Collection of regulogs for FUR transcription factor

Transcription factor Fur (Ferric Uptake Regulator) controls iron homeostasis in diverse taxonomic groups of Bacteria. In the classical Fur regulation paradigm, Fur binds ferrous ions and the dimeric Fe2+?Fur complex (holo-Fur) recognizes target sequences upstream of iron-regulated genes and represses their transcription [19130263, 17216355]. In addition to regulating genes involved in iron homeostasis, Fur has been shown to play an important role in the modulation of bacterial virulence, acid, nitrosative, and oxidative resistances, and redox metabolism [17216355, 19854902, 12746439, 19520766]. more

Fur proteins consistently fold into two domains consisting of an N-terminal DNA-binding domain linked by a hinge region to a C-terminal dimerization domain. In contrast to the common fold of these proteins, the coordination, number, and geometry of the metal binding sites within Fur-family proteins diverge. Comparative genomic analysis identified DNA binding motifs of Fur in taxonomic groups of alpha-proteobacteria [17173478], gamma-proteobacteria [11812853], Delta-proteobacteria [15535866], Firmicutes [23504016, 23398941, 21531804]. Despite the observed difference in the Fur regulon content, the consensus sequences of the Fur-binding sites are well-conserved in various lineages of Bacteria.