Regulon of Fur in Actinobacillus pleuropneumoniae serovar 7 str. AP76

Properties
Regulator type:	Transcription factor
TF locus tag:	APP7_1269
Regulator family:	FUR
Regulation mode:	repressor (activator)
Biological process:	Iron homeostasis
Effector:	Iron ion, (Fe2+)
Regulog:	Fur - Pasteurellales
Statistics of regulated genes:
- Genes	37
- Operons	16
Visualization:
	Allows to visualize regulon content in the context of metabolic pathways

Built upon 151 sites [see more]

Member of regulog collections

By taxonomy - Pasteurellales
By trascription factor - FUR
By TF family - FUR
By effector - Iron ion, (Fe2+)
By pathway - Iron homeostasis

Regulated operons
	Locus Tag	Name	Function
Position: -55 Score: 4.6 Sequence: AGTATTAATTGTCATTATC Position: -49 Score: 4.4 Sequence: AATTGTCATTATCATTACC Locus tag: APP7_0722 Name: hpt Funciton: Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)
	APP7_0722	hpt	Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)
Position: -50 Score: 4.6 Sequence: ATTATTGCTAATCATTTTC Position: -44 Score: 4.4 Sequence: GCTAATCATTTTCATTACA Locus tag: APP7_0756 Name: ceuA Funciton: ABC-type enterochelin transport system, periplasmic component Locus tag: APP7_0757 Name: ceuB Funciton: ABC-type enterochelin transport system, permease component Locus tag: APP7_0758 Name: ceuC Funciton: ABC-type enterochelin transport system, permease component Locus tag: APP7_0759 Name: ceuD Funciton: ABC-type enterochelin transport system, ATPase component
	APP7_0756	ceuA	ABC-type enterochelin transport system, periplasmic component
	APP7_0757	ceuB	ABC-type enterochelin transport system, permease component
	APP7_0758	ceuC	ABC-type enterochelin transport system, permease component
	APP7_0759	ceuD	ABC-type enterochelin transport system, ATPase component
Position: -131 Score: 5 Sequence: GTTATTGATAATGATTTTC Position: -125 Score: 4.9 Sequence: GATAATGATTTTCAATAAT Locus tag: APP7_0606 Name: fcuA Funciton: Ferrichrome receptor, TonB-dependent Locus tag: APP7_0607 Name: fcuA Funciton: Ferrichrome receptor, TonB-dependent
	APP7_0606	fcuA	Ferrichrome receptor, TonB-dependent
	APP7_0607	fcuA	Ferrichrome receptor, TonB-dependent
Position: -63 Score: 4.3 Sequence: GCAAACCATTTTCATTATA Locus tag: APP7_0078 Name: exbB Funciton: Ferric siderophore transport system, biopolymer transport protein ExbB Locus tag: APP7_0077 Name: exbD Funciton: TonB system transport protein ExbD type-2/biopolymer transport protein Locus tag: APP7_0076 Name: tonB Funciton: Ferric siderophore transport system, periplasmic binding protein TonB
	APP7_0078	exbB	Ferric siderophore transport system, biopolymer transport protein ExbB
	APP7_0077	exbD	TonB system transport protein ExbD type-2/biopolymer transport protein
	APP7_0076	tonB	Ferric siderophore transport system, periplasmic binding protein TonB
Position: -64 Score: 4.7 Sequence: AAAATTGAGAATTATTTTC Locus tag: APP7_1152 Name: hex Funciton: Beta-hexosaminidase (EC 3.2.1.52)
	APP7_1152	hex	Beta-hexosaminidase (EC 3.2.1.52)
Position: -123 Score: 4.7 Sequence: TATAATAATTATCATAAAT Locus tag: APP7_1067 Name: pbg Funciton: Porphobilinogen deaminase (EC 2.5.1.61) Locus tag: APP7_1066 Name: hemX Funciton: Uroporphyrinogen III synthase HEM4 Locus tag: APP7_1065 Name: hemX Funciton: HemX protein Locus tag: APP7_1064 Name: hemY Funciton: HemY protein
	APP7_1067	pbg	Porphobilinogen deaminase (EC 2.5.1.61)
	APP7_1066	hemX	Uroporphyrinogen III synthase HEM4
	APP7_1065	hemX	HemX protein
	APP7_1064	hemY	HemY protein
Position: -31 Score: 4.4 Sequence: ATTAACCATAATTATTTTA Locus tag: APP7_0978 Name: irp Funciton: iron-regulated outer membrane protein/TonB-dependent receptor
	APP7_0978	irp	iron-regulated outer membrane protein/TonB-dependent receptor
Position: -132 Score: 4.6 Sequence: AAAAATGTTTTTTATTATC Locus tag: APP7_0845 Name: ssb Funciton: Single-stranded DNA-binding protein
	APP7_0845	ssb	Single-stranded DNA-binding protein
Position: -118 Score: 4.1 Sequence: GGTAAGAAAAATAATTCTC Position: -112 Score: 4.7 Sequence: AAAAATAATTCTCATTTAT Position: -71 Score: 4.1 Sequence: GTTTATAATTGTAATTATT Position: -68 Score: 4.3 Sequence: TATAATTGTAATTATTTGT Locus tag: APP7_2040 Name: null Funciton: hypothetical protein Locus tag: APP7_2041 Name: hpuB Funciton: Hemoglobin-haptoglobin utilization protein B Locus tag: APP7_2042 Name: hpuB Funciton: Hemoglobin-haptoglobin utilization protein B Locus tag: APP7_2043 Name: hpuB Funciton: Hemoglobin-haptoglobin utilization protein B
	APP7_2040		hypothetical protein
	APP7_2041	hpuB	Hemoglobin-haptoglobin utilization protein B
	APP7_2042	hpuB	Hemoglobin-haptoglobin utilization protein B
	APP7_2043	hpuB	Hemoglobin-haptoglobin utilization protein B
Position: -54 Score: 4.4 Sequence: GAGATTTATTCTCAATTTC Locus tag: APP7_0274 Name: sitA Funciton: Manganese ABC transporter, periplasmic-binding protein SitA Locus tag: APP7_0273 Name: sitB Funciton: Manganese ABC transporter, ATP-binding protein SitB
	APP7_0274	sitA	Manganese ABC transporter, periplasmic-binding protein SitA
	APP7_0273	sitB	Manganese ABC transporter, ATP-binding protein SitB
Position: -68 Score: 4.3 Sequence: ATAATTAATAATCGTTTTT Position: -62 Score: 4.8 Sequence: AATAATCGTTTTTATTATC Locus tag: APP7_1104 Name: hugZ Funciton: Putative heme iron utilization protein Locus tag: APP7_1103 Name: hgp Funciton: Probable hemoglobin and hemoglobin-haptoglobin-binding protein, TonB-dependent receptor
	APP7_1104	hugZ	Putative heme iron utilization protein
	APP7_1103	hgp	Probable hemoglobin and hemoglobin-haptoglobin-binding protein, TonB-dependent receptor
Position: -65 Score: 4.3 Sequence: TGTTTTGATAATGATTATT Position: -59 Score: 4.7 Sequence: GATAATGATTATTAATAAG Locus tag: APP7_0708 Name: COG2822 Funciton: Predicted periplasmic lipoprotein involved in iron transport Locus tag: APP7_0709 Name: COG2387 Funciton: Predicted iron-dependent peroxidase Locus tag: APP7_0710 Name: ftr1 Funciton: High-affinity Fe2+/Pb2+ permease
	APP7_0708	COG2822	Predicted periplasmic lipoprotein involved in iron transport
	APP7_0709	COG2387	Predicted iron-dependent peroxidase
	APP7_0710	ftr1	High-affinity Fe2+/Pb2+ permease
Position: -56 Score: 4.1 Sequence: TTAAATGCTAATAATTTTT Locus tag: APP7_2100 Name: fhuC Funciton: Ferrichrome ABC transport system, ATP-binding protein Locus tag: APP7_2101 Name: fhuD Funciton: Ferrichrome ABC transport system, periplasmic component Locus tag: APP7_2102 Name: Asuc_1018 Funciton: Ferrichrome ABC transport system, permease protein Locus tag: APP7_2103 Name: fhuA Funciton: Ferrichrome-iron receptor, TonB-dependent
	APP7_2100	fhuC	Ferrichrome ABC transport system, ATP-binding protein
	APP7_2101	fhuD	Ferrichrome ABC transport system, periplasmic component
	APP7_2102	Asuc_1018	Ferrichrome ABC transport system, permease protein
	APP7_2103	fhuA	Ferrichrome-iron receptor, TonB-dependent
Position: -240 Score: 4.1 Sequence: TCAAATGATAAAGATTCTC Position: -234 Score: 4.5 Sequence: GATAAAGATTCTCATTTGT Position: -183 Score: 5.2 Sequence: GAGAATTATTATCATTAAC Locus tag: APP7_1484 Name: tyrS Funciton: Tyrosyl-tRNA synthetase (EC 6.1.1.1)
	APP7_1484	tyrS	Tyrosyl-tRNA synthetase (EC 6.1.1.1)
Position: -202 Score: 4.1 Sequence: ATATTTGATTATAATTAAT Locus tag: APP7_0149 Name: nrdB Funciton: Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1) Locus tag: APP7_0150 Name: nrdA Funciton: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
	APP7_0149	nrdB	Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)
	APP7_0150	nrdA	Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)
Position: -76 Score: 4.2 Sequence: ATTGATAAGAATCAATATC Position: -70 Score: 4.7 Sequence: AAGAATCAATATCATTTAC Locus tag: APP7_1583 Name: hutW Funciton: Radical SAM family protein HutW, similar to coproporphyrinogen III oxidase, oxygen-independent, associated with heme uptake / Putative heme iron utilization protein # hutX Locus tag: APP7_1582 Name: COG0702 Funciton: hypothetical protein
	APP7_1583	hutW	Radical SAM family protein HutW, similar to coproporphyrinogen III oxidase, oxygen-independent, associated with heme uptake / Putative heme iron utilization protein # hutX
	APP7_1582	COG0702	hypothetical protein

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Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes -- version 3.2 --

Regulon of Fur in Actinobacillus pleuropneumoniae serovar 7 str. AP76

Collection of Manually Curated Inferences of Regulons in Prokaryotic Genomes
-- version 3.2 --