase (EC 4.1.3.3)	Haemophilus ducreyi 35000HP Gene: HD1850: N-acetylneuraminate lyase (EC 4.1.3.3)	Haemophilus parasuis SH0165 Gene: HAPS_0406: N-acetylneuraminate lyase (EC 4.1.3.3)	N-acetylneuraminate lyase (EC 4.1.3.3)
nagB	Haemophilus influenzae Rd KW20 Gene: HI0141: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_0549: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	* Pasteurella multocida subsp. multocida str. Pm70 Site: position = -99 score = 4.06676 sequence = ATTGAAAAAAAAATTGATG Gene: PM0875: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	Mannheimia succiniciproducens MBEL55E Gene: MS2205: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	Actinobacillus succinogenes 130Z	* Haemophilus somnus 2336 Site: position = -56 score = 5.18547 sequence = TCTGAAATAAAACTTCATT Gene: HSM_1505: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_1840: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	Haemophilus ducreyi 35000HP Gene: HD1847: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	* Haemophilus parasuis SH0165 Site: position = -42 score = 5.29198 sequence = AATGAAGTTTTATTTCAAA Gene: HAPS_2072: Glucosamine-6-phosphate deaminase (EC 3.5.99.6)	Glucosamine-6-phosphate deaminase (EC 3.5.99.6)
nagA	Haemophilus influenzae Rd KW20 Gene: HI0140: N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_0550: N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM0874: N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)	Mannheimia succiniciproducens MBEL55E Gene: MS2204: N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)	Actinobacillus succinogenes 130Z Gene: Asuc_1103: N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)	Haemophilus somnus 2336 Gene: HSM_1504: N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)	Actinobacillus pleuropneumoniae serovar 7 str. AP76 Gene: APP7_1841: N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)	Haemophilus ducreyi 35000HP Gene: HD1845: N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)	Haemophilus parasuis SH0165 Gene: HAPS_2071: N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)	N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)
neuA	Haemophilus influenzae Rd KW20	Aggregatibacter aphrophilus NJ8700	Pasteurella multocida subsp. multocida str. Pm70	Mannheimia succiniciproducens MBEL55E	Actinobacillus succinogenes 130Z	* Haemophilus somnus 2336 Site: position = -95 score = 4.1005 sequence = TCTGGAGTAAAACACCAAA Site: position = -145 score = 4.41624 sequence = TATAGAGTTTTATTTCAGA Gene: HSM_1111: Putative N-acylneuraminate cytidylyltransferase (EC 2.7.7.43)	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -40 score = 4.41535 sequence = AATGGTGTATTTATTCATA Gene: APP7_1836: Putative N-acylneuraminate cytidylyltransferase (EC 2.7.7.43)	Haemophilus ducreyi 35000HP	Haemophilus parasuis SH0165	Putative N-acylneuraminate cytidylyltransferase (EC 2.7.7.43)
yhcH	Haemophilus influenzae Rd KW20 Gene: HI0227: Uncharacterized protein yhcH	Aggregatibacter aphrophilus NJ8700 Gene: NT05HA_1461: Uncharacterized protein yhcH	Pasteurella multocida subsp. multocida str. Pm70 Gene: PM1713: Uncharacterized protein yhcH	Mannheimia succiniciproducens MBEL55E Gene: MS2206: Uncharacterized protein yhcH	Actinobacillus succinogenes 130Z Gene: Asuc_2062: Uncharacterized protein yhcH	Haemophilus somnus 2336 Gene: HSM_1108: Uncharacterized protein yhcH	* Actinobacillus pleuropneumoniae serovar 7 str. AP76 Site: position = -86 score = 5.318 sequence = ATTGAAGTATATCTTCATT Gene: APP7_0749: Uncharacterized protein yhcH	* Haemophilus ducreyi 35000HP Site: position = -86 score = 4.4204 sequence = ATTGGAGTAGGTTTTCATT Gene: HD1379: Uncharacterized protein yhcH	* Haemophilus parasuis SH0165 Site: position = -80 score = 4.80955 sequence = TATGGAGTATATTTTCTTT Site: position = -153 score = 4.37415 sequence = AATCAAGTAAATTGTGATT Gene: HAPS_0408: Uncharacterized protein yhcH	Uncharacterized protein yhcH

Bluish color - the gene is in regulated operon. Different regulated operons are shown in different shades of blue.

Red color - the gene is in non-regulated operon.

Gray color - the orthologous gene is absent.

The star symbol - the TFBS is located in upstream region of this gene.

The number - the numeber of homologs (shown only if it is greater than one).

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulog SiaR - Pasteurellales

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --